RU2568438C1 - METHOD OF OBTAINING PLATINUM (IV) CYCLOHEXANE-TRANS-1,2-d,l-DIAMINOTETRACHLORIDE - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: method includes formation of hexachloroplatinate (IV) of cyclohexane-trans-1,2-d,l-diammonium from solution of chloroplatinic acid, with separation of hexachloroplatinate (IV) of cyclohexane-trans-1,2-d,l-diammonium being carried out by addition into hydrochloric acid solution of chloroplatinic acid of cyclohexane-trans-1,2-d,l-diamine in icy acetic acid, with its further separation and hydrolysis, which is realised with dissolution of hexachloroplatinate (IV) of cyclohexane-trans-1,2-d,l-diammonium in water sodium acetate solution with concentration 50-250 g of CH₃COONa·3H₂O per 100 ml of water, taken in amount (300-800) % of molar quantity of platinum in initial solution of chloroplatinic acid, at 20-60°C for 0.5-5 hours. Hydrolysis process is carried out in reactor, protected from direct sun light and illumination, and separation of platinum (IV) cyclohexane-trans-1,2-d,l-diaminotetrachloride from hexachloroplatinate (IV) of cyclohexane-trans-1,2-d,l-diammonium solution is carried out by addition of concentrated hydrochloric acid to solution pH 1-3, drying obtained suspension at 60-90°C, dissolution of residue in diethyl ether, or acetone, or chloroform, filtration of solution from sodium chloride and evaporation of diethyl ether, or acetone, or chloroform. versions of method are also claimed.

EFFECT: invention makes it possible to improve method of obtaining compound with high degree of purity, increase synthesis stability, achieve high output of target compound.

18 cl, 9 tbl, 10 ex

Description

The invention relates to the field of production of platinum metal compounds and pharmaceuticals, in particular the synthesis of platinum compounds, namely the synthesis of cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) (tetraplatin, ormaplatin), which is an antitumor drug.

A known method of producing cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV), including the allocation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II), in the interaction of potassium tetrachloroplatinate (II) and cyclohexane -trans-d, l-1,2-diamine, followed by chlorination of the product of their interaction (Eastland GJ // Drugs Fut. 1987. V. 12.i.2. p. 139-141; Anderson WK, Quagliato DA, Haugwitz RD, et al., // Cancer Treat. Rep. 1986. V. 70. P. 997-1002). The synthesis process can be represented by the following scheme (cyclohexane-trans-1,2-d, l-diamine - C ₆ H ₁₀ (NH ₂ ) ₂ ):

The disadvantage of this method is the duration and the complexity of obtaining the initial tetrachloride complex of Pt (II). The yield of the target product, taking into account the yield of the original K ₂ [PtCl ₄ ] (when synthesized from K ₂ PtCl ₆ or H ₂ PtCl ₆ ), is less than 65%.

A known method for producing cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV), based on the interaction of potassium hexachloroplatinate (IV) with cyclohexane-trans-1,2-d, l-diammonium dichloride (Wyrig SD, Chaney SG // J. Label. Compounds Radiopharm. 990. V. 28.i.7. P. 753-756; Upjohn. Natl Canser Inst. // Drugs Fut. 1991. V. 16.i.2. P. 187) . The synthesis can be represented by the scheme:

The disadvantage of this method is also a significant duration (more than 10 hours) and a low yield of the target product (less than 55%). Moreover, in the process (2), the sparingly soluble compound K ₂ [PtCl ₆ ] is used, which greatly complicates the necessary chemical reactions.

A known method for producing cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV), in which the initial stage is the interaction of platinum chloride and cyclohexane-trans-1,2-d, l-diammonium dichloride in a solution of hydrochloric acid with the allocation of the ionic compound cyclohexane-trans-1,2-d, l-diammonium hexachloroplatinate (IV), which is then hydrolyzed in the presence of lithium hydroxide (Mulagaleev R.F., Starkov A.K., Kirik S.D. // RF Patent No. 2457838 dated 08/10/2012 Bull. No. 22). The general process can be represented by the scheme:

This method is adopted as a prototype.

The disadvantage of this method is to reduce the yield of the target compound due to the partial replacement of chloride ligands with hydroxide and water with the addition of lithium hydroxide. The presence of lithium ions in the crystallization solution of cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) makes it necessary to further purify the target product from them, and this leads to both an increase in the duration of synthesis and a decrease in the yield of the product.

The objective of the invention is to develop an affordable and stable method for producing cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) (tetraplatin, ormaplatin) in a crystalline monophase state [Pt {C ₆ H ₁₀ (trans-1,2- d, l-NH ₂ ) ₂ } Cl ₄ ] · 1 / 3H ₂ O with a high degree of purity and high yield.

To solve this problem, a method was developed for hydrolysis of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium in an aqueous solution of sodium acetate to the target cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) and a method reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium in an aqueous solution of oxalic acid, or sodium oxalate, or sodium formate or hydrazine hydrate with sodium acetate additives to cyclohexane-tyrans-1,2-d, l -diaminodichloride of platinum (II), which is converted to the target product by chlorination or oxidized hydrogen peroxide followed by treatment with hydrochloric acid.

The technical result to which the invention is directed is to improve the method for producing cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) in a crystalline phase-uniform state [Pt {C ₆ H ₁₀ (trans-1,2 -d, l-NH ₂ ) ₂ } Cl ₄ ] · 1 / 3H ₂ O with a high degree of purity, increasing the stability of the synthesis, as well as achieving a high yield of the target compound.

The task is achieved in that the formation of cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) is carried out by hydrolysis of the precursor compound - hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium or its reduction with subsequent hydrolysis to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II), which is oxidized with chlorine. Hydrolysis of the precursor compound is carried out when it is dissolved in an aqueous solution of sodium acetate with a concentration of (50-250) g CH ₃ COONa · 3H ₂ O per 100 ml of water taken in an amount of (300-800)% of the molar amount of platinum in the initial solution of platinum chloride hydrochloric acid at (20-60) ° C for (0.5-5) hours, while the hydrolysis process is carried out in a reactor with stirring and protected from direct sunlight and lighting. Isolation of cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) from a solution of hydrolysis of chloroplatinate (IV) trans-1,2-d, l-diammoniumcyclohexane with sodium acetate is carried out by adding hydrochloric acid to a pH of a solution (1-3) by drying the resulting suspension at (60-90) ° C, dissolving the residue in diethyl ether or acetone or chloroform, filtering the solution from sodium chloride and evaporating diethyl ether or acetone or chloroform. Isolation of the precursor compound is carried out from a solution of platinum chloride in concentrated hydrochloric acid with a concentration of platinum (50-300) g / l, the action of an acetic acid or ethanol solution of cyclohexane-trans-1,2-d, l-diamine, in which 1 g of cyclohexane tetrais-1,2-d, l-diamine accounts for (5-20) ml of glacial acetic acid or ethanol, in an amount of (100-120)% of the molar content of platinum in solution, at a temperature of (20-60) ° C.

The reduction of the precursor compound to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) is carried out when it is dissolved in an aqueous solution of oxalic acid with a concentration of H ₂ C ₂ O ₄ * 2H ₂ O (5-100) g per 100 ml of water in an amount of (100-200)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (50-90) ° C for (1-3) hours, with the addition of sodium acetate with a concentration of in the amount of (400-800)% of the molar amount of platinum in the initial solution of platinum chloride stout acid. Also, the reduction of the precursor compound to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) is carried out in an aqueous solution of sodium oxalate with a concentration of (3-6) g of Na ₂ C ₂ O ₄ per 100 ml of water in an amount of (100 -400)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (50-90) ° C for (1-3) hours with the addition of sodium acetate in the amount of (200-400)% CH in the resulting solution ₃ COONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum chloride or in aqueous solution of sodium formate with a concentration of HCOONa (10-150) g per 100 ml of water in an amount of (95-100)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (30-50) ° C for ( 1-3) hours, with the addition of sodium acetate to the resulting solution in an amount of (300-400)% CH ₃ COONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum hydrochloric acid or in an aqueous solution of hydrazine chloride with a concentration of N ₂ H ₄ · 2HCl (5-50) g per 100 ml of water in the amount of (50-55)% of the molar number of boards us in the initial solution of chloroplatinic acid, while maintaining the resulting solution at (30-50) ° C for (1-3) hours, with the addition of the resulting sodium acetate in an amount (400-800)% CH ₃ COONa · 3H ₂ O from the molar amount of platinum in the initial solution of platinum hydrochloric acid.

The oxidation of the intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) is carried out by separating it from the solution by filtration, suspending the precipitate in a 10% aqueous solution of hydrochloric acid or chloroform taken in an amount of (10-25) ml per 1 g of platinum in the initial solution of platinum hydrochloric acid, and passing chlorine into the resulting suspension until the precipitate is dissolved, followed by evaporation of the solution at (60-90) ° C or with stirring a suspension of platinum cyclohexane-trans-1,2-d, l-diaminodichloride (II) in (20-100) ml (5-30)% by weight solution hydrogen peroxide based on 1 g of platinum in the initial solution of platinum hydrochloric acid, for (2-4) hours at (40-80) ° C, adding to the resulting suspension of concentrated hydrochloric acid in the amount of (2-5) ml per 1 g platinum in the initial solution of platinum hydrochloric acid and stirring the resulting suspension to dissolve the precipitate with further evaporation of the resulting solution at (60-90) ° C.

The process of reducing the precursor compound to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) can also be carried out without isolating the precursor, and the reduction followed by hydrolysis to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) is carried out in an aqueous solution of oxalic acid with a concentration of H ₂ C ₂ O ₄ * 2H ₂ O (20-100) g per 100 ml of water in an amount of (100-150)% of the molar amount of platinum in the initial solution of platinum chloride, at keeping the resulting solution at (50-90) ° C for (1-3) hours, adding to the image schiysya sodium acetate solution in an amount (400-800)% of the molar amount of platinum in the feed solution of chloroplatinic acid. The precursor compound is also reduced in an aqueous solution of sodium oxalate with a concentration of (3-6) g Na ₂ C ₂ O ₄ per 100 ml of water in an amount of (100-400)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (50-90) ° C for (1-3) hours with the addition of sodium acetate in the amount of (200-400)% CH ₃ COONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum chloride or in aqueous sodium formate solution with a concentration of HCOONa (10-150) per 100 ml of water in an amount of (95-100)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (30-60) ° C for (1-3) hours, with sodium acetate added to the resulting solution in the amount of (300-400)% CH ₃ COONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum hydrochloric acid or in aqueous hydrazine chloride with a concentration of N ₂ H ₄ · 2HCl (5-50) g per 100 ml of water in the amount of ( 50-55)% of the molar amount of platinum in the initial solution of platinum chloride, at keeping the resulting solution at (30-60) ° C for (1-3) hours, with the addition of sodium acetate in the amount of (400-800)% CH ₃ COONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum chloride acids. The formation of the precursor compound is carried out from an aqueous solution of platinum chloride with a concentration of platinum (50-150) g / l, the action of an aqueous solution of cyclohexane-trans-1,2-d, l-diamine, in which 1 g of cyclohexane-trans-1 , 2-d, l-diamine accounts for (5-20) ml of water, in an amount of (99-101)% of the molar content of platinum in solution at (15-60) ° C.

The essence of the method lies in the fact that in the cyclohexane-trans-1,2-d, l-diammonium-hexachloroplatinate (IV) system, a number of cation-anionic compounds of the composition {C ₆ H ₁₀ (NH ₃ ) ₂ } _x [PtCl ₆ ] are formed _y zL (where L is the solvate molecule, x, y, z are stoichiometric coefficients) that can be hydrolyzed, accompanied by the reaction of exchange of intrasphere chloride ligands into groups playing the role of counterions (Anderson rearrangement), or can be reduced to cation-anionic compounds of Pt (II) {C ₆ H ₁₀ (NH _{3) 2} x} [PtCl _{4] y} * zL, which have a greater degree of Verger hydrolysis with parallel inner-substitution of the chloride ligands (Anderson rearrangement).

Studies of phase formation in the cyclohexane-trans-1,2-d, l-diammonium-hexachloroplatinate (IV) system showed that a number of crystalline phases can be distinguished by varying the temperature, acidity of the solution, and changing the chemical and physical properties of the solvent. Under the experimental conditions studied, the following compounds were isolated in a phase-homogeneous state and characterized by chemical analysis, X-ray phase analysis, and differential scanning calorimetry with analysis of the evolved gases: α- and β- {C ₆ H ₁₀ (NH ₃ ) ₂ } [PtCl ₆ ]; {C ₆ H ₁₀ (NH ₃ ) ₂ } [PtCl ₆ ] * H ₂ O; α- and β- {C ₆ H ₁₀ (NH ₃ ) ₂ } [PtCl ₆ ] * HCl; {C ₆ H ₁₀ (NH ₃ ) ₂ } [PtCl ₆ ] * 2HCl; {C ₆ H ₁₀ (NH ₃ ) ₂ } 2 [PtCl ₆ ] * 2Cl. In the proposed method, the isolated precursor for the synthesis of tetraplatin is a mixture of crystalline phases α- {C _b H ₁₀ (NH ₃ ) ₂ } [PtCl ₆ ], {C ₆ H ₁₀ (NH ₃ ) ₂ } [PtCl _b ] * H ₂ O and α - and β- {C ₆ H ₁₀ (NH ₃ ) ₂ } [PtCl ₆ ] * HCl, where the main component (with a content of more than 60%, depending on crystallization conditions) is the first phase, respectively.

Due to their ionic nature, the compounds {C _b H ₁₀ (NH ₃ ) ₂ } _x [PtCl ₆ ] _y * zL have the ability to interact with many polar solvents, which makes it possible to effectively control their release from solution. Therefore, such cation-anionic compounds can be effective precursors of cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV).

Hydrolysis of the cation-anionic compound formed in the cyclohexane-trans-1,2-d, l-diammonium-hexachloroplatinate (1U) system leads to the deprotonization of diamine, which is accompanied by the replacement of chloride ligands by amine in the coordination environment of platinum (Anderson rearrangement):

In the case of the synthesis of a compound with a cationic and anionic ratio of 1: 1, the composition of the starting compound {C ₆ H ₁₀ (NH ₃ ) ₂ } [PtCl] regulates the ratio between [PtCl ₆ ] ^{2 -} and amine, which leads to the formation of only tetrachloride complex .

Since water is less prone to protonization than diaminocyclohexane, the introduction of additional proton acceptors is necessary to shift equilibria (4) - (5). In aqueous solutions, this role is usually played by hydroxides. In this regard, in order to implement equilibria (4) - (5) that occur in an aqueous solution, it is necessary to suppress the possible substitution of chloride ligands for water and hydroxide (E. Blasius, W. Preetz, R. Schmitt // J. Inorg. Nucl. Chem. 1961. V. 19.i.1-2. P. 115-132; S.I. Ginzburg, N.A. Yezerskaya, I.V. Prokofiev, etc. // Analytical chemistry of platinum metals. M. Science . 1972. S. 70-73.):

Therefore, the formation of [Pt {C ₆ H ₁₀ (NH ₂ ) ₂ } Cl ₄ ], through equilibria (4) - (5), is caused by the neutralization of protons without shifting the acidity of the solution to the neutral or alkaline region and the stability of amine complexation to Pt (IV) . Since the stability of the coordination bond of Pt (IV) -NH ₂ R is higher than Pt (IV) -Cl, the formation of the tetrachloride complex according to reactions (4) - (5) will be due to the acid-base balance in the reaction system.

In this case, sodium acetate may be a suitable reagent for suppressing excess acidity. His hydrolysis:

allows to realize interactions (4) - (5) and maintain the necessary acid-base balance without side interactions (6) - (7). Therefore, the proposed process, in General, can be represented by the equation:

During the hydrolysis of sodium acetate (8), acetic acid is formed, which slows down the process (9), in this regard, sodium acetate is used in excess, which levels the acidity of the released acetic acid and allows the interaction (9) to be carried out almost completely. The solution in which reaction (9) is carried out is aqueous, which contributes to the partial dissolution of the target product. To prevent such losses, evaporation of the solution is used. However, this requires maintaining the product at relatively elevated temperatures, at which side processes are realized, leading to a decrease in its yield. Therefore, hydrochloric acid is added before the solution is evaporated, which stabilizes the resulting diamine tetrachloride and converts the excess sodium acetate to sodium chloride, which is removed by filtration when the target compound is dissolved in an organic solvent (acetone or diethyl ether or chloroform) in which sodium chloride is insoluble.

Due to the good solubility of tetraplatin in aqueous solution and other organic solvents, as well as the attendant difficulties associated with the isolation of this compound in a pure state in high yield, it is more convenient to use the recovery process {C ₆ H ₁₀ (NH ₃ ) ₂ } [PtCl _b ] to {C ₆ H ₁₀ (NH ₃ ) ₂ } [PtCl ₄ ] with the further formation of [Pt {C ₆ H ₁₀ (NH ₂ ) ₂ } Cl ₂ ], which is slightly soluble and due to the lower inertness of Pt (II) compared to Pt (IV) forms faster:

Next, the diamindichloride complex is oxidized to the desired tetrachloride:

The isolation of [Pt {C ₆ H ₁₀ (NH ₂ ) ₂ } Cl ₄ ] from system (11) no longer presents difficulties, because of the low solubility of [Pt {C ₆ H ₁₀ (NH ₂ ) ₂ } Cl ₂ ] one can achieve its high purity and yield, and oxidation due to the greater stability of the considered Pt (IV) complexes in comparison with Pt (II) proceeds practically quantitatively.

Oxalic acid, or sodium oxalate, or sodium formate, or hydrazine chloride is used as a reducing agent in process (10). The advantages of oxalic acid and sodium oxalate are that they do not reduce platinum to metal and can be used in excess, and sodium formate and sodium oxalate, in addition to reducing properties, also exhibit the properties of an acid-base buffer, which can later be used for hydrolytic translation ionic compound Pt (II) in the molecular complex Pt (II).

The final stage of the synthesis of the target compound according to the process (10) - (11) is carried out by chlorination of [Pt {C ₆ H ₁₀ (NH ₂ ) ₂ } Cl ₂ ] in a hydrochloric acid aqueous solution or in chloroform in the presence of residual water (after separation of [Pt {C ₆ H ₁₀ (NH ₂ ) ₂ } Cl ₂ ] by filtration and suspension in chloroform without drying from water), as this contributes to better solubility of the diamine tetrachloride compound and its final crystallization in a stable hydrated form - [Pt {C ₆ H ₁₀ (NH ₂ ) ₂ } Cl ₄ ] · 1 / 3H ₂ O. The milder oxidation of [Pt {C ₆ H ₁₀ (NH ₂ ) ₂ } Cl ₂ ] is carried out with hydrogen peroxide to daily [Pt {C ₆ H ₁₀ (NH ₂ ) ₂ } (OH) ₂ Cl ₂ ], which, by heating in hydrochloric acid, passes into the target tetrachloride.

In the course of the studies, it was found that for the process of obtaining cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) through the formation of chloroplatinate (IV) trans-1,2-d, l-diammoniumcyclohexane, the optimal parameters are:

- the concentration of platinum in the initial solution of platinum hydrochloric acid in concentrated hydrochloric acid (for the isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) - (50-300) g / l;

- deposition temperature of the precursor compound - hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (20-60) ° C;

- the amount of cyclohexane-trans-1,2-d, l-diamine for precipitation - (100-120)% of the molar content of platinum in solution;

- the volume of glacial acetic acid or ethanol to dissolve cyclohexane-trans-1,2-d, l-diamine and obtain its solution for precipitation of the precursor compound - (5-20) ml per 1 g of cyclohexane-trans-1,2-d, l-diamine;

- the amount of CH ₃ COONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum hydrochloric acid for hydrolysis of the precursor compound - (300-800)%;

- the content of CH ₃ COONa · 3H ₂ O in an aqueous solution for hydrolysis of the precursor compound - (50-250) g per 100 ml of water;

- the hydrolysis temperature of the precursor compound is (20-70) ° C;

- the duration of hydrolysis of the precursor compound is (0.5-5) hours;

- pH of the acidity of the solution when concentrated hydrochloric acid is added to the suspension obtained after hydrolysis to dry it - (1-3);

- the drying temperature of the suspension obtained by hydrolysis - (60-90) ° C;

- the amount of H ₂ C ₂ O ₄ · 2H ₂ O for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (100-200)% of the molar amount of platinum in the initial solution of platinum chloride;

- the concentration of H ₂ C ₂ O ₄ · 2H ₂ O for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (5-100) g per 100 ml of water;

- the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid or hydrazine chloride to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II) - (400-800)% of the molar amount of platinum in the initial solution of platinum hydrochloric acid;

- the reduction temperature of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid or sodium oxalate - (50-90) ° C;

- the duration of the aging solution for the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid, or sodium oxalate, or sodium formate, or hydrazine chloride - (1-3) hours;

- the volume of the liquid phase of chloroform or a 10% aqueous solution of hydrochloric acid in suspension for the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) chlorine - (10-25) ml per 1 g of platinum in the initial solution platinum hydrochloric acid;

- the evaporation temperature of the solution after oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) with chlorine - (60-90) ° C;

- the amount of Na ₂ C ₂ O ₄ for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (100-400)% of the molar amount of platinum in the initial solution of platinum chloride;

- the concentration of Na ₂ C ₂ O ₄ for the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (3-6) g per 100 ml of water;

- the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (sodium oxalate) to cyclohexane-trans-1,2-d, l-diaminodichloride platinum ( II) - (200-400)% of the molar amount of platinum in the initial solution of platinum hydrochloric acid;

- the amount of HCOONa for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (95-100)% of the molar amount of platinum in the initial solution of platinum chloride;

- the concentration of HCOONa for the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (10-150) g per 100 ml of water;

the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium formate to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) - (300-400)% of the molar amount of platinum in the initial solution of platinum hydrochloric acid;

- the temperature of the solution for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium formate or hydrazine chloride - (30-60) ° C;

- the amount of N ₂ H ₄ · 2HCl for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (50-55)% of the molar amount of platinum in the initial solution of platinum chloride;

- the concentration of N ₂ H ₄ · 2HCl to restore hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (5-50) g per 100 ml of water;

- the concentration of platinum in the initial solution of platinum hydrochloric acid in water (for the formation, but not the allocation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) - (50-150) g / l;

- the amount of cyclohexane-trans-1,2-d, l-diamine (for the formation, but not the allocation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) - (99-101)% of the molar content platinum in solution;

- the volume of water for dissolving cyclohexane-trans-1,2-d, l-diamine (for the formation, but not isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) - (5-20) ml per 1 g of cyclohexane-trans-1,2-d, l-diamine;

- the temperature of formation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (for the formation, but not isolation) - (15-60) ° C;

- the volume of an aqueous solution of hydrogen peroxide for the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) - (20-100) ml per 1 g of platinum in the initial solution of platinum hydrochloric acid;

- the mass content of hydrogen peroxide in an aqueous solution for the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) - (5-30)%;

- the duration of the mixing of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-4 / -diaminodichloride of platinum (II) - (2-4) h;

- the heating temperature of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) with stirring - (40-80) ° C;

- the volume of concentrated hydrochloric acid added to the suspension of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) after stirring is (2-5) ml per 1 g of platinum in the initial solution of platinum chloride;

- the evaporation temperature of the solution obtained after adding hydrochloric acid to the suspension of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) - (60-90) ° C.

An increase in the concentration of platinum in the initial solution of platinum hydrochloric acid in concentrated hydrochloric acid (the case of the isolation of the precursor hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) over 300 g / l leads to the formation of a too dense suspension during crystallization of the precursor. This causes mixing difficulties and creates conditions for incomplete interaction, which leads to a decrease in the yield of the precursor and its crystalline heterogeneity. A decrease in the concentration of platinum in the initial solution of platinum hydrochloric acid in concentrated hydrochloric acid less than 50 g / l leads to a dilution of the crystallization solution, which can lead to a decrease in the yield of the precursor, causes an excessive consumption of hydrochloric acid and (after separation of the precursor by filtration) leads to an increase in filtration (mother liquors) solutions.

An increase in the deposition temperature of the precursor compound (hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) above 60 ° C can lead to side effects of the interaction of the organic amine and the platinum chloride complex, which leads to contamination of the precursor compound, which can go to the target connection. A decrease in the deposition temperature of the precursor compound (hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) below 20 ° C leads to a relatively large decrease in the dispersion of the precipitate, which leads to a longer filtration process and may be accompanied by a partial passage of the precipitate through filter.

An increase in the amount of cyclohexane-trans-1,2-d, l-diamine to precipitate a precursor of more than 120% of the molar content of platinum in the solution leads to its excessive consumption, which leads to an increase in the cost of the process. In this case, an excess of organic diamine can cause the formation of a cation-anionic compound with a ratio of platinum and organic diamine 1: 2 in it, which upon further hydrolysis leads to a partial formation of the tetraamine complex of platinum, which can both pollute the target product and reduce its yield. A decrease in the amount of cyclohexane-trans-1,2-d, l-diamine to precipitate a precursor of less than 100% of the molar content of platinum in the solution leads to its lack, which reduces the yield of the precursor.

An increase in the volume of glacial acetic acid or ethanol to dissolve cyclohexane-trans-1,2-d, l-diamine and obtain its solution for precipitation of the precursor compound, more than 20 ml per 1 g of cyclohexane-trans-1,2-d, l- diamine leads to excessive dilution of the resulting suspension of the precursor and excessive consumption of solvent, which increases the cost of the process. Reducing the volume of glacial acetic acid or ethanol to dissolve cyclohexane-trans-1,2-d, l-diamine and obtain its solution for precipitation of the precursor compound, less than 5 ml per 1 g of cyclohexane-trans-1,2-d, l- diamine leads to an overly dense solution of diamine or even its incomplete dissolution, which leads to uneven crystallization of cyclohexane-trans-1,2-d, l-diammonium hexachloroplatinate (IV) and may be accompanied by a partial capture of unreacted reagents into the crystalline shell of the precursor, which leads to incomplete inter action and lowers the yield of the precursor.

An increase in the amount of CH ₃ COONa · 3H ₂ O over 500% of the molar amount of platinum in the initial solution of platinum hydrochloric acid for hydrolysis of the precursor compound leads to excessive consumption of the reagent, which increases the cost of the process. Moreover, a large excess of sodium acetate can lead to the occurrence of side interactions of the replacement of chloride ligands by water and hydroxide (equilibrium 6-7), which leads to contamination of the target compound and a decrease in its yield. The decrease in the amount of CH ₃ COONa · 3H ₂ O less than 300% of the molar amount of platinum in the initial solution of platinum chloride for hydrolysis of the precursor compound leads to incomplete hydrolysis of the precursor, which reduces the yield of the target product.

An increase in the content of CH ₃ COONa · 3H ₂ O in an aqueous solution for hydrolysis of the precursor compound over 250 g per 100 ml of water can lead to incomplete dissolution of sodium acetate and, as a result, to its incomplete consumption and deficiency in the reaction system, which reduces the yield of the target connections. Moreover, the hydrolysis in a too concentrated solution can lead to a partial capture of unreacted reagents in the crystalline shell of the product, which also leads to incomplete interaction and a decrease in the yield of the target product. A decrease in the content of CH ₃ COONa · 3H ₂ O in an aqueous solution to hydrolyze the precursor compound to less than 50 g per 100 ml of water leads to a dilution of the solution, which further requires longer evaporation, which increases the duration of the process.

An increase in the hydrolysis temperature of the precursor compound over 70 ° C can lead to the occurrence of side interactions of the replacement of chloride ligands by water and hydroxide (equilibria 6–7), which leads to contamination of the target compound and a decrease in its yield. A decrease in the hydrolysis temperature of the precursor compound less than 20 ° C leads to an increase in the duration of the hydrolysis and the entire process and can lead to incomplete interaction, which reduces the yield of the target compound.

An increase in the duration of hydrolysis of the precursor compound for more than 5 hours increases the duration of the process without a qualitative improvement in the properties of the target compound. Reducing the duration of hydrolysis of the precursor compound to less than 0.5 hours can lead to incomplete interaction, which reduces the yield of the product.

The increase in the acidity of the solution when concentrated hydrochloric acid is added to the suspension obtained after hydrolysis to dry it below pH 1 leads to an excess of hydrochloric acid, which further increases the duration of evaporation. Reducing the acidity of the solution by adding concentrated hydrochloric acid to the suspension obtained after hydrolysis to dry it above pH 3 can lead to a lack of hydrochloric acid to convert all sodium acetate to sodium chloride, which can subsequently lead to contamination of the target product with sodium acetate ( for its solubility in organic solvents). Moreover, insufficient acidity during evaporation of the suspension after hydrolysis can lead to the occurrence of side interactions of the replacement of chloride ligands by water and hydroxide (equilibrium 6-7), which leads to contamination of the target compound and a decrease in its yield.

An increase in the drying temperature of the suspension obtained by hydrolysis of more than 90 ° C can lead to side processes of solid-phase reduction of the target product into cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) and, due to the partial removal of chloride ligands, can be formed polynuclear compounds, which leads to a decrease in the yield of the target compound and its contamination. A decrease in the drying temperature of the suspension obtained by hydrolysis, less than 60 ° C increases the drying time, which increases the duration of the whole process.

An increase in the amount of H ₂ C ₂ H4 · 2H ₂ O for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium more than 200% of the molar amount of platinum in the initial solution of platinum chloride can lead to an increase in the acidity of the solution, which leads to incomplete recovery of the precursor and causes a decrease in the yield of intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II). A decrease in the amount of H ₂ C ₂ H4 · 2H ₂ O for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium less than 100% of the molar amount of platinum in the initial solution of platinum chloride leads to a lack of a reducing agent, which is the reason incomplete recovery of the precursor, and reduces the yield of intermediate (cyclohexane-trans-1,2-d, l-diamine) platinum (II) dichloride.

An increase in the concentration of H ₂ C ₂ H4 · 2H ₂ O for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium over 100 g per 100 ml of water can lead to incomplete dissolution of oxalic acid during reduction of the precursor, which leads to incomplete interaction and a decrease in the yield of the target compound. A decrease in the concentration of H ₂ C ₂ H4 · 2H ₂ O to reduce cyclohexane-trans-1,2-d, l-diammonium hexachloroplatinate (IV) per 100 ml of water leads to a dilution of the solution and a decrease in the yield of the intermediate (cyclohexane-trans 1,2-d, l-diamine) platinum (II) dichloride.

An increase in the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid or hydrazine chloride to cyclohexane-trans-1,2-4, / - platinum diaminodichloride (II) more than 800% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to excessive consumption of the reagent, which increases the cost of the process. Reducing the amount of CH ₃ COONa · 3H ₂ O to hydrolyze the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid or hydrazine chloride to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II) less than 400% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to incomplete hydrolysis of the precursor, which reduces the yield of the target product.

An increase in the reduction temperature of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid or sodium oxalate more than 90 ° C can lead to partial removal and replacement of chloride ligands by hydroxo and oxo groups, which leads to the formation of poorly soluble polynuclear compounds, which leads to contamination of the intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) and a decrease in the yield of the target compound and its pollution. Reducing the reduction temperature of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid or sodium oxalate less than 50 ° C increases the recovery time, which increases the duration of the whole process.

An increase in the length of the aging solution for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid, or sodium oxalate, or sodium formate, or hydrazine chloride for more than 3 hours increases the duration of the process without improving the properties of the obtained target product. Reducing the residence time of the solution for reducing hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid or sodium oxalate, or sodium formate, or hydrazine chloride for less than 10 hours can lead to incomplete recovery, which reduces the yield intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) and, as a consequence, the target compound.

An increase in the volume of the liquid phase of chloroform or a 10% aqueous hydrochloric acid solution in a suspension for the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) with chlorine of more than 25 ml per 1 g of platinum in the initial solution of platinum chloride results in the formation of a relatively dilute solution of the target compound, which, in the future, increases the duration of evaporation of the solution. A decrease in the volume of the liquid phase of chloroform or a 10% aqueous solution of hydrochloric acid in a suspension for the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) with chlorine of less than 10 ml per 1 g of platinum in the initial solution of platinum chloride can lead incomplete chlorination due to crystallization of the product on the surface of crystals of the intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II), which reduces its reactivity and reduces the yield of the target compound.

An increase in the solution evaporation temperature after the oxidation of cyclohexane-trans-1,2-d, l-platinum (II) diaminodichloride with chlorine above 90 ° C can lead to side processes of solid-phase reduction of the target product to cyclohexane-trans-1,2-d, l -diaminodichloride of platinum (II) and, due to the partial removal of chloride ligands, polynuclear compounds can form, which leads to a decrease in the yield of the target compound. A decrease in the evaporation temperature of the solution after oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) with chlorine less than 60 ° C increases the drying time, which increases the duration of the whole process.

An increase in the amount of Na ₂ C ₂ O ₄ for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium over 400% of the molar amount of platinum in the initial solution of platinum chloride leads to excessive consumption of the reagent, which increases the cost of carrying out process. A decrease in the amount of Na ₂ C ₂ O ₄ for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is less than 100% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to its lack and leads to incomplete recovery, which reduces the yield of the intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II).

An increase in the concentration of Na ₂ C ₂ O ₄ for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium over 6 g per 100 ml of water can lead to incomplete dissolution of sodium oxalate during reduction of the precursor, which leads to incomplete interaction and a decrease in the yield of intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II). A decrease in the concentration of Na ₂ C ₂ O ₄ to restore cyclohexane-trans-1,2-d, l-diammonium hexachloroplatinate (IV) per 100 ml of water leads to a dilution of the solution and a decrease in the yield of the intermediate cyclohexane-trans-1,2- d, l-diaminodichloride of platinum (II).

The increase in the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium oxalate to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) more than 400% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to excessive consumption of the reagent, which increases the cost of the process. Reducing the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium oxalate to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) less than 200% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to a lack of sodium acetate, which causes incomplete hydrolytic interaction and leads to a decrease in the yield of the intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II).

An increase in the amount of HCOONa for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium by more than 100% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to a partial reduction of platinum to metal and pollutes the intermediate cyclohexane-trans-1, 2-d, l-diaminodichloride of platinum (II) and requires an additional operation to recrystallize it. A decrease in the amount of HCOONa for the reduction of cyclohexane-trans-1,2-d, l-diammonium hexachloroplatinate (IV) less than 95% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to incomplete recovery and reduces the yield of the intermediate cyclohexane-trans-1,2- d, l-diaminodichloride of platinum (II).

An increase in the concentration of HCOONa for the reduction of cyclohexane-trans-1,2-d, l-diammonium hexachloroplatinate (IV) over 150 g per 100 ml of water can lead to incomplete dissolution of sodium formate during reduction of the precursor, which leads to incomplete interaction and a decrease in the yield of intermediate cyclohexane trans-1,2-d, l-diaminodichloride of platinum (II). A decrease in the concentration of HCOONa to reduce cyclohexane-tyrans-1,2-d, l-diammonium hexachloroplatinate (IV) per 100 ml of water leads to a dilution of the solution and a decrease in the yield of intermediate cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II).

Increasing the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium formate to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) more than 400% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to excessive consumption of the reagent, which increases the cost of the process. Reducing the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of a reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium formate to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) less than 300% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to a lack of sodium acetate, which causes incomplete hydrolytic interaction and reduces the yield of the intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II).

An increase in the reduction temperature of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium formate or hydrazine chloride over 60 ° C can lead to partial reduction of platinum to metal, which pollutes the intermediate cyclohexane-trans-1,2-d , l-diaminodichloride of platinum (II) and requires an additional operation to recrystallize it. A decrease in the reduction temperature of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium formate or hydrazine chloride below 30 ° C slows down the recovery, which increases the duration of the whole process.

An increase in the amount of N ₂ H ₄ · 2HCl for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium more than 55% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to a partial reduction of platinum to metal and pollutes the intermediate cyclohexane -trans-1,2-d, l-diaminodichloride of platinum (II) and requires an additional operation to recrystallize it. Reducing the amount of N ₂ H ₄ · 2HCl to reduce hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium to less than 50% of the molar amount of platinum in the initial solution of platinum hydrochloric acid leads to incomplete recovery and reduces the yield of intermediate cyclohexane-trans -1,2-d, l-diaminodichloride of platinum (II).

An increase in the concentration of N ₂ H ₄ · 2HCl for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium over 50 g per 100 ml of water can lead to incomplete dissolution of hydrazine chloride during reduction of the precursor, which leads to incomplete interaction and a decrease in the yield of intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II). A decrease in the concentration of N ₂ H ₄ · 2HCl for the reduction of cyclohexane-trans-1,2-d, l-diammonium hexachloroplatinate (IV) per 100 ml of water leads to a dilution of the solution and a decrease in the yield of the intermediate cyclohexane-trans-1,2- d, l-diaminodichloride of platinum (II).

An increase in the concentration of platinum in the initial solution of platinum hydrochloric acid in water (for the formation, but not the release of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) more than 150 g / l can lead to partial crystallization of the precursor, which further its reduction can cause incomplete interaction, which leads to a decrease in the yield of intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) and its contamination with a precursor. A decrease in the concentration of platinum in the initial solution of platinum hydrochloric acid in water (for the formation, but not the release of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) less than 50 g / l leads to dilution of the solution and, with further recovery, reduces the yield intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II).

An increase in the amount of cyclohexane-trans-1,2-d, l-diamine (for the formation, but not the isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) more than 101% of the molar content of platinum in the solution, upon further restoration of the resulting solution, leads to the partial formation of a non-target tetraamine complex of platinum with the ratio of platinum: cyclohexane-trans-1,2-d, l-diamine equal to 1: 2, which will reduce the yield of the intermediate cyclohexane-trans-1,2-d , l-diaminodichloride of platinum (II), and may lead to its pollution, which will require additional operations for its recrystallization. A decrease in the amount of cyclohexane-trans-1,2-d, l-diamine (for the formation, but not isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) of less than 99% of the molar content of platinum in the solution causes its lack will lead to a decrease in the yield of intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II).

An increase in the volume of water for dissolving cyclohexane-trans-1,2-d, l-diamine (for the formation but not isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) more than 20 ml per 1 g of cyclohexane -trans-1,2-d, l-diamine leads to a dilution of the solution, which is then reduced, which will reduce the yield of the intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II). Reducing the volume of water for dissolving cyclohexane-trans-1,2-d, l-diamine (for the formation, but not isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) less than 5 ml per 1 g of cyclohexane -trans-1,2-d, l-diamine leads to the formation of a viscous solution, which will lead to the loss of cyclohexane-trans-1,2-d, l-diamine remaining on the inner surface layer of the vessel in which the solution was prepared. This is especially noticeable when carrying out a process with a small amount of substances. Therefore, additional washing of the inner surface layer of the vessel where the solution was prepared will be necessary.

An increase in the temperature of formation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (in an aqueous solution) of more than 60 ° C can lead to the partial realization of side interactions of the replacement of chloride ligands by water and hydroxide (equilibrium 6-7), which will lead to contamination of the intermediate cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II), lowering its yield and will require an additional operation to recrystallize it. A decrease in the temperature of formation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (in aqueous solution) below 15 ° C is not effective, since it will require additional cooling of the solution.

An increase in the volume of an aqueous solution of hydrogen peroxide for the oxidation of cyclohexane-trans-1,2-d, l-platinum (II) diaminodichloride more than 100 ml per 1 g of platinum in the initial solution of platinum hydrochloric acid leads to excessive consumption of the reagent and, further, upon evaporation of the solution leads to an increase in the duration of the entire process. The decrease in the volume of an aqueous solution of hydrogen peroxide for the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) less than 20 ml per 1 g of platinum in the initial solution of platinum hydrochloric acid leads to an increase in the viscosity of the resulting suspension, which may lead to insufficient wettability oxidized compounds of platinum (II), and to incomplete oxidation and lower yield of the target compound.

An increase in the mass content of hydrogen peroxide in an aqueous solution for the oxidation of cyclohexane-trans-1,2-d, l-platinum (II) diaminodichloride more than 30% requires the use of a non-standard aqueous solution of hydrogen peroxide, which, in turn, will require special methods for producing hydrogen peroxide , which will increase its cost, which means it will increase the cost of obtaining the target compound. A decrease in the mass content of hydrogen peroxide in an aqueous solution for the oxidation of cyclohexane-trans-1,2-d, l-platinum (II) diaminodichloride by less than 5% will lead to a dilution of the solution, which will further increase the duration of the evaporation of the solution of the target compound. In this case, a decrease in the concentration of hydrogen peroxide can lead to incomplete oxidation and a decrease in the yield of the target compound.

An increase in the duration of mixing an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-platinum (II) diaminodichloride for more than 4 hours will lead to an unreasonable increase in the duration of the process without a qualitative improvement in the process and properties of the target compound. Reducing the duration of mixing an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-platinum (II) diaminodichloride for less than 2 hours can lead to incomplete oxidation of the Pt (II) complex to Pt (IV), which will lead to a decrease output of the target connection.

An increase in the heating temperature of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-platinum (II) diaminodichloride with stirring above 80 ° C can lead to unnecessarily intensive decomposition of hydrogen peroxide, which is accompanied by intense gas evolution, and can lead to removal substances from the reactor. At the same time, the rate of thermal decomposition of hydrogen peroxide can cause its lack of oxidation, which will lead to a decrease in the yield of the target compound. A decrease in the heating temperature of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) with stirring below 40 ° C will slow down the oxidation, which will require an increase in the duration of the whole process.

An increase in the volume of concentrated hydrochloric acid added to the suspension of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) after stirring, more than 5 ml per 1 g of platinum in the initial solution of platinum chloride leads to excessive consumption hydrochloric acid, which increases the cost of the process. A decrease in the volume of concentrated hydrochloric acid added to the suspension of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) after stirring, less than 2 ml per 1 g of platinum in the initial solution of platinum chloride can lead to its a disadvantage for the replacement of hydroxide ligands with chloride, which leads to contamination of the target compound.

An increase in the evaporation temperature of the solution obtained after adding hydrochloric acid to the suspension of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II), more than 90 ° C, can lead to partial decomposition of the target product and a decrease in its yield . A decrease in the evaporation temperature of the solution obtained after adding hydrochloric acid to the suspension of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) less than 60 ° C leads to an increase in the duration of evaporation of the solution, which increases the duration of the whole process .

Examples of the method

Example 1

The prepared solution of platinum hydrochloric acid in concentrated hydrochloric acid with the necessary platinum content is brought to the required temperature and the acetic or ethanol solution of cyclohexane-trans-1,2-d, l-diamine is added in the required amount with stirring. The resulting suspension is filtered, the precipitate is washed with glacial acetic acid or ethanol and dried on a filter in a stream of dry air. The mother and wash solution was sent for platinum regeneration. The experimental data are shown in table 1. Experiments 1-8 show the process under boundary conditions. Experiments 9-10 are close to optimal.

The precipitate of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is dissolved with stirring in the required amount of an aqueous solution of sodium acetate at a given temperature and in a reactor protected from direct sunlight and light. The resulting mixture with stirring is kept for the required time, then an excess of concentrated hydrochloric acid is poured to the required pH and the resulting suspension is dried at a given temperature. The dry residue is mixed with diethyl ether, or acetone, or chloroform and stirred to a uniform consistency of the resulting suspension and filtered. The operation of washing the precipitate is carried out repeatedly until it is discolored. The mother liquor is evaporated, the target compound is dried and, if necessary, recrystallized from diethyl ether, or acetone, or chloroform. The organic solvent after condensation is mixed with a desiccant, distilled and reused. The experimental data are shown in table 2. Experiments 1-12 show the process under boundary conditions. Experiments 13-14 are close to optimal.

The target product is obtained in the form of crystalline hydrate - [Pt {C ₆ H ₁₀ (trans-1,2-d, l-NH ₂ ) ₂ } Cl ₄ ] · 1 / 3H ₂ O, which is characterized by elemental analysis, x-ray phase analysis, differential scanning calorimetry. The data of x-ray phase analysis are completely consistent with the data of x-ray structural analysis (Khokhar AR, Xu Q., Al-Baker S. // J. Inorg. Biochem. 1993. V. 52.i.1. P. 51-58) .

Example 2

The isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is carried out in accordance with Example 1. The resulting precursor is dissolved with stirring in the required amount of an oxalic acid aqueous solution, the required amount of sodium acetate is added, and the temperature is maintained at a given temperature for necessary time and secrete cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) by filtration. The precipitate is suspended in a 10% aqueous hydrochloric acid solution or chloroform. Chlorine is passed into the resulting suspension with stirring until the precipitate is dissolved, then the solution is evaporated. The target compound is dried and, if necessary, recrystallized from diethyl ether, or acetone, or chloroform. The experimental data are shown in tables 3 and 4. Experiments 1-10 (table. 3) and 13-16 (table. 4) show the process under boundary conditions, experiments 11-12 (table. 3) and 17-18 (table. 4 ) are close to optimal.

The x-ray phase analysis of the products obtained according to example 2, coincides with the data of x-ray phase analysis of samples of the target compound obtained in example 1.

Example 3

Isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is carried out in accordance with Example 1. The resulting precursor is dissolved with stirring in the required amount of an aqueous solution of sodium oxalate, the required amount of sodium acetate is added, and the temperature is maintained at a given temperature for necessary time and secrete cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) by filtration. The precipitate is chlorinated in accordance with example 2. The experimental data are shown in tables 5 and 4. Experiments 1-10 (table. 5) and 13-16 (table. 4) show the process under boundary conditions, experiments 11-12 (table. 5 ) and 17-18 (tab. 4) are close to optimal.

The x-ray phase analysis of the products obtained according to example 3, coincides with the data of x-ray phase analysis of samples of the target compound obtained in example 1.

Example 4

Isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is carried out in accordance with Example 1. The resulting precursor is dissolved with stirring in the required amount of an aqueous solution of sodium formate, the required amount of sodium acetate is added, and maintained at a given temperature for necessary time and secrete cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) by filtration. The precipitate is chlorinated in accordance with example 2. The experimental data are shown in tables 6 and 4. Experiments 1-10 (table. 6) and 13-16 (table. 4) show the process under boundary conditions, experiments 11-12 (table. 6 ) and 17-18 (tab. 4) are close to optimal.

X-ray phase analysis of the products obtained in example 4, coincides with the data of x-ray phase analysis of samples of the target compound obtained in example 1.

Example 5

Isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is carried out in accordance with Example 1. The resulting precursor is dissolved with stirring in the required amount of an aqueous solution of hydrazine chloride, the required amount of sodium acetate is added, and the temperature is maintained at a given temperature for necessary time and secrete cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) by filtration. The precipitate is chlorinated in accordance with example 2. The experimental data are shown in tables 8 and 4. Experiments 1-10 (table. 8) and 13-16 (table. 4) show the process under boundary conditions, experiments 11-12 (table. 8 ) and 17-18 (tab. 4) are close to optimal.

The x-ray phase analysis of the products obtained according to example 5, coincides with the data of x-ray phase analysis of samples of the target compound obtained in example 1.

Example 6

In the prepared aqueous solution of platinum hydrochloric acid with the required concentration of platinum is brought to the required temperature and an aqueous solution of cyclohexane-trans-1,2-d, l-diamine is added in the required amount with stirring. From the resulting solution, reduction with oxalic acid and hydrolysis with sodium acetate additives, in accordance with Example 2, platinum (II) cyclohexane-trans-1,2-d, l-diaminodichloride is isolated. The precipitate is chlorinated in accordance with example 2. The experimental data are shown in tables 7, 3 and 4. Experiments 1-8 (table. 7), 1-10 (table. 3) and 13-16 (table. 4) show the process at boundary conditions, experiments 9-10 (table. 7), 11-12 (table. 3) and 17-18 (table. 4) are close to optimal.

The x-ray phase analysis of the products obtained according to example 6, coincides with the data of x-ray phase analysis of samples of the target compound obtained in example 1.

Example 7

An aqueous solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is prepared in accordance with Example 6. Cyclohexane-trans- is isolated from the resulting solution by reduction with sodium oxalate and hydrolysis with sodium acetate additives in accordance with Example 3. Platinum (II) 1,2-d, l-diaminodichloride. The precipitate is chlorinated in accordance with example 2. The experimental data are shown in tables 7, 5 and 4. Experiments 1-8 (table. 7), 1-10 (table. 5) and 13-16 (table. 4) show the process at boundary conditions, experiments 9-10 (table. 7), 11-12 (table. 5) and 17-18 (table. 4) are close to optimal.

The x-ray phase analysis of the products obtained according to example 7, coincides with the data of x-ray phase analysis of samples of the target compound obtained in example 1.

Example 8

An aqueous solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is prepared in accordance with Example 6. Cyclohexane-trans is isolated from the resulting solution by reduction with sodium formate and hydrolysis with sodium acetate additives in accordance with Example 4. Platinum (II) 1,2-d, l-diaminodichloride. The precipitate is chlorinated in accordance with example 2. The experimental data are shown in tables 7, 6 and 4. Experiments 1-8 (table. 7), 1-10 (table. 6) and 13-16 (table. 4) show the process at boundary conditions, experiments 9-10 (table. 7), 11-12 (table. 6) and 17-18 (table. 4) are close to optimal.

X-ray phase analysis of the products obtained in example 8, coincides with the data of x-ray phase analysis of samples of the target compound obtained in example 1.

Example 9

An aqueous solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is prepared in accordance with Example 6. Cyclohexane-trans- is isolated from the resulting solution by reduction of hydrazine chloride and hydrolysis with sodium acetate additives in accordance with Example 5. Platinum (II) 1,2-d, l-diaminodichloride. The precipitate is chlorinated in accordance with example 2. The experimental data are shown in tables 7, 8 and 4. Experiments 1-8 (table. 7), 1-10 (table. 8) and 13-16 (table. 4) show the process at boundary conditions, experiments 9-10 (table. 7), 11-12 (table. 8) and 17-18 (table. 4) are close to optimal.

The x-ray phase analysis of the products obtained according to example 9, coincides with the data of x-ray phase analysis of samples of the target compound obtained in example 1.

Example 10

The isolation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) is carried out in accordance with examples 2-5 or 6-9. The precipitate of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) is suspended with the required amount of an aqueous solution of hydrogen peroxide and kept under stirring and heating at a given temperature for the required time. Then add the required amount of concentrated hydrochloric acid and continue stirring until the precipitate dissolves. The resulting solution is evaporated under reduced pressure and a predetermined temperature. The target compound is dried and, if necessary, recrystallized from diethyl ether, or acetone, or chloroform. The experimental data are shown in table 9. Experiments 1-11 (Table 9) show the process under boundary conditions, experiments 12-13 (Table 9) are close to optimal.

X-ray phase analysis of the products obtained according to example 10, coincides with the data of x-ray phase analysis of samples of the target compound obtained in example 1.

Explanation of the tables:

I is the concentration of Pt in the initial solution of platinum chloride in concentrated hydrochloric acid (g / l);

II - deposition temperature of the precursor compound (° C);

III - the amount of C ₆ H ₁₀ (NH ₂ ) (%) of the molar content of platinum in the solution;

IV - the volume of glacial acetic acid or ethanol per 1 g of C ₆ H ₁₀ (NH ₂ ) ₂ (ml);

V is the yield (%) of the amount of platinum in a solution of platinum chloride;

VI - the amount of CH ₃ COONa · 3H ₂ O (%) of the molar amount of platinum in the initial solution of platinum hydrochloric acid for hydrolysis of the precursor compound;

VII - the content of CH ₃ COONa · 3H ₂ O in an aqueous solution per 100 ml of water for hydrolysis (g);

VIII - the temperature of the hydrolysis solution (° C);

IX is the duration of hydrolysis (h);

X is the pH of the acidity of the solution when concentrated hydrochloric acid is added to the suspension obtained by hydrolysis to dry it;

XI is the drying temperature of the suspension obtained by hydrolysis (° C);

XII - the amount of H ₂ C ₂ O ₄ · 2H ₂ O for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (%) from the molar amount of platinum in the initial solution of platinum chloride;

XIII - concentration of H ₂ C ₂ O ₄ · 2H ₂ O to restore hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (g) per 100 ml of water;

XIV - the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (oxalic acid) to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II) (%) of the molar amount of platinum in the initial solution of platinum chloride;

XV — temperature of the solution for reducing hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid (° C);

XVI - the duration of the aging solution for the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with oxalic acid (h);

XVII - the volume of the liquid phase in the suspension for the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) with chlorine (ml) per 1 g of platinum in the initial solution of platinum chloride;

XVIII - solution evaporation temperature after oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) with chlorine (° C);

XIX - the amount of Na ₂ C ₂ O ₄ for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium - (%) of the molar amount of platinum in the initial solution of platinum chloride;

XX is the concentration of Na ₂ C ₂ O ₄ for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-4, / - diammonium (g) per 100 ml of water;

XXI - the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (sodium oxalate) to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II) (%) of the molar amount of platinum in the initial solution of platinum chloride;

XXII - solution temperature for reducing hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium oxalate (° C);

XXIII - the duration of the aging solution for the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium sodium oxalate (h);

XXIV - the amount of HCOONa for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (%) of the molar amount of platinum in the initial solution of platinum chloride;

XXV - concentration of HCOONa for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (g) per 100 ml of water;

XXVI - the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (sodium formate) to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II) (%) of the molar amount of platinum in the initial solution of platinum chloride;

XXVII — temperature of the solution for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium with sodium formate (° C);

XXVIII - the duration of the aging solution for the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium sodium formate (h);

XXIX - the concentration of platinum in the initial solution of platinum hydrochloric acid in water (for the formation, but not the allocation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) (g / l);

XXX - the amount of cyclohexane-trans-1,2-d, l-diamine (for the formation, but not isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) (%) of the molar content of platinum in solution ;

XXXI is the volume of water for dissolving cyclohexane-trans-1,2-d, l-diamine (for the formation, but not isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium) (ml) per 1 g cyclohexane-trans-1,2-d, l-diamine;

XXXII - the temperature of formation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (for formation, but not isolation) (° C);

XXXIII - the amount of N ₂ H ₄ · 2HCl for the reduction of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (%) from the molar amount of platinum in the initial solution of platinum chloride;

XXXIV - the concentration of N ₂ H ₄ · 2HCl to restore hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (g) per 100 ml of water;

XXXV - the amount of CH ₃ COONa · 3H ₂ O for hydrolysis of the reduced solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium (hydrazine chloride) to (cyclohexane-trans-1,2-d, l-diamine ) platinum (II) dichloride (%) of the molar amount of platinum in the initial solution of platinum hydrochloric acid;

XXXVI — temperature of the solution for reducing hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium hydrazine chloride (° C);

XXXVII - the duration of the aging solution for the recovery of hexachloroplatinate (IV cyclohexane-trans-1,2-d, l-diammonium hydrazine chloride (h);

XXXVIII - the volume of an aqueous solution of hydrogen peroxide for the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) (ml) per 1 g of platinum in the initial solution of platinum chloride;

XXXIX - mass content of hydrogen peroxide in an aqueous solution for the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) (%);

XL is the duration of mixing an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) (h);

XLI is the heating temperature of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) with stirring (° C);

XLII - the volume of concentrated hydrochloric acid added to the suspension of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) after stirring, (ml) per 1 g of platinum in the initial solution of platinum chloride;

XLIII is the evaporation temperature of the solution obtained after adding hydrochloric acid to a suspension of an aqueous solution of hydrogen peroxide and cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II), (° C).

As shown in the examples, the use of the proposed method allows to improve the method for producing cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) in a crystalline phase-uniform state [Pt {trans-1,2-d, lC ₆ H ₁₀ (NH ₂ ) ₂ } Cl ₄ ] · 1 / 3H ₂ O with a high degree of purity, increase the stability of the synthesis, and also achieve a high yield of the target compound.

Claims (18)

1. The method of obtaining cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV), comprising the formation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium from a solution of platinum chloride, characterized in that the isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is carried out by adding to the hydrochloric acid solution of platinum chloride-cyclohexane-trans-1,2-d, l-diamine in glacial acetic acid, followed by its separation and hydrolysis, which is carried out when dissolving hexachloroplatinate (IV) cyclo Xan-trans-1,2-d, l-diammonium in an aqueous sodium acetate solution with a concentration of (50-250) g CH ₃ COONa · 3H ₂ O in 100 ml of water was taken in an amount (300-800)% of the molar amount of platinum in the initial solution of platinum chloride, at (20-60) ° C for (0.5-5) hours, while the hydrolysis process is carried out in a reactor protected from direct sunlight and lighting, and the isolation of cyclohexane-trans-1,2- d, l-diaminotetrachloride of platinum (IV) from a hydrolysis solution of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is carried out by adding concentrated salt minutes until pH acid solution (1-3) obtained by drying slurry at (60-90) ° C, dissolving the residue in diethyl ether, or acetone, or chloroform, filtration of the sodium chloride solution and evaporation of the diethyl ether or acetone or chloroform. 2. The method according to claim 1, characterized in that the allocation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is carried out from a solution of platinum chloride in concentrated hydrochloric acid with a concentration of platinum (50-300) g / l by the action of an acetic acid or ethanol solution of cyclohexane-trans-1,2-d, l-diamine, in which (5-20) ml of glacial acetic acid or ethanol per 1 g of cyclohexane-trans-1,2-d, l-diamine , in the amount of (100-120)% of the molar content of platinum in solution, at a temperature of (20-60) ° С. 3. The method of obtaining cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV), comprising the formation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium from a solution of platinum chloride, characterized in that the isolation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is carried out by adding to the hydrochloric acid solution of platinum chloride-cyclohexane-trans-1,2-d, l-diamine in glacial acetic acid, followed by its separation and reduction hydrolysis to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) which is separated by filtration and oxidized to cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV). 4. The method according to claim 3, characterized in that the allocation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is carried out from a solution of platinum chloride in concentrated hydrochloric acid with a concentration of platinum (50-300) g / l by the action of an acetic acid or ethanol solution of cyclohexane-trans-1,2-d, l-diamine, in which (5-10) ml of glacial acetic acid or ethanol per 1 g of cyclohexane-trans-1,2-d, l-diamine , in the amount of (100-120)% of the molar content of platinum in solution, at a temperature of (20-60) ° С. 5. The method according to claim 3, characterized in that the recovery-hydrolysis of the isolated hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II ) is carried out when it is dissolved in an aqueous solution of oxalic acid with a concentration of H ₂ C ₂ O ₄ · 2H ₂ O (5-100) g per 100 ml of water in an amount of (100-200)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (50-90) ° C for (1-3) hours, with the addition of sodium acetate in the amount of (400- 800)% CH ₃ COONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum hydrochloric acid. 6. The method according to claim 3, characterized in that the recovery-hydrolysis of the selected hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II ) is carried out when it is dissolved in an aqueous solution of sodium oxalate with a concentration of (3-6) g Na ₂ C ₂ O ₄ per 100 ml of water in an amount of (100-400)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (50-90) ° C for (1-3) hours, with the addition of sodium acetate in the amount of (200-400)% CH ₃ CO in the resulting solution ONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum hydrochloric acid. 7. The method according to claim 3, characterized in that the recovery-hydrolysis of the isolated hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II ) is carried out when it is dissolved in an aqueous solution of sodium formate with a concentration of HCOONa (10-150) g per 100 ml of water in the amount of (95-100)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (30-60 ) ° C for (1-3) hours, with the addition of sodium acetate in the amount of (300-400)% CH ₃ COONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum hydrochloric acid. 8. The method according to claim 3, characterized in that the recovery-hydrolysis of the isolated hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II ) is carried out when it is dissolved in an aqueous solution of hydrazine chloride with a concentration of N ₂ H ₄ · 2HCl (5-50) g per 100 ml of water in an amount of (50-55)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (30-60) ° C for (1-3) hours, with the addition of sodium acetate in the amount of (400-800)% CH ₃ in the resulting solution COONa · 3H ₂ O of the molar amount of platinum in the initial solution of platinum hydrochloric acid. 9. The method according to claim 3, characterized in that the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) to cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) is carried out by chlorination its suspension with a 10% aqueous solution of hydrochloric acid or chloroform, taken in an amount of (10-25) ml per 1 g of platinum in the initial solution of platinum chloride, passing chlorine to dissolve the precipitate and evaporating the resulting solution at (60-90) ° С . 10. The method according to claim 3, characterized in that the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) to cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) is carried out by stirring its suspension in (20-100) ml (5-30)% by weight hydrogen peroxide solution based on 1 g of platinum in the initial solution of platinum hydrochloric acid, for (2-4) hours at (40-80) ° C, adding to the resulting suspension of concentrated hydrochloric acid in an amount of (2-5) ml per 1 g of platinum in the initial solution of platinum hydrochloric acid and stirring slurry to dissolve the precipitate with subsequent evaporation of the resultant solution at (60-90) ° C. 11. A method of producing cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV), comprising the formation of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium from a solution of platinum chloride, characterized in that chloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is formed by adding an aqueous solution of trans-1,2-d, l-diaminocyclohexane to an aqueous solution of platinum chloride, followed by its reduction and hydrolysis in an aqueous solution to cyclohexane- trans-1,2-d, l-diaminodichloride of platinum (II), which is separated by fil tion and is oxidized to trans-cyclohexane-1,2-d, l-diaminotetrahlorida platinum (IV). 12. The method according to claim 11, characterized in that the hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium is formed from an aqueous solution of platinum hydrochloric acid with a concentration of platinum (50-150) g / l, the action of an aqueous solution cyclohexane-trans-1,2-d, l-diamine, in which (5-20) ml of water is present per 1 g of cyclohexane-trans-1,2-d, l-diamine, in an amount of (99-101)% of molar platinum content in solution at (15-60) ° С. 13. The method according to claim 11, characterized in that the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium, followed by hydrolysis to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II ) is carried out in an aqueous solution of oxalic acid with a concentration of H ₂ C ₂ O ₄ · 2H ₂ O (5-100) g per 100 ml of water in an amount of (100-200)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (50-90) ° C for (1-3) hours, with the addition of the resulting sodium acetate in an amount (400-800)% CH ₃ COONa · 3H ₂ O t molar amount of platinum in the feed solution of chloroplatinic acid. 14. The method according to claim 11, characterized in that the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium, followed by hydrolysis to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II ) is carried out in an aqueous solution of sodium oxalate with a concentration of (3-6) g Na ₂ C ₂ O ₄ per 100 ml of water in an amount of (100-400)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (50 -90) ° C for (1-3) hours, with the addition of sodium acetate in the amount of (200-400)% CH ₃ COONa · 3H ₂ O from mol the amount of platinum in the initial solution of platinum hydrochloric acid. 15. The method according to claim 11, characterized in that the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium, followed by hydrolysis to cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II ) is carried out in an aqueous solution of sodium formate with a concentration of HCOONa (10-150) g per 100 ml of water in an amount of (95-100)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (30-60) ° С for (1-3) hours, with the addition of the resulting sodium acetate in an amount (300-400)% CH ₃ COONa · 3H ₂ O from molnog amount of platinum in the feed solution of chloroplatinic acid. 16. The method according to claim 11, characterized in that the recovery of hexachloroplatinate (IV) cyclohexane-trans-1,2-d, l-diammonium, followed by hydrolysis to cyclohexane-trans-1,2-d, l-diaminodichloride platinum (II ) spend in an aqueous solution of hydrazine chloride with a concentration of N ₂ H ₄ · 2HCl (5-50) g per 100 ml of water in an amount of (50-55)% of the molar amount of platinum in the initial solution of platinum chloride, while maintaining the resulting solution at (30 -60) ° C for (1-3) hours, with the addition of the resulting sodium acetate in an amount (400-800)% CH ₃ COONa · 3H ₂ O by mole Nogo number of platinum in the feed solution of chloroplatinic acid. 17. The method according to claim 11, characterized in that the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) to cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) is carried out by chlorination its suspension with a 10% aqueous solution of hydrochloric acid or chloroform, taken in an amount of (10-25) ml per 1 g of platinum in the initial solution of platinum chloride, passing chlorine to dissolve the precipitate and evaporating the resulting solution at (60-90) ° С . 18. The method according to claim 11, characterized in that the oxidation of cyclohexane-trans-1,2-d, l-diaminodichloride of platinum (II) to cyclohexane-trans-1,2-d, l-diaminotetrachloride of platinum (IV) is carried out by stirring its suspension in (20-100) ml (5-30)% hydrogen peroxide solution per 1 g of platinum in the initial solution of platinum hydrochloric acid for (2-3) hours at (40-80) ° C, adding to the resulting suspension of concentrated hydrochloric acid in an amount of (2-5) ml per 1 g of platinum in the initial solution of platinum hydrochloric acid and stirring the resulting suspension to p stvoreniya precipitate and evaporation of the resultant solution at (60-90) ° C.