RU2424797C1 - Nanocomposite polymer material, production method thereof and disinfectant based on said material - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: invention relates to production of nanocomposite materials and more specifically to production of bactericidal composite materials, and can be used in the national economy and medicine. The nanocomposite polymer material based on inorganic layered clay, modified with additives in form of (co)polymers of guanidine and a quaternary ammonium salt, containing groups capable of radical polymerisation, and additionally contain synthetic gutta-percha with a defined ratio of components (wt %). The method of producing the nanocomposite polymer material involves modification of inorganic clay via a cation-exchange reaction in which modification of clay takes place in two steps: one modifier is added at the first step and at the second step and another modifier is added at the second step, wherein a combination of two modifiers is used such that, one of them is guanidine methacrylate. The disinfectant contains clay which is modified with additives with a defined ratio of components (wt %).

EFFECT: invention enables production of transparent medical articles (eg splints used in case of fractures), which enable to take X-ray pictures without removing the articles.

6 cl, 6 dwg, 8 tbl

Description

The present invention relates to the field of production of nanocomposite materials and more specifically to the production of bactericidal composite materials and can be used in the national economy and medicine as bactericidal disinfectants, as well as substitutes for heavy non-bactericidal gypsum tires in fractures, etc.

Due to the fact that inorganic clay particles are ultrafine, they have a thickness of 10-20 nm, on the one hand, and the ability of inorganic clays to conduct ion-exchange reactions due to the presence of exchange cations in the interlayer space, on the other hand, make this natural material extremely interesting for researchers and developers in terms of obtaining nanomaterials based on it.

For example, a stably dispersive composite of metal nanoparticles is known, described in US 20090148484 A1, according to which charges in the intermediate layer of inorganic clay are replaced by metal cations having preferably a spherical structure, for example, Au, Ag, Cu and Fe. As inorganic clay, the composite contains various types of clays, including montmorillonite. The cationic capacity of inorganic clay is 0.1-5.0 meq / g. This technical solution was chosen by us for the prototype.

The disadvantage of the described composite is that it can be used in the form of a powder or suspension, as indicated by the authors of the application.

Its use as a composite material or products from it is possible by mixing it with polymers. However, clay modified with these metals remains polar, and therefore, mixing with a non-polar or weakly polar polymer matrix will inevitably lead to the formation of aggregates and possibly a partial loss of its properties.

The task of the invention is to eliminate the disadvantages of the prototype and to develop a nanocomposite polymer material that preserves the mechanical properties of the nanocomposite and the method for its preparation.

The problem is solved in that the nanocomposite polymer material based on inorganic layered clay, modified with additives, contains (co) polymers of guanidine derivatives and quaternary ammonium salts containing groups capable of radical polymerization, and additionally contains synthetic gutta-percha in the following ratio components, wt.%:

gutta-percha 20-80 clay modified with (co) polymer of guanidine derivatives and quaternary ammonium salt 80-20

when the content of (co) polymer in clay is from 10 to 80 wt.%.

As a quaternary ammonium salt containing groups capable of a radical polymerization reaction, it contains N, N-diallyl-N, N-dimethylammonium chloride, 2- (methacryloyloxyethyl) triethylammonium bromide, 2- (methacryloyloxyethyl) methyldiethylammonium iodide methacryloyloxyethyl) trimethylammonium iodide.

The problem is also solved by the fact that the proposed method for producing nanocomposite polymer material, including the modification of inorganic clay by cation-exchange reaction, in which the clay is modified in two stages: in the first stage, the clay is suspended in water with its content of not more than 4 wt.% one modifier is introduced, taken in an amount corresponding to 1 cationic clay exchange capacity (1 ECO), stirred for the time necessary for complete ion exchange, the resulting compound is isolated by drying , at the second stage of modification, another modifier is introduced and a radical polymerization reaction is carried out in the presence of ammonium persulfate in an inert gas atmosphere at a temperature that ensures the copolymerization of two modifiers, dried, and then the organomodified clay obtained is added to the synthetic gutta-percha, taken in an amount of 20 80 wt.% With respect to the weight of the total composite material, and the resulting composite polymer material is isolated.

The modifiers used are compounds selected from the series guanidine hydrochloride, diguanidine carbonate, guanidine methacrylate, N, N-diallyl-N, N-dimethylammonium chloride, 2- (methacryloyloxyethyl) triethylammonium bromide, 2- (methacryloyloxyethylamide 2) (methacryloyloxyethyl) -trimethylammonium iodide, N-allyl-N, N-dimethyl-N- (α-isopropyl acetate) -ammonium chloride.

Moreover, combinations of two modifiers are used in such a way that one of them is guanidine methacrylate.

The obtained technical result from the use of the proposed technical solution is to obtain a polymer nanocomposite material that has the high mechanical properties necessary to create products: elastic modulus up to 60 MPa, strength up to 6 MPa and strain at break up to 400%.

Get nanocomposite polymer material in accordance with the procedure described below.

The following examples illustrate, but in no way limit the scope of its application.

Obtaining nanocomposite polymer material

To obtain modified clay use its ability to conduct cation-exchange reactions with amines.

For modification, natural clay such as sodium montmorillonite (MMT) of the Cloisite® Na ⁺ brand (EKO 95 mmol equiv. Per 100 g of clay) manufactured by Southern Clay Products (USA) is used, the particle size of which in the dried state is:

no more than 2 microns no more than 6 microns no more than 13 microns 10% fifty% 90%

The charge of silicate plates is compensated by sodium ions, which can be replaced by ammonium cations. Exchange cations are fairly evenly located in the interplanar spaces of layered silicates.

Clay modified with guanidine derivatives or its copolymers with quaternary ammonium salts in the interplanar spaces have the ability to swell in water, which allows obtaining stable dispersions of particles for subsequent (co) polymerization.

The method of obtaining modified clay (stage 1)

Examples 1-8

The first stage of clay modification is carried out by a cation-exchange reaction according to the scheme: MMT-Na ⁺ + M ⁺ Cl ^- → MMT-M ⁺ + NaCl

1. Distillate is poured into the reaction vessel (a three-necked round bottom flask equipped with a mechanical stirrer), the required amount of layered silicate - montmorillonite is added (for the ratio of MMT to water, see Table 1) and the reaction mixture is stirred.

Table 1 Modified Clay Reagent Content Example Modifier The mass of the modifier, g Mass MMT, g Volume H ₂ O, ml one Guanidine Hydrochloride (GHC) 0.4536 5 300 2 Methacrylate Guanidine (MAG) 0.6888 5 300 3 Diguanidine Carbonate (DHA) 0.4275 5 300 four N, N-Diallyl-N, N-dimethylammonium chloride (DADMAC) 0.7671 5 300 5 2- (methacryloyloxyethyl) -triethylammonium bromide (DEAEMA · C ₂ H ₅ Br) 0.5586 2 fifty 6 2- (methacryloyloxyethyl) -methyldiethylammonium iodide (DEAEMA · CH ₃ I) 0.6300 2 fifty 7 2- (methacryloyloxyethyl) -trimethylammonium iodide (DMAEMA · CH ₃ I) 0.5681 2 fifty 8 N-allyl-N, N-dimethyl-N- (α-isopropyl acetate) -ammonium chloride (ADMA + IPCA) 0.4210 2 fifty

2. A modifier is added to the reaction vessel. At the end of the loading, the reaction mixture is continued to mix for the time required to carry out the cation-exchange reaction, which is shown below on the example of GHC as a modifier:

3. At the end of the reaction, the modified clay is filtered on a glass filter, the precipitate is washed with distilled water to remove unreacted modifier, then dried. The resulting powder is ground in a mortar to a homogeneous mass.

Modified clays with various modifiers are obtained, the content of which is 1 ECO. The methodology and experimental conditions were the same in all cases. The content of starting materials is given in table. one.

table 2 The amount of modifier that has entered into an ion exchange reaction with sodium cations in montmorillonite Example Modifier The mass of the modifier, replacing sodium in clay in grams per 1 g of MMT in ECO experiment theoretical experiment one GHC 4,5 · 10 ^-2 5.7 · 10 ^-2 0.79 2 MAG 5.0410 ^-2 5.7 · 10 ^-2 0.88 3 DHA 7.410 ^-2 5.7 · 10 ^-2 1.3 four DADMAH 18.5 · 10 ^-2 11.9710 ^-2 2.08 5 DEAEMA CH ₃ I 23.75 · 10 ^-2 19.0 · 10 ^-2 1.25 6 DEAEMA · C ₂ H ₅ Br - - - 7 DMAEMA CH ₃ I 12.7 · 10 ^-2 16.3 · 10 ^-2 0.78 8 DADMA + IPHA 15.2 · 10 ^-2 17.6710 ^-2 0.86

In the table. 2 presents the results of determining the amount of modifier adsorbed on clay, obtained from the analysis of washing water for the presence of sodium cations taken after MMT modification with various modifiers introduced into the solution in an amount of 1 ECO.

From the obtained data, it can be concluded that in all cases, Na ⁺ cations are almost completely replaced by modifier cations.

Another evidence that the modification of montmorillonite takes place is the results of elemental analysis of organically modified clay (with a modifier content of 1 ECO). The results are presented in table.3.

Table 3 The results of elemental analysis of organically modified montmorillonite Example Modifier The content of elements, wt.% Fireproof residue experiment theoretical FROM N N FROM N N one GHC 1,5 0.9 2.6 1,1 0.55 3.85 87.8 2 MAG - - - 1,1 0.55 3.85 - 3 DHA 2,8 0.9 2.6 1,1 0.55 3.85 84.45 four DADMAH 8.45 1.45 1.05 6.34 0.95 0.925 84.8 5 DEAEMA CH ₃ I 8.8 1.8 1.00 10.53 1.76 1.12 81.50 6 DEAEMA · C ₂ H ₅ Br 8.65 1.85 0.85 11.58 1.92 1.13 81.85 7 DMAEMA CH ₃ I 7.65 1.55 0.9 8.98 1,5 1.17 81.7 8 ADMA + IPHA 8.45 1,6 0.9 9.87 1.65 1.15 82,4 Na-MMT 0.2 0.65 0,03 0.2 0.65 0,03 94

The content of carbon, hydrogen, and nitrogen in the clay modified with monomers is much higher than in the pure (unmodified) MMT, which indicates the presence of organic cations in the interlayer space of the layered silicate.

This fact is also indicated by the lower mass of the solid residue compared to pure clay remaining after calcination of the samples. The organic phase in the interlayer space of the modified MMT during calcination is degraded and gasified, which leads to an additional mass loss of the sample compared to sodium montmorillonite.

The percentage of the elements that make up the modifiers in organo-modified clay is close to theoretical, from which we can conclude that when the modifier is adsorbed in an amount equal to 1 ECO, almost all modifier cations participate in cation exchange and replace Na ⁺ .

Thus, the results of the analysis of wash water for the presence of sodium cations, as well as the elemental analysis shown in Tables 2 and 3, obtained by organically modified clay, allow us to assert with confidence that organic modifier ions are adsorbed in the interlayer spaces of sodium montmorillonite, and the degree of clay modification is close to theoretical value.

The effect of the amount of adsorbed modifier on the interplanar spacing in montmorillonite was studied by X-ray diffraction analysis (XRD) in the "reflection" mode.

Figure 1, where the abscissa axis is the diffraction angle in 2 Θ, degrees, and the ordinate axis is the scattering intensity in conventional units, the diffraction patterns of clay modified by MAG (a), GHC (b), DEAEMA · C _{2 are} presented H ₅ Br (c) and DMAEMA · C ₂ H ₅ Br (g), as well as pure modifiers.

Pure modifiers (before application to clay) have a crystalline structure, as indicated by characteristic reflexes that can be observed in their diffraction patterns. However, in the diffractograms of modified clay, reflexes of organodi modifiers are absent, from which we can conclude that upon intercalation of montmorillonite into the interlayer space they lose their crystallization ability.

The effect of modifiers on the change in the distance between silicate plates was studied. So, in figure 2, where the abscissa axis is the diffraction angle in 2 Θ, degrees, and the ordinate axis is the scattering intensity in conventional units, the diffraction patterns of clays modified with various compounds in the amount of 1 ECO are presented, as well as pure clay.

According to the experimental data presented in FIG. 2, the distances between silicate plates in organomodified clay (MMT) were determined. When MMT is modified (Table 4), the interplanar distance increases, which depends on the structure of the modifier and increases with its branching.

Table 4 Interplanar distance d in organically modified clays Organoclay d, nm Organoclay d, nm Na-MMT 1.26 DEAEMA · C ₂ H ₅ -MMT 1,62 G-MMT, G from GHH 1.27 DEAEMA · CH ₃ -MMT 1.45 DADMA-MMT 1.33 DMAEMA · CH ₃ -MMT 1.44 (ADMA + IPA) -MMT 1.43

Method for producing clay modified with biocidal (co) polymers of guanidine derivatives (stage 2)

Examples 9-15

The polymerization of guanidine derivatives, as well as copolymerization is carried out in the presence of ammonium persulfate (PSA) in an inert atmosphere of argon.

1. In the reaction vessel (a three-necked round-bottom flask equipped with a mechanical stirrer), organically modified clay (montmorillonite) is prepared according to the procedure described above (in examples 2, 4 and 7, table 1, when copolymers based on MAG and DADMAC monomers are prepared, add DADMAC is simultaneously with MAG; in examples 13 and 14, the clay is preliminarily modified with guanidine (13) or DEAEMA · CH ₃ I (14), and then MAK (13) or MAG (14)) are added. After creating an inert atmosphere with argon, the required amount of PSA is added to the reaction mixture. Thermostat the reaction flask at a temperature of 60 ° C.

2. In examples 9 and 10, at the end of the reaction, the modified clay is collected on a filter, washed with distilled water to remove unreacted modifier, and then dried. The resulting powder is ground in a mortar to a homogeneous state. In examples 11-15, at the end of the reaction, the bulk of the water is removed on a rotary evaporator and then dried.

The methodology and experimental conditions were the same in all cases. The content of the starting materials and the time of the experiments are given in table. 5.

The structure of the obtained polymers is confirmed by NMR spectrograms (see figa, a, b, 3c, d, 3d, e, where the chemical shift of signals in ppm is located on the abscissa axis, and the signal intensity in conventional units is on the ordinate axis) .

In Fig. 4, where the abscissa axis is the diffraction angle in 2 граду, degrees, and the ordinate axis is the scattering intensity in conventional units, diffraction patterns of organoclay modified with polymers and copolymers are presented (see Table 5), as well as pure MMT. The numbers next to the basal reflexes of each clay indicate the numerical value of the interplanar distance (in nm).

From the presented diffraction patterns, it can be seen that the interplanar spacing, which increased during sorption of the monomer, then practically did not change as a result of polymerization.

Differential scanning calorimetry curves (DSC curves) of the obtained polymer-clay systems, both during the first and second heating, are of a similar nature (Fig. 5, where the temperature in ° C along the abscissa axis and the thermal effects intensity along the ordinate axis) , in conventional units). During the second heating, in all cases, there is no effect on the DSC curve, which confirms the complete destruction of the organic phase during the first heating to 300 ° C. Upon the first heating in all systems, an endothermic effect is observed in the temperature range of 25-150 ° C, which indicates a similar temperature range for the evaporation of residual water from the samples.

The method of obtaining nanocomposite polymer material based on modified clays and synthetic gutta-percha

Examples 16-22

Nanocomposites based on synthetic gutta-percha - transpoliisoprene (TPI) and organically modified clay "DADMAX-MAG / MMT" copolymer (OMMMT), prepared according to Example 15, at various ratios of TPI and OMMMT are prepared by melt mixing on laboratory rollers.

1. First, the gap between the rolls, which are heated to a temperature of 120 ° C, is adjusted.

2. Pre-carry out the mixing at room temperature in the apparatus of the type "drunk barrel" TPI and the corresponding amount of OMMMT. The resulting mixture is poured between the rolls. During loading, the rolls rotate at a constant speed (52 rpm). Stirring lasts 5 minutes, after which the sample is unloaded.

Under the same conditions, a sample of pure TPI was prepared (Example 16).

The content of starting materials for producing TPI - OMMMT is given in table. 6.

To study the mechanical and thermophysical properties of a nanocomposite polymer material, samples in the form of films are used. To this end, the obtained composites are crushed and pressed 1 g in a limiting aluminum ring at a temperature of 100 ° C and a pressure of 0.7 MPa for 5 min between sheets of a polyimide film.

Films of pure TPI (Example 16) and the original organically modified clay (Example 22) were prepared in the same way. The results are presented below.

Table 6 The content of reagents in the preparation of nanocomposites based on modified clays and synthetic gutta-percha Example TPI matrix OMMMT filler wt.% m, g wt.% m, g 16 one hundred 3.0 0 0 17 80 2,4 twenty 0.6 eighteen 60 1.8 40 1,2 19 fifty 1,5 fifty 1,5 twenty 40 1,2 60 1.8 21 twenty 0.6 80 2,4 22 0 0 one hundred 3.0

Properties of the obtained nanocomposite polymer materials based on TPI

Mechanical properties

The use of layered silicates modified with biocidal substances capable of adsorbing onto clay as fillers significantly changes the mechanical properties of composites compared to pure synthetic gutta-percha (Table 7): the module, at 50% filling, increases by about 4 times with a decrease in yield strength 25% and strength 2 times. In this case, the elongation at break drops by 2 times. When the clay content is more than 80 wt.%, The composites become brittle.

Table 7 Mechanical Properties of TPI-Based Nanocomposites Containing Clay Modified with DADMAH-MAG Copolymer The content of OMMMT (example 15), wt.% Modulus of elasticity, MPa Yield Strength, MPa Strength, MPa The strain at break,% 0 19 four twenty 574 twenty 28 four 10 396 40 39 3 3 286 fifty 84 3 6 239 60 62 3 5.8 198 80 60 2 2.6 87 one hundred fragile

Thermophysical Properties

Figure 6, where the temperature in ° C is located on the abscissa axis and the intensity of thermal effects is on the ordinate axis, in conventional units, DSC curves of the obtained nanocomposites based on TPI and OMMMT are presented. Up to 170 ° С, the composite curve represents a superposition of the thermograms of the individual components, then destruction of both the polymer matrix and the polymer modifier on clay is observed. As you can see, the filler practically does not affect the crystallization of TPI.

It was found that the obtained nanocomposite material has bactericidal activity and can be used in the synthesis of new disinfectants (DS).

For the prevention of infectious diseases, healthcare practice needs effective DS with a wide spectrum of antimicrobial activity.

The current difficult epidemiological situation (high incidence of viral and bacterial infections, the emergence of new and the return of old infections, the formation of multiresistant strains of pathogens, precedents for bioterrorism) justifies the growth of requirements for DS and stimulates the search for new drugs with bacteriological activity.

Today, there are a large number of DS based on various active substances. Based on the data of the scientific literature and analysis of the range of DS, it is shown that Quaternary ammonium compounds (QAC), which make up more than 35% of all known DS, are most widely used.

HOURs exhibit moderate biocidal activity. The antimicrobial activity of QAS depends on the type of substituents on the nitrogen atom, the length of the carbon chain of the radical, its degree of saturation and branching, the presence of hydroxyl, ether groups, etc. Compounds containing radicals with a carbon atom number <8 at the Quaternary nitrogen atom are lacking or exhibit moderate antimicrobial properties [Problems of modern disinfection and ways to solve them. Materials of the All-Russian Scientific Conference. October 22-24, 2003].

Polyguanidine class preparations, in particular polyhexamethylene guanidine (PHMG), were also widely used [Gembitsky PA, Topchiev DA, Vointseva II Polyhexamethylguanidine. Synthesis, chemical transformations, biocidal properties and scope. Overview]. The antimicrobial effect of guanidine derivatives has been known for a long time, guanidine antiseptics are widely used in the world because they are much more effective than HOURs, surfactants, phenol derivatives and chlorine disinfectants, are stable and non-aggressive, do not form toxic products, are not inactivated by proteins, are biodegradable.

In Russia, DS of this class is produced by the factory method in the form of PHMG chloride ("metacid") and PHMG phosphate ("Fogucid") [2].

However, their rather prolonged use led to a significant decrease in the effect of biological activity in most cases.

It should be noted that over the past 10 years not a single fundamentally new chemical compound with antimicrobial activity has appeared, and most DS are multicomponent compositions [1, p. 45].

Due to the fact that microorganisms have the ability over time to develop resistance to a number of them, including HOUR, PHMG, chlorine-containing, etc., therefore, the search for new substances and preparations that allow expanding a number of DS is always an urgent task.

One of the methods for creating biocide in the development of new bactericidal disinfectants is the use of biocidal additives that impede the development of microbial flora in multicomponent compositions.

Thus, for example, a biocidal disinfectant based on water-insoluble layered silicates is known, in particular clay, described in US 20090148484 A1, according to which the clay contains biocidal additives in the form of silver (Ag) or copper (Cu). This technical solution is the closest to the proposed.

A disadvantage of the described biocidal disinfectant is the fact that the described disinfectant can only be used in the form of powders or suspensions and, as a result, is easily removed from the treated object.

However, it should be borne in mind that prosthetic and biocidal materials are poorly compatible, so that the latter are easily removed from the object without any binding component.

Therefore, as carriers for the immobilization of biocidal substances, it seems promising to use water-insoluble layered silicates, which also have high sorption ability and allow uniform and dosage distribution of biocidal substances.

The objective of the invention is to eliminate the disadvantages of the prototype and to develop a bactericidal disinfectant that can be applied to the processed object to remain on it for as long as circumstances require.

The problem is solved by the fact that a bactericidal disinfectant based on clay modified with bactericidal additives is proposed, which as a bactericidal additive contains (co) polymers of guanidine and quaternary ammonium salt, containing groups capable of radical polymerization, and additionally contains synthetic gutta-percha in the following the ratio of components, wt.%:

gutta-percha 20-80 clay modified with (co) polymer N, N-diallyl-N, N-dimethylammonium chloride and guanidine methacrylate 80-20 the content of (co) polymer in clay is 10-80 wt.%

Tests of biocidal properties carried out by agar test on St. Aureus, for which they place a square film of disinfectant size (4 cm ² ) on a culture of Staphylococcus aureus. The optimal indicator is a zone of death of bacteria of at least 4 mm. The test results are given in table.8.

Table 8 Biocidal Test Data Example Composition, wt.% St. Agar culture test Aureus, death zone TPI OMMMT 16 one hundred 0 0 mm 17 80 twenty 0 mm eighteen 60 40 1 mm 19 fifty fifty 3 mm twenty 40 60 4 mm 21 twenty 80 5 mm 22 0 one hundred 6 mm Note: OMMMT composition: (DADMAH-MAG) / MMT = 64/36

The proposed technical solution allows to obtain nanocomposite polymer materials with high mechanical properties: elastic modulus up to 60 MPa, strength up to 6 MPa and tensile strain at break up to 400%, necessary to create polymer products for various purposes.

In addition, the obtained nanocomposite materials have bactericidal activity comparable to known bactericidal disinfectants, on the one hand, and the plasticity and strength inherent in polymeric materials, on the other hand, which greatly expands the possibilities of using this bactericidal disinfectant. For example, for coatings and the creation of materials for prosthetic and orthopedic products; substitutes for heavy and non-bactericidal gypsum tires for fractures. Moreover, the absolute transparency of the tire from the resulting material for x-ray radiation will allow you to make control radiographs in people with fractures without removing it.

Explanations for the drawings.

Figure 1 - Diffraction patterns of clay modified with various biocidal monomers: MAG (a), GHC (b), DEAEMA · C ₂ H ₅ Br (c) and DMAEMA · C ₂ H ₅ Br (g), and pure modifiers.

Figure 2 - Diffraction patterns of pure clay and clay modified with various biocidal monomers in the amount of 1 ECO. (a) G-MMT, DADMA-MMT; (b) (ADMA + IPA) MMT, DMAEMA * CH ₃ -MMT, DEAEMA * CH ₃ -MMT, DEAEMA * C ₂ H ₅ -MMT.

Figa, b - NMR spectra of the obtained polymer-clay systems and the clay copolymer are presented in table 5 (a) example 9, (b) example 10.

Figv, d - NMR spectra of the obtained polymer-clay systems and the clay copolymer are presented in table 5 (c) example 11, (g) example 12.

Fig.3d, e - NMR spectra of the obtained polymer-clay systems and the clay copolymer are presented in table 5 (e) example 13, (e) example 15.

Figure 4 - Diffraction patterns (a) of pure montmorillonite and clay modified with polymers and copolymers (b-h).

Figure 5 - DSC curves of the obtained organically modified clays.

6 - DSC curves of nanocomposites based on TPI and OMMMT (No. 15 in Table 5), curve 1 - pure TPI, curve 2 - pure OMMMT, curve 3 - obtained nanocomposite (see table 6).

Claims (4)

1. Nanocomposite polymer material based on inorganic layered clay, modified with additives, characterized in that as additives it contains (co) polymers of guanidine derivatives and Quaternary ammonium salt, containing groups capable of radical polymerization, and additionally contains synthetic gutta-percha in the following the ratio of components, wt.%:
gutta-percha 20-80 clay modified with (co) polymer of guanidine and quaternary ammonium salt 80-20
when the content of (co) polymer in clay is from 10 to 80%. 2. The nanocomposite material according to claim 1, characterized in that as a quaternary ammonium salt containing groups capable of a radical polymerization reaction, it contains N, N-diallyl-N, N-dimethylammonium chloride, 2- (methacryloyloxyethyl) -triethylammonium bromide, 2- (methacryloyloxyethyl) -methyldiethylammonium iodide, 2- (methacryloyloxyethyl) -trimethylammonium iodide. 3. The method of producing nanocomposite polymer material according to claim 1, which consists in a two-stage modification of inorganic clay by a cation-exchange reaction, in which at the first stage a first modifier is introduced into the suspension of clay in water with its content of not more than 4 wt.% - a quaternary ammonium salt selected from the series: N, N-diallyl-N, N-dimethylammonium chloride, 2- (methacryloyloxyethyl) -triethylammonium bromide, 2- (methacryloyloxyethyl) -methyldiethylammonium iodide, 2- (methacryloyloxyethyl) -trimethylamide-di-iodiamide -N- (α-iso-propyl acetate) - ammonium chloride, or guanidine salt - guanidine hydrochloride, diguanidine carbonate, guanidine methacrylate, taken in an amount corresponding to 1 cationic clay exchange capacity, is stirred for the time required for the complete cation exchange reaction, the obtained compound is isolated, dried, introduced in the second stage of modification the second modifier is a radical polymerizable monomer selected from the series: guanidine methacrylate, N, N-diallyl-N, N-dimethylammonium chloride, 2- (methacryloyloxyethyl) triethylammonium bromide, 2- (methacryloyloxyethyl) - methyldiethylammonium iodide, 2- (methacryloyloxyethyl) -trimethylammonium iodide, and carry out a radical polymerization reaction in the presence of ammonium persulfate in an inert gas atmosphere at a temperature that ensures the copolymerization of the modifier and monomer, the product is dried, and then the organomodified clay is added to a synthetic mill with mixing, in an amount of 20-80 wt.% in relation to the weight of the total composite material, and the resulting composite polymer material is isolated. 4. Clay-based bactericidal disinfectant according to claim 1.

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