RU2542491C1 - Using water low-deuterium water for increasing body resistance to aircraft flight - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: as an ingredient of drinking water or beverage, water containing ¹H¹⁶OD isotopologue in an amount from 0.0002 to 0.0278 molecular %. The invention provides higher individual's body resistance to the flight factors, such as: height gain, cabin and compartment noise increase, vibration, rolling, humidity disposal, time zone change.

EFFECT: higher resistance of the mammalian body to the effect of the flight factors on an aircraft.

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Description

The invention relates to medicine, namely to the use of water with a reduced content of deuterium as drinking water to increase the body's resistance to the adverse effects of flight factors on an aircraft.

Flying in an aircraft has an adverse, complex and unique in its characteristics effect on the human body. Flight factors that have an adverse effect include acceleration and pitching, barometric pressure drops, altitude, noise, vibration, increased background radiation and desynchronization of biological rhythms when crossing time zones, especially during long flights. The rise to a height is accompanied by a decrease in the total barometric pressure and the partial pressure of oxygen. Humidity in the cabin of an air vehicle during a flight is reduced to 20%, which contributes to the dehydration of the body. The flight is accompanied by noise up to 125-130 dB and vibration in a wide range of frequencies from units to several thousand hertz, most often from 30 to 250 Hz, which can lead to symptoms of noise-vibration disease. Air pumping can lead to the development of symptoms of air sickness (motion sickness or motion sickness), such as poor health, decreased performance, increased sweating, tremor of the fingers, nausea and vomiting. The intersection of time zones during the flight can lead to a significant mismatch of biological rhythms (desynchronosis), accompanied by impaired appetite, decreased performance, especially with temporary shifts of 4 hours or more. Thus, there is a need for safe and effective means that increase the nonspecific resistance of the body to the complex effects of adverse flight factors on an aircraft.

It is known that natural water is a composition of nine water molecules that differ only in their isotopic composition (“isotopologists”). Rothman et al., J. Quant. Spectrosc. Radiat. Transfer 1998, 60, 665. Rothman et al., J. Quant. Spectrosc. Radiat. Transfer, 2003, 82, p. 9. These nine isotopologues of water are ¹ H ₂ ¹⁶ O, ¹ H ₂ ¹⁷ O, ¹ H ₂ ¹⁸ O, ¹ H ¹⁶ OD, ¹ H ¹⁷ OD, ¹ H ¹⁸ OD, D ₂ ¹⁶ O, D ₂ ¹⁷ O, D ₂ ¹⁸ O are formed by stable isotopes of hydrogen and oxygen (hereinafter, the hydrogen isotope ¹ H is denoted by H, and the hydrogen isotope ² H (deuterium) is denoted by D). The content of the main isotopologue ¹ H ₂ ¹⁶ O in natural water (the international standard for oceanic natural water - VSMOW) is 99.7317 molecular% (hereinafter “mol.%”), And the content of the main deuterium-containing isotopologue ¹ H ¹⁶ OD is 0.031069 mol. % The proportion of the isotopologue D ₂ ¹⁶ O is 0.000062 mol. %, which means that almost all deuterium in water is in the form of an isotopologue ¹ H ¹⁶ OD.

It is known that water with a reduced isotopologic content of ¹ H ¹⁶ OD has biological properties different from ordinary drinking water with an isotopologic content of ¹ H ¹⁶ OD of 0.031 mol. % RF patent No. 2338542 describes the use of water with an isotopologic content of ¹ H ¹⁶ OD of less than 0.018 mol. % for the preparation of treatments for neurodegenerative diseases. RF patent No. 2482706 describes therapeutic nutrition for the dietary management of depression and anxiety disorders containing water with an isotopologue content of ¹ H ¹⁶ OD from 0.0002 to 0.0278 mol. % However, nothing is known from the prior art that water with an isotopologue content of ¹ H ¹⁶ OD is from 0.0002 to 0.0278 mol. % can increase the body's resistance to the adverse complex effects of flight factors on an aircraft.

The essence of the invention lies in the fact that water with an isotopologic content of ¹ H ¹⁶ OD is from 0.0002 to 0.0278 mol. % is used to increase the resistance of a mammal to the adverse effects of flight factors on an aircraft.

Methods for producing water with an isotopologic content of ¹ H ¹⁶ OD from 0.0002 to 0.0278 mol. % are well known in the art and include an electrochemical method and vacuum distillation. In order to implement the present invention, water with an isotopologic content of ¹ H ¹⁶ OD is from 0.0002 to 0.0278 mol. % can be obtained by any of these methods.

Known methods for determining the content of the isotopologue ¹ H ¹⁶ OD in water samples. Isotopic laser spectrometry makes it possible to directly determine the amount of ¹ H ¹⁶ OD in a water sample. R. Van Trigt. R. van Trigt, Laser Spectrometry for Stable Isotope Analysis of Water Biomedical and Paleoclimatological Applications, 2002, Groningen: University Library Groningen. In addition, the content of ¹ H ¹⁶ OD in water can be determined by isotopic mass spectrometry, including determining the ratio D / ¹ H in parts per million in water samples and calculating the content of ¹ H ¹⁶ OD (mol%) according to the formula: ^l H ¹⁶ OD = 2 × 10 ⁻⁴ × (D / ¹ H). For the purposes of the present invention, both of these methods can be used to determine the content of ¹ H ¹⁶ OD in water samples.

According to the present invention, the content of the remaining 8 isotopologues of water, namely ¹ H ₂ ¹⁶ O, ¹ H ₂ ¹⁷ O, ¹ H ₂ ¹⁸ O, ¹ H ¹⁶ OD, ¹ H ¹⁷ OD, ¹ H ¹⁸ OD, D ₂ ¹⁶ O, D ₂ ¹⁷ O, D ₂ ¹⁸ O, can vary without limitation, provided that the content of the isotopologue ¹ H ¹⁶ OD in the water of the present invention is from 0.0002 to 0.0278 mol. %

According to the present invention, water with an isotopologic content of ¹ H ¹⁶ OD is from 0.0002 to 0.0278 mol. % can be used in drinking water, beverages and solutions. According to the present invention, drinking water may contain minerals in the form of cations and anions, for example, sodium, potassium, magnesium, calcium, hydrogen carbonate, sulfate, chloride, fluoride, iodide. Drinking water may contain dissolved gases, for example carbon dioxide. According to the present invention, drinks may contain extracts, sweeteners, colorants, vitamins and other ingredients in dissolved form. Preferably, drinking water and / or drinks with an isotopologic content of ¹ H ¹⁶ OD from 0.0002 to 0.0278 mol. % used before the flight or during the flight.

The term "mammal" according to the present invention means any mammal, including domestic animals and humans.

The term "aircraft" according to the present invention means an aircraft supported in the atmosphere by interacting with air, and includes, for example, a gyroplane, aerostat, helicopter, rotorcraft, airship, propeller, glider and airplane.

The term "flight", according to the present invention, means the independent movement of the aircraft in the air.

The term "flight factor", according to the present invention, means any change caused by the flight of a physical or physico-chemical parameter that can adversely affect the human body inside the aircraft. Flight factors include, for example, elevation, increased noise in the cabin and cabin, the appearance of vibration, the occurrence of acceleration, the appearance of pitching, a decrease in humidity, and a change in time zone.

The following examples demonstrate the invention. The examples are presented for illustration only and do not limit the scope of the invention.

Example 1. The example illustrates the use of water with an isotopologic content of ¹ H ¹⁶ OD from 0.0002 to 0.0278 mol. % to increase the resistance of the mammal to the effects of lifting to a height.

Male Wistar rats are randomly assigned to 9 rats per group. Rats have access to drinking water with a low isotopologic content of ¹ H ¹⁶ OD from 0.0002 to 0.0278 mol. % or ordinary water with an isotopologic content of ¹ H ¹⁶ OD 0.031 mol. % unlimited for 10 days. Next, the rats are placed in a glass vessel of 1 l. Using a vacuum pump, atmospheric pressure in the vessel is reduced, simulating a rise to a height of 11,200 m at a speed of 200 m / s. The atmospheric pressure in the vessel is restored and the recovery time of the rat posture is recorded as a parameter of resistance to the flight factor, ascent to altitude. The data are presented in table 1 as the average parameter value for each group ± standard deviation.

Table 1 shows that water consumption with a content of ¹ H ¹⁶ OD is from 0.0002 to 0.0278 mol. % increases the resistance of the mammal to the effects of flight factors.

Example 2. The example illustrates the use of water with an isotopologic content of ¹ H ¹⁶ OD from 0.0002 to 0.0278 mol. % to increase the stability of the human body to the effects of changing time zones caused by a long flight.

Eight people (men, average age 45 ± 6 years) consumed water with an isotopologic content of ¹ H ¹⁶ OD 0.018 mol. % (n = 4) or 0.031 mol. % (control, n = 4) within 14 days before the flight. The level of physical endurance was estimated as the time of work until it stops on the treadmill before the flight and on the first day after the flight east with the intersection of 7 time zones. The data are presented in Table 2 as mean ± standard deviation of the work to the stop in% relative to the value before the flight (taken as 100%).

Table 2 demonstrates that the consumption of water with a reduced content of ¹ H ¹⁶ OD increases the resistance of the human body to the effects of flight factors.

Claims (2)

1. The use of water with an isotopologic content of ¹ H ¹⁶ OD from 0.0002 to 0.0278 molecular% to increase the resistance of a mammal to the effects of flight factors on an aircraft. 2. The use according to claim 1, characterized in that the water is used as part of drinking water or a drink.