RU2639562C1 - Активная биологическая субстанция "ингалипт актив плюс" (ingaliptum active plus), полученный на её основе препарат местного действия - Google Patents
Активная биологическая субстанция "ингалипт актив плюс" (ingaliptum active plus), полученный на её основе препарат местного действия Download PDFInfo
- Publication number
- RU2639562C1 RU2639562C1 RU2016150430A RU2016150430A RU2639562C1 RU 2639562 C1 RU2639562 C1 RU 2639562C1 RU 2016150430 A RU2016150430 A RU 2016150430A RU 2016150430 A RU2016150430 A RU 2016150430A RU 2639562 C1 RU2639562 C1 RU 2639562C1
- Authority
- RU
- Russia
- Prior art keywords
- atcc
- biologically active
- active substance
- strains
- eucalyptus
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 239000000126 substance Substances 0.000 title claims abstract description 11
- 229940088623 biologically active substance Drugs 0.000 claims abstract description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 230000000694 effects Effects 0.000 claims abstract description 18
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 14
- 244000063299 Bacillus subtilis Species 0.000 claims abstract description 12
- 235000014469 Bacillus subtilis Nutrition 0.000 claims abstract description 12
- 241000222122 Candida albicans Species 0.000 claims abstract description 12
- 241001360526 Escherichia coli ATCC 25922 Species 0.000 claims abstract description 12
- 241000191967 Staphylococcus aureus Species 0.000 claims abstract description 12
- 229940095731 candida albicans Drugs 0.000 claims abstract description 12
- 241000588767 Proteus vulgaris Species 0.000 claims abstract description 11
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims abstract description 11
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims abstract description 11
- 229940007042 proteus vulgaris Drugs 0.000 claims abstract description 11
- 235000019477 peppermint oil Nutrition 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000010642 eucalyptus oil Substances 0.000 claims abstract description 8
- 235000011187 glycerol Nutrition 0.000 claims abstract description 8
- 239000008213 purified water Substances 0.000 claims abstract description 8
- 239000005844 Thymol Substances 0.000 claims abstract description 7
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 7
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940007062 eucalyptus extract Drugs 0.000 claims abstract description 7
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract description 7
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 7
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 7
- 229940068968 polysorbate 80 Drugs 0.000 claims abstract description 7
- 229960000790 thymol Drugs 0.000 claims abstract description 7
- 229940044949 eucalyptus oil Drugs 0.000 claims abstract description 6
- -1 eucalyptus extract Substances 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims description 23
- 229940079593 drug Drugs 0.000 claims description 22
- 230000000699 topical effect Effects 0.000 claims description 20
- 230000002458 infectious effect Effects 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 210000000214 mouth Anatomy 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 208000035473 Communicable disease Diseases 0.000 claims description 4
- 208000027866 inflammatory disease Diseases 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 244000166124 Eucalyptus globulus Species 0.000 claims description 3
- 210000002345 respiratory system Anatomy 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 abstract 4
- 230000000844 anti-bacterial effect Effects 0.000 description 17
- 230000000843 anti-fungal effect Effects 0.000 description 14
- 241000196324 Embryophyta Species 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 230000003385 bacteriostatic effect Effects 0.000 description 7
- 239000002609 medium Substances 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 235000010419 agar Nutrition 0.000 description 5
- 230000000813 microbial effect Effects 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 239000008272 agar Substances 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 206010053759 Growth retardation Diseases 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 231100000001 growth retardation Toxicity 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 2
- 244000042664 Matricaria chamomilla Species 0.000 description 2
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940124350 antibacterial drug Drugs 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000004332 deodorization Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000006651 lactation Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 229950008188 sulfamidochrysoidine Drugs 0.000 description 2
- 229960001544 sulfathiazole Drugs 0.000 description 2
- JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 description 2
- 229940124530 sulfonamide Drugs 0.000 description 2
- 150000003456 sulfonamides Chemical class 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 208000027244 Dysbiosis Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 201000008197 Laryngitis Diseases 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028034 Mouth ulceration Diseases 0.000 description 1
- 208000006595 Necrotizing Ulcerative Gingivitis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000003300 oropharynx Anatomy 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- ABBQGOCHXSPKHJ-WUKNDPDISA-N prontosil Chemical compound NC1=CC(N)=CC=C1\N=N\C1=CC=C(S(N)(=O)=O)C=C1 ABBQGOCHXSPKHJ-WUKNDPDISA-N 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- GWIJGCIVKLITQK-UHFFFAOYSA-N sodium;(4-aminophenyl)sulfonyl-(1,3-thiazol-2-yl)azanide Chemical compound [Na+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CS1 GWIJGCIVKLITQK-UHFFFAOYSA-N 0.000 description 1
- WLURHQRAUSIQBH-UHFFFAOYSA-N sodium;hexahydrate Chemical compound O.O.O.O.O.O.[Na] WLURHQRAUSIQBH-UHFFFAOYSA-N 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960005476 sulfathiazole sodium Drugs 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 201000008587 ulcerative stomatitis Diseases 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA201611135 | 2016-11-04 | ||
| UAA201611135A UA117523C2 (uk) | 2016-11-04 | 2016-11-04 | Активна біологічна субстанція, отриманий на її основі препарат місцевої дії |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2639562C1 true RU2639562C1 (ru) | 2017-12-21 |
Family
ID=62076975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016150430A RU2639562C1 (ru) | 2016-11-04 | 2016-12-20 | Активная биологическая субстанция "ингалипт актив плюс" (ingaliptum active plus), полученный на её основе препарат местного действия |
Country Status (3)
| Country | Link |
|---|---|
| RU (1) | RU2639562C1 (uk) |
| UA (1) | UA117523C2 (uk) |
| WO (1) | WO2018084824A1 (uk) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA67784C2 (uk) * | 2000-04-27 | 2004-07-15 | Yurii Semenovych Kryvoshein | Антисептична пігулка для смоктання |
| CN103843835A (zh) * | 2013-04-02 | 2014-06-11 | 叶向明 | 一种天然植物源广谱净菌制剂及其制备方法和应用 |
| WO2014189352A1 (en) * | 2013-05-21 | 2014-11-27 | University Of Malaya | Disposable ablution pack |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2283645C2 (ru) * | 2004-12-16 | 2006-09-20 | Светлана Николаевна Киппер | Средство для орошения полости рта |
-
2016
- 2016-11-04 UA UAA201611135A patent/UA117523C2/uk unknown
- 2016-12-20 RU RU2016150430A patent/RU2639562C1/ru not_active IP Right Cessation
-
2017
- 2017-10-10 WO PCT/UA2017/000095 patent/WO2018084824A1/ru active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA67784C2 (uk) * | 2000-04-27 | 2004-07-15 | Yurii Semenovych Kryvoshein | Антисептична пігулка для смоктання |
| CN103843835A (zh) * | 2013-04-02 | 2014-06-11 | 叶向明 | 一种天然植物源广谱净菌制剂及其制备方法和应用 |
| WO2014189352A1 (en) * | 2013-05-21 | 2014-11-27 | University Of Malaya | Disposable ablution pack |
Also Published As
| Publication number | Publication date |
|---|---|
| UA117523C2 (uk) | 2018-08-10 |
| WO2018084824A1 (ru) | 2018-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20201221 |