RU2622646C2 - Калмангафодипир, новое химическое соединение и другие смешанные комплексные соединения с металлами, способы получения, композиции и способы лечения - Google Patents

Калмангафодипир, новое химическое соединение и другие смешанные комплексные соединения с металлами, способы получения, композиции и способы лечения Download PDF

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RU2622646C2
RU2622646C2 RU2014132184A RU2014132184A RU2622646C2 RU 2622646 C2 RU2622646 C2 RU 2622646C2 RU 2014132184 A RU2014132184 A RU 2014132184A RU 2014132184 A RU2014132184 A RU 2014132184A RU 2622646 C2 RU2622646 C2 RU 2622646C2
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manganese
pathological condition
complex compound
metals
mixed complex
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RU2014132184A
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RU2014132184A (ru
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Ян Олоф КАРЛССОН
Карл РЕИНЕКЕ
Тино КУРЦ
Рольф АНДЕРССОН
Майкл ХОЛЛ
Кристина МАКЛАФЛИН
Свен ЯКОБССОН
Жак НЕССТРЕМ
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Пледфарма Аб
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    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • C07F19/005—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00 without metal-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
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    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00

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  • Animal Behavior & Ethology (AREA)
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  • Hematology (AREA)
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  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
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  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2014132184A 2012-01-05 2012-12-04 Калмангафодипир, новое химическое соединение и другие смешанные комплексные соединения с металлами, способы получения, композиции и способы лечения RU2622646C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261583377P 2012-01-05 2012-01-05
US61/583,377 2012-01-05
US201261656178P 2012-06-06 2012-06-06
US61/656,178 2012-06-06
US201261668679P 2012-07-06 2012-07-06
US61/668,679 2012-07-06
US201261721575P 2012-11-02 2012-11-02
US61/721,575 2012-11-02
PCT/IB2012/056959 WO2013102806A1 (en) 2012-01-05 2012-12-04 Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment

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RU2017119660A Division RU2765805C2 (ru) 2012-01-05 2012-12-04 Калмангафодипир, новое химическое соединение и другие смешанные комплексные соединения с металлами, способы получения, композиции и способы лечения

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RU2014132184A RU2014132184A (ru) 2016-02-27
RU2622646C2 true RU2622646C2 (ru) 2017-06-19

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RU2017119660A RU2765805C2 (ru) 2012-01-05 2012-12-04 Калмангафодипир, новое химическое соединение и другие смешанные комплексные соединения с металлами, способы получения, композиции и способы лечения

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US (3) US9187509B2 (index.php)
EP (1) EP2800755B1 (index.php)
JP (2) JP6131271B2 (index.php)
KR (1) KR102086022B1 (index.php)
CN (2) CN107353313B (index.php)
AU (1) AU2012364227B2 (index.php)
BR (1) BR112014016497B1 (index.php)
CA (1) CA2862736C (index.php)
ES (1) ES2683038T3 (index.php)
HK (1) HK1245276B (index.php)
IN (1) IN2014MN01495A (index.php)
MX (1) MX2014008247A (index.php)
RU (2) RU2622646C2 (index.php)
WO (1) WO2013102806A1 (index.php)
ZA (1) ZA201404904B (index.php)

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IN2014MN01495A (index.php) * 2012-01-05 2015-04-17 Pledpharma Ab
US20150313921A1 (en) * 2012-11-02 2015-11-05 Pledpharma Ab Cancer Treatment Methods
US10233205B2 (en) 2015-08-07 2019-03-19 Auburn University Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species
EP3402475B1 (en) 2016-01-11 2021-10-20 Egetis Therapeutics AB Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions
JP7065866B2 (ja) * 2016-11-14 2022-05-12 カールソン－タナー インベスト エーエス 化学療法で誘発されたｐｓｎを防止および処置するための非遷移金属配位ジピリドキシル化合物の使用
KR102843447B1 (ko) 2021-05-18 2025-08-06 가부시키가이샤 엘티티 바이오파마 항암제의 투여에 수반되는 장애를 치료 또는 예방하기 위한 의약 조성물

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EP0290047A2 (en) * 1987-05-08 1988-11-09 Nycomed Salutar, Inc. Dipyridoxyl phosphate nuclear magnetic resonance imagery contrast agents
RU2157213C2 (ru) * 1992-12-07 2000-10-10 Юкэрион, Инк. Фармацевтическая композиция и способ предупреждения, подавления или лечения заболевания, ассоциированного с присутствием свободных радикалов
US20090155184A1 (en) * 2007-12-17 2009-06-18 Ge Healthcare As Magnetic resonance imaging method

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US6204259B1 (en) 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
GB9613182D0 (en) 1996-06-24 1996-08-28 Nycomed Imaging As Method
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EP1060174B1 (en) 1997-12-23 2004-09-22 Amersham Health AS Nitric oxide releasing chelating agents and their therapeutic use
FR2823977B1 (fr) 2001-04-26 2006-12-01 Univ Rene Descartes Utilisation du mangafodipir dans le traitement des effets d'un stress oxydatif
DE10359628A1 (de) 2003-12-18 2005-07-21 Oxeno Olefinchemie Gmbh Katalysator und Verfahren zur Herstellung von 1-Olefinen aus 2-Hydroxyalkanen
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CA2708113C (en) 2007-12-14 2017-08-22 Pledpharma Ab Compounds for use in the treatment of cancer
MX336359B (es) * 2009-07-06 2016-01-15 Pledpharma Ab Composiciones farmaceuticas y metodos teraputicos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto.
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EP0290047A2 (en) * 1987-05-08 1988-11-09 Nycomed Salutar, Inc. Dipyridoxyl phosphate nuclear magnetic resonance imagery contrast agents
RU2157213C2 (ru) * 1992-12-07 2000-10-10 Юкэрион, Инк. Фармацевтическая композиция и способ предупреждения, подавления или лечения заболевания, ассоциированного с присутствием свободных радикалов
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WO2013102806A1 (en) 2013-07-11
IN2014MN01495A (index.php) 2015-04-17
MX2014008247A (es) 2015-03-09
AU2012364227B2 (en) 2017-12-07
BR112014016497A8 (pt) 2017-07-04
CA2862736A1 (en) 2013-07-11
CN104169291B (zh) 2017-08-15
EP2800755A1 (en) 2014-11-12
JP6316479B2 (ja) 2018-04-25
HK1245276B (zh) 2020-05-08
CN107353313A (zh) 2017-11-17
BR112014016497B1 (pt) 2021-02-23
US20170165281A1 (en) 2017-06-15
EP2800755B1 (en) 2018-05-30
US20150005259A1 (en) 2015-01-01
JP2015504066A (ja) 2015-02-05
KR102086022B1 (ko) 2020-03-06
CN104169291A (zh) 2014-11-26
KR20140117480A (ko) 2014-10-07
JP2017132801A (ja) 2017-08-03
RU2765805C2 (ru) 2022-02-03
ES2683038T3 (es) 2018-09-24
US9597334B2 (en) 2017-03-21
CA2862736C (en) 2020-09-08
US9187509B2 (en) 2015-11-17
RU2014132184A (ru) 2016-02-27
HK1203203A1 (en) 2015-10-23
JP6131271B2 (ja) 2017-05-17
CN107353313B (zh) 2019-04-09
US10111893B2 (en) 2018-10-30
BR112014016497A2 (pt) 2017-06-13
US20160038507A1 (en) 2016-02-11
AU2012364227A1 (en) 2014-07-24
RU2017119660A (ru) 2018-11-08
RU2017119660A3 (index.php) 2020-07-30
ZA201404904B (en) 2024-01-31

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