RU2586280C1 - Method for complex therapy of functional digestive disorders in pre-school children - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine and is intended for functional digestive disorders treatment in preschool age children. Lactofiltrum by 1 tablet 3 times a day, 1 hour before meal, for 14 days; Trimedat by 25 mg × 3 times for 14 days; Creon 10,000 Units a day during meal for 10 days, are administered. Additionally, aqueous tincture of Moneses uniflora by 10 ml 2 times a day (morning and evening), 20 minutes after meal for 3 week course, and medical foodstuff "Bifilife" by 100 g 2 times a day (morning and evening) for 3 months, are administered.

EFFECT: method can improve coprology indices and correct intestinal dysbacteriosis in out-patient treatment.

1 cl, 16 tbl

Description

The invention relates to medicine, in particular to pediatrics and gastroenterology, and can be used for complex therapy of functional digestive disorders in preschool children.

One of the pressing problems of modern pediatrics are functional digestive disorders, which are characterized by a high prevalence in children.

Functional digestive disorders are a diverse combination of gastrointestinal symptoms without structural or biochemical disorders. At present, speaking of functional digestive disorders, impaired motor skills are implied, which inevitably cause secondary changes, the main of which are a violation of the processes of digestion and absorption, as well as violations of the intestinal microbiocenosis (Belmer S.V., Khavkin A.I., Scherbakov P . L. Gastroenterology of childhood. M: Medpraktika, 2010, p. 30-33).

All of the above indicates the need to expand the capabilities of complex therapy of functional digestive disorders in preschool children.

The known drug Lactofiltrum is an enterosorbent, the pharmacological effect of which is due to the properties of the active components included in its composition - lignin and lactulose. The complex effect of the drug is aimed at normalizing the microbiocenosis of the large intestine and reducing the intensity of endogenous toxic conditions (Instructions for medical use of the drug Lactofiltrum, registration number LSR-008904/08).

The disadvantage of this drug is a possible decrease in the therapeutic effect of some drugs taken simultaneously inside.

Known drug Trimedat - an antispasmodic that restores the normal physiological activity of intestinal muscles in various diseases of the gastrointestinal tract associated with impaired motor skills (Instructions for medical use of the drug Trimedat, registration number LSR-005534/08).

The disadvantage of this drug is individual sensitivity to the components that make up the drug.

Known drug Creon - an enzyme, the indication for use of which is replacement therapy of exocrine pancreatic insufficiency in children and adults caused by various diseases of the gastrointestinal tract (Instructions for medical use of the drug Creon, registration number P No. 015581/01).

The disadvantage of this drug is individual sensitivity to the components that make up the drug.

The product of clinical nutrition "Bifilife" - developed on the basis of bifidobacteria FSBI Moscow Research Institute of Epidemiology of Microbiology named after G.N. Gabrichevsky, containing 5 types of biologically active bifidobacteria, B vitamins, folic acid and vitamin C, contributing to the normalization of intestinal function and increase the body's immune status. http://vita-irk.ru/produkty/biojgurt/

The disadvantage of this product is an individual food allergy to cow's milk protein.

The monotone is single-flowered, the teletype has an antimicrobial effect on the intestinal microflora, has anti-inflammatory properties (Telyatyev V.V. Healing treasures. Irkutsk: East Siberian Book Publishing House, 1991, p. 188-189).

The disadvantage of one-color one-flowering is individual intolerance.

When conducting a patent search, the use of the enterosorbent Lactofiltrum, the antispasmodic Trimedat, the enzyme preparation Creon, the one-color water infusion of the same color and the Bifilife therapeutic food product for the complex therapy of functional digestive disorders in preschool children was not found.

In 2014, 67 children with functional digestive disorders of preschool age were examined at the clinic of the Federal State Budget Scientific Institution Scientific Center of the National Center for the Development of Human Rights and Health.

Our studies have confirmed that with the use of the enterosorbent Lactofiltrum, the antispasmodic Trimedat, the enzyme preparation Creon, the one-color water infusion of the same color, and the Bifilife therapeutic food product for the complex therapy of functional digestion disorders in preschool children, deterioration, disease progression, and side effects were not observed.

The objective of the invention is to provide a method for the complex therapy of functional digestive disorders in preschool children through the use of the enterosorbent Lactofiltrum, the antispasmodic Trimedat, the enzyme preparation Creon, the one-color water infusion of the same color and the Bifilife therapeutic food product.

This task is achieved in that a method of complex therapy of functional digestive disorders in preschool children, including the enterosorbent Lactofiltrum 1 tablet 3 times a day 1 hour before meals for 14 days, antispasmodic Trimedat 25 mg × 3r for 14 days, enzymatic Creon preparation of 10 thousand units per day during meals for 10 days, characterized in that it is additionally prescribed for intestinal sanitation, an aqueous infusion of the same color 10 ml 2 times a day in the morning and evening 20 minutes after a meal for 3 weeks, for the formation of intestinal microflora, a product of therapeutic food "Bifilife" 100 grams 2 times a day in the morning and evening for 3 months.

The one-flowered one-flowering, which is part of the water infusion, must be in a dried state, the plant is crushed on a grinder with a capacity of 100 watts. The finished product can be stored for two years.

A water infusion of the same-flowered one-flower is prepared as follows: 0.5 grams of this dried and ground plant material per 200 ml of boiling water, leave for five minutes and strain. Drink infusion of 10 ml 2 times a day in the morning and in the evening 20 minutes after a meal for 3 weeks.

The effectiveness of the use of the enterosorbent Lactofiltrum, the antispasmodic Trimedat, the enzyme preparation Creon, the one-flowered water infusion of the same color, and the Bifilife therapeutic food product for the complex treatment of functional digestive disorders in preschool children are shown in the following examples:

Sofia S, 6 years old. Diagnosis: Functional digestive disorders, intestinal dysbiosis, subcompensated.

I was examined and treated at the Department of Gastroenterology of the Clinic of the Federal State Budget Scientific Institution Scientific Center for CCD RF from September 10, 2014 to September 15, 2014 with continued outpatient treatment for 3 months.

Complaints at admission: for periodic abdominal pain, without a clear connection with food intake, nausea, belching with air and the taste of eaten food, decreased appetite, unstable stools: sometimes liquefied, undigested, sometimes every other day, “sheep”.

Anamnesis of the disease: these complaints within six months, in February 2014 suffered an acute intestinal infection (AII) of rotavirus etiology.

Objectively: of proper physique, moderate physical development, harmonious, normal skin, dry to the touch, visible mucous membranes, peripheral lymph nodes are not enlarged, the tongue is covered with a white coating on the root, the abdomen is soft, painful in mesogastrium, left iliac region, on palpation +0.5 cm from under the edge of the costal arch, the symptoms of Kehr and Ortner are negative, the stool is daily or every other day, “unstable”, without pathological impurities.

Survey conducted:

General blood test from 09/11/2014

Enzyme-linked immunosorbent assay (ELISA) for lamblia, toxocara, roundworm, opisthorchia - negative

Ultrasound of the abdominal cavity (examination on the device MEQAS GP) 09/14/2014

Conclusion: Organic pathology was not detected.

FGDS (fibrogastroduodenoscopy with cytological and histological examination of the biopsy): endoscopic norm, Helicobacter pylori was not detected.

Intestinal dysbiosis from 09/14/2014

Treatment was prescribed: enterosorbent Lactofiltrum 1 tablet 3 times a day 1 hour before meals for 14 days, antispasmodic Trimedat 25 mg × 3r for 14 days, enzyme preparation Creon 10 thousand units per day with meals for 10 days, additionally, for intestinal sanitation, an infusion of the same-color one-flowered extract of 10 ml 2 times a day in the morning and in the evening 20 minutes after a meal for 3 weeks, to restore intestinal microflora, the Bifilife therapeutic food product is 100 grams 2 times a day in the morning and evening for 3 months.

Examination results after 3 months:

General blood test dated 12/17/2014

Ultrasound of the abdominal cavity: no pathology detected.

Intestinal dysbiosis from 12/21/2014

Against the background of the indicated therapy with the use of the enterosorbent Lactofiltrum, the antispasmodic Trimedat, the enzyme preparation Creon, the one-color water infusion of the same color and the Bifilife therapeutic food product, there was an improvement in overall well-being, rapid relief of painful abdominal and dyspeptic syndrome, and coprogram and bowel dysbacteriosis normalized.

For comparison, we present the results of treatment of a patient carried out using the enterosorbent Lactofiltrum, antispasmodic Trimedat, the enzyme preparation Kreon without the use of an aqueous infusion of the same-color monoflore and the Bifilife therapeutic food product.

Nikita Ch., 5 years old. Diagnosis: Functional digestive disorders, intestinal dysbiosis, subcompensated.

He was examined and treated at the Department of Gastroenterology of the Clinic of the Federal State Budget Scientific Institution Scientific Center of CCD RF from 11.24.2014 to 11.29.2014 with the continuation of outpatient treatment for 3 months.

Complaints upon admission: for periodic abdominal pain, without a clear connection with food intake, nausea, burping air, decreased appetite, unstable stools: liquefied, undigested, bloating.

Anamnesis of the disease: these complaints within 7 months, in April 2014 suffered an acute intestinal infection (AII) of rotavirus etiology.

Objectively: of the correct physique, average physical development, harmonious, normal skin, the face is slightly pale, the “shadows” under the eyes, the visible mucous membranes are clean, the peripheral lymph nodes are not enlarged, the tongue is covered with a white coating on the root, the abdomen is soft, painful in mesogastria upon palpation. , “rumbling” is noted along the intestine, the liver is +0.5 cm from under the edge of the costal arch, the symptoms of Kehr and Ortner are negative, the stool is daily 2-3 times a day, gruff, undigested, without pathological impurities.

Survey conducted:

General blood test dated 11.25.2014

Enzyme-linked immunosorbent assay (ELISA) for lamblia, toxocara, roundworm, opisthorchia - negative

Ultrasound of the abdominal cavity (examination on the device MEQAS GP) 11.25.14.

Conclusion: Organic pathology was not detected.

FGDS (fibrogastroduodenoscopy with cytological and histological examination of the biopsy): endoscopic norm, Helicobacter pylori was not detected.

Intestinal dysbiosis from 11/27/2014

Prescribed treatment: enterosorbent Lactofiltrum 1 tablet 3 times a day 1 hour before meals for 14 days, antispasmodic Trimedat 25 mg × 3r for 14 days, enzyme preparation Creon 10 thousand units per day with meals for 10 days.

Examination results after 3 months

General blood test dated February 25, 2015

Intestinal dysbiosis from 01/27/2015

Against the background of the indicated therapy with the use of the enterosorbent Lactofiltrum, the antispasmodic Trimedat, the enzyme drug Creon, an improvement in general well-being was noted, the pain abdominal syndrome stopped, but complaints about unstable stool persisted and the indicators of coprogram and intestinal dysbiosis did not normalize.

This method of complex therapy of functional digestive disorders in preschool children with the use of Lactofiltrum enterosorbent, Trimedat antispasmodic, Creon enzyme preparation, monoflow single-color water infusion and Bifilife therapeutic food product improves overall well-being, shortens the duration of treatment, gives a stable clinical effect and normalizes the norm indicators of coprograms and intestinal dysbiosis, is not required to be in a hospital, does not have harmful effects GOVERNMENTAL action on the body and has no significant contraindications.

The proposed method is effective in the treatment of functional digestive disorders in preschool children.

Claims (1)

The method of complex therapy of functional digestive disorders in preschool children, including enterosorbent lactofiltrum 1 tablet 3 times a day 1 hour before meals for 14 days, antispasmodic trimedate 25 mg × 3 r for 14 days, enzyme preparation Creon 10 thousand units per day during meals for 10 days, characterized in that it is additionally prescribed for intestinal sanitation an aqueous infusion of the same color 10 ml 2 times a day in the morning and evening 20 minutes after a meal for 3 weeks, to restore intestinal microflora Bifilife therapeutic food product, 100 grams 2 times a day, morning and evening for 3 months.