RU2552668C2 - Method for face and neck skin rejuvenation - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to physiotherapy, dermatology and cosmetology, and can be used in stimulating regenerative processes in the face and/or neck skin. That is ensured by performing three stages, first two of which involve preparing to the third one. The first stage involves blood sampling from the patient, recovering the blood plasma, and enriching it with thrombocytes; the purified and enriched plasma is administered intradermally under the skin. Two days later, the second stage follows that involves the subcutaneous injections of hyaluronic acid. The third stage is performed 2-3 days later to expose different skin layers to laser light passing through different face and/or neck sections two to five times for one procedure. Passing once involves the alternating short-wave and long-wave laser exposure at a wave length of 1564-2940 nm. The procedure is repeated every 3-5 days with an increasing laser beam pulse energy from 35 mJ to 65 mJ.

EFFECT: method provides the safe effective stimulation of the regenerative processes in the face and/or neck skin ensured by the complex exposure covering different layers of derma and epidermis and involving different regeneration links.

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Description

The invention relates to medicine, in particular to physiotherapy of dermatology and cosmetology, and is intended to stimulate regenerative processes in the skin of the face and / or neck.

The prior art method of stimulating reparative and trophic processes in the skin, including blood sampling, centrifugation to obtain a plasma preparation rich in platelets, intradermal administration of the obtained drug in volume per course, determined by the degree of the disease, in which, after centrifugation in the plasma preparation, determine the number of active platelets Ta and with a value of 60 <Ta <80% inject 3-5 ml per session, with 40 <Ta <60% inject 5-8 ml per session, with Ta <40% inject 8-10 ml per session, with Ta> 80% is administered 1-3 ml per session (RU 2470677 C1, A61M 1 / 38 10/19/2011).

There is also known a method of skin rejuvenation, including applying a photosensitizer to the skin and subsequent exposure to laser radiation, characterized in that a gel containing glucurin salt of chlorin E6 or sodium salt of chlorophyllin copper is applied to previously cleaned skin until the photosensitizer penetrates the epidermis, then the photosensitizer is removed and the skin is exposed to laser radiation in a continuous mode at a wavelength corresponding to the maximum absorption of photosensi ilizatora, wherein when used as a photosensitizer glucamine salt chlorin E6 to laser radiation with a power density of 96 mW / cm ^2, the specific dose of 72 J / cm ² and the total dose of 1440 J or with a power density of 105 mW / cm ^2, the specific dose 126 J / cm ² and a total dose of 2520 J, or a specific power of 80 mV / cm ² , a specific dose of 72 J / cm ² and a full dose of 1800 J, and when using the sodium salt of chlorophyllin, copper is exposed to laser radiation with a specific power of 70 mV / cm ² , with a specific dose of 50.4 J / cm ² and a full dose of 2200 J (RU 2336106 C2, A61N 5/067, 20.10.2 008).

The closest analogue to the claimed invention is a method of rejuvenating the face, neck and body, including exposure to the skin with electric current and laser electromagnetic radiation, in which the laser radiation is red and / or infrared, and the exposure to the skin surface is electric high-frequency current and laser electromagnetic radiation are carried out simultaneously (RU 2190436 C1, A61N 5/067, 10.10.2002).

The disadvantage of the closest analogue is the increased invasiveness of the method, a relatively long rehabilitation period, as well as pain during the procedures, the need for painkillers, etc.

The problem to which the claimed invention is directed, is to increase the efficiency and durability of the effect of the procedures.

The problem is solved due to the fact that the method of stimulating regenerative processes in the skin of the face and / or neck is carried out for several days, in three stages, the first two of which are preparatory to the third, and at the first stage, blood is taken from the patient, isolation from plasma and its enrichment with platelets, after which intradermal administration of purified and enriched blood plasma under the skin is carried out, at the second stage, two days later, subcutaneous injections of hyaluronic acid are performed, after which 2-3 days, n and in the third stage, a multi-level pulsed laser action is applied to different skin layers along its depth, making from two to five passes, while both short-pulse and long-pulse laser radiation with a wavelength of 1564-2940 nm are alternately applied in one pass; laser exposure is repeated several times at intervals of 3-5 days, gradually increasing the intensity of exposure.

The technical result is to reduce the traumatic component from laser exposure, accelerate skin healing after exposure, shortening the intervals between multilevel laser exposure.

A method of stimulating regenerative processes in the skin of the face and / or neck is carried out for several days, in three stages, the first two of which are preparatory to the third. Moreover, at the first stage, blood sampling from the patient is carried out, plasma is extracted from it and it is enriched with platelets, after which intradermal administration of purified and enriched blood plasma under the skin is carried out.

At the second stage, two days later, hyaluronic acid is injected subcutaneously, after which, after 2-3 days, at the third stage, a multi-level pulsed laser effect is applied to different layers of the skin along its depth, making from two to five passes, while in one pass it is applied alternately both short-pulse and long-pulse exposure to laser radiation with a wavelength of 1564-2940 nm.

In this case, the laser exposure is repeated several times at intervals of 3-5 days, gradually, with each subsequent procedure, increasing the intensity of the exposure (the energy of the laser pulses is increased in the range from 35 mJ to 65 mJ at an energy density of 50 to 140 J / cm ² ).

At the first two stages, the preparation of the skin of the face and neck of the patient for complex multilevel laser exposure is carried out.

At the first stage, in the conditions of the doctor’s office, the patient takes the necessary amount of blood, which is processed using high-tech equipment. Plasma isolated from blood by centrifugation is enriched with its own platelets. It is in these cells that huge restoration resources are hidden. Then, the resulting preparation, in which no foreign substances are added, is subcutaneously administered to the patient by the mesotherapeutic method (a series of microinjections).

The platelet plasma introduced into the patient’s skin normalizes tissue respiration, water balance, causes the formation of new fibroblast cells, osteoblasts, chondroblasts and endothelial cells. At the same time, the process of formation of collagen, elastin and intercellular substance occurs. After this procedure, the protective system of the skin is activated, accelerated healing and restoration are launched.

This procedure is known in cosmetology under the name "Plasmolifting" and is known in cosmetology as an independent cosmetology procedure (see, for example, RU 2470677 C1). In the context of the present invention, this procedure, together with injections of hyaluronic acid (the second stage), plays the role not of a cosmetic procedure, but of the preparatory procedure necessary to reduce the traumatic side effects of multilevel laser exposure.

The second stage is the introduction of hyaluronic acid, since with aging in the dermis, the content of hyaluronic acid decreases, which leads to a decrease in the amount of moisture in the skin and the deterioration of its turgor. Injections of hyaluronic acid not only compensate for the lack of moisture in the main substance and contribute to deep hydration of the skin, but also actively stimulate fibroplasts to produce collagen. In order to combine the two steps, a simultaneous administration of a mixture of enriched plasma and hyaluronic acid is possible.

2-3 days after the end of the injections, microhematomas are partially absorbed, and the processes initiated by the injections mentioned above are intensified, after which the skin receives the potential for regeneration and becomes prepared for multilevel laser exposure.

Next, a multi-level laser effect is applied to different skin layers along its depth, combining short-pulse exposure (ablation) and long-pulse exposure (coagulation), which alternate in an automatic sequence.

Multilevel laser exposure has been successfully applied and has good clinical results, since changes in tissue temperature play a key role in stimulating neocollagenesis and extracellular matrix production. Consistently in one procedure, both short-pulse exposure and long-pulse exposure to laser radiation with a wavelength of 1564-2940 nm are used. Preferably, the use of an Er: YAG laser with a wavelength of 2940 nm, equipped with a fractional nozzle in which the laser beam, passing through the diffraction optical grating and the applicator microlens, is divided into many individual microbeams that focus on the skin surface with a diameter of 100-200 microns each, forming microthermal treatment zones.

Short-pulse radiation (duration 200-350 μs, repetition rate 3-10 Hz) minimizes skin damage, leaving islands of intact tissue from which healing proceeds, causes moderate intradermal edema and a delayed moderate increase in collagen dermis production. The regenerative resource of the skin is maintained, which ensures quick rehabilitation and the patient returns to his usual life. At the same time, skin structure is improved and dyschromia is eliminated.

The use of long-pulse radiation (duration 1-5 ms, repetition frequency 3-5 Hz) leads to the development of more pronounced edema in the deeper layers of the dermis, which allows you to rejuvenate the epidermal layer, capturing the uppermost layers of the dermis. The formation of a large number of damaged microcolumns surrounded by heating microzones leads to a reduction in the epidermis area, an improvement in the microrelief of the skin, and stimulates the contraction of the dermis.

Individual reactions in different parts of the face and neck may vary. It is recommended to start treatment at low energies with a gradual increase in the intensity of exposure (pulse energy and energy density) until the degree and duration of the patient's response are known and well tolerated. This may require additional procedures to achieve the desired effect and reduce the potential risk of adverse reactions. The number of passes on the face - up to 3 passes, around the eyes - up to 2-3 passes, around the mouth - 2-5 passes, neck - up to 2 passes.

With a long-pulse exposure to tissues, the thermal component is more pronounced, accompanied and controlled by a burn, partial coagulation of the microvascular bed, partial direct denaturation of the quaternary collagen structure. In the area of aseptic inflammation, the mechanisms of early revascularization, the appearance of young fibroplasts and neocollagenesis are ultimately initiated and maintained. The use of only short-pulse or only long-pulse exposure within a single radiation procedure limits the possibility of obtaining the maximum clinical and aesthetic effect. More pronounced results are obtained by procedures that allow the skin to be exposed to alternately short-pulse and long-pulse radiation, including those with different wavelengths, which leads to complex rejuvenation of both different layers of the dermis and epidermis. However, this effect is more traumatic and requires a longer recovery period. To reduce the invasiveness of exposure and prepare the skin allow the procedures carried out in the first two stages of the proposed method.

Claims (1)

A method of stimulating regenerative processes in the skin of the face and / or neck, characterized in that it is carried out for several days, in three stages, the first two of which are preparatory to the third, and at the first stage, blood is collected from the patient, plasma is extracted from it and its enrichment with platelets, after which intradermal administration of purified and enriched blood plasma under the skin is carried out, at the second stage, two days later, hypodermic hyaluronic acid is injected, after which 2-3 days later, at the third stage carry out laser action on different layers of the skin, making from two to five passes on different parts of the face and / or neck in one procedure, while during one pass, both short-pulse and long-pulse laser radiation with a wavelength of 1564-2940 are alternately nm, the procedure is repeated at intervals of 3-5 days, increasing the energy of the laser pulses from 35 mJ to 65 mJ.