RU2481815C1 - Method of increasing mineral density of bone tissue - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to orthopedics and restorative medicine, and can be used for increasing mineral density of bone tissue. For this purpose human body is subjected to impact of uniformly accelerated physical loading created by movement of simulator vibration platform in three mutually perpendicular planes with increase of intensity of physical loading and mode. Alendronic acid in dose 70 mg 1 time per week, calcium preparations in dose 1000 mg per day, vitamin D in dose 800 IU per day, as well as functional foodstuff "Samarskiy zdorovyak" No 83 in volume 90 g per day are additionally introduced. Treatment course constitutes 24 weeks.

EFFECT: method ensures increase of mineral density of bone tissue by 4,33%, as well as increase of duration of therapeutic effect action due to stimulation of processes of bone tissue formation, normalisation of gastrointestinal tract functions and metabolism at the background of antiresorptive therapy.

4 cl, 1 tbl

Description

The invention relates to medicine and can be used in the treatment of patients with a progressive decrease in bone mineral density.

Currently, the problem of treating patients with a decrease in bone mineral density is solved in a combined therapeutic effect on the pathogenesis of a decrease in bone mineral density and the occurrence of osteoporetic fractures that would increase bone mass and at the same time restore the functional parameters of muscle tissue.

Known drug methods for increasing bone density. Bisphosphonate is used to prepare a medicine used in the treatment of osteoporosis according to medication regimens, including a thirty-day treatment period, which provides for the appointment of bisphosphonate and parathyroid hormone (see RF application No. 94031209, priority 16.06.94). However, antiresorptive drugs (in particular, bisphosphonates) inhibit bone metabolism. Moreover, drugs are effective in osteoporosis with a high level of bone remodeling. However, in women in late menopause, the level of bone metabolism is reduced, and the effectiveness of such agents may be limited.

Known is a combined method of influencing bone tissue, when, in addition to the use of drugs, they affect large bone zones (lower extremity bones, pelvic bones, spinal column, shoulder girdle bones) by a high-frequency electromagnetic field formed by a sinusoidal signal with a carrier frequency in the range of 100-300 kHz , amplitude-modulated low-frequency signal with a constantly changing frequency in the range of 10-1000 Hz using an inductive emitter. In this case, the electric field strength at the surface of the emitter should be in the range of 2.0-3.0 V / m. The procedure is carried out twice a day for 30 minutes. The cycle is 10-15 procedures. The method allows to increase the duration of remission of the disease, as well as slow down the progression of osteopathy (see RF patent No. 2371214, priority July 14, 2008). However, this method is used only at the initial stage of the disease.

Closest to the proposed is the method described in the dissertation "Functional features of respiratory, osteogenic and immune reactions of the human body during uniformly accelerated training." Samara 2009. Scientific adviser - Pyatin V.F.

In the work, a uniformly accelerated training technique of 24 weeks was used, which was used for bone remodeling processes in elderly women. As a source of uniformly accelerated physical load, the Power Plate simulator (Holland) was used. The main stimulating factor is the acceleration created by the movement of the simulator platform in three mutually perpendicular planes. Equally accelerated training was carried out under the simulator operating mode: the oscillation frequency was 35 Hz, the amplitude of the platform displacement was 4 mm, the training frequency was 3 times a week with rest intervals of 48 hours between each subsequent sessions. The duration of one training session was 30 minutes, including a warm-up and recovery. However, modern simulators used to increase the mineral density of bone tissue using the method of uniformly accelerated training, does not allow to achieve a stable normalization of the mineral density of bone tissue.

The present invention is aimed at achieving a technical result, which consists in increasing the effectiveness of treatment of elderly people and post-menopausal women with a progressive decrease in bone mineral density, increasing the duration of the obtained therapeutic effect.

The specified technical result is achieved by the fact that when using the method of uniformly accelerated training (uniformly accelerated physical activity) using the simulator in the mode: vibration frequency of the vibration platform is 30-50 Hz, the duration of one exercise is 30-60 seconds, the amplitude of the platform displacement is 2-4 mm, pulse acceleration 2.28-5.09 G, medications are introduced: alendronic acid 70 mg once a week in combination with calcium (1000 mg / day) and vitamin D (800 IU / day) for 24 weeks, as well as a functional product Power Supply (FPP) "Samarski th healthy man ”No. 83 - 90 g / day.

In the study, the Power Plate simulator was used as a source of uniformly accelerated physical activity. In this case, the operating mode was: the platform oscillation frequency was 30–40 Hz, the platform displacement amplitude was 2–4 mm, the pulse acceleration was 2.28–5.09 G. The optimal mode for increasing bone mineral density (BMD) in postmenopausal women is as follows .

The frequency of training is 3 times a week (total: 72 sessions). The duration of one session is 30 minutes. The duration of one exercise is 30-60 seconds. The rehabilitation period is 24 weeks (6 months).

The program of one session includes up to 15 static strength exercises on the muscles of the upper and lower (mainly) limbs. The level and intensity of uniformly accelerated load is systematically increased according to the principle of progression: the training regimen increases throughout the entire 24-week cycle by increasing the number of series of one exercise and / or the number of different exercises; training intensity is increased by shortening the rest time (60-30 sec), increasing the frequency (30-40 Hz), the duration of one exercise (30-60 sec) and the amplitude of the maximum platform displacement (2-4 mm). The training was held 3 times a week with rest intervals of 48 hours between sessions. The duration of one training session was 30 minutes, including the time to complete the exercises (30-45 s), the rest period between exercises (60-30 s), as well as the warm-up and recovery.

Consistently, exercises performed mainly on two legs are replaced by exercises on one leg.

Table Author's program for optimal BMD increase Mode indicators 1 month 2 month 3 month 4 month 5 months 6 months frequency Hz thirty thirty 30/40 30/40 30/40 40 Amplitude, mm 2 2 2 2/4 2/4 2/4 Exercise time, sec thirty thirty 45 45 60 60 Rest time, sec 60 45 45 thirty thirty thirty Number of exercises per session 8 10 12 12 fifteen fifteen

When using the technology of uniformly accelerated training, the main factor influencing the neuro-muscular system is acceleration. Activation of the proprioceptive apparatus in conditions of uniformly accelerated training causes local and systemic responses in the human body. The high efficiency of this training in high-performance sports, in restorative medicine and gerontological practice, including the rehabilitation of motor disorders in Parkinson's disease, multiple sclerosis and in people with a history of stroke, the treatment of age-related muscle hypotrophy, and the recovery of patients after a long stay in a hospital bed is shown. An increase in bone mineral density under the influence of physical activity indicates that muscle contractions and longitudinal mechanical load on the bone activate bone remodeling processes in the elderly. Equally accelerated training technology was applied to restore bone mineral density in women in the postmenopausal period. It was shown that after a 24-week training program in subjects, the mineral density of the bone tissue of the femur increased on average by 1.56%.

Venous blood served as the material for the study of serum concentrations of total calcium and phosphorus and bone remodeling markers (osteocalcin and β-CrossLaps) in elderly women. The research protocol included three stages: material sampling before the implementation of the research program, after 12 and 24 weeks. The time interval from the training session to the blood sampling for the study was 24 hours.

In the group of women who took antiresorptive therapy drugs for 24 weeks, the mineral density of the femur increased by an average of 2.01%.

In the group of women who took Samara Zdorovyak No. 83 FPP for 24 weeks, they received antiresorptive drugs and uniformly accelerated training was conducted, the mineral density of the femur increased by an average of 4.33%.

The results obtained indicate the clinical effectiveness of the combined treatment (drug and non-drug) increase in bone mineral density.

It was found that the osteogenic effect of uniformly accelerated training in elderly women is due to the stimulation of bone formation processes, which is expressed in an increase in the serum concentration of the osteocalcin marker for bone formation, however, the absence of antiresorptive therapy drugs and the stimulating effect of FPP do not allow this effect to be maintained for a long time.

FPPs are special-purpose products of natural origin that are intended for systematic use and are aimed at filling the lack of energy, plastic, or regulatory food substances in the body. By providing a regulatory effect on the functioning of all organs and systems of the body, on physical functions, biochemical reactions and psychosocial behavior of a person, such products support physical and spiritual health and reduce the risk of diseases.

FPP Samara Zdorovyak No. 83 includes the following components:

milk thistle seeds, pumpkin seeds, rose hips, flax seeds, wheat grains, pine nuts, grape seeds, watermelon seeds, corn grains, pomegranate seeds, walnuts.

In the diet of healthy people living in a temperate climate and not engaged in physical labor, proteins should be 13%, fats - 33%, and carbohydrates - 54% of the daily energy value of the diet, taken as 100%.

The approximate ratio of carbohydrates in the diet: starch - 75-80%, easily digestible carbohydrates - 15-20%, fiber and pectins - 5%. The ratio of basic vitamins per 1000 kcal (4.184 mJ) of the diet: vitamin C - 25 mg, B ₁ - 0.6 mg, B ₂ - 0.7 mg, B ₆ - 0.7 mg, PP - 6.6 mg . The ratio of calcium, phosphorus and magnesium, which provides the best absorption by the body, is 1: 1.5: 0.5.

Based on this information, a concept was developed to create a new product that ensures the achievement of rational (balanced), macrobiotic and functional nutrition, while the following should be included in the diet:

- 50-60% of whole grains and grain products,

- 5-10% flax seeds, oatmeal,

- 5-10% of legumes

- 5-10% of phytoproducts,

- 2-3% of watermelon and pumpkin seeds,

- 2-3% of pomegranate seeds, pine nuts, walnuts,

- 2-3% milk thistle, etc.

With this diet, protein provides about 12% of total calorie intake, fat - 15%, complex carbohydrates - 73%. Whole foods are eaten as naturally as possible.

Porridge includes:

- Vitamins: A, group B, C, E.

- Minerals: iron, magnesium, copper, selenium, zinc.

- Complex: whole (with preservation of the shells) wheat grain - a source of carbohydrates, proteins, fats, vitamins of group B, E, trace elements: iron, zinc, magnesium, copper, selenium, dietary fiber (fiber).

The Siberian Zdorovyak FPP is made of: washed, whole grain (wheat, oats, corn), heat-treated using explosion technology, and contains natural non-heat-treated vegetable additives: milk thistle, flax seeds, rose hips, pine nuts, watermelon, pumpkin seeds, grape seed, pomegranate seeds. The innovativeness of the preparation of the finished therapeutic food product consists in the use of modern nanotechnology using thermal pulsed exposure lasting 9 seconds. The pulse provides explosive loosening and grinding of pectin bonds in plant materials, thereby improving the bioavailability of plant cells.

A method for the production of durum wheat grains for FPP (in the form of instant porridge) involves heating and exploding a grain that has been previously washed from inorganic particles (stones, sand, ore particles, etc.) over its entire mass due to overpressure inside the grain and pressure relief in volume. The explosion of grain throughout its mass occurs as a result of its compression to a pressure of 31.2 kg / cm ² , exposure, with the formation of excessive vapor pressure inside the grain, followed by a sharp increase in the volume of the working chamber. Next, produce the formation of a slice, crushing the resulting slice and the addition of crushed particles of plant material in the form of meal.

The choice of pressure during heat treatment of a portion of grain by explosion with heating in the volume of the working chamber depends on the variety, type and technological properties of wheat grain, as well as on the size of the grain slice

Plant raw materials - rose hips, walnut kernels, milk thistle, flax seeds, rose hips, pine nuts, watermelon, pumpkin seeds, grape seed, pomegranate seeds are used in the form of crushed particles (dried).

The practical result of the invention is as follows. In a container with a capacity of 200 ml, add 3-5 tablespoons of porridge, add sugar or honey to taste. Pour 150-170 ml of hot milk, mix thoroughly and cover. After a minute, the product is ready for use. You can also cook on water with the addition of salt, butter or vegetable, mushroom or cube to taste. When using a microwave oven, pour cold milk or water, mix thoroughly and heat to a temperature of 60 ° C. The product is perfectly divorced with any natural juices and fermented milk products in the cold.

The consequence of the application of the Samara Zdorovyak FPP is: normalization of the gastrointestinal tract functions (gastrointestinal tract), normalization of liver functions, strengthening of joints, anti-cellulite effect, normalization of metabolism, source of protein, proteins and amino acids, restoration of strength, slowing down of aging (antioxidant), decrease risk of stroke, normalization of blood pressure, reducing risk and preventing heart attack, ischemia, calcification of heart valves. The product is a source of carbohydrates, minerals and trace elements, vitamins.

Alendronic acid (sodium alendronate) - bisphosphonate; bone tissue metabolism corrector; effective non-hormonal specific inhibitor of osteoclastic bone resorption. It stimulates osteogenesis, restores a positive balance between resorption and bone restoration, progressively increases the mineral density of the bones of the spine, pelvis and other bones of the skeleton, promotes the formation of bone tissue with a normal histological structure. It is used to treat osteoporosis in postmenopausal women (postmenopausal osteoporosis) and osteoporosis in men (senile osteoporosis) in order to prevent fractures, Paget's disease (deforming osteitis), and malignant hypercalcemia.

Vitamin D regulates the absorption of calcium and phosphorus minerals.

The claimed features are essential and interconnected with the formation of a stable set of essential features sufficient to obtain the desired technical result.

During 2010-2011, clinical studies were conducted in the Clinics of the Samara State Medical University and the State Health Institution of the Samara Region “Geriatric Scientific and Practical Center” to establish the content of calcium and phosphorus in the blood serum of groups of women, with the combined therapeutic effect of uniform acceleration training, antiresorptive therapy and FPP. The methodology did not change during the 24-week research program.

The report on the method for increasing bone mineral density of September 01, 2011 indicates an increase in bone mineral density due to the osteogenic effect due to the stimulation of bone formation processes, including physical exercises that can positively affect the maintenance of bone mineral density, increase muscle strength and improved coordination of movements in humans. The clinical use of uniformly accelerated training in conjunction with the use of drugs: alendronic acid 70 mg once a week in combination with calcium (1000 mg / day) and vitamin D (800 IU / day) for 24 weeks, as well as a functional food product (FPP ) Samara Zdorovyak No. 83 - 90 g / day is an effective method in clinical gerontological practice for the combined treatment and prevention of osteoporosis.

Claims (4)

1. A method of increasing the mineral density of bone tissue, providing for the impact on the human body of uniformly accelerated physical exertion created by the movement of the simulator’s vibroplatform in three mutually perpendicular planes, with an increase in the intensity of physical exertion and regimen, intake of alendronic acid in a volume of 70 mg once a week, calcium preparations in the amount of 1000 mg per day and vitamin D in the amount of 800 IU per day, as well as the functional food product "Samara healthy man" No. 83 in the amount of 90 g per day for 24 weeks. 2. The method according to claim 1, providing that the intensity of uniformly accelerated physical activity is increased by increasing the number of series of one exercise and / or the number of different exercises, and the intensity of the training regime is increased by shortening the rest time from 60 to 30 s, increasing the vibration frequency of the vibration platform from 30 up to 40 Hz, the duration of one exercise from 30 to 60 s and the amplitude of the maximum displacement of the vibration platform from 2 to 4 mm, with pulse acceleration of the vibration platform 2.28-5.09 g. 3. The method according to claim 2, providing that the training regimen increases over a 24-week cycle. 4. The method according to claim 2, providing that the frequency of training is 3 times a week, the duration of one session is 30 minutes, the rehabilitation period is 24 weeks.