RU2428183C1 - Adaptogen for meteosensitive patients with stenocardia and arterial hypertension and application of melatonin as adaptogen - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to field of medicine and pharmaceutics and deals with adaptogen for treatment of meteosensitive patients with stenocardia and arterial hypertension, representing N-acertyl-5-methoxytryptamine (melatonin) and melatonin application as adaptogen in treatment of meteosensitive patients with stenocardia and arterial hypertension at the background of traditional treatment.

EFFECT: substantiation of applying melatonin as adaptogen in treatment of meteosensitive patients with stenocardia and arterial hypertension at the background of traditional treatment.

2 cl, 6 dwg, 2 tbl, 1 ex

Description

The present invention relates to the field of medicine and pharmacology and relates to pharmaceuticals for regulating adaptive processes.

Meteosensitivity, as a reaction of the body to the influence of weather factors, is quite widespread and occurs under any, but often unusual for a given person climatic conditions. According to medical statistics, in about one third of men in different countries, almost half of women are hypersensitive to changes in weather conditions. 65-75% of patients with cardiovascular diseases suffer from meteosensitivity. Currently, despite a large number of studies in the field of pharmacotherapy of arterial hypertension (AH) and coronary heart disease (IHD), its effectiveness remains extremely low. Among the reasons explaining the insufficient effectiveness of therapy, a special place is occupied by meteorological dependence and the absence of seasonal correction of treatment. The study of the influence of meteorological factors on the hemodynamic state of patients with cardiovascular diseases and the development of appropriate adaptogens are relevant.

Known adaptogen a wide spectrum of action of tris- (2-hydroxyethyl) -ammonium ortho-cresoxyacetate (trekrezan) [1]. It is reported about its adaptogenic effect, which contributes to the preservation of homeostasis when exposed to unfavorable factors of a physical, chemical and biological nature on the human body.

It is known to use herbal medicines as adaptogens: ginseng, aralia, eleutherococcus, Chinese magnolia vine, etc. [2]. The disadvantage of these adaptogens is the possibility of allergic reactions, often of the type of polyvalent ones, with prolonged use of drugs. In addition, the disadvantage should be limited to the range of their use, for example, with hypertension, insomnia, fever, due to the stimulating effect of drugs. Melatonin, otherwise melaxen (Unifarm, USA), the chemical name N-acetyl-5-methoxytryptamine, is an epiphysis neurohormone and is an indole derivative that is converted from 5-hydroxytryptophan.

About 80% of the melatonin circulating in the blood is produced by the pineal gland, being the “biochemical key” of the “biological clock”. The formation of melatonin is subject to daily periodism and depends on ambient light. Melatonin levels begin to rise in the blood in the evening, reaching a maximum by the middle of the night, and then progressively decrease, reaching a minimum in the morning. It is known to use melatonin to normalize circadian rhythm in people with latitudinal (in flights in the latitudinal direction) desynchrosis [3] and the treatment of arterial hypertension [4].

To date, the adaptogenic properties of melatonin with respect to the impact of weather factors on hemodynamic parameters in patients with arterial hypertension (AH) and coronary heart disease (CHD) have not been known.

The present invention is the development of a new adaptogen for weather-sensitive patients with angina pectoris and hypertension.

In accordance with the invention, an adaptogen for meteosensitive patients with angina pectoris and arterial hypertension is described, which is N-acetyl-5-methoxytryptamine (melatonin), as well as the use of melatonin as an adaptogen in the treatment of meteosensitive patients with angina pectoris and arterial hypertension against the background of traditional treatment. The following examples illustrate the present invention.

Examples.

Two groups of patients suffering from hypertension in combination with coronary heart disease were examined. The first group consisted of 14 people (12 women and two men aged 52 to 70 years). Stage II hypertension suffered 12 people, III - two patients. AH of the II degree was detected in 11, stage III - in three patients. Five suffered from angina pectoris, one patient had post-infarction cardiosclerosis, and eight had atherosclerotic cardiosclerosis. Patients received conventional therapy: nitrates, β-blockers, calcium antagonists, ACE inhibitors (angiotensin converting enzyme), antiplatelet agents and diuretics. The second group consisted of 17 people (9 women and 8 men aged 41 to 67 years). AH of the I degree suffered one patient, II degree - 14, and III degree - two patients. Stage I hypertension was detected in one, stage II in 10, and stage III in six patients. Two suffered from angina pectoris, two patients had post-infarction cardiosclerosis. Patients on the background of traditional therapy received melatonin (melaxen, Unipharm, USA) at a dose of 3 ... 6 mg at 22 h. Systolic (SBP), diastolic (DBP) pressure and pulse were measured in the morning (9:00) and evening (19: 00) hours for 2 ... 3 weeks daily. The effect of air temperature, atmospheric pressure, relative humidity, cloud cover, dew point, wind direction and speed on the state of hemodynamics was assessed and a correlation analysis was performed. Weather factors were received from the Weather of Russia server.

In patients of the first group, 64 significant correlations were revealed between hemodynamic parameters and weather factors. It was found that the level of morning SBP correlates with indicators of atmospheric pressure (p <0.01), air temperature (p <0.001) and dew point (p <0.001). Atmospheric pressure (p <0.04) affects the evening level of SBP. The parameters of morning DBP correlate with atmospheric pressure (p <0.04) and relative humidity drop (p <0.04). The parameters of morning DBP correlate with air temperature (p <0.001), with dew point indicators (p <0.001), and evening DBP values only correlate with parameters of dew point (p <0.02). The morning pulse is affected by all the studied meteorological factors: wind direction and speed (p <0.001), temperature (p <0.001), dew point (p <0.04), relative humidity (p <0.001) and upper cloud cover (p <0.01). All weather factors also influence the evening pulse: upper cloud cover (p <0.04), wind direction and speed (p <0.001), atmospheric pressure (p <0.001), relative humidity (p <0.001), air temperature (p <0.001 ) and dew point (p <0.001). It should be noted that the influence of meteorological factors was noted both at the time of measurement and on the eve of the study and the next day. To a lesser extent affect the hemodynamic indicators, differences in weather indicators.

In patients of the second group, 35 significant correlations were revealed between hemodynamic parameters and weather factors. The parameters of morning SBP correlate with atmospheric pressure (p <0.001), relative humidity (p <0.03) and upper cloud cover (p <0.02). The evening level is influenced by atmospheric pressure (p <0.004) and relative humidity (p <0.01). The parameters of the morning DBP value only correlate with atmospheric pressure indicators (p <0.01).

Evening DBP values are influenced by atmospheric pressure (p <0.001) and relative humidity (p <0.04). The values of morning DBP correlate with atmospheric pressure (p <0.001), relative humidity (p <0.001), air temperature (p <0.03) and upper cloud cover (p <0.05).

The research results are shown in tables 1,2 and figures 1-6.

Thus, a correlation was found between weather factors and hemodynamic parameters in patients with hypertension and ischemic heart disease. With traditional treatment, 64 significant correlations were identified. Under the influence of melaxen, the number of correlations decreased to 35. Patients receiving conventional treatment are mainly affected by weather factors such as temperature, atmospheric pressure, and dew point. The most sensitive to weather conditions are the heart rate. Patients receiving treatment with melaxen are less affected by weather factors. The influence of temperature decreased, the absence of the influence of the dew point, direction and wind speed on hemodynamic parameters was revealed. It is obvious that melaxen has a meteoprotective effect. The drug helps to reduce weather sensitivity and, therefore, reduces the risk of cardiovascular complications.

Table 1 Correlation between hemodynamic parameters and weather factors in patients with hypertension and coronary heart disease receiving conventional treatment GARDEN in the morning DBP in the morning Pulse in the morning GARDEN in the evening DAD in the evening Pulse in the evening Atmosphere pressure: - at the time of measurement -0.193 (p <0.01) -0.148 (p <0.05) 0.328 (p <0.001) -0.153 (p <0.04) 0.323 (p <0.001) - on the eve of the study - - 0.384 (p <0.001) - 0.384 (p <0.001) - the next day 0.230 (p <0.003) -0.177 (p <0.02) 0.253 (p <0.001) -0.220 (p <0.004) 0.246 (p <0.001) - differential - - - - - Temperature: - at the time of measurement 0.419 (p <0.001) 0.244 (p <0.002) -0.286 (p <0.001) - 0.300 (pO.001) - on the eve of the study 0.407 (p <0.001) 0.246 (p <0.001) -0.305 (p <0.001) - 0.319 (p <0.001) - the next day 0.424 (p <0.001) 0.250 (p <0.001) -0.265 (p <0.001) -0.284 (p <0.001) - differential - - - - - Relative humidity: - at the time of measurement 0.419 (p <0.001) 0.244 (p <0.002) -0.286 (p <0.001) - 0.300 (p <0.001) - on the eve of the study 0.407 (p <0.001) 0.246 (p <0.001) -0.305 (p <0.001) - 0.319 (p <0.001) - the next day 0.424 (p <0.001) 0.250 (p <0.001) -0.265 (p <0.001) -0.284 (p <0.001) - differential - - - - - Dew point: - at the time of measurement 0.354 (p <0.001) 0.288 (p <0.002) -0.555 (p <0.001) 0.171 (p <0.02) -0.575 (p <0.001) - on the eve of the study 0.335 (p <0.001) 0.284 (p <0.001) -0.578 (pO.001) 0.188 (p <0.01) -0.597 (p <0.001) - the next day 0.378 (p <0.001) 0.288 (p <0.001) -0.265 (p <0.001) 0.179 (p <0.002) -0.554 (p <0.001) - differential - - - -

Clouds upper: - at the time of measurement - 0.167 (p <0.04) - on the eve of the study 0.198 (p <0.01) 0.163 (p <0.04) - the next day 0.205 (p <0.01) 0.178 (p <0.03) - differential - - Direction of the wind: - at the time of measurement -0.273 (p <0.001) -0.250 (p <0.001) - on the eve of the study -0.210 (p <0.005) -0.205 (p <0.006) - the next day -0.294 (p <0.001) -0.285 (p <0.001) - differential 0.155 (p <0.04) 0.165 (p <0.03) Wind speed: - at the time of measurement -0.193 (p <0.01) -0.149 (p <0.05) - on the eve of the study -0.196 (p <0.009) -0.174 (p <0.02) - the next day -0.162 (p <0.03) - - differential - - Note: empty cells in tables 1, 2 reflect the lack of correlation.

table 2 Correlation between hemodynamic parameters and weather factors in patients with hypertension and coronary heart disease receiving treatment with melaxen (melatonin) GARDEN in the morning DBP in the morning Pulse in the morning GARDEN in the evening DAD in the evening Pulse in the evening Atmosphere pressure: - at the time of measurement 0.249 (p <0.001) 0.177 (p <0.01) -0.311 (p <0.001) 0.205 (p <0.004) 0.248 (p <0.001) 0.180 (p <0.009) - on the eve of the study 0.288 (p <0.001) 0.191 (p <0.006) -0.307 (p <0.001) 0.224 (p <0.002) 0.261 (p <0.001) 0.148 (p <0.03) - the next day 0.197 (p <0.005) 0.182 (p <0.009) -0.323 (p <0.001) 0.187 (p <0.007) 0.210 (p <0.003) 0.185 (p <0.008) - differential - - - -0.152 (p <0.03) - - Temperature: - at the time of measurement 0.148 (p <0.03) - on the eve of the study 0.145 (p <0.04) - the next day 0.159 (p <0.02) - differential - Relative humidity: - at the time of measurement 0.149 (p <0.03) -0.265 (p <0.001) 0.194 (p <0.006) 0.139 (p <0.04) - on the eve of the study 0.140 (p <0.04) -0.258 (p <0.001) 0.197 (p <0.005) - - the next day 0.196 (p <0.005) -0.246 (p <0.002) 0.223 (p <0.002) 0.139 (p <0.03) - differential - - - - Dew point: - at the time of measurement - on the eve of the study - the next day - differential

Clouds upper: - at the time of measurement 0.185 (p <0.02) - - on the eve of the study - 0.153 (p <0.05) - the next day - - - differential - - Direction of the wind: - at the time of measurement - on the eve of the study - the next day - differential Wind speed: - at the time of measurement - on the eve of the study - the next day - differential

Literature

1. Patent RU 2063749, A61K 31/205, 07.20.1996.

2. Kaplan E.F., Sokolov I.K. "Comparative characteristics of the adaptogenic activity of certain drugs of natural origin", All-Union Scientific Conference: "Research on the search for drugs of natural origin", 1981.

3. Patent US 5591768, A61K 31/40, 01/07/1997.

4. Patent RU 2134108, A61K 31/405, 08/10/1999.

Claims (2)

1. Adaptogen for the treatment of weather-sensitive patients with angina pectoris and hypertension, which is N-acetyl-5-methoxytryptamine (melatonin). 2. The use of melatonin as an adaptogen in the treatment of weather-sensitive patients with angina pectoris and arterial hypertension against the background of traditional therapy.

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