RU2444352C2 - Method of treating alcoholic dependence and opium addiction 'universal psychopharmacological neurophysiological block' - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and aims at treating alcoholic dependence and opium addiction. That is ensured by a psychological, emotional stress and pharmacological complex followed by pharmacological consolidation of a therapeutic effect. The complex is performed sequentially. General relaxation is followed by emotional stress. 25% Magnesium 4-6 ml, 1% nicotinic acid 0.5-3 ml and 0.9% sodium chloride 5-12 ml are introduced intravenously. An imperative suggestion is attended by ethanol vapour inhalation in treating alcoholic dependence. The following stage involves pharmacological exposure by introducing the preparations desulphirame and/or cyanamide in treating alcoholic dependence, and opiate receptors in treating opiate addiction. Finally, the therapeutic effect is consolidated by the intramuscular introduction of pyrogenal 50-100 mcg in treating alcoholic dependence and 100-1500 mcg in treating opiate addiction.

EFFECT: method provides clinical effectiveness in alcoholic dependence and opiate addiction.

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Description

The invention relates to psychiatry-narcology, namely to the treatment of alcohol dependence syndrome, tobacco dependence syndrome, opiate dependence syndrome.

From the patent No. 2067878 RU, 1995.04.24, a composition is known for the treatment of alcoholism, including drugs, including psychotropic drugs, namely ketamine, tegretol, analgin, piracetam, relanium, nicotinic acid, 15-30 g of a decoction of rose hips, viburnum or rose hips and mountain ash, as well as a method of treating alcohol dependence, which provides for an exposure session before the patient has an acute need for alcohol; at the beginning of the session, the indicated composition is orally administered, stress-psychotherapy is carried out aimed at eliminating alcohol and complete indifference to it, then the patient's eyes are illuminated sequentially with light of various colors, then a hypnotic psychotherapeutic effect is performed, creating a comfortable state for the patient and immersing him in sleep, all of which the stages of the session carry out a suggestive effect. The method features are unloading diet therapy, the patient inhaling alcohol vapor during the session, accompanying the session with music, aromatizing the room, exposure of the patient to the nape and forehead of the patient with a cool stream of air or chloroethyl, and warm air is applied to the shoulders and chest.

A known method of treating alcoholism (patent No. 2129887 RU, 1995.11.30), including the introduction of drugs containing ketamine hydrochloride, verbal heterosuggestive effect, as well as psychotherapeutic effect.

From patent No. 2080131 RU, 1995.10.11, a method for treating alcoholism using psychopharmacological therapy is known, which consists in administering ketamine in a mixture with magnesium sulfate, doses, forming an indifferent attitude to alcohol using verbal-suggestive treatment, which is carried out simultaneously with the massage of the superciliary arches and the epigastric region and / or the solar plexus region, inducing the patient to mentally sense a localized foreign body, suggesting that this body is an "energy parasite volume, "associate it with the negative aspects of the alcohol lifestyle, followed by the suggestion of its removal.

A known method of treating alcoholism (AS USSR No. 1806743, 02/07/91), which consists in the simultaneous administration of teturam and apomorphine hydrochloride after a course of detoxification therapy.

The aim of the invention is to reduce the cost of treatment procedures for treatment of alcohol and opioid addiction, increasing the effectiveness of treatment.

The goal is achieved due to the fact that the patient undergoes a pharmacological unit procedure, which uses methods of mediated, aggressive psychotherapy and pharmacological treatment. In this case, at the first stage after general relaxation, they carry out an emotionally-stressful effect, which is the case for treatment of opioid dependence and alcoholism in the introduction of 25% magnesium solution of 4% to 6 cm ³ of nicotinic acid and 1% of nicotinic acid in an amount of from 0.5 to 3 cm ³ , a solution of sodium chloride 0.9% in an amount of 5 to 12 cm ³ . Against the background of the stressful effects of these drugs, imperative suggestion is carried out, the doctor tells the patient about the harmful effects of using drugs or alcohol and through the method of suggestion brings to the patient's awareness the need to refuse to use harmful substances. In the treatment of alcohol dependence, the effect on the patient is reinforced by inhalation of ethanol vapor. Further, in the procedure of the pharmacological unit, a pharmacological effect is carried out, for this, in the treatment of opioid dependence, an antagonist of the opiate receptors is orally administered, and in the treatment of alcoholism, sensitization therapy with desulfiram drugs is prescribed. As a result, the patient has a psychological, emotional, stress and pharmacological effects. At the second stage, the emotional stress effect is fixed, for which the patient is injected intramuscularly with a solution of pyrogenal in the following amounts:

1) in the treatment of dependence on opioids in an amount of from 100 μm to 1500 μm,

2) in the treatment of alcoholism in an amount of from 50 to 1500 microns.

As a result of the procedure, a conditioned reflex is created in the patient. Subsequently, within six months, 1 time per month, and after 6 months no less than 1 time in 3 months, the patient undergoes the procedure of fixing this effect, which consists in the intravenous administration of the drug in one of the following formulations:

1) 25% magnesium solution in an amount of 4 to 6 cm ³ , 1% nicotinic acid solution in an amount of 0.5 to 3 cm ³ , 0.9% sodium chloride solution in an amount of 5 to 12 cm ³ ;

2) a solution of sodium thiosulfate 30% in an amount of from 7 to 12 cm ³ , a solution of sodium chloride 0.9% in an amount of from 5 to 12 cm ³ .

As a result of the implementation of the method of treating alcohol dependence, remission of patients exceeds 10 years, and in the treatment of opioid dependence, remissions of one to five years and above are achieved. Moreover, the cost of treatment is low due to the use of common and low-cost drugs.

The implementation of the invention

The procedure of the pharmacological unit.

Against the background of relaxing audio melodies, a general relaxation of the patient’s body is carried out by touching the doctor’s frontal, temporal and occipital areas with the fingertips of the patient. Then, a 25% magnesium solution in an amount of 4 to 6 cm ³ , a nicotinic acid solution of 1% in an amount of 0.5 to 3 cm ³ , a sodium chloride solution of 0.9% in an amount of 5 to 12 cm ³ are administered intravenously. Then, an imperative suggestion of harm to the use of harmful substances is carried out, the doctor tells the patient about the consequences and through the method of suggestion brings the patient's awareness of the need to abandon addiction. In the treatment of alcohol dependence, the patient is allowed to inhale vapors of ethanol. Further, in the treatment of opioid dependence, an opiate antagonist of the opiate receptors is orally administered, and in the treatment of alcoholism, sensitization therapy with desulfiram drugs is prescribed.

After this, the patient is injected intramuscularly with a pyrogenal solution, in the treatment of alcohol dependence in an amount of from 50 to 1500 microns, in the treatment of opioid dependence from 100 microns to 1500 microns.

Subsequently, within six months, 1 time per month, and after 6 months no less than 1 time in 3 months, the patient undergoes the procedure of fixing this effect, which consists in the intravenous administration of the drug in one of the following formulations:

1) 25% magnesium solution in an amount of 4 to 6 cm ³ , 1% nicotinic acid solution in an amount of 0.5 to 3 cm ³ , 0.9% sodium chloride solution in an amount of 5 to 12 cm ³ ;

2) a solution of sodium thiosulfate 30% in an amount of from 7 to 12 cm ³ , a solution of sodium chloride 0.9% in an amount of from 5 to 12 cm ³ .

Examples

Example No. 1

Sick man - 35 years old

Chronic alcoholism I st

Alcohol abuse complaint. There is an alcohol withdrawal syndrome. Pathological craving for alcohol. Formed physical and mental dependence.

After detoxification therapy, the patient underwent a psychopharmoblock (PFB) procedure for a period of 12 months.

After that, the patient showed signs of obsessive craving for alcohol. An attitude of sobriety was developed, sleep, appetite, mood normalized, and denied craving for alcohol. At a preventive appointment, a month later, an injection was made. Subsequent intake after 3 months. Remission of 10 months.

Example No. 2

The sick man is 42 years old. Chronic alcoholism - II Art.

The complaint of an addiction to alcohol, which has a compulsive character, poor sleep, loss of appetite, mood, was repeatedly treated in a drug treatment hospital.

History: persistent formation of a pathological craving for alcohol, alcohol withdrawal syndrome (AAS). Mental and physical dependence on alcohol is fully formed. Moved twice on the date of different cancellation of alcohol delirium F 10.41. 5 days in a drinking bout. After detoxification therapy, PFB was performed for 3 years. Given the installation of sobriety. Normalized sleep, appetite, mood. Denies craving for alcohol. After 1 month at the examination, the mood is even. There is full motivation for sobriety. Subsequent administration 1 time in 3 months. Remission of 10 months.

Example No. 3

The sick man is 19 years old. Mental and behavioral disorders resulting from the use of opiates. Addiction syndrome. Previously not treated.

Complaints about the attraction to the use of surfactants, insomnia, muscle pain, lacrimation, rhinorrhea. After inpatient treatment, I turned to the center where the PFB + oral procedure was performed with Anataxone 500 mg.

After 1 month, the patient notes a lack of craving for the drug, normalized sleep, appetite, mood. Make-up + toxoid 500 mg made.

Given the installation of sobriety, within 10 months of remission. I visited monthly recharge.

Example No. 4

Sick man 19 years old.

Notes attraction to opiates. Consumes intranasally for 2 months.

Formed heroin addiction syndrome. Appealed at the insistence of the parents.

Complaints of low mood, short temper, unstable sleep. Academic failure, frequent absenteeism at the institute. Complicated relationships with parents. Formed mental dependence. After a psychotherapeutic setting for sobriety, an PFB for 1 year + anataxone 500 mg for 1 year was carried out with subsequent rehabilitation measures. After 1 month recharge. Normalized sleep, mood. I pulled myself up in school. Good relationship with parents, denies craving for a drug. Remission for 10 months with recharge after 1 month.

Example No. 5

Woman 35 years old. Complaints of craving for alcohol, unstable sleep, tremor of limbs, ataxia, anxiety. Diagnosed with chronic stage 1 alcoholism, mental and physical dependence formed. 5 days in a drinking bout. After detoxification therapy, PFB was performed with 3 years of sobriety.

Normalized sleep, appetite, mood. Good, good relations were restored in the family, with her husband and children. After 1 month recharge. Completely denies craving for alcohol, condemns his alcoholization, began to participate in sobriety circles. In remission 10 months. He regularly visits recharge once a month.

Example No. 6

Woman - 42 years old. Notes craving for alcohol. Drinks on weekends (Saturday, Sunday). He doesn’t use on weekdays, as he works as a seller in a store. Psychic and physical dependence is fully formed. The dose of alcohol began to gradually increase. Consumes up to 0.5 liters of vodka daily on weekends. Absenteeism at work began to appear more often. Lost situational and quantitative control. The craving for alcohol is obsessively compulsive. Conducted detoxification therapy. After that, the SFP procedure is set for 3 years. Normalized sleep, appetite, mood, addiction to alcohol denies. Met a man. Plans to create a family. In remission 10 months. Replenishment visits 1 time in 3 months.

Example No. 7

Woman 21 years old. Marks an irresistible craving for opiate use. He is an injecting drug user (IDU) for 3 years. Diagnosis F 11.242 opiate addiction syndrome. She underwent repeated psychotherapeutic treatment. Complaints about difficult relationships with parents, peers, bodies of the Ministry of Internal Affairs. Does not work, does not study, is not married. Life cannot be without surfactant.

From the anamnesis: mental and physical dependence on heroin is fully formed. The habitual way of life, sleep, appetite, mood are disturbed, the patient is embittered all over the world. At the reception, it is motivated to begin treatment. Passed a course of detoxification therapy. Correction of insomnia, algic and anxiety disorders. After that, the procedure PFB + anataxone 500 mg was done. Normalized sleep, appetite, mood. After 1 month recharge. Denies drug craving. Relations with parents became positive. I attended recharge once a month + anataxone 500 mg. After 6 months, she met a man without bad habits. He wants to start a family, have children. In remission 10 months. With disgust, he recalls his past related to drugs. I got a job, began to engage in fitness. He continues to go to recharge.

Example No. 8

The man is 56 years old. Alcohol complaints. Consumes hard drinking up to 14 days. Notes insomnia, lack of appetite, shallow forgetfulness with nightmare dreams. Binges are noted once a quarter. Fired from work for drunkenness.

From the anamnesis: was treated regularly twice. Remissions are short. Passed coding, after which after 2-3 weeks the binges began again. Marks a heart failure. The liver is enlarged by 3 cm, painful. After detoxification therapy, the PFB procedure was performed. Normalized sleep, appetite, mood. Examination after 1 month. Visits recharge once a month. Remission of 10 months.

Claims (1)

A method of treating addiction to alcohol and opiates, including psychological and pharmacological effects, characterized in that after conducting general relaxation, they carry out an emotional-stressful effect by intravenous administration of a solution of magnesium 25% 4-6 ml, a solution of nicotinic acid 1% 0, 5-3 ml and a solution of sodium chloride 0.9% 5-12 ml, then an imperative suggestion is carried out, which is accompanied in the treatment of alcohol dependence by inhaling ethanol vapor, the next step is pharmacological action by introducing preparations of the desulfiram series and / or cyanamide in the treatment of alcohol dependence and opiate receptor antagonists in the treatment of opiate addiction, and in conclusion, the therapeutic effect is fixed by intramuscular injection of a pyrogenal solution in an amount of 50-100 μg in the treatment of alcohol dependence and 100-1500 μg in the treatment of opiate addiction.