RU2455019C1 - Herbal tea for treating constipations in patients suffering cerebrovascular diseases - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely agents for treating constipations in the patients suffering cerebrovascular diseases. A herbal tea for treating constipations contains common licorice roots, black currant leaves, linseed, wild chamomile heads, pale indian plantain leaves, alexandrine senna leaves, common nettle leaves, an elevated part of field sow thistle, burdock roots, an elevated part of peppermint, an elevated part of melancholy thistle, fennel fruits, anise fruits, coriander fruits, alder buckthorn bark, an elevated part of common St. John's wort, red haw, an elevated part of meadow crane, an elevated part of wild germander taken in certain proportions. The tea is intended for long-term unremarkable administration in treating constipations in the patients suffering cerebrovascular diseases.

EFFECT: herbal tea has an effective laxative effect, eliminates bloat, has no limitations with a wide spectrum of somatic and neurological diseases and differs by economic availability.

2 ex, 1 tbl

Description

The invention relates to medicine, namely to agents for the treatment of constipations in patients with cerebrovascular diseases.

Known agents for the treatment of constipation, increasing the volume of intestinal contents, such as flax seeds, methyl cellulose (synthetic preparation), forlax, mucofalk. These drugs hold water in the intestinal lumen and make feces more voluminous and soften them. Such medications are used for chronic atonic constipation (constipation in patients undergoing surgery, trauma) or for constipation caused by malnutrition. Means are well tolerated, but practically do not affect flatulence, and in some cases (especially in the first days of admission), their use can cause diarrhea or bloating. Studies evaluating the effectiveness of psyllum and mucofalk preparations with a short observation period have an insufficient sample size. It has been proven that drugs in this group contribute to less firm stools. (Avksentieva M.V., Vorobyov P.A. Gerasimov V.B. et al. Economic evaluation of the effectiveness of drug therapy (pharmacoeconomic analysis). M.: Newdiamed, 2000. - 80 pp.).

Known funds for the treatment of constipation, contributing to the softening of feces, they include mineral and natural oils (petrolatum, olive, almond). These products not only soften feces, but also lubricate the walls of the rectum, helping the contents of the intestine to “glide” along the intestine. They are safe, effective, easy to use, help in a short time, but are not suitable for long-term use and are not always effective for flatulence. With prolonged use, diarrhea may occur with metabolic disorders, dehydration, decreased intestinal enzyme function, impaired motor activity of the large intestine. (Adler G. Crohn's disease and ulcerative colitis: Translated from German. - M .: GEOTAR-Med., 2001. 257 p., Grinevich VB, Simanenkov V.I., Uspensky Yu.P., Kutuev X .A. Irritable bowel syndrome (clinic, diagnosis, treatment). St. Petersburg, 2000. - S.33-34.).

Known agents for the treatment of constipation affecting the receptors of the colon. Herbal remedies and some synthetic oils, as well as herbal preparations (anthracoids) can irritate the intestine and increase its motility, which in turn helps to quickly get rid of intestinal contents. These drugs include Senada (from senna leaves), buckthorn bark, castor oil, bisacodyl. The effect of taking these drugs develops in no less than 7-8 hours, so such drugs are taken at night. Long-term use of these drugs can cause impaired motor activity of the large intestine. (Alexander Williams J., Binder H.J. Gastroenterology (in three volumes), M .: Medicine. 1985., Grigoryeva G.A., Meshalkina N.Yu. Crohn's Disease. M .: Medicine. - 2007. - C .181).

Known means for the treatment of plant constipation, which includes senna leaves, honey is used as a base, apricot apricot, flax seeds, kelp thallus, large plantain leaves, dill, citric acid and microcrystalline cellulose are additionally introduced (RU 2134044, publ. 08/10/1999) or in combination with hay, peppermint leaves, chamomile flowers, fennel fruits (RU 2197979, publ. 02/10/2003) are used in another invention, senna leaves are combined with flaxseed and mint (RU 2103000, publ. 27.01. 1998).

Known collection for the treatment of constipation, containing thallus kelp, grass string, lingonberry leaves, motherwort grass, rose hips, chamomile flowers, buckthorn bark (RU 2103004, publ. 01.27.1998).

Despite the fact that in the indications for the use of this collection, as well as the above funds, a group of elderly patients is noted, the drawback of the collection is the lack of components in it to improve cerebral circulation.

The technical result of the invention is to expand the arsenal of funds aimed at treating constipations in patients with cerebrovascular diseases by creating a collection that includes a complex effect on various links in the pathogenesis of the disease, which does not cause complications during long-term treatment, eliminates the side effects of drug therapy, which does not have limitations for a wide range somatic and neurological diseases and characterized by economic affordability.

The technical result is achieved by the fact that a collection is proposed for the treatment of constipations in patients with cerebrovascular diseases, containing licorice roots, black currant leaf, seed flax seed, flower chamomile baskets, speckled caclius leaf, cassia leaves, dicotyledonous nettle, nadz. h. field sow thistle, burdock root large, nadz. including peppermint including thistle variegated, fruits of common fennel, fruits of common anise, fruits of coriander seed, buckthorn bark, breaking, oversight. including St. John's wort perforated, the fruits of the hawthorn blood-red, Hopes. h. meadow geranium, Hopes. including Veronica narrow-leaved in the following ratio of components, wt.%:

Licorice roots 7-9 Blackcurrant leaf 7-9 Sowing flax seed 7-9 Daisy flower baskets 3-5 Speckled cacalya leaf 3-5 Holly cassia leaf 7-9 Stinging nettle leaf 7-9 Supervision h. field sow thistle 3-5 Burdock root 7-9 Supervision h peppermint 3-5 Supervision h. 3-5 Fennel Ordinary Fruits 3-5 Fruits of anise 3-5 Seed coriander fruits 3-5 Unbreakable buckthorn bark 3-5 Supervision h. Hypericum perforatum 7-9 Fruits of hawthorn blood red 3-5 Supervision h. meadow geranium 3-5 Supervision h. Veronica narrow-leaved 3-5

Studies have shown that the multicomponent effect of the collection is confirmed by its laxative, reducing flatulence, improving cerebral circulation, tonic, energizing, detoxifying effects. The multicomponent collection is due to the inclusion of several “groups” of medicinal plants: The first group includes medicinal plants with a proven laxative effect - licorice, currant, flax, cassia, cassia, nettle, sow thistle, burdock, chamomile, butan, buckthorn. In the second group - medicinal plants with a proven flatulence-reducing effect - anise, fennel, mint, chamomile. In the third group - medicinal plants with a proven effect improving cerebral circulation - hawthorn, geranium, veronica, mint, St. John's wort, currant. In the fourth group - medicinal plants with proven general strengthening, energizing, optimizing neuroendocrine regulation action - St. John's wort, anise, nettle, licorice, flax. The fifth group includes medicinal plants with a proven detoxifying effect - licorice, currants, St. John's wort, mint, sow thistles, as well as plants that are included in the first group mentioned above.

Moreover, the technical result due to the multicomponent collection is not the sum of the expected effects from the use of medicinal plants of known property. To determine the composition of the collection, a preliminary review of medicinal plants and their compositions used in traditional medicines of Asian countries (India, Tibet, Korea, Japan, Iran, Tajikistan) was performed, then the optimal and affordable combinations were selected, confirmed by clinical testing of the collection efficiency.

When choosing the plants that make up the collection, we considered plants that have not one, but several useful properties. For example, licorice root has a laxative, anti-atherogenic, general strengthening effect, cassia acutifoliate (senna) is a commonly accepted laxative, detoxifying, optimizing neuroendocrine regulation, currant leaf weakens, desensitizes, optimizes the functions of the endocrine glands, lax is an absorbent, laxative, and adsorbent. , burdock root - a common laxative, optimizes regeneration processes, hawthorn - a common vasoprotector, improves regional blood circulation tion, prevents vascular events, detoksikant.

Clinical studies have shown the effectiveness of inclusion in the collection of medicinal plants with proven angioprotective and improving cerebral circulation properties: hawthorn, geranium, veronica, St. John's wort, mint.

Clinical studies have shown that the treatment of constipation in patients with cerebrovascular disease gives a new technical result when using a collection that has not only a laxative effect, but also affects the underlying disease. In addition to improving cerebral circulation, this collection eliminates the threat of stroke during attempts, bowel movements. The detoxifying effect of the infusion of collection has been clinically noted: improving the color and turgor of the skin, optimizing the psycho-emotional status, reducing the severity of depressive experiences, negativity, asthenization. The collection eliminates flatulence and associated pain, discomfort along the small intestine.

Thus, the action of the collection can be considered as polymechanism, affecting not one or two links in the pathogenesis of the disease.

In studies using the proposed collection, 34 patients with chronic cerebrovascular accidents and constipation underwent treatment. Table 1 presents a comparative assessment of the effectiveness of laxatives of plant origin in patients with chronic cerebrovascular disorders.

The collection is used as follows.

Prepare the broth from the collection according to GF X (State Pharmacopoeia of the 10th revision) in the following way: crushed dried raw materials 30-40 g (3-4 tablespoons) are poured with hot boiled water in a ratio of 1: 20, covered with a lid and simmer in a water bath in for 40 minutes, then the infusion together with the raw material is poured into a thermos and insisted for 8-10 hours (preparation in the evening, infusion during the night, reception in the morning). The volume of the resulting broth is adjusted to 800.0 ml and drunk during the day 20 minutes before meals in 5-6 doses. The method is illustrated by the following clinical examples.

Example 1. Patient T., 59 years old, complained of almost constant aching, bursting headaches, mainly fronto-parieto-occipital localization, against which there are attacks of intense headache, sometimes with nausea, without vomiting, more often with psycho-emotional provocations. Notes meteorological dependence of headaches. Periodically, blood pressure rises to 150/90 mm RT. (initially sick hypotonic). By evening, pain in the eyes, a transient decrease in vision. Emotionally not stable, irritable, tearful, anxious. Notes fatigue. Suffers from constipation in the last 2-3 years, 2-3 stools per week, regularly takes a senade, biscadil.

In neurological status: anisoreflexion of deep reflexes D> S.

When assessing anxiety on the Tsung scale - 0.49 points (maximum - 1), depression on the Beck scale - 24 points (moderate depression). In the biochemical analysis of blood - an increase in the level of total blood cholesterol (6.31 mmol / L) and low-density lipoprotein cholesterol (4.92 mmol / L), the atherogenic index - 4.62. Coagulogram indicators are within normal limits. The functional activity of platelets is changed in the direction of increasing the content of active forms of platelets and aggregates: the content of discocytes is normal (84%), the content of discoechinocytes is increased - 19.5%. The amount of active platelet forms was increased to 22.9%, and the number of platelets involved in aggregates was 11.3%, the number of small aggregates exceeded the norm (8.0). Dopplerography of extra- and intracranial arteries has no hemodynamically significant stenosis; vasomotor reactivity to vasoconstriction is reduced (1.15). Computed tomography of the brain - pathological formations were not detected. Duplex scanning of the arteries of the neck - without significant pathology.

Diagnosis: Stage 1 dyscirculatory encephalopathy. Hypertension (GB) stage 1. Climax Chronic constipation.

A course of treatment was carried out with the proposed collection for 3 months with the following ratio of components: licorice roots - 9, black currant leaf - 9, sowing flax seed - 9, chamomile flower baskets - 3, speckled leaf-cassia - 3, cassia leaves - 7 , nettle leaf dioecious - 8, Hopes. including field sow thistle - 3, burdock root - 7, superv. h. peppermint - 3, Hopes. including variegated thistle - 3, ordinary fennel fruits - 3, ordinary anise fruits - 4, sowing coriander fruits - 4, buckthorn bark - 4, supervision. including St. John's wort perforated - 7, the fruits of the hawthorn blood-red - 4, Hopes. h. meadow geranium - 5, nadz. h. Veronica narrow-leaved - 5

After treatment, the patient noted a significant improvement in health. Permanent, aching headaches disappeared, a sensation of a "light, light" head appeared. Paroxysmal, intense headaches have become less frequent and better relieved by analgesics. The dose of analgesic drugs decreased by 5 times, which became more effective. During treatment there was only one increase in blood pressure to 140/85 mm Hg. Art., which quickly stopped on their own. Emotionally became more balanced. The stool returned to normal, it became daily and painless. Upon repeated examination: anisoreflexion of deep reflexes D> S is preserved. The indicators of anxiety more than halved - 0.23 points on the Tsung scale and depression - 8 points on the Beck scale, which corresponds to the absence of anxiety and depression. The level of total blood cholesterol (6.14 mmol / l) was normalized in the lipid profile. The cholesterol content of low density lipoproteins remained elevated (4.87 mmol / L). The content of triglycerides, cholesterol, high and very low density lipoproteins remained normal. Atherogenicity index slightly decreased, but did not reach normal values - 4.44. Coagulogram indicators are within normal limits. The functional activity of the platelets is completely normal. Repeated dopplerography showed normalization of the vasomotor reserve for vasodilation (1.25).

Example 2. Patient V., 58 years old, an engineer, complained of intense diffuse almost daily headaches of a bursting nature, more often in the evening, decreased performance (forced to take sick leave), constant pulsating noise in the head, sleep disturbance (insomnia at night and drowsiness during the day), episodes of rising blood pressure, accompanied by increased headaches. Constipation for 3-4 days, the absence of the effect of senade, against the background of forlax notes unformed stool and flatulence. Considers himself ill for the last 3-4 months.

Diagnosis: Discirculatory encephalopathy of the 1st stage against the background of hypertension of the 2nd stage, atherosclerosis of the arteries of the brain. Chronic constipation.

In the anamnesis: chronic cholecystitis, type 2 diabetes mellitus (diet), thrombophlebitis of the veins of the lower extremities.

When viewed in neurological status: horizontal nystagmus in the extreme leads, asymmetry of the facial muscles, pathological hand marks on both sides, anisoreflexia. The patient is depressed, anxious. With neuropsychological testing, attention and mental performance are reduced.

In the biochemical analysis of blood, pronounced hypercholesterolemia: total cholesterol - 9.5 mmol / L, triglycerides - 0.99 mmol / L, β-lipoproteins - 48 units, atherogenic index - 3.64, prothrombin - 133%, glucose (fasting) - 7.4 mmol / L.

When conducting ultrasound dopplerography of the bracheocephalic and intracranial arteries: there are no hemodynamically significant stenoses and tortuosity of the arteries. Decreased reactivity in the middle cerebral arteries for vasodilation and vasoconstriction. The blood flow is located along the spinal venous plexus in a supine position on both sides.

For 2.5 months, the patient took the proposed collection of medicinal plants according to the invention as monotherapy with the following ratio of components: licorice roots - 7, black currant leaf - 7, sowing flax seed - 7, chamomile flower baskets - 5, spear-shaped leaf - 5, a sheet of cassia holly leaves - 8, a leaf of nettle dioecious - 7, Hopes. including field sow thistle - 5, burdock root - 9, superv. h. peppermint - 3, Hopes. including variegated thistle - 3, ordinary fennel fruits - 3, ordinary anise fruits - 4, sowing coriander fruits - 4, buckthorn bark - 4, supervision. including St. John's wort perforated - 7, the fruits of the hawthorn blood-red - 4, Hopes. h. meadow geranium - 4, supervision. h. Veronica narrow-leaved - 4.

Upon re-examination: headaches, noise in the head decreased, sleep normalized, blood pressure normalized, working capacity increased (went to work). Stool normalized, flatulence is absent. During the collection, I did not notice pain and discomfort in the right hypochondrium, pain and swelling of the legs decreased. Neurologically: deep reflexes are symmetrical, carpal pathological signs disappeared. The mood background is good, there is no alarm. Neuropsychological testing showed an improvement in attention and mental performance. In the biochemical analysis of blood: total cholesterol - 7.1 mmol / L, triglycerides - 0.88 mmol / L, b-lipoproteins - 42 units, atherogenic index - 2.2, prothrombin - 120%, glucose (on an empty stomach) - 5.2 mmol / l, i.e. there was a decrease in total cholesterol, atherogenic index, normalized: prothrombin and blood sugar. During ultrasound dopplerography of the bracheocephalic and intracranial arteries: vascular reactivity in both middle cerebral arteries normalized, there are no signs of venous discirculation.

The proposed collection is used for long-term use without complications in the treatment of constipation in patients with cerebrovascular diseases. Acting on the pathogenesis of the underlying disease, the collection has an effective laxative effect, eliminates flatulence, has no side effects of drug therapy, has no limitations with a wide range of somatic and neurological diseases and is economically accessible.

Claims (1)

A collection for the treatment of constipations in patients with cerebrovascular diseases, containing licorice roots, blackcurrant leaf, seed of flax seed, flower chamomile baskets, speckled cacia leaf, cassia leaves, nettle leaf, dicotyledonous nettle, ground sow thistle, burdock root, aerial part peppermint, the aerial part of the thistle multifolia, the fruits of ordinary fennel, the fruits of anise ordinary, the fruits of coriander seeds, buckthorn bark breaking, the aerial part of St. John's wort perforated, ode Crataegus sanguinea, aerial parts Geranium pratense, narrow-leaved speedwell aboveground part of the following component ratio, wt.%:
licorice roots 7-9 black currant leaf 7-9 sowing flax seed 7-9 chamomile flower baskets 3-5 speckled cacalya leaf 3-5 cassia leaves 7-9 dioica nettle leaf 7-9 aerial part of field sow thistle 3-5 burdock root 7-9 aboveground peppermint 3-5 the aerial part of the thistle 3-5 common fennel fruits 3-5 fruits of anise 3-5 fruits of coriander seed 3-5 buckthorn bark 3-5 aerial part of Hypericum perforatum 7-9 the fruits of hawthorn blood red 3-5 aerial part of meadow geranium 3-5 aerial part of veronica narrow-leaved 3-5