RU2692249C2 - Dentifrice based on metal ions with low water content - Google Patents

Abstract

FIELD: hygiene.SUBSTANCE: invention refers to dental care products. Disclosed dental care composition contains in one phase: water in amount of 0 to less than 4 wt% of composition weight; a source of metal ions, wherein the metal ion source contains 0.454 wt% tin fluoride and 2 wt% zinc citrate of weight of composition; at least one polyphosphate salt having four or more phosphorus atoms and selected from a group comprising sodium hexapyrophosphate and sodium hexapolyphosphate; and a thickener consisting of cross-linked polyvinylpyrrolidone. At least one polyphosphate salt is contained in amount of 1–10 wt% of composition weight; cross-linked polyvinylpyrrolidone in amount of 0.05 to 15 wt% of composition weight. Composition is presented in form of paste or gel.EFFECT: composition of a composition containing an effective combination of ion sources of bivalent tin, fluorine and zinc with polyphosphates containing 4 or more phosphorus atoms, in a single-phase system with low water content using cross-linked polyvinylpyrrolidone as a single thickening agent provides constant viscosity of the composition, low enough for storage of composition for a long storage life.9 cl, 1 tbl, 1 ex

Description

Technical field

Embodiments of the present invention relate to dentifrice compositions. In particular, the present embodiments of the invention relate to teeth care compositions with a small volume of the aqueous phase containing significant amounts of antimicrobial reagents - divalent tin, copper and zinc ions contained in water-soluble polyphosphates in order to reduce the binding properties and corrosion associated with metal ions. The formulations include a thickener consisting of cross-linked polyvinylpyrrolidone and providing excellent rheological properties.

The level of technology

Polyphosphates are used in dental care products to promote oral health. Polyphosphates are known as anti-tartar agents to help prevent the formation of stones. Metal ions, such as bivalent tin ion or zinc ion, are known as effective antimicrobial agents. These ions prevent inflammation of the gums and the formation of plaque and can also improve breathing and reduce sensitivity. Bivalent tin fluoride has been used in dentistry since the 1950s as a source of fluoride to prevent dental caries. Similarly, zinc citrate has the ability to prevent the formation of plaque, inflammation of the gums and the formation of stones. In addition, zinc is also effective as an agent for eliminating bad breath.

During the use of the above active substances in the means for the care of teeth, it was proved the prospect of sharing these active substances in one stable phase. The only technical problem is the preservation of the bioavailability of divalent tin ions and the maximum increase in chemical stability of the divalent tin ion source. Some polyphosphates are not stable in high water content systems. Polyphosphates of this kind in aqueous systems are prone to hydrolysis, except when the medium has a high pH, which is not compatible with the high bioavailability of divalent tin. Bivalent tin fluoride in aqueous media has a tendency to form a precipitate with metal ions, thus reducing the effectiveness of metal ions in oral care compositions. In addition, in compositions for caring for the oral cavity, polyphosphates react with fluoride ions at room temperature to produce monofluorophosphate ions and a change in the pH of the composition. This reaction adversely affects the effectiveness of oral care compositions and leads to the formation of stable ionic fluorides and polyphosphates on the surfaces of the oral cavity.

Other attempts to improve the effectiveness of this kind of dentifrice compositions have been reduced to reducing the amount of water presented in the composition. The decrease in the amount of water should theoretically reduce or eliminate stability problems associated with fluorides, polyphosphates and other ionic active substances. However, reducing the water level and the optional replacement of its entire volume or part of it with a wetting agent creates problems in obtaining acceptable rheological and sealing qualities in the composition. When reducing the amount of water, which is a highly polar solvent, standard thickeners, such as carboxymethyl cellulose (CMC), tend to thicken rapidly. Attempts to reduce the water content in dentifrice compositions include dentifrices that are described, for example, in European Patent 0638307 B1; US Pat. No. 4,647,451; and US Pat. No. 5670137. Known compositions of this kind have demonstrated the ability to progressively thickening in time, which prolongs the time period or even prevents the formation of a rheologically stable state of dental care products. Ideally, it would take two weeks for a consumer to recognize a dentifrice formulation to form a steady state. If the viscosity of the composition increases steadily over time, the delivery of the composition becomes difficult, which may cause consumer discontent to a probable degree.

In this document, the description of some of the advantages and disadvantages of the known compositions, methods and apparatus is not intended to limit the scope of the embodiments of the present invention to exclude them (or to include them, if possible). Indeed, some variations may include one or more well-known compounds, methods, or apparatus without the disadvantages described above.

Brief description of the invention

Based on the level of technology, there is a need to obtain compositions for the care of teeth, effectively combining sources of divalent tin ions, fluorides and zinc ions with polyphosphates containing 4 or more phosphorus atoms in a single-phase system with low water content, which has the ability to effectively release from unstable water active ingredients and / or active substances that react with each other in the same phase. There is also a need for single-phase, low-water dental care compositions having improved rheological properties.

Additional areas of applicability of the present invention will be disclosed in the detailed description provided hereinafter. The applicant notes that the detailed description and specific examples pointing to the preferred embodiment of the present invention are given in this document for the purpose of illustration only and not for the purpose of limiting the scope of the present invention.

Detailed description of embodiments

The following description of preferred embodiments is provided for illustrative purposes only, and not for the purpose of limiting the present invention, its application or application. All percentages used hereafter are weight ratios of preferred components, unless otherwise indicated. All measurements were made at 25 ° C, unless otherwise specified. Throughout the document, the series shown are used as abbreviations to describe each value within the series. Any value inside the series can be selected as the final value of the series.

A dentifrice composition is a product that is not deliberately swallowed with the usual method of application for the purpose of systemic use of certain therapeutic agents, but is delayed in the oral cavity for a time sufficient for significant contact with the surface of the teeth and / or tissues of the mouth for activity in the cavity mouth According to the present invention, the dentifrice composition can be provided in the form of a toothpaste or dentifrice. By the term “dentifrice”, as used herein, the applicant understands pasta or gel formulations unless otherwise indicated. Composition for the care of teeth can be represented in any desired form, for example, to have deep stripes, surface stripes, layering, gel around the paste or a combination of them.

By the term "aqueous carrier" as used herein, the applicant understands any safe and effective material for use in the compositions of the embodiments of the present invention. Such materials include thickeners, moisturizers, ionic active ingredients, buffering agents, anti-tartar agents, abrasive polishing materials, peroxide sources, alkali metal bicarbonates, surfactants, titanium dioxide, dyes, flavors, sweeteners, antimicrobial agents , herbal agents, desensitizing agents, agents that reduce plaque on the teeth and their mixtures.

The embodiments of the present invention described herein relate to a dentifrice composition having a phase with low water content and containing an oral carrier, a source of fluoride ions, a source of zinc ions, and at least one polyphosphate. The polyphosphate may be an inorganic polyphosphate containing 4 or more phosphorus atoms. The total water content in the composition for the care of teeth can reach at least about 6% of the total weight of the composition.

The carrier may include a thickener containing at least one crosslinked polyvinylpyrrolidone. A crosslinked polyvinylpyrrolidone may contain a homopolymer of N-vinyl-2-pyrrolidone. Cross-linked polyvinylpyrrolidone may contain from 0.05 to 15% (mass.) By weight of the composition, preferably from 0.75 to 1.25% (mass.) By weight of the composition.

At least one polyphosphate may be selected from the group consisting of alkali metal pyrophosphate or tripolyphosphate, preferably at least one polyphosphate is selected from the group consisting of sodium hexaprophosphate or sodium hexapolyphosphate. At least one polyphosphate may contain a mixture of sodium hexaprophosphate and sodium hexapolyphosphate, and preferably, a mixture of sodium hexaprophosphate and sodium hexapolyphosphate containing sodium hexaprophosphate and sodium hexapolyphosphate in a ratio of 2: 3 by weight. At least one polyphosphate may contain from 1 to 10% (mass.) By weight of the composition, preferably from 3 to 7% (mass.) By weight of the composition.

Preferably, the source of fluoride ions and the source of ions of divalent tin includes fluoride of divalent tin. Preferably, the zinc ion source contains a salt of zinc and an organic acid, more preferably zinc citrate. The zinc ion source may also contain a zinc compound, including, for example, zinc oxide, zinc tartrate, zinc gluconate, and the like.

In a dentifrice composition, the composition may also contain at least one moisturizer selected from the group consisting of glycerin, polyethylene glycol, propylene glycol, and mixtures thereof.

Preferably, the composition also contains a water buffer system as a source of divalent tin ions. Preferably, the buffer system is adapted to chelate divalent tin ions in the composition. The buffer system may contain at least one organic acid or its alkali metal salt, the organic acid is preferably citric acid. The buffer system may contain a mixture of citric acid and sodium citrate. The composition may contain a buffer system in an amount of from 1 to 5% (mass.) By weight of the composition. The buffer system can be represented, by weight, in an amount greater than the amount of the divalent tin ion source, by weight.

The present invention also provides a dentifrice composition containing in one phase an oral carrier, a carrier comprising a thickener containing a thickener containing crosslinked polyvinylpyrrolidone, where the total water content of the dentifrice composition is less than about 10% of the total mass composition.

Not intentionally limited to any method of use, the present applicants believe that the addition of a specific thickener, including cross-linked polyvinylpyrrolidone, makes it possible to achieve a single-phase, low-viscosity dental care composition that is low enough to store the dental care composition in over a long shelf life. Without being limited to any technique, the applicant believes that the addition of cross-linked polyvinylpyrrolidone makes it possible to hydrate a thickener containing cross-linked polyvinylpyrrolidone in a system with a low water content, which allows the process of complete primary hydration of the polymer to be carried out during the manufacture of a dental care composition.

The options described in this document represent a dentifrice composition containing, in one phase, an oral carrier, a source of fluoride ions, a source of divalent tin ions, a source of zinc ions and at least one polyphosphate selected from the group consisting of inorganic polyphosphates containing 4 or more phosphorus atoms; where the total water content in the composition for the care of teeth is less than 10% by weight of the entire composition.

As will be demonstrated in this document, the preferred options are a dentifrice agent that has many therapeutic benefits by combining divalent tin ions and fluoride ions, for example, tin divalent fluoride and zinc ions, for example, zinc citrate and polyphosphates, for example, sodium hexaprophosphate / sodium hexapolyphosphate. The use of a specific buffer system can stabilize divalent tin ions in the presence of zinc ions and polyphosphates, without affecting the activity of divalent tin ions in a single-phase composition with low water content, for effective antimicrobial action during tooth brushing.

Preferred embodiments of the present invention may also represent a dentifrice composition containing a stable source of divalent tin ions and a polyphosphate, for example, sodium hexaprophosphate and / or sodium hexapolyphosphate, in a single tube.

Preferred embodiments of the present invention may also be a low-water dental care system combining tin bivalent fluoride, zinc citrate and polyphosphates, in particular having 4 or more phosphorus atoms, for example sodium hexaprophosphate and / or sodium hexapolyphosphate, in one tube single-phase system that ensures the bioavailability of tin, zinc, fluoride and polyphosphate on the surfaces of the oral cavity.

While the description of the invention contains conclusions with specifically noted statements that specifically characterize the invention, the applicant considers that the present invention will be better understood from the following description of preferred embodiments thereof.

Polyphosphate source

The present embodiments of the present invention may include a source of polyphosphates. Polyphosphates are known to prevent the formation of tartar. However, it is also known that polyphosphates with an average chain length of 4 or more atoms in oral compositions react at room temperature with ionic fluorides to form monofluorophosphate ions, as well as a change in the pH of the composition. This reaction can reduce the effectiveness of the composition for oral administration and suppress the formation of stable fluoride ions and polyphosphates on the surfaces of the oral cavity. It is also known that a necessary condition for the formation of a stable polyphosphate is the control of the total water content and the pH of the dentifrice composition in order to reduce the hydrolysis of the polyphosphate.

Typically, a polyphosphate consists of two or more phosphate molecules, mostly in a linear configuration, although cyclic derivatives may also be present. According to the present invention, preferred inorganic polyphosphates, preferably alkali metal salts, used in dentifrice compositions, have 4 or more phosphorus atoms, such as pyrophosphate, for example, sodium hexaprophosphate or polyphosphate, for example, sodium hexapolyphosphate. These polyphosphates may be used alone or in any combination thereof.

The effective amount of polyphosphate source may be from about 0.1% to about 30%; preferably, from about 1% to about 26%; more preferably, from about 4% to about 20% and, most preferably, from about 5% to about 13% by weight of the total dentifrice composition. A typical range is from about 1% to about 10% by weight of the total dentifrice composition, more typically from about 3% to about 7% by weight of the total dentifrice composition.

Water carriers

During the preparation of the present compositions, it is desirable to add one or more aqueous carrier to the composition. Such materials are well known in the art and are easily chosen by a person skilled in the art based on their physical and aesthetic qualities desired for preparing the compositions. The content of aqueous carriers is usually from about 40% to about 99%, preferably from about 70% to about 98%, and more preferably from about 90% to about 95% of the total weight of the dentifrice composition.

Total water content

The water used to make orally formulated compositions on an industrial scale should preferably contain a low amount of ions and should be free from organic impurities. In a dentifrice composition, water is preferably less than about 6%, and preferably from about 0% to less than 4% of the total weight of the composition of the present invention. The polyphosphates and active substances, such as fluoride and divalent tin, of the present invention do not dissolve in compositions with such a low level of water. However, these components can be dissolved in the present compositions in other weakly polar solvents with the formation of non-ionic molecular structures. In this and in another case, the active substances in the compositions remain stable during storage. If fluoride ions and divalent tin ions are present in the composition, they are released from their salts or non-ionic soluble forms during the interaction with saliva and / or water during tooth brushing. Therefore, there is no need to physically separate the polyphosphate-containing part of the composition from the active ionic part of the composition, for example, by using a package divided into two compartments. In addition, fluoride ion from a variety of different sources can be effectively used in the present composition; the applicant does not prefer the use of sodium monofluorophosphate as a source of fluoride ions, described previously in US Pat. 6190644, "Compositions for the care of the oral cavity, containing polyphosphate and sodium monofluorophosphate" as the most appropriate.

The water contained includes unbound water added in addition to water introduced with other materials such as silica, surfactant solutions and / or dye solutions.

Humidifier

A moisturizer is needed to prevent toothpaste formulations from hardening during use in air; some moisturizers can also give your toothpaste compositions the desired sweet taste. Humidifiers suitable for use in the invention include glycerin, sorbitol, polyethylene glycol, propylene glycol, xylitol and other food polyols. Preferred are glycerin, polyethylene glycol, polypropylene glycol and mixtures thereof, especially mixtures thereof. The content of the humidifier is usually from about 0.1% to 70%, preferably from about 1% to about 60% and more preferably from about 15% to 55% of the total weight of the composition.

The applicant believes that the humidifier significantly affects the viscosity of a substance with a low water content. For example, when used in a polysaccharide thickener in a composition, the viscosity of a substance increases with increasing levels of glycerol or polyethylene glycol. Conversely, the viscosity of the substance decreases with decreasing levels of propylene glycol in the composition.

Ion active component

According to the present invention, the dentifrice compositions preferably contain an effective amount of an ionic active component selected from the group consisting of a source of fluoride ions, a source of divalent tin ions, a source of zinc ions, and mixtures thereof.

Fluoride ion source

In this document, the fluoride ion source is a soluble fluoride ion source that provides free fluoride ions. Soluble fluoride ion sources include sodium fluoride, stannous fluoride, indium fluoride, zinc fluoride, and sodium monofluorophosphate. Sodium fluoride and stannous bivalent fluoride are preferred soluble sources of fluoride ions. Norris et al., US Pat. No. 2946725, published July 26, 1960, and Widder et al., US Pat. 3678154, published July 18, 1972, disclose this kind of fluoride ion sources in the same way as others.

Preferably the presence in these compositions of the source of fluoride ions in the form of solids, dispersed during storage prior to use of the composition by the consumer for cleaning teeth. The water level in these compositions is too low to dissolve the source of fluoride ions in the composition during storage. Therefore, during storage, the visible interaction between the fluoride ion and the polyphosphate or silica, if present, is not observed, which ensures the stability of the composition during storage. During the interaction of the composition with saliva and / or water during brushing, it is preferable to disperse the fluoride ion source and release the active ions in the mouth.

These compositions may contain a soluble fluoride ion source providing from about 50 ppm (parts per million) to about 3500 ppm, preferably from about 500 ppm to about 3000 ppm free fluoride ions. To provide the desired amount of fluoride ions, the fluoride ion source can be present in an amount of about 0.1% to about 5%, preferably from about 0.2% to about 1%, and more preferably from about 0.3% to about 0.6% of the total weight of the dentifrice composition.

Metal ion source

The present invention may contain a source of metal ions providing ions of divalent tin, zinc ions, copper ions, and mixtures thereof. The source of metal ions may be a soluble or insoluble compound of divalent tin or zinc with inorganic or organic counterions. Examples include fluoride, chloride, fluoride chloride, acetate, hexafluorozirconate, sulfate, tartrate, gluconate, citrate, malate, glycinate, pyrophosphate, metaphosphate, oxalate, phosphate, carbonate and oxides of divalent tin and zinc. Sources of metal ions include copper bisglycinate, copper glycinate, zinc citrate, and zinc lactate.

The ions of divalent tin and zinc have been found to help reduce gum inflammation, plaque formation, sensitivity and improve breathing. Polyphosphate does not reduce the effectiveness of these metal ions in the present compositions.

The divalent ions of tin and zinc are obtained from the source (s) of metal ions represented in the composition for the care of teeth in effective amounts. An effective amount is from at least about 1000 ppm (parts per million) of metal species, preferably from about 2000 ppm to about 15000 ppm. More preferably, the metal ions are present in an amount from about 3,000 ppm to about 13,000 ppm, and even more preferably from about 4,000 ppm to about 10,000 ppm. This is the total amount of metal ions (divalent tin and zinc, and mixtures thereof) represented in the compositions to provide surfaces of the oral cavity.

Preferably, the metal ion sources in the present compositions are not fully ionized in the composition during storage, prior to the consumer using the composition for cleaning teeth. The water level in the present composition is too low to dissolve the source of metal ions in the composition during storage. But some salts, such as stannous chloride and stannous fluoride, can be dissolved in glycerol or propylene glycol. Both humidifiers can provide strong protection for the stability of these kinds of salts of divalent tin and can also provide better palatability compared to an aqueous solution of divalent tin. During the interaction of the composition with saliva and / or water during tooth brushing, the ion source of divalent tin is completely ionized and provides the oral cavity with active ions.

Teeth care products containing divalent tin ions, in particular tin fluoride and divalent tin chloride, are described in US Pat. 5004597, Majeti et al. Other descriptions of dentifrices containing salts of divalent tin are provided in US Pat. 5578293. Preferred salts of divalent tin are divalent fluoride of tin and chloride of divalent tin divalent. Other suitable salts of divalent tin include divalent tin acetate, divalent tin tartrate and sodium citrate and divalent tin. Examples of suitable zinc ion sources are zinc oxide, zinc sulfate, zinc chloride, zinc citrate, zinc lactate, zinc gluconate, zinc malate, zinc tartrate, zinc carbonate, zinc phosphate, and other salts listed in US Pat. 4022880.

Combined metal ion sources are present in an amount from about 0.25% to about 11% by weight of the total composition. Preferably, the metal ion sources are present in an amount from about 0.4% to about 7%, more preferably from about 0.45% to about 5%.

Buffering agent

The compositions described herein may also contain a buffering agent in addition to a chelating agent for divalent tin ions, used, as described above, as a pre-mixed mixture. In this document, buffering agents refer to agents used to maintain the pH of the compositions in the range of from about pH 3.0 to about pH 10. The liquid phase of the dentifrice containing divalent tin usually has a pH from about 3.0 to about 5 , 5, preferably from about 3.25 to about 5, and more preferably from about 3.4 to about 4.5. The liquid phase of the composition for the care of teeth, containing polyphosphate, usually has a pH from about 4.0 to about 10, preferably from about 4.5 to about 8, and more preferably from about 5.0 to about 7.0. A dentifrice containing both divalent tin and polyphosphate in one phase typically has a pH of from about 4 to about 7, preferably from about 4.5 to about 6, and more preferably from about 5 to about 5.5.

Buffering agents include alkali metal hydroxides, ammonium hydroxide, organic ammonium compounds, carbonates, sesquicarbonates, borates, silicates, phosphates, imidazole, and mixtures thereof. Specific buffering agents include sodium monophosphate, sodium triphosphate, sodium benzoate, benzoic acid, sodium hydroxide, potassium hydroxide, alkali metal carbonates, sodium carbonate, imidazole, pyrophosphates, citric acid, and sodium citrate. The buffering agents are contained in an amount from about 0.1% to about 30%, preferably from about 0.1% to about 10%, and more preferably from about 0.3% to about 3% of the total weight of the present composition. If bivalent tin is present in the composition, the preferred buffering agents are sodium hydroxide, potassium hydroxide and ammonium hydroxide.

Anti-tartar

The compositions described herein may also contain polyphosphates as anti-tartar agents, effectively reducing the deposition of mineral calcium phosphates associated with the formation of tartar. Agents include pyrophosphates and tripolyphosphates. The compositions may also contain synthetic anionic polymers [including polyacrylates and copolymers of maleic anhydride or acid and methyl vinyl ether (for example, GANTREZ®), as described, for example, in US Pat. 4627977, Gaffar et al .; as well as, for example, polyaminopropanesulfonic acid (AMPS)], zinc citrate trihydrate, diphosphonates (eg, EHDP; AHP), polypeptides (such as polyaspartic or polyglutamic acid), and mixtures thereof.

Materials for abrasive polishing

Material for abrasive polishing can also be included in the composition of toothpastes. Materials for abrasive polishing, suitable for use in the compositions of the present invention, can be any material that does not severely damage dentin. Typically, abrasive polishing materials include silica, including gels and sludges; alumina; phosphates, including orthophosphates, polymetaphosphates and pyrophosphates; and mixtures thereof. Specific examples include dicalcium dihydrogen phosphate, calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, insoluble sodium polymetaphosphate, aluminum hydroxide, beta-calcium pyrophosphate, calcium carbonate, and resinous abrasive materials such as partial urea condensation products and formaldehyde, and other. described in US Pat. No. 3070510, Cooley et al., Published December 25, 1962. Mixtures of abrasive materials may also be used. If the dentifrice composition or its separate phase contains a polyphosphate with an average chain length of 4 or more atoms, the preferred abrasive materials do not include calcium-containing abrasive materials and alumina. The most preferred abrasive material is silica.

Silicon dioxide-based materials for abrasive polishing of teeth of various types are preferred due to their unique advantages: excellent tooth brushing and polishing without excessive damage to the tooth enamel and dentin. In this document, the average particle size of abrasive materials based on silica, as well as other abrasive materials, is usually from about 0.1 to about 30 microns, and preferably from about 5 to about 15 microns. Abrasive materials may be precipitated silica or silica gels, such as silica-based xerogels, as described in US Pat. 3538230, Pader et al., Issued March 2, 1970., and DiGiulio, US Pat. 3862307, published January 21, 1975. Preferred silica-based xerogels are xerogels available under the trade name "SYLOID®" W.R. Grace & Company, Davidson Chemical Division. Also preferred are precipitated silica-based materials, such as those sold under the trade name “ZEODENT®”, J.M. Huber Corporation, in particular a silica-based material called "Zeodent 119". A variety of silica-based abrasive polishing materials used in the toothpastes of the present invention are described in more detail in Rice, U.S. Pat. 5589160; 5603920; 5651958; 5658553 and 5716601. The abrasive materials of the toothpaste compositions described herein are generally present in an amount from about 6% to about 70% by weight of the entire composition. Preferably, the toothpastes contain abrasive materials in an amount from about 10% to about 50% by weight of the entire dentifrice composition.

Peroxide source

The composition of the present invention may include a source of peroxide. The peroxide source is selected from the group consisting of hydrogen peroxide, calcium peroxide, urea peroxide, and mixtures thereof. The preferred source of peroxide is calcium peroxide. The following amounts are the quantities of raw material peroxide, however, the source of peroxide may also contain components other than raw material peroxide. The amount of peroxide source in the present composition may be from about 0.01% to about 10%, preferably from about 0.1% to about 5%, more preferably from about 0.2% to about 3%, and more preferably from about 0 , 3% to about 0.8% by weight of the composition for the care of teeth.

Alkali Metal Bicarbonate

The compositions may also include an alkali metal bicarbonate. Water soluble and unstable alkali metal bicarbonates tend to release carbon dioxide in aqueous systems. Sodium bicarbonate, also known as baking soda, is the preferred alkali metal bicarbonate. Alkali bicarbonate also functions as a buffering agent. The alkali metal bicarbonate content of the present composition may be from about 0.5% to about 50%, preferably from about 0.5% to about 30%, more preferably from about 2% to about 20%, and more preferably from about 5% up to about 18% by weight of the composition for the care of teeth.

Additional water carriers

The compositions may also include surfactants, also commonly related to foaming agents. Suitable surfactants are moderately stable and foam forming in a wide pH range. The surfactant may be anionic, non-ionic, amphoteric, zwitterionic, cationic, or a mixture thereof. The anionic surfactants used herein include water-soluble alkyl sulfates having from 8 to 20 carbon atoms in the alkyl radical (eg, sodium alkyl sulfate), and water-soluble sulfonated monoglycerides of fatty acids having from 8 to 20 carbon atoms. Sodium lauryl sulfate and coconut monoglyceride sodium sulfate are examples of anionic surfactants of this type. Other suitable anionic surfactants are sarcosinates, such as sodium lauryl sarcosinate, taurates, sodium lauryl sulfoacetate, sodium lauryl isethionate, sodium laureth carboxylate and sodium dodecyl benzenesulfonate. Mixtures of anionic surfactants may also be used. Many suitable anionic surfactants are disclosed in U.S. Pat. 3959458, Agricola et al., Published May 25, 1976.

Titanium dioxide may also be added to this composition. Titanium dioxide is a white powder, giving the compositions turbidity. Titanium dioxide generally comprises from about 0.25% to about 5% by weight of the total composition.

Dyes may also be added to the present composition. The dye may be presented in the form of an aqueous solution, preferably 1% dye in a solution of water. Dye solutions generally comprise from about 0.01% to about 5% by weight of the composition.

Flavoring systems may also be added to the present composition. Suitable flavoring agents include oil of wintergreen, peppermint oil, spearmint oil, clove oil of flower buds, menthol, anethole, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, parsley oil, oxanone, alpha-irisone, marjoram , lemon, orange, propenylgvaetol, cinnamon, vanillin, ethyl vanillin, heliotropin, 4-cis-heptenal, diacetyl, methyl para-tert-butyl phenylacetate, and mixtures thereof. Refrigerants can also be part of a flavoring system. Preferred refrigerants in the present composition are para-aminocarboxyamide-based agents, such as N-ethyl-p-menthane-3-carboxamide (known as "WS-3") and mixtures thereof. Typically, the flavor system comprises from about 0.001% to about 5% by weight of the composition.

Sweeteners can also be added to the present composition, including saccharin, dextrose, sucrose, lactose, xylitol, maltose, levulose, aspartame, sodium cyclamate, D-tryptophan, dihydrochalcones, acesulfame, and mixtures thereof. Various dyes may also be included in the present invention. Sweeteners and dyes are usually used in toothpastes in an amount from about 0.005% to about 5% by weight of the composition.

The present invention may also include other agents, such as additional antimicrobial agents. This kind of means included into the composition are water insoluble non-cationic antimicrobial agents such as halogenated diphenyl ethers, phenolic compounds including phenol and its homologs, mono and polyalkyl and aromatic galofenoly, resorcinol and its derivatives, bisphenolic compounds and halogenated salicylanilides, benzoic ethers and halogenated carbanilides, polyphenols and herbs. Water-soluble antimicrobial agents include quaternary ammonium compounds, including those where one or two of the substituents on quaternary nitrogen have a carbon chain (usually an alkyl group) of from about 8 to about 20 carbon atoms, usually from about 10 to about 18 carbon atoms, while the remaining substituents (usually alkyl or benzyl groups) have fewer carbon atoms, for example, from about 1 to about 7 carbon atoms, usually methyl or ethyl groups. Dodecyl trimethylammonium bromide, tetradecylpyridinium chloride, domiphene bromide, methane pyridinium tetradecyl-4-ethyl chloride, dodecyl dimethyl (2-phenoxyethyl) ammonium bromide, benzyldimethyl stearyl ammonium chloride, methane cetyl methyl bromide, ammonium benzyl dimethyl stearyl ammonium chloride, methylated bromide ethylhexyl) -5-methyl hexahydropyrimidine, benzalkonium chloride, benzene chloride and methylbenzene chloride are examples of typical quaternary ammonium antibacterial agents. Other compounds are the bis [4- (R-amino) -1-pyridium] alkanes disclosed in US Pat. 4206215, Bailey, published June 3, 1980.

Enzymes are also used, including endoglycosidase, papain, dextranase, mutanase, and mixtures thereof. Such remedies are described in US Pat. 2946725, Norris et al. of July 26, 1960, US Patent 4,051,234, Gieske et al. September 27, 1977. Specific antimicrobial agents include chlorhexidine, triclosan, triclosan monophosphate, and aromatic oils such as thymol. Triclosan is the preferred antimicrobial agent for inclusion in the present compositions. Triclosan and other drugs of this type are described in US Pat. 5015466, Parran et al., Issued May 14, 1991 and US Pat. 4894220, Nabi et al. from January 16, 1990. Water-insoluble antimicrobial agents, water-soluble agents and enzymes can be presented in both the first and second dental care compositions. In the second dentifrice composition, quaternary ammonium agents, salts of divalent tin, and substituted guanidines are preferably presented. These agents may be present in an amount from about 0.01% to about 1.5% by weight of the dentifrice composition.

Herbal remedies, including but not limited to gold extract, honeysuckle extract, and mixtures thereof, can also be represented in the compositions of this document in an amount from about 0.01% to about 0.05%. It is believed that this kind of herbal remedies have antibacterial activity. Polyphenols can also be included in compositions in an amount from about 0.01% to about 2%. The preferred polyphenol is tea polyphenol.

Effective amounts of a desensitizing agent may also be added to the present compositions. Desensitizing agents include substances selected from chlorides, alkali metal sulphate nitrate, or group II or aluminum metal acetates, or polymerizable monomer to seal tubes, ammonium or alkali metal nitrate, ammonium oxylate, citric acid and sodium citrate. Preferred salts are potassium nitrate, potassium citrate, and mixtures thereof. Such desensitizing agents are described, for example, in US Pat. 5718885.

In compositions containing divalent tin, a dye such as polyvinylpyrrolidone (GDG) or aluminum hydroxide can also be added. Preferably, the PVP has an average molecular weight of from 10,000 to 700,000. In this document, small and medium molecular weights (from about 10,000 to about 100,000) are preferred. In order to reduce the effectiveness of the dye, the PVP level is preferably from about 0.5% to about 10%, more preferably from about 1.0% to about 7%, and even more preferably from about 1.5% to about 5.0% .

Compositions for the care of teeth can be in the form of a paste, gel or any configuration or combination thereof. A dispensing device for a dentifrice composition can be a tube, pump, or any other container suitable for dispensing toothpaste.

Ways to use

To implement the embodiments of the invention, the consumer only needs to apply the dental care composition described herein on the surfaces of human or animal teeth to desired areas in order to achieve the desired effect, for example, bleaching, breath freshening, caries prevention, pain relief, healing gums, prevention of tartar, erosion control, etc. The use of dental care products to combat erosion of tooth surfaces or prevent demineralization is described, for example, in US Pat. 6685920, the full content of which is hereby incorporated into this application by reference. Compositions can also be applied to other oral surfaces, such as gum tissue and mucous membranes, although it is believed that the benefits of the present composition are best achieved when applying the dentifrice compositions to the surface of the teeth. The dentifrice composition may be in contact with the teeth and / or the surface of the oral cavity, either directly or indirectly, however, it is preferable to directly apply the dentifrice composition. Composition for the care of teeth can be applied in any way, but preferably its application with a toothbrush or by rinsing with a solution for the care of teeth.

According to the present invention, the manufacture of an oral composition can be carried out by any of various techniques of manufacturing such compositions. To form a dentifrice, the carrier may contain a humectant, for example, one or more, selected from the series: glycerin, glycerol, sorbitol, and propylene glycol; thickener and antibacterial agent; then the carrier is mixed with a polishing agent, as well as with fluorides, with preliminary mixing. At the end, add flavoring, and adjust the pH in the range from 6.8 to 7.0.

The following examples also illustrate the preferred embodiments of the present invention, but do not limit it.

Example 1

Compositions for the care of teeth were prepared from the compositions described in Table 1.

Table 1 COMPONENT Formula A Formula B Polyethylene glycol 600 ten ten Glycerol 49,946 49,946 Hexametaphosphate eight eight Divalent Fluoride Tin 0.454 0.454 Zinc Citrate 2 2 Deionized water 3 3 Sodium Saccharin 0.3 0.3 Crospovidone 4.5 0 Carrageenan 0 4.0 Xanthan 0 0.5 Zeodent 114 15 15 Zeodent 165 3 3 Titanium dioxide one one Sodium lauryl sulfate 1.5 1.5 Flavoring 1,3 1,3 TOTAL 100 100 Rheology (cps) 191,400 46,400

Each of the compositions contains 0.454% (mass.) Bivalent tin fluoride, 2% (mass.) Zinc citrate and a polyphosphate system for preventing the appearance of tartar, containing 8% (mass.) Hexametaphosphate.

Compositions in accordance with Formula A and Formula B contain various thickeners. The rheological properties of the formulations were tested to determine viscosity. The viscosity of each compound was determined using a Brookfield Viscometer RVT or RVTDV, associated with the Brookfield Spiral Motion Rack, using an RV T-Bar Spindle Set. Viscosity parameters were determined on a 1200 line instrument. (Brookfield Engineering Laboratories, Stroughton, Ma.) The Brookfield viscosity of the composition was measured under ambient conditions, the results are shown in Table 1. It can be seen that in the prior art thickeners formed a product with insufficient viscosity whereas the product of the present invention has a suitable level of viscosity.

In addition, it can be noted that the thickener, used in accordance with the preferred embodiments of the present invention, contributed to the achievement of the used rheological state.

Throughout the document, intervals are used to shorten the description of each value falling within a given interval. Each value within the interval can be selected as the final value of the interval. In addition, all references used in this document are hereby incorporated into this application in its entirety. In the event of a conflict between the meaning of the present description and the description mentioned in the reference, the priority belongs to the present description.

Unless otherwise indicated, all percentages and quantities used in this document and elsewhere in the specification are based on weight percentages. The amounts given are based on the active weight of the material.

Claims (15)

1. Composition for the care of teeth, containing in one phase: water in an amount of from 0 to less than 4% wt. by weight of the composition; the source of metal ions, while the source of metal ions contains 0,454% wt. tin fluoride and 2% wt. zinc citrate by weight of the composition; at least one polyphosphate salt having four or more phosphorus atoms and selected from the group comprising sodium hexaprophosphate and sodium hexapolyphosphate; while at least one polyphosphate salt is contained in an amount of from 1 to 10% wt. by weight of the composition; and a thickener consisting of crosslinked polyvinylpyrrolidone; cross-linked polyvinylpyrrolidone is present in an amount of from 0.05 to 15% wt. by weight of the composition, where the composition for the care of teeth is presented in the form of a paste or gel. 2. The composition according to claim 1, where at least one polyphosphate salt is contained in an amount of from 3 to 7% wt. by weight of the composition. 3. The composition according to claim 1, further comprising a water buffer system for the source of metal ions. 4. The composition of claim 3, wherein the buffer system is used to chelate metal ions in the composition. 5. The composition according to p. 4, where the buffer system contains at least one organic acid or its salt with an alkali metal. 6. The composition according to claim 5, wherein the organic acid is citric acid. 7. The composition according to claim 5, where the buffer system contains a mixture of citric acid and trisodium citrate. 8. The composition according to claim 5, where the buffer system is from 0.1 to 10% wt. by weight of the composition. 9. The composition according to claim 5, where the buffer system is represented by mass in an amount greater than the mass of the source of metal ions.