RU2527834C1 - Method for prevention and treatment of computer fatigue syndrome (cfs) and cellular transmission fatigue syndrome (ctfs) - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves administration of low-mineralised chloride-hydrocarbonate sodium, alkaline, boron high-magnesium, -iodine, -fluorine natural mineral water 'Lazarevskaya Tselebnaya' No.11-M of the Soloniki deposit and No. 84-M of the Volkonskoye deposit in Sochi. Mineral water is administered 17-19 minutes before meals in a dose of 170-190 ml in gulps at 23-24°C. The water is administered daily, six times a day for at least 24-30 days. The course of water administration is repeated every three months for three years.

EFFECT: method provides higher clinical effectiveness ensured by improving the metabolic processes in the brain.

2 cl, 7 tbl

Description

domain of technology

The invention relates to medicine, in particular, to the prevention and treatment of computer fatigue syndrome (CFS) or fatigue from cellular communications (SUOSS).

State of the art

Prevention of a symptom of computer fatigue is called domestic and foreign researchers (OA Goldobina, VA Treshutin, 2002 [Appendix 1, paragraph 9]; G. Dyukova, 2008 [Appendix 1, paragraph 11]; B. A. Klebanova, 2010 [Appendix 1, paragraph 5]; G.V. Kozlovskaya, LF Kremneva, 2012 [Appendix 1, paragraph 16]; BD Carter, 2005 [Appendix 1, paragraph 31]; WG Kronenberger, 2009 [Appendix 1, paragraph 32] of one of the pressing problems of our time.

The Ministry of Health of Russia officially issued guidelines (LN Sobchik, 2010 [Appendix 1, p. 26]), where, on the basis of modern methods of psychological diagnosis, information is provided that “every three out of three people suffer from computer fatigue and fatigue from cellular communications user ". According to Russian researchers (B. L. Vinokurov, S. V. Torosyan, 2012 [Appendix 1, item 6]), “the problem of non-drug prevention of chronic fatigue, which includes the development of special modes of drinking bottled mineral water (labeled with the methodology ”, which relieves computer fatigue), and the scientifically predicted circle of the Russian consumer of the new line of the proposed method for treating this syndrome is about 23 million people every day.” This figure seems far from final, since according to official statistics of the Ministry of Health of the Russian Federation (V. I. Skvortsova, 2012 [Appendix 1, paragraph 24]), “the prevalence of overwork syndrome (Z 73.0) in adults was 10,000 people (ages 18- 49 years - 186.37 cases of the total and 115.62 cases of primary morbidity) against the background of the fact that among the children and adolescents of Russia (from 7 to 17 years) in 2012, the similar incidence rate per 10,000 people was 791.25 cases, and the primary the incidence reached 318.46 cases. "

According to S.N. Mamisheva and N.P. Gogilova (2003 [Appendix 1, p.20]), “The consequences of prolonged work on the computer were (in 68-73% of respondents) headaches, memory loss, sleep disturbance, morning tension and generalized weakness." At the same time, in his research G.V. Kabak (2006 [Appendix 1, p.14]), in addition to the named clinic for patients with computer fatigue syndrome, notes (with a disease duration of 3 to 5 years) “the appearance of lymph node pain and even the appearance of evening subfebrile condition with myalgia”. As noted by M.Yu. Yusupov (2009 [Appendix 1, paragraph 30]) “an increase in lymph nodes should be regarded as a result of a general deformation of the immune and biochemical status of patients with computer fatigue syndrome, which requires constant monitoring of their LPO and response in the antioxidant defense system (AOD) ".

At present, domestic researchers (NN Shongina, 2007 [Appendix 1, paragraph 28, paragraph 29]); V.D. Ostapishin, 2011 [Appendix 1, paragraph 23]); M.V. Nikitin, 2012 [Appendix 1, item 21]) actively use methods and means of treating computer fatigue syndrome, including:

- Optimal optical correction - glasses or contact lenses are selected to work at the computer;

- pharmacotherapy - vitamins for the eyes are prescribed, as well as special drops that moisturize the cornea and relieve the feeling of tiredness and dryness of the eye;

- physiotherapy: laser therapy, color therapy, electrotherapy, magnetotherapy, etc.

Our own analytical review of relevant scientific publications on the issue raised allowed us to compare the positive and negative consequences of the excessive enthusiasm of researchers from a number of foreign and domestic scientific schools only with medical regimens for treating patients with fatigue due to both prolonged computer work and abuse of session duration (totaling more than 3 hours per day) cellular communication, which is reflected in table 1.

Table 1 Information about the methods of pharmacotherapy and non-drug correction of computer fatigue syndrome. The content of the official thematic publications of leading scientific schools: Interpretation by other authors of the sanatorium treatment of patients with computer fatigue: 1. Schemes for the pharmacocorrection of dyslipidemia (statins, fibrates or nicotinic acid with a gradual increase in the daily dose to 3 g for a month) according to EA Walker (2005). 1.1. Immunostimulating therapeutic effect of biocontrolled aeroionotherapy in combination with UHF-therapy of Zakharyin-Geda reflexogenic zones (scheme by N. N. Shongina, 2007). 2. The use of pharmacotherapy with antiplatelet agents (pentoxifylline) and cerebral vasodilators (cinnarizine) for the prevention (A. V. Smulevich, 2007) of deformation of cerebral vascular resistance in computer 2.1. Reducing the intensity of manifestations of parasympatheticotonia and increasing tolerance to psychophysiological stress during low-frequency magnetotherapy of sympathetic nodes on a two-channel apparatus “Magnet-MedTeko” (according to EG Orekhova, 2006).

Fundamental research by scientists at the Sochi Scientific Research Center of Balneology and Physiotherapy, as well as the Sochi Research Institute of Neuroorthopedics and Restorative Medicine (I.A. Balabanova, 2002 [Appendix 1, paragraph 2]; V.V. Bartashevich, 2006 [Appendix 1, p. 3]; B. A. Ermakov, 2007 [Appendix 1, item 12]; GD Ibadova, 2008 [Appendix 1, item 13]; A.V. Krinichansky, 2010 [Appendix 1, item 19] and others) revealed a commonality of the clinical manifestations of computer fatigue syndrome (CFS) and fatigue syndrome from cellular communications (SUOSS), where symptoms prevail:

1) headache, dizziness, tinnitus;

2) sleep disturbances, subjective feelings of increased fatigue;

3) memory loss.

One of the main ways of compensating for the increased level of cerebral vascular resistance that occurs in both adults and children in the form of a reactive response to the negative factors of computer exposure caused by prolonged work at the computer was previously the medication method of anti-aggregation, i.e. prevention of gluing (sticking) of platelets among themselves (including when using pentoxifylline). Such pharmacotherapy was actively promoted not only by Ukrainian and Belarusian researchers (E.V. Korsun, 2005 [Appendix 1, p.18]; A.V. Smulevich, 2007 [Appendix 1, 25]), but also supported by Russian scientific schools (A . G. Galyamov, 2005 [Appendix 1, paragraph 8]). However, there was another (no less successful) scientific direction of Russian schools of physiotherapists actively publishing their own research (V.L. Kokorin, 2004 [Appendix 1, paragraph 17]; E.G. Orekhova, 2006 [Appendix 1, paragraph 22 ]), where a decrease in the intensity of manifestations of parasympatheticotonia (ie, a sharp increase in the tone of the parasympathetic nervous system), coupled with an increase in tolerance to psychophysiological stresses, was demonstrated using low-frequency magnetotherapy of sympathetic nodes on a two-channel Magnit-MedTeko apparatus.

A known method of preventing computer fatigue syndrome called “Professor Pankov's Glasses”, where the light pulses emitted by the device, improve blood circulation inside the eye and stimulate drainage of the eye fluid. The stimulant-dietary supplement taken at the same time, patented under the name "Pankov's Balm", is an extract of Siberian plants and various microelements (see http://pankovmedikl.ru/Kompjuternaja-bolezn-glaza-a-13.html).

For the prevention and treatment of diseases associated with fatigue syndrome (specifically, chronic fatigue syndrome), methods have been developed and used for the rehabilitation therapy of patients with CFS in the resort using natural mineral waters for oral administration. For example, there are known methods of treating CFS according to the patents of the Federal State Institution “Pyatigorsk State Research Institute of Physics and Medicine of Russia”: No. 2305570 (2007.09.10) Method of treating patients with chronic fatigue syndrome [1]; No. 2256456 (2005.07.20) A method for the correction of adaptation disorders in patients with chronic fatigue syndrome [2]; No. 2406525 (2010.12.20) A method for the treatment of chronic fatigue syndrome (options) [3].

The above methods of treating computer fatigue syndrome do not include the use of Sochi’s halogen-containing natural mineral waters for oral administration.

The mechanism of action of halogen-containing natural mineral waters is based on the ability of monovalent fluoride ions, the content of which in the chemical formula of, for example, Lazarevskaya healing mineral water reaches 3.5 mg / l as a specific component with a total salinity of 5.9-6, 1 mg / l, more actively than traditional drug regimens, to optimize not only the level of oxygen saturation of the blood in the microcirculatory circulation, but also positively affect the difference in optical properties of fra of hemoglobin contained in the test blood volume (1 ml) of patients with computer fatigue syndrome and cellular fatigue syndrome.

At the same time, probing the dermis with a laser source of the domestic LAKK-02 analyzer (at a wavelength of radiation of the green part of the spectrum of 0.53 μm and the red part of the spectrum of 0.65 μm) within the framework of the method of optical tissue oximetry (GR) revealed the normalization of the specific oxygen saturation index small venules, arterioles and capillaries of the skin of the studied contingent of patients from the main observation group (from 1.64 ± 0.17 conventional units for admission to health centers to 2.39 ± 0.08 for discharge from the same sanatoriums). It should be noted that the norm of this indicator varies among healthy individuals in the range of 2.3-2.5 conventional units. [Appendix 1.1].

Based on the mechanism of increasing oxygen saturation of blood, the author first investigated the effect of drinking balneotherapy using low-mineralized hydrocarbonate-chloride sodium, alkaline, boric, with a high content of magnesium, iodine and fluorine of the Lazarevskaya healing water mineral water of well No. 11-M of the Soloniki deposit and wells No. 84-M of the Volkonskoye field in the resort of Sochi (see "Lazarevskaya" according to GOST R 54316-2011. Mineral natural drinking water. General technical conditions).

The prototype of the claimed invention is not. The analysis of the problem and the data of our own studies have allowed the author to conclude the feasibility of treating computer fatigue syndrome and fatigue syndrome from cellular communications to achieve a high therapeutic effect by the claimed method of drinking balneotherapy using natural mineral water "Lazarevskaya healing."

Technical result

The technical result achieved by the claimed invention is to improve health indicators, i.e. relieving headache, dizziness, tinnitus, feelings of increased fatigue, normalizing sleep, improving memory. Also the technical result is the fact that as a result of using the above-described author's complex of rehabilitation procedures, 64.6% of adults (n = 181, p <0.05) and 68.9% of minors (n = 193, p <0.05) out the main group, when discharged from health resorts, were categorized as “practically healthy” according to the dynamics of their clinical, functional and laboratory parameters.

SUMMARY OF THE INVENTION

The technical result is achieved by the fact that a method for the prevention and treatment of patients with computer fatigue syndrome and fatigue syndrome from cellular communication involves the use of low-mineralized hydrocarbonate-chloride sodium, alkaline, boric, with a high content of magnesium, iodine and fluorine of the Lazarevskaya healing mineral water of well No. 11 -M of the Soloniki deposit and wells No. 84-M of the Volkonskoye field of the Sochi resort according to the following scheme: 17-19 minutes before a meal in large sips, six times a day daily, 170-190 ml at t ° = (23-24) ° C, for at least 24-30 days, with a repeat of the treatment every three months for three years. The method includes daily use of mineral water at 8.00, 10.00, 12.00, 14.00, 16.00, 18.00 hours.

Disclosure of the invention.

The inventive method includes scientifically based balneotherapy techniques for correcting the effects of generalized fatigue (R 53 according to ICD-X) in individuals who abuse the duration of cellular communication sessions (total more than 3 hours per day) or are forced to undergo computer exposure for more than 5 hours a day as part of a work or school employment.

The leading clinical manifestations are headaches, dizziness, tinnitus, sleep disturbance (especially the falling asleep phase), memory loss, a subjective feeling of severe physical fatigue and psychological depression bordering on apathy (see table 3 below).

The inventive method for the prevention and treatment of patients with computer fatigue syndrome and fatigue syndrome from cellular communications involves the use of sodium, alkaline, boric, hydrocarbonate-chloride, with a high content of magnesium, iodine and fluorine of natural mineral water "Lazarevskaya healing" well No. 11-M of the field "Soloniki" and wells No. 84-M of the Volkonskoye deposit in the resort of Sochi according to the following scheme: 17-19 minutes before a meal in large sips, 6 times a day, i.e. at 8-10-12-14-16-18 hours daily, 170-190 ml at t ° = (23-24) ° C., course intake of at least 24-30 days with a mandatory repeat of the course of treatment on a quarterly basis for 3- x years.

Drinking mineral water with the trade name "Lazarevskaya healing" refers to the waters with low salinity of the Volkonskoye deposit of mineral medicinal-table water "Lazarevskaya" and is obtained from sources:

a) well No. 11-M Soloniki: (mineral water of low salinity, sodium bicarbonate-chloride, alkaline, boric, with a high fluorine content);

b) well No. 84-M Volkonka: mineral water of low salinity, sodium bicarbonate-chloride, alkaline, boric, with a high fluorine content.

The formula of the ionic composition and other characteristics of water are given in table 2.

table 2 No. Well State Registration Name and Trade Name Formula of ionic composition Specificity, mg / dm ³ DEBIT, m ³ / day Using No. 11-M Soloniki "Lazarevskaya healing"

$$M2.6\frac{Cl70\left(HC{O}_3^{-}+C{O}_3^{2-}\right)\mathrm{29th}}{Na99}pH9.1$$

H ₃ BO ₃ 310 Bottling plants, balneotherapy facilities (for shared baths, drinking and local procedures). 150.8 F3.0 No. 84-M Volkonka "Lazarevskaya healing" $$M4.2\frac{Cl76\left(HC{O}_3^{-}+C{O}_3^{2-}\right)23}{Na99}pH8.7$$

H ₃ BO ₃ 569.5 274.4 F3.5

The content of halogens (fluorine) in the chemical formula of the natural mineral water “Lazarevskaya Healing” reaches 3.0-3.5 mg / l as a specific component with a total mineralization of the named water of 5.9-6.1 mg / l).

As mentioned above, the mechanism of action of halogen-containing natural mineral waters is based on the ability of monovalent fluoride ions more actively than traditional drug regimens to optimize not only the level of oxygen saturation of the blood in the microcirculatory circulation, but also positively affect the difference in the optical properties of the hemoglobin fractions contained in the test volume blood (1 ml) of patients with computer fatigue syndrome and cellular fatigue syndrome.

The Federal Service for Supervision of Consumer Rights Protection and Human Well-Being (Rospotrebnadzor) signed by the chief sanitary doctor G.G. Onishchenko issued Certificate of State Registration No. 77.99.19.6. U.11657.11.06 of 01/01/2006 that the mineral water drinking medical and table "Lazarevskaya healing" (TU 9185-002-95093915-06) passed state registration, entered into The state register is also allowed for manufacturing on the territory of the Russian Federation, import and turnover on the territory of the Russian Federation (Appendix 2). This certificate was issued on the basis of the balneological conclusion of the Research Center of Balneology and Rehabilitation of the Black Sea Area Administration of the specialized sanatoriums of the Ministry of Health and Social Development of 08.08.06, No. 75, protocol of the AIL ITC “Quality” (No. ROSS RU.0001.21AYU17) of 08.08.06, No. 1290. The validity period of this certificate of state registration is established by Rospotrebnadzor for the entire period of industrial production of Russian products or supplies of imported products (Certificate number 0037130).

In addition, the Federal Service for Supervision of Consumer Rights Protection and Human Well-being on Water, the Lazarevskaya Healing Mineral Drinking Medical-Dining-Table (TU 9185-002-95093915-06) issued the Sanitary and Epidemiological Conclusion No. 77.99.15.006.T.002079.11. 06 dated 01/01/2006 on the compliance of this mineral drinking medicinal-table water with the state sanitary and epidemiological rules and regulations of Sanitary and epidemiological regulations 2.3.2. 1078-01 "Hygienic requirements for safety and nutritional value of food products." This Sanitary and Epidemiological Conclusion is also signed by G.G. Onishchenko (Appendix 3).

Using the proposed method with the indicated drinking balneotherapy regimes allowed to stop (within 30 to 40 days of continuous use) the main manifestations of computer fatigue syndrome and fatigue syndrome from cellular communications, when headaches, dizziness, tinnitus were the leading of these clinical manifestations, sleep disturbance (especially the phase of falling asleep), memory loss, subjective feeling of sharp physical fatigue and psychological depression, bordering on apathy.

In addition, the claimed method at a statistically significant level of observations (n = 560, p <0.05) contributes to the positive dynamics of kinetic tests and tests for mental performance coupled with optimization of indicators of echoencephalodopplerography (table 4).

The regular use of the above-described method of curative drinking of natural mineral water “Lazarevskaya Healing” acts as an innovative technology for balneoprophylaxis of myopia and hyperopia in adults and children with a high degree of computer dependence or increased fatigue from cellular communications. The resulting component of this technology was the normalization of ophthalmolability of the eye, which usually decreases by 60-70% with prolonged use of the computer (table 5). The proposed method allows to prevent the following clinical manifestations observed in 68-72% of patients with computer fatigue syndrome and fatigue syndrome from cellular communication:

1) the destabilization of lipid peroxidation and rheological properties of blood (table 6);

2) deformation of the characteristics of cerebral hemodynamics in conjunction with a decrease in the phagocytic activity of peripheral blood neutrophils (table 7).

An illustration of the therapeutic effectiveness of the proposed method is the fact that, as a result of using the above-described author's complex of rehabilitation procedures, 64.6% of adults (n = 181, p <0.05) and 68.9% of minors (n = 193, p <0.05 ) from the main group, when discharged from health resorts, were classified as “practically healthy” according to the dynamics of their clinical, functional and laboratory parameters. In the control group, where patients were treated on the same research bases (CJSC Sanatorium Lazarevskoye (354200, Russia, Krasnodar Territory, Sochi, Sochi highway, 6; introduction act No. 37 of 01/23/2013); sanatorium named after N. .A. Semashko of the Ministry of Health of the Russian Federation (354200, Russia, Sochi, Lazarevsky district, Uch-Dere village; Implementation Act No. 20 dated 01/22/2013); Sea Star Sanatorium CJSC (354200, Russia, Sochi, Lazarevsky district, Pobedy St., 15; act of introduction No. 98 dated 01/22/2013) using standard methods of therapy, that is, without using Lazarevskaya healing mineral water, the number of healthy people (as among adults and among children) it turned out to be 2.1 times less at discharge from health centers, which is presented in table 7.

Patients with SKU and SUOSS were observed at three research bases. These research bases were three large sanatoriums of the Lazarevsky recreation zone of the Kuban, namely:

1) Closed Joint-Stock Company "Sanatorium" Sea Star ";

2) CJSC Sanatorium Lazarevskoye;

3) children's sanatorium them. ON. Semashko of the Ministry of Health of the Russian Federation.

The following units were formed as observation units (during unintentional selection in the above health resorts):

a) the main group of units of observation (n = 560);

b) a control group (also n = 560).

In each observation group, 50% (n = 280) were adults aged 18-29 years, and 50% were children and adolescents of school age from 7 to 17 years (n = 280). Features of professional work (as adults selected as observation units were programmers, secretaries, clerks, employees of large bookkeeping departments, etc.) forced these working individuals to spend up to 6 hours a day at the computer. The observed children and adolescents of school age (due to the fulfillment of educational tasks or in games of computer addiction) performed 1.3 times more with computers (according to the data of the medical sociological survey) than the examined adults, i.e. an average of 7.5 hours per day. In the observation groups, there were 50% of men (boys) and 50% of women (girls).

To determine the functional state of patients with SKU and SUOSS, we used step rating scales with standardized criteria for assessing the severity of each subjective symptom, as well as Schulte’s test for mental performance using 5 standard tables. As kinetic samples used:

a) the time of three searches - with the first finger of the hand, the patient touched the second, third, fourth, and fifth fingers of the same hand, and then sorted them in the reverse order, starting with the fifth finger; at the same time, the time was fixed for which he managed to carry out three complete enumerations;

b) the number of squeezes of the brush for 10 s for each hand.

The aforementioned assessment of the neurological and psychophysiological status of patients with computer fatigue syndrome was supplemented by cerebral blood flow in the main arteries of the head based on data from ultrasound dopplerography (Doppler ultrasound) using a domestic computerized echoencephalodopplerograph EchEDG-Complex-M and transcranial dopplerography (TCD), which was carried out using the TCD method (BV Gaidar et al., 2004 [Appendix 1, item 7]) with the location of the carotid arteries on the neck, middle, them, posterior cerebral artery, vertebral and basilar arteries. Systolic, diastolic and average linear blood flow velocities were evaluated. The peripheral resistance index, the ripple Gosling index (PI), was calculated. To assess the vasodilatational reserve (Cr +), a breath-holding test was used, and the vasoconstrictor (Kr-) sample was used with hyperventilation. The vasomotor reactivity index (IVMR) was calculated, which is an integral indicator of cerebrovascular adaptation. To verify the degree of temporary vascular microischemia of local areas of the cerebral cortex, an MRI scan was performed on a Siemens Somaton Emotion apparatus with a field strength of 0.2 T. With morphometry, the width of the third ventricle was determined at the level of the Monroe opening, the lateral ventricles at the level of the front horns in the transvisory and coronal planes, and the width of the sylvian grooves. The rheological properties of blood were evaluated by indicators:

1) blood viscosity (VK), determined on capillary and rotational (ARK-2) viscometers (units of VK - cP - centipoiseuil);

2) hematocrit (GT) according to the modified A.G. Amintaeva et al. Methodology;

3) the content of fibrinogen (FG), which was investigated by dry air method according to R.A. Rutberg

4) platelet aggregation, determined by the method of G. Born, improved J. O'Brien when exposed to ADP and adrenaline;

5) the values of the prothrombin index;

6) fibrinolytic activity (FA) of the blood and fibrinolysis index (IF) according to the method of E. Bidwell.

Cerebral hemodynamics was studied by the REG method on a 4-RG-1 brand rheograph connected to an electrocardiograph; recording was performed in frontastomoidal and occipitomastoidal leads. Along with the visual characteristics of the rheographic curves, a quantitative analysis was carried out according to the method of I.V. Falcon. The following parameters were determined: the amplitude of the arterial component (A), the indicator of peripheral vascular resistance (B / A), the indicator of venous outflow (BO), the asymmetry coefficient (CA). To assess the standard EEG indicators in the framework of this study, an EEGP 4-02 brand encephalograph with an IM-789 monitor was used. Electroencephalography was performed in a state of calm wakefulness (8 brain regions with the location of the electrodes according to the international scheme 10-20: O2-A2, P4-A2, C4-A2, F4-A2, O1-A1, P3-A1, C3-A1, F3- A1). For analysis, 60-second artifact-free EEG fragments were used, from which absolute power spectra were calculated in the range 0.5–30.0 Hz with a quantization step of 0.4 Hz. In determining the spectral characteristics, a fast Fourier transform and a Kaiser-Bessel smoothing window were used. In the framework of the presented study, we studied the dynamics of lipid peroxidation (LP) processes and a comparison of this indicator with the characteristic of the antioxidant activity index (AOA) according to the method of M.V. Bilenko (2001 [Appendix 1, paragraph 5]) and the activity of ceruloplasmin in blood plasma according to the method of C.V. Bestuzheva and V.G. Flask (2002 [Appendix 1, paragraph 4]). To control the rehabilitative treatment of the observed patient population, the phagocytic activity of peripheral blood neutrophils was studied in the calculations (according to the method of V.V. Menshikov) of the following phagocytosis indices: phagocytic index, opsonic absorption index, phagocytic number coefficient, neutrophil bactericidal index, etc. The level of electrical ophthalmolability (EL) of a patient who was using a computer for 6 hours or more was determined by applying an electrode of the domestic 3COM apparatus to the temporal point of the closed eyelid of the right eye, taking into account the individual reaction of the patient at the time of fusion of flicker of phosphene. The study of the critical frequency of flicker fusion (as a test of the professional activity of the visual analyzer) was carried out using the method of K.V. Golubtsova (2002 [Appendix 1, paragraph 10]). Quantitative data were processed by the method of variation statistics with the determination of: arithmetic means (the difference between them was considered significant at p <0.05); the criterion for the significance of differences and the correlation coefficient of Spearman ranks on an IBM computer in Windows operating systems using Microsoft Excel.

Treatment of patients with computer fatigue and fatigue syndrome from cellular communications included the above-described methodology for prescribing drinking balneotherapy using sodium, alkaline, boric, with a high content of magnesium, iodine and fluorine in the Lazarevskaya healing water mineral water of well No. 11-M of the field “11” M Soloniki ”and wells No. 84-M of the Volkonskoye deposit in the resort of Sochi according to the following method: 17-19 minutes before meals in large sips, 6 times a day, i.e. at 8-10-12-14-16-18 hours daily, 170-190 ml at t ° = 23-24 ° C.

It was taken into account that according to the national Standard GOST R 54316-2011 (Natural mineral drinking water), this mineral water with a mineralization of 5.0-6.0 g / dm ³ does not imply restrictions in daily and course doses of consumption, but in the composition of its active biological components boron, magnesium and fluorine ions are present in conditioned concentrations.

Drinking balneotherapy was not used for patients of the control observation group (both adults and children) while they were in the health centers, and standard “pearl” baths based on sea water were used as external balneotherapy procedures. Physiotherapeutic effect of the control group of patients was carried out using the procedures of electric sleep and transcerebral amplipulse therapy according to the standard orbital-occipital technique.

Table 3 Characteristics of neurological status (p <0.05) The main group (n = 560) Control group (n = 560) before treatment after before treatment after 1. Headache, dizziness, tinnitus 275 ± 2 42 ± 6 271 ± 3 94 ± 4 263 ± 4 35 ± 3 257 ± 2 75 ± 2 2. Sleep disturbance, subjective feeling of increased fatigue 279 ± 1 29 ± 2 273 ± 1 63 ± 3 276 ± 2 38 ± 4 269 ± 1 79 ± 5 3. Complaints of memory loss 95.4% (267) 10.7% (30) 94.6% (265) 30.3% (85) 92.9% (260) 9.6% (27) 92.1% (258) 27.8% (78)

Note. Hereinafter: in the numerator, adults (n = 280); in the denominator are children (n = 280). One patient may have had two or more symptoms of computer fatigue.

Table 3 gives a comparison of the treatment results for patients with fatigue due to prolonged work at the computer or increased fatigue from cellular communications (R 53 according to ICD-X) according to the claimed method (Main group) and according to the known method (Control group). As can be seen from table 3, the result of treatment by the present method is superior in effectiveness to the traditional method of rehabilitation treatment in the health resorts of patients with computer fatigue syndrome.

This is confirmed by the following result: if, upon admission to the sanatorium, the research base among patients of the main and control observation groups (both adults and children), a significant percentage of people suffering from headache, dizziness, and tinnitus were observed (96-98% of the total the number of observations), after the treatment according to the claimed method, the similar symptoms (in adults from the main observation group) decreased by 6.5 times, and in children - by 7.5 times. The results of the survey look even more convincing, indicating the relief of complaints of memory loss (due to computer fatigue or increased fatigue from cellular communications), since after completion of the treatment by the claimed method, only 10.7% of adults and 9.6% of such symptoms were noted. children, although 95.4% of adults and 92.9% of children expressed similar complaints upon arrival at the resort. The total result of all the above indicators was 1.5-2.1 times worse in patients of the control group who were treated in the same resorts, but according to traditional methods.

Table 4 shows the results of the study of the correction of the degree of fatigue in the process of employment or academic employment in people who received treatment according to the claimed method (main group), and in the traditional way (control group). This is confirmed by the fact that Schulte’s samples, which were initially increased by 1.4 times (compared with the norm) in patients of both observation groups, decreased to optimal values only in patients of the main group. In the control group, similar psychophysiological characteristics at the time of discharge from the health resorts continued to exceed the normal values of Schulte's test and the kinetics of samples of 3 finger searches (psychocorrection test of generalized fatigue) by 1.2 times. This was objectified by echoencephalodopplerography when the vasomotor reactivity index (coupled with the dynamics of 60-second artifact-free EEG fragments) returned to normal in almost 70% of patients from the main observation group, not even reaching the upper limit of the norm in patients from the control group. A similar dynamics of the level indicators of the vasoconstrictor and vasodilation reserve was reliably recorded on a domestic computerized echoencephalodopplerograph, which makes it possible to simultaneously determine the Gosling pulsation index and average linear blood flow velocity.

Table 4 Indicator (p <0.05) The main column (n = 560) Control gr (n = 560) before treatment after before treatment after 1. The dynamics of kinetic tests and tests for mental performance Schulte's test results for mental performance (N = 36-39 s) 51 ± 2 37 ± 2 50 ± 3 44 ± 2 54 ± 5 39 ± 1 52 ± 2 46 ± 1 Kinetics of samples of three finger enumerations (N = 10-11 s) 27 ± 4 11 ± 2 26 ± 5 18 ± 1 29 ± 6 12 ± 2 28 ± 3 18 ± 2 2. Computerized indicators of echoencephalodopplerography: Gosling Ripple Index (PI), N = 0.27-0.29 0.62 ± 0.07 0.28 ± 0.02 0.61 ± 0.04 0.34 ± 0.03 0.59 ± 0.03 0.29 ± 0.01 0.60 ± 0.06 0.37 ± 0.05 Assessment of vasodilation reserve for breath holding (Cr +), N = 67-69% 51.7 (145) 67.5 (189) 51.4 (144) 57.8 (162) 52.8 (148) 66.0 (185) 52.5 (147) 57.1 (160) Assessment of the vasoconstrictor reserve for hyperventilation (Cr-), N = 34-37% 26.7 (75) 36.8 (103) 27.1 (76) 31.7 (89) 26.4 (74) 26.0 (101) 26.0 (73) 30.7 (86) Vasomotor reactivity index (IVMR), N = 69-71% 53.9 (151) 69.6 (195) 53.5 (150) 59.6 (167) 53.2 (149) 69.2 (194) 52.8 (148) 60.0 (168) The dynamics of 60 seconds of artifact-free fragments of the EEG, N α-rhythm = 9.0-10.2 Hz 8.4 ± 0.2 9.5 ± 0.4 8.5 ± 0.1 8.8 ± 0.1 8.1 ± 0.3 9.3 ± 0.1 8.1 ± 0.2 8.6 ± 0.2 The average linear blood flow velocity, N = 67-68 cm / s 64.02 ± 0.09 67.34 ± 0.03 64.13 ± 0.05 65.44 ± 0.02 63.83 ± 0.04 67.21 ± 0.02 63.98 ± 0.03 65.27 ± 0.01

Table 5 The effectiveness of balneotherapy measures (P <0.05) The main group (n = 560) Control gr (n = 560) before treatment after before treatment after 1. Ophthalmolability 81.4% (228) 11.4% (32) 80.7% (226) 29.3% (82) eyes when working on a computer is reduced 84.6% (237) 12.5% (35) 83.2% (233) 32.5% (91) 2. A positive test on the frequency of merging test flickers 33.9% (95) 89.6% (251) 34.6% (97) 67.8% (190) 35.3% (99) 95.7% (268) 35.7% (100) 71.7% (201) 3. Positive test for attention and spatial orientation 28.2% (79) 94.2% (264) 28.9% (81) 78.2% (219) 27.1% (76) 92.1% (258) 27.8% (78) 73.2% (205) Changing the parameters of magnetic resonance imaging of the brain in patients: Width of the third ventricle, 0.53 ± 0.01 0.42 ± 0.01 0.50 ± 0.02 0.47 ± 0.01 N = 0.40-0.42 mm 0.51 ± 0.02 0.42 ± 0.02 0.51 ± 0.02 0.46 ± 0.01 Lateral ventricle on the right, 1.65 ± 0.02 1.61 ± 0.01 1.66 ± 0.02 1.64 ± 0.01 N = 1.60-1.62 mm 1.64 ± 0.01 1.61 ± 0.02 1.64 ± 0.01 1.64 ± 0.01 Lateral ventricle on the left, 1.67 ± 0.02 1.58 ± 0.01 1.67 ± 0.01 1.61 ± 0.01 N = 1.57-1.58 mm 1.68 ± 0.01 1.57 ± 0.02 1.68 ± 0.02 1.62 ± 0.01 Sylvian furrow width on the right, N = 0.62-0.64 mm 0.69 ± 0.02 0.63 ± 0.02 0.69 ± 0.02 0.67 ± 0.01 0.68 ± 0.01 0.61 ± 0.02 0.66 ± 0.01 0.65 ± 0.01 The width of the sylvian furrow on the left, N = 0.71-0.73 mm 0.76 ± 0.02 0.72 ± 0.01 0.75 ± 0.02 0.74 ± 0.01 0.76 ± 0.01 0.71 ± 0.01 0.76 ± 0.02 0.74 ± 0.01

According to table 5, there is a direct correlation between the indicators of the level of electric ophthalmolability, as well as tests of the professional activity of the visual analyzer with a change in magnetic resonance imaging of the brain in children and adolescents with a high degree of computer dependence or increased fatigue from cellular communications. In this regard, a positive test for the frequency of fusion of test flickers (initially reduced in both observation groups to the level of 33-35%) reached 89.6% upon discharge from health resorts in patients of the main group (95.7% in children), remaining in adults from the control group at the level of 67.8% and 71.7% in minors.

The results of the study, set forth in table 6, indicate the ability to use natural mineral water "Lazarevskaya healing" to normalize lipid peroxidation (LP). This is confirmed by the fact that the content of ceruloplasmin in the blood plasma of patients with computer fatigue syndrome from the main observation group turned out to be 2b, 98 ± 0.23 mg% in adults and 2b, 71 ± 0.18 mg% in patients from the study base children, although before treatment in these same patients the named indicator was more than 30 mg% (with N = 26-27 mg%).

Table 6 Clinical and laboratory characteristics (p <0.05) The main group (n = 560) Control gr (n = 560) before treatment after before treatment after Blood plasma: ceruloplasmin, mg% (N = 26-27) 30.85 ± 0.64 26.98 ± 0.23 30.76 ± 0.44 28.82 ± 0.11 30.39 ± 0.56 26.71 ± 0.18 30.27 ± 0.12 28.51 ± 0.13 FLOOR, E = 232/220 (conventional d.): heptane phase (N = 0.77-0.79) 0.96 ± 0.08 0.78 ± 0.02 0.92 ± 0.06 0.84 ± 0.01 0.95 ± 0.04 0.77 ± 0.01 0.90 ± 0.05 0.86 ± 0.02 isopropanol phase 0.48 ± 0.05 0.38 ± 0.01 0.47 ± 0.03 0.43 ± 0.01 (N = 0.36-0.38) 0.47 ± 0.02 0.37 ± 0.02 0.46 ± 0.02 0.42 ± 0.02 The state of the rheological and coagulation properties of blood during computer fatigue: The content of fibrinogen according to the method of R.A. Rutberg, N = 2.0-2.4 g / l 3.6 ± 0.4 2.3 ± 0.1 3.5 ± 0.2 2.9 ± 0.2 3.4 ± 0.2 2.2 ± 0.1 3.4 ± 0.1 2.8 ± 0.1 Hematocrit (Ht,%), 45.8 ± 0.7 40.5 ± 0.3 45.9 ± 0.6 42.2 ± 0.3 N = 40.4-40.8 45.2 ± 0.5 40.6 ± 0.1 45.1 ± 0.4 42.1 ± 0.2 Platelet aggregation according to the method of G. Born with adrenaline, N = 41.3-41.6 47.6 ± 0.3 41.4 ± 0.2 47.4 ± 0.5 43.0 ± 0.6 47.5 ± 0.4 41.5 ± 0.2 47.3 ± 0.3 42.9 ± 0.1

The same factor, i.e. the drinking regimen prescribed by the invention for the administration of natural mineral water “Lazarevskaya healing” was decisive in compensating for patients of the main observation group of initially deformed rheological and coagulating blood properties. At the same time, the content of fibrinogen in the blood plasma and the level of platelet aggregation, significantly increased upon admission to the research base, returned to normal after completing the above author's schemes of sanatorium rehabilitation, while standard approaches to treatment in the resorts of the same contingent of patients were able to (in the control group) only indicate trends to improve these biochemical characteristics.

The study presents statistically significant evidence (table 7) of the effectiveness of the proposed method in the study of health indicators in various age groups of the population with computer fatigue syndrome or increased fatigue from cellular communications. Attention should be paid to the dependence of the characteristics of REG-cerebral hemodynamics and the intensity of the application of the developed treatment methods for SKU and SUOSS. An illustration of the therapeutic effectiveness of the proposed method in comparison with traditional ones is the comparative data of physiological constant recovery schemes in adults and children prone to computer fatigue syndrome and cellular fatigue syndrome (R 53 according to ICD-X), are shown in table 7.

Table 7 Physiological constants (p <0.05) The main group (n = 560) Control gr (n = 560) before treatment after before treatment after Leading characteristics of cerebral hemodynamics in adults with computer fatigue syndrome (* frontomastoid and ** occipitomastoid REG - leads): The indicator of peripheral vascular resistance (V / A,%) 57.2 ± 0.4 * 91.1 ± 0.6 * 57.9 ± 0.8 * 69.7 ± 0.2 * 58.2 ± 0.3 ** 93.5 ± 0.2 ** 58.6 ± 0.5 ** 70.9 ± 0.1 ** Amplitude of arterial component (A, Ohm) 0.138 ± 0.03 * 0.162 ± 0.01 * 0.137 ± 0.04 * 0.150 ± 0.02 * 0.141 ± 0.02 ** 0.164 ± 0.01 ** 0.143 ± 0.02 ** 0.151 ± 0.01 * The coefficient of cerebral asymmetry (KA,%) 36.7 ± 1.2 * 24.4 ± 0.6 * 36.4 ± 0.9 * 30.5 ± 0.2 * 29.2 ± 1.0 ** 19.1 ± 0.2 ** 29.0 ± 0.3 ** 24.7 ± 0.2 ** Optimization of the phagocytic activity of peripheral blood neutrophils: Phagocytic index, 120 min. incubation (N = 90-92%) 96.4 ± 0.2 91.5 ± 0.2 96.2 ± 0.1 94.3 ± 0.2 96.8 ± 0.4 90.8 ± 0.3 96.7 ± 0.2 94.0 ± 0.1 Neutrophil bactericidal index (N = 66-68%) 76.5 ± 0.6 66.9 ± 0.5 76.8 ± 0.4 71.7 ± 0.1 76.3 ± 0.2 66.4 ± 0.2 76.6 ± 0.3 70.8 ± 0.2 The criterion of objective health indicators for discharge from health resorts: Almost healthy no 64.6% (181) no 30.7% (86) 68.9% (193) 31.4% (88) Improvement 31.1% (87) 58.9% (165) 25.7% (72) 57.5% (161) No improvement 4.3% (12) 10.4% (29) 5.4% (15) 11.1% (31)

As follows from the data in Table 7, the indices of peripheral vascular resistance, the amplitudes of the arterial component, and the cerebral asymmetry coefficient exceeded 1.3-1.4 times in the study group the same indices in patients from the control group. Moreover, it was in patients from the main observation group that the recommended Lazarevskaya healing mineral water treatment technology for natural mineral water was the basic ingredient for the non-drug normalization of the characteristics of non-specific immunity, including the neutrophil bactericidal index, as one of the clinical manifestations of computer fatigue syndrome and cellular fatigue syndrome. In the control group, the same indicator had only a tendency to optimization. The result of the proposed method can be considered the following: 64.6% of adults (n = 181, p <0.05) and 68.9% of minors (n = 193, p <0.05) from the main group, when discharged from health resorts, were assigned to categories of “practically healthy” according to the dynamics of their clinical, functional and laboratory parameters. In the control group, the number of practically healthy ones (both among adults and among children) turned out to be at discharge from health resorts - the research bases, which were the three large sanatoriums of the Lazarevsky recreation zone of the Kuban, namely: 1) Closed Joint-Stock Company Sanatorium Sea Star; 2) CJSC Sanatorium Lazarevskoye; 3) children's sanatorium them. ON. Semashko of the Ministry of Health of the Russian Federation, 2.1 times less.

Examples of the method.

Example 1. Patient Mikhlov, 32 years old, and / b No. 781, was treated at CJSC Sanatorium Lazarevskoye (354200, Russia, Krasnodar Territory, Sochi, Sochi Highway 6) from 03.12.2012 to 27.12 .2012. Diagnosis upon arrival at the spa card: computer fatigue syndrome associated with professional activities. For 10 years he has been working as a programmer in a large Krasnodar company producing a product for distance learning of students of technical universities. Over the past 5 years, she complains of headache, dizziness, tinnitus, sleep disturbance (especially in the phase of falling asleep). She is registered in the municipal health care institution at the place of residence for the past 3 years regarding computer (chronic) fatigue syndrome. The treatment was carried out using cerebral vasodilators (cinnarizine), nicotinic acid. The biocontrolled aeroionotherapy method was also used in combination with UHF therapy of Zakharyin-Geda reflexoson according to the classical N.N. Shongina (2007). Due to the lack of the planned therapeutic effect, he was sent by the municipal health institution of the city of Krasnodar to a balneotherapy course at ZAO Lazarevskoye Sanatorium (Sochi resort). On admission: complaints of headache, dizziness, tinnitus, subjective feeling of increased fatigue and memory loss. Objectively: a patient of the correct physique, thin (with a height of 176 cm has a weight of 68.3 kg). The vesicular breathing, no wheezing. Heart sounds are rhythmic, somewhat muffled. Percussion: the limits of relative cardiac dullness are within normal limits, the tongue is moist, covered with a whitish bloom. The abdomen is soft, painless. Percussion border of the liver along the edge of the costal arch. The chair is irregular (prone to constipation). Urination is free, painless, non-frequent. Pasternatsky’s symptom is negative on both sides. The color of the urine is straw yellow.

During laboratory examination: a general blood test - hemoglobin 134 g / l, color index 0.9, platelets 210 × 10 ⁹ , white blood cells 5,4 × 10 ⁹ , eos. 3, fell. 1, seg. 73, lymph. 26, mon. 8, ESR 15 mm / h; total a.m. urine - beats. weight 1012, clear full reaction acidic, there is no protein, there is no sugar, the epithelium is flat, a small amount, white blood cells 2-4 in n / a., no mucus.

Kinetic tests and tests for mental performance: 1) Schulte test 51 ± 2 at N = 36-39 s; 2) the kinetics of samples of three finger searches 27 ± 4 s at N = 10-11 s.

Computerized indicators of echoencephalodopplerography: Gosling pulsation index (PI), 0.62 ± 0.07 with N = 0.27-0.29 (PI); vasomotor reactivity index (IVMR), 53.9% at N = (69-71)%; 60-second speaker. artifact-free fragments of EEG = 8.4 ± 0.2 Hz at N α-rhythm = (9.0-10.2) Hz.

Clinical and laboratory characteristics: POL, E = 232/220 (conventional units): - heptane phase 0.96 ± 0.08 with N = 0.77-0.79); - isopropanol phase 0.48 ± 0.05 at N = 0.36-0.38. Platelet aggregation according to the method of G. Born with adrenaline, 47.6 ± 0.3 at N = 41.3-41.6 g / l. The indicator of peripheral vascular resistance (V / A,%): in the frontomastoid REG - leads 57.2 ± 0.4%; in occipitomastoid REG - leads of 58.2 ± 0.3. The neutrophil bactericidal index 76.5 ± 0.6 at N = (66-68)%.

According to the anamnesis, clinical, laboratory, instrumental and functional studies, upon admission to the sanatorium the diagnosis was established: Computer fatigue syndrome, marked clinical course amid decreased kinetic tests and tests for mental performance. Clinical and functional deformation (worsening) of indicators of echoencephalodopplerography, characteristics of LP, cerebral hemodynamics, rheological properties of blood and neutrophil bactericidal index.

The treatment method was prescribed: a gentle-training regimen of physical activity, indifferent air baths (EET = 21-23С °) in the mode of weak dynamics, free swimming in the water of the sea medical beach lasting 3-5-7 minutes along the rise at water temperature t = 23 ° C and higher. Modes of drinking balneotherapy using bicarbonate-chloride sodium, alkaline, boric, with a high content of magnesium, iodine and fluorine of natural mineral water “Lazarevskaya healing” of well No. 11-M of the Soloniki deposit of the Volkonsky deposit in the resort of Sochi according to the following method: 17 minutes before food in large sips, 6 times a day, i.e. at 8-10-12-14-16-18 hours daily, 170 ml each at t ° = 23 ° C, course administration for 24 days.

As a result of the treatment: normalization of sleep is noted (falls asleep quickly, sleeps at least 8 hours, sleep is calm, without dreams); headache, dizziness, tinnitus is not notes. Subjectively, the disappearance of forgetfulness into small everyday episodes, i.e. notes memory improvement. Objectively: the Schulte test for mental performance was restored to values of 37 ± 2 s, N = 36-39 s. Computerized indicators of echoencephalodopplerography: pulsating Gosling index = 0.28 ± 0.02 (PI) at N = 0.27-0.29 (PI); vasomotor reactivity index (IVMR) = 69.6% at N = 69-71%; 60-second speaker. artifact-free fragments of EEG = 9.5 ± 0.4 Hz at N α-rhythm = (9.0-10.2) Hz. Clinical and laboratory characteristics: POL, E = 232/220 (conventional units): - heptane phase 0.77 ± 0.01 at N = 0.77-0.79 conventional units; - isopropanol phase 0.38 ± 0.01 at N = 0.36-0.38 conventional units Platelet aggregation according to the method of G. Born with adrenaline = 41.4 ± 0.2 at N = 41.3-41.6 g / l. The indicator of peripheral vascular resistance (V / A,%): in the frontomastoid REG - leads 91.1 ± 0.6% at N = (90-92)%; in occipitomastoid REG - leads 93.5 ± 0.2% at N = (93-94)%. The neutrophil bactericidal index 66.9 ± 0.5% at N 66-68%. Thus, according to the current criteria for objective health indicators, a 32-year-old Mikhail Mikhlov patient, patient # 781, who underwent an original treatment at ZAO “Lazarevskoye Sanatorium” (354200, Russia, Krasnodar Territory, Sochi, Sochi highway, 6 ) from 03/12/2012 to 12/27/2012 when discharged from the sanatorium was found to be practically healthy. Recommendation - a mandatory repeat of the treatment every three months for 3 years.

Example 2. Patient K-va, 23 years old, and / b No. 733 was treated at CJSC Sanatorium Lazarevskoye (354200, Russia, Krasnodar Territory, Sochi, Sochi Highway 6) from 10/29/2012 to 11/21/2012. 2012. Diagnosis upon arrival at the spa card: fatigue syndrome from cellular communications associated with professional activities. For the past 4 years, she has been working as a secretary - clerk, which (according to the conditions of professional activity) obliges her to conduct cellular communication sessions with clients of the company during the day. The total duration of negotiations by cell phone per day is more than 7 hours daily. Complains of constant headaches, sleep disturbance (especially in the phase of falling asleep), tinnitus, dizziness. Consists for 4 years at the dispensary registration with a neurologist at the municipal health care institution at the place of residence (Moscow) with the diagnosis: Fatigue Syndrome from Cellular Communications. The treatment was carried out with medication (statins, fibrates or nicotinic acid with a gradual increase in the daily dose to 3 g per month, cerebral vasodilators, including cinnarizine for the prevention of deformation of cerebral vascular resistance in case of fatigue from cellular communication). Due to the lack of the planned therapeutic effect, she was sent by the municipal healthcare institution of Moscow for a balneotherapy course at ZAO Sanatorium Lazarevskoye (Sochi resort). On admission: complaints of headache, dizziness, tinnitus, subjective feeling of increased fatigue with even short-term cellular communications, irritability, social conflict in small household disputes, a feeling of psychological fatigue bordering on apathy. Objectively: a patient of the correct physique. In the lungs, vesicular breathing, no wheezing. Heart sounds are rhythmic, somewhat muffled. Percussion: the limits of relative cardiac dullness are normal, the tongue is moist, clean. The abdomen is soft, painless. Percussion border of the liver along the edge of the costal arch. The chair is regular. The consistency and color of the chair is not changed. Urination is free, painless, non-frequent. Pasternatsky’s symptom is negative on both sides. The color of the urine is straw yellow.

During a laboratory examination: a general blood test - hemoglobin 150 g / l, color 1.0, platelets 208 × 10 ⁹ , white blood cells 5.6 × 10 ⁹ , eos. 4, fell. 1, seg. 68, lymph. 23, mon. 6, ESR 14 mm / h; total a.m. urine - beats. weight 1011, clear full reaction acidic, there is no protein, there is no sugar, the epithelium is flat, a small amount, white blood cells 2-4 in n / a., no mucus.

Kinetic tests and tests for mental performance: 1) Schulte test 54 ± 5 at N = 36-39 s; 2) kinetics of samples of three finger enumerations 29 ± 6 s at N = 10-11 s.

Computerized indicators of echoencephalodopplerography: Gosling pulsation index (PI), 0.59 ± 0.03 at N = 0.27-0.29 (PI); vasomotor reactivity index (IVMR), 53.2% at N = 69-71%; 60-second speaker. artifact-free fragments of EEG = 8.1 ± 0.3 Hz at N α-rhythm = 9.0-10.2 Hz.

Clinical and laboratory characteristics: POL, E = 232/220 (conventional units): - heptane phase 0.95 ± 0.04 at N = 0.77-0.79); - isopropanol phase 0.47 ± 0.02 with N = 0.36-0.38. Platelet aggregation according to the method of G. Born with adrenaline, 47.5 ± 0.4 at N = 41.3-41.6 g / l. The indicator of peripheral vascular resistance (V / A,%): in the frontomastoid REG - leads 57.9 ± 0.2%; in occipitomastoid REG - leads of 58.6 ± 0.1. Neutrophil bactericidal index 76.3 ± 0.2 at N = 66-68%.

According to the anamnesis, clinical, laboratory, instrumental and functional studies, upon admission to the sanatorium, the diagnosis was established: Fatigue from cellular communication, a pronounced clinical course against the background of a decrease in kinetic tests and tests for mental performance. The treatment method was prescribed: a gentle-training regimen of physical activity, indifferent air baths (EET = 21-23 ° C) in a mode of weak dynamics, free swimming in the water of the sea medical beach lasting 3-5-7 minutes along the rise at a water temperature t = 23 ° C and above. Drinking balneotherapy regimen using bicarbonate-chloride sodium, alkaline, boric, with a high content of magnesium, iodine and fluoride of natural mineral water “Lazarevskaya healing” of well No. 84-M of the Volkonskoye deposit in the resort of Sochi, according to the following method: 19 minutes before meals in large sips 6 times a day, i.e. at 8-10-12-14-16-18 hours daily for 190 ml at t ° = 24 ° C, course administration for 30 days.

As a result of the treatment: there is a positive dynamics of subjective symptoms: the absence of complaints of headache and a feeling of increased fatigue when talking on a mobile phone. Normalization of sleep in all its phases is noted. Kinetic tests and tests for mental performance: 1) Schulte test 37 ± 1 at N = 36-39 s; 2) kinetics of samples of three finger enumerations 10 ± 1 s at N = 10-11 s. Computerized indicators of echoencephalodopplerography: pulsating Gosling index = 0.29 ± 0.01 (PI) at N = 0.27-0.29 (PI); vasomotor reactivity index (IVMR) = 69.2% at N = 69-71%; 60-second speaker. artifact-free fragments of EEG = 9.3 ± 0.1 Hz at N α-rhythm = 9.0-10.2 Hz. Clinical and laboratory characteristics: POL, E = 232/220 (conventional units): - heptane phase 0.78 ± 0.01 at N = 0.77-0.79 conventional units; - isopropanol phase 0.37 ± 0.02 at N = 0.36-0.38. conv.ed Platelet aggregation according to the method of G. Born with adrenaline = 41.5 ± 0.2 at N = 41.3-41.6 g / l. The indicator of peripheral vascular resistance (V / A,%): in the frontomastoid REG - leads 91.6 ± 0.3% at N = 90-92%; in occipitomastoid REG - leads 93.2 ± 0.1% at N = 93-94%. The neutrophil bactericidal index b6.4 ± 0.1% at N 66-68%. Thus, according to the existing criteria for objective health indicators, a patient of K-va, 23 years old, and / b No. 733, who underwent an author's course of treatment at CJSC Sanatorium Lazarevskoye (354200, Russia, Krasnodar Territory, Sochi, Sochi highway, 6 ) from 10/29/2012 to 11/21/2012. On December 27, 2012, when discharged from the sanatorium, she was found to be practically healthy. Recommendation - a mandatory repeat of the treatment every three months for 3 years.

The data presented allow us to conclude that the proposed method for the prevention and treatment of computer fatigue syndrome (CFS) and fatigue syndrome from cellular communications (SUOSS) using drinking mineral water with the trade name "Lazarevskaya Healing" at the spa stage is effective. The recommended method can be carried out in an identical mode at the stage of outpatient treatment of patients with SKU and SUOSS in outpatient facilities.

INFORMATION SOURCES

1. RF patent No. 2305570 (2007.09.10) A method for the treatment of patients with chronic fatigue syndrome.

2. RF patent No. 2256456 (2005.07.20) A method for the correction of adaptation disorders in patients with chronic fatigue syndrome.

3. RF patent No. 2406525 (2010.12.20) A method for the treatment of chronic fatigue syndrome (options).

Annex 1

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Claims (2)

1. A method for the prevention and treatment of patients with computer fatigue syndrome and fatigue syndrome from cellular communications, including the ingestion of low-mineralized hydrocarbonate-chloride sodium, alkaline, boric, with a high content of magnesium, iodine and fluorine in natural mineral water “Lazarevskaya healing” well No. 11-M Soloniki deposits and wells No. 84-M of the Volkonskoye field in the resort of Sochi according to the following scheme: 17-19 minutes before meals in large sips, six times a day, 170-190 ml daily at a temperature of 23-24 ° C at least 24-30 days, with a repeat of the treatment every three months for three years. 2. The method according to claim 1, comprising daily consumption of mineral water at 8.00, 10.00, 12.00, 14.00, 16.00, 18.00 hours