RU2482838C2 - Органические соединения - Google Patents
Органические соединения Download PDFInfo
- Publication number
- RU2482838C2 RU2482838C2 RU2010128246/15A RU2010128246A RU2482838C2 RU 2482838 C2 RU2482838 C2 RU 2482838C2 RU 2010128246/15 A RU2010128246/15 A RU 2010128246/15A RU 2010128246 A RU2010128246 A RU 2010128246A RU 2482838 C2 RU2482838 C2 RU 2482838C2
- Authority
- RU
- Russia
- Prior art keywords
- salt
- drug substance
- hours
- glycopyrrolate
- glycopyrronium salt
- Prior art date
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- KCEHVJZZIGJAAW-FERBBOLQSA-N olodaterol hydrochloride Chemical compound Cl.C1=CC(OC)=CC=C1CC(C)(C)NC[C@H](O)C1=CC(O)=CC2=C1OCC(=O)N2 KCEHVJZZIGJAAW-FERBBOLQSA-N 0.000 description 1
- 229960002657 orciprenaline Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229960000797 oxitropium Drugs 0.000 description 1
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960004017 salmeterol Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 238000004441 surface measurement Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 description 1
- 229960000257 tiotropium bromide Drugs 0.000 description 1
- MQLXPRBEAHBZTK-SEINRUQRSA-M tiotropium bromide hydrate Chemical compound O.[Br-].C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 MQLXPRBEAHBZTK-SEINRUQRSA-M 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07123164 | 2007-12-13 | ||
| EP07123164.1 | 2007-12-13 | ||
| PCT/EP2008/067359 WO2009074662A2 (en) | 2007-12-13 | 2008-12-11 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010128246A RU2010128246A (ru) | 2012-01-20 |
| RU2482838C2 true RU2482838C2 (ru) | 2013-05-27 |
Family
ID=39472711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010128246/15A RU2482838C2 (ru) | 2007-12-13 | 2008-12-11 | Органические соединения |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100247658A1 (OSRAM) |
| EP (1) | EP2234595B1 (OSRAM) |
| JP (1) | JP2011506399A (OSRAM) |
| KR (1) | KR20100099281A (OSRAM) |
| CN (1) | CN101896162B (OSRAM) |
| AU (1) | AU2008334543B2 (OSRAM) |
| BR (1) | BRPI0821186A2 (OSRAM) |
| CA (1) | CA2708083C (OSRAM) |
| ES (1) | ES2396471T3 (OSRAM) |
| PL (1) | PL2234595T3 (OSRAM) |
| PT (1) | PT2234595E (OSRAM) |
| RU (1) | RU2482838C2 (OSRAM) |
| WO (1) | WO2009074662A2 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010253770B9 (en) * | 2009-05-29 | 2015-02-12 | Pearl Therapeutics, Inc. | Compositions for respiratory delivery of active agents and associated methods and systems |
| US9393202B2 (en) | 2013-04-26 | 2016-07-19 | Chiesi Farmaceutici S.P.A | Particle size reduction of an antimuscarinic compound |
| GB201307659D0 (en) | 2013-04-26 | 2013-06-12 | Korea Coast Guard Commissioner | Preparation of drug particles by micronisation |
| SG11201700536XA (en) | 2014-09-09 | 2017-02-27 | Vectura Ltd | Formulation comprising glycopyrrolate, method and apparatus |
| US9925168B2 (en) | 2016-01-22 | 2018-03-27 | Chiesi Farmaceutici S.P.A. | Preparation of micronized particles of an antimuscarinic compound by hydrodynamic cavitation |
| US10888500B2 (en) | 2016-07-29 | 2021-01-12 | Inke, S.A. | Particle size stabilization process |
| CN112137957B (zh) * | 2019-06-26 | 2022-07-29 | 长风药业股份有限公司 | 一种药用吸入气雾剂及其制备方法 |
| CN112972384B (zh) * | 2019-12-02 | 2022-03-18 | 长风药业股份有限公司 | 一种格隆溴铵和茚达特罗原料药微粉混合物的制备方法 |
| IT202300022716A1 (it) | 2023-10-30 | 2025-04-30 | Ind Chimica Srl | Processo di condizionamento di fluticasone furoato micronizzato |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5562923A (en) * | 1991-04-11 | 1996-10-08 | Aktiebolaget Astra | Process for conditioning of water-soluble substances |
| WO2001076575A2 (en) * | 2000-04-07 | 2001-10-18 | Arakis Ltd. | The treatment of respiratory diseases |
| US20060210625A1 (en) * | 2003-11-04 | 2006-09-21 | Shire Laboratories, Inc. | Sustained release of positively charged pharmacologically active molecules from a matrix containing polymers with polarized oxygen atoms |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747002A (en) * | 1995-04-05 | 1998-05-05 | Genentech, Inc. | Preparation of sodium chloride aerosol formulations |
| US6613795B2 (en) * | 1996-11-11 | 2003-09-02 | Christian Noe | Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments |
| PT2283817T (pt) * | 2000-11-30 | 2016-08-22 | Vectura Ltd | Método de fabrico de partículas para utilização numa composição farmacêutica |
| KR101179393B1 (ko) * | 2004-03-23 | 2012-09-07 | 노파르티스 아게 | 제약 조성물 |
| GB0409703D0 (en) * | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
| WO2006073154A1 (ja) * | 2005-01-07 | 2006-07-13 | Eisai R&D Management Co., Ltd. | 医薬組成物及びその製造方法 |
| GB0613161D0 (en) * | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
-
2008
- 2008-12-11 EP EP08859423A patent/EP2234595B1/en active Active
- 2008-12-11 CN CN2008801205425A patent/CN101896162B/zh not_active Expired - Fee Related
- 2008-12-11 KR KR1020107015330A patent/KR20100099281A/ko not_active Ceased
- 2008-12-11 US US12/745,790 patent/US20100247658A1/en not_active Abandoned
- 2008-12-11 ES ES08859423T patent/ES2396471T3/es active Active
- 2008-12-11 RU RU2010128246/15A patent/RU2482838C2/ru not_active IP Right Cessation
- 2008-12-11 WO PCT/EP2008/067359 patent/WO2009074662A2/en not_active Ceased
- 2008-12-11 CA CA2708083A patent/CA2708083C/en not_active Expired - Fee Related
- 2008-12-11 AU AU2008334543A patent/AU2008334543B2/en not_active Ceased
- 2008-12-11 JP JP2010537455A patent/JP2011506399A/ja active Pending
- 2008-12-11 PL PL08859423T patent/PL2234595T3/pl unknown
- 2008-12-11 BR BRPI0821186-8A patent/BRPI0821186A2/pt not_active IP Right Cessation
- 2008-12-11 PT PT88594239T patent/PT2234595E/pt unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5562923A (en) * | 1991-04-11 | 1996-10-08 | Aktiebolaget Astra | Process for conditioning of water-soluble substances |
| WO2001076575A2 (en) * | 2000-04-07 | 2001-10-18 | Arakis Ltd. | The treatment of respiratory diseases |
| US20060210625A1 (en) * | 2003-11-04 | 2006-09-21 | Shire Laboratories, Inc. | Sustained release of positively charged pharmacologically active molecules from a matrix containing polymers with polarized oxygen atoms |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009074662A3 (en) | 2009-09-24 |
| EP2234595A2 (en) | 2010-10-06 |
| CA2708083C (en) | 2016-06-28 |
| ES2396471T3 (es) | 2013-02-21 |
| CN101896162B (zh) | 2013-06-05 |
| PT2234595E (pt) | 2013-01-24 |
| CN101896162A (zh) | 2010-11-24 |
| RU2010128246A (ru) | 2012-01-20 |
| CA2708083A1 (en) | 2009-06-18 |
| BRPI0821186A2 (pt) | 2015-06-16 |
| AU2008334543B2 (en) | 2011-07-28 |
| WO2009074662A2 (en) | 2009-06-18 |
| EP2234595B1 (en) | 2012-11-28 |
| AU2008334543A1 (en) | 2009-06-18 |
| JP2011506399A (ja) | 2011-03-03 |
| PL2234595T3 (pl) | 2013-04-30 |
| KR20100099281A (ko) | 2010-09-10 |
| US20100247658A1 (en) | 2010-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20171212 |