RU2403034C2 - Application of madopar for correction of cognitive, motivation, emotional disturbances in children with autistic spectrum disorders - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and concerns application of Madopar as a medicinal agent for correction motivation, cognitive and emotional disturbances in autistic spectrum disorders in children.

EFFECT: enhanced correction of motivation, cognitive and emotional disturbances in children with autistic spectrum disorders due to the administration of Madopar.

1 cl, 12 tbl

Description

The invention relates to medicine, namely to pediatrics, in particular to neurology, psychiatry, and can be used to correct motivational, cognitive and emotional disorders with autistic disorders in children.

Known methods of treating neuropsychiatric diseases with the use of metabolic, neuroprotective, nootropic drugs (various groups of pharmacotherapeutic drugs), similar in essence to the effects and improvement of neurotransmission through specific receptors [1].

The disadvantages of these methods is the complexity of the diagnosis of NMDA receptor insufficiency and the selection of the pharmaceutical composition.

Known methods of treatment using L-DOPA and its derivatives (madopar) in Parkinson's disease, deforming muscular dystrophy, stuporous conditions [2].

The use of madopar in medicine for the correction of cognitive, motivational, emotional disorders in children with autistic disorders is unknown.

The objective of the invention is to expand the correction of motivational, cognitive and emotional disorders with autistic disorders in children through the use of madopar.

This task is achieved by using Madopar as a drug for the correction of motivational, cognitive and emotional disorders in children with autistic disorders against the background of standard treatment regimens.

As a medicine, a synthetic levorotatory isomer of dioxiphenylalanine - L-DOPA with dopa-decarboxylase inhibitors - Madopar is used. Dioxyphenylalanine (dopa, dopa) is a nutrient that is formed in the body from tyrosine and is a precursor of dopamine, catecholamines. Madopar helps to increase the level of L-dopa and catecholamines in the brain tissues, which affect the functional state of the synaptic apparatus, participate in the processes of nervous excitation, play the role of a hormonal substance that affects metabolic processes, are in close causal relationship with behavioral acts and intellectually -mnestic activity [3].

Madopar is used in the form of tablets of 125 and 250 mg, is prescribed in a dose of 15-30 mg once a day or every other day, during or after meals, more often in the morning.

The effectiveness of the drug Madopar is shown in the following examples.

Patient J.A. 6 years. The diagnosis: “Disorders of psychological development, children's autism of endogenous genesis”, was treated at the clinic from April 10 to April 30, 2007. Complaints of speech, attention, difficulty concentrating, lack of interest in communication, selective interest in games with a predominance of manipulative nature games, unfocused physical activity, episodes of excitement in situations of prohibition, stereotypical movements.

The treatment: Madopar 30 mg in the morning 1 time per day - 14 days. Additionally, neurotropic drugs, physiotherapy, massage, classes with a psychologist were prescribed.

Tables 1-5 show the results of studies: data on the dynamics of indicators of visual memory, auditory-speech memory, attention, thought processes, emotional sphere carried out according to the methods: hardly verifiable figures, 10-word technique, proof-reading tests, Koos cubes, fourth extra test, picture tests (house -tree-man).

Table 6 shows a comparative analysis of the dynamics of the mental activity of children who have undergone a course of treatment with madopar.

Table 1 Data dynamics indicators of visual memory Indicators Before treatment After treatment Visual memory 2 figures (arithmetic mean) 3.25 figures (arithmetic mean)

From table 1 it can be seen that the amount of RAM increased by 1.62 times.

table 2 Data on the dynamics of indicators of auditory speech memory Indicators Before treatment After treatment The amount of auditory speech memory 3 words (arithmetic mean) 4.45 words (arithmetic mean)

From table 2 it can be seen that the amount of auditory-speech memory has increased by 1.48 times and is approaching the lower limit of the norm.

Table 3 Attention Index Dynamics Data Indicators Before treatment After treatment Number of errors in 1 min. 8 (arithmetic mean) 5.5 (arithmetic mean)

From table 3 it is seen that arbitrary attention has become more stable, the number of errors has decreased by 1.45 times.

Table 4 Data on the dynamics of indicators of productivity of thinking Indicators Before treatment After treatment Number of completed tasks 3.7 (arithmetic mean) 4.8 (arithmetic mean)

From table 4 it is seen that after the last course of treatment with Madopar, the child was able to complete an average of 1.1 more tasks.

Table 5 Data dynamics indicators of the emotional sphere Indicators Before treatment After treatment Phobias 7.9 5.7 Anxiety 8.3 6.5 Aggressive reactions 5.7 4.3

From table 5 it is seen that after the last course of treatment with Madopar, phobia decreased by 1.4 times, anxiety decreased by 1.3, and aggressive reactions by 1.3 times.

According to the results of the studies, a comparative analysis of the dynamics of the mental activity of children who underwent treatment with madopar was carried out, the data are shown in table 6.

All children were divided into four groups:

1. 0 points - children who did not have the dynamics of mental activity; 2. 1 point - children who had a weak dynamics of mental activity and slight dynamics in one of the studied indicators; 3. 2 points - children who showed slight dynamics in all studied indicators; 4. 3 points - children who showed significant positive dynamics in all studied indicators.

Table 6 Analysis of indicators of the dynamics of mental activity of children Indicators 0 points -
lack of dynamics 1 point -
weak dynamics 2 points -
moderate dynamics 3 points -
pronounced dynamics Groups one 2 3 four Amount of children (%) 19 40 36 5

From table 6 it is seen that in 41% of cases in children (see indicators of groups 3 and 4) who took madopar, there was a positive dynamics of cognitive activity of moderate and pronounced degree, in 40% of children there was a weak positive dynamics and only in 19% of cases there was no speakers. 5% of children have positive dynamics of a pronounced degree, these children have a significant improvement in their emotional state, the appearance of voluntary activity, a decrease in motor stereotypes, and the appearance of a communicative function of speech.

In patients receiving this therapy, there is an increase in the volume of visual, auditory and speech memory, an improvement in the concentration of attention, the appearance of productivity in thinking (the appearance of visual-figurative thinking), a decrease in phobias, anxiety, initial manifestations of the motivational component, a decrease in motor stereotypes, an increase in speech activity and an increase vocabulary, the appearance in your own speech of all parts of speech.

The state of memory, thinking, perception, emotional background and motivational readiness depends on many factors, including the state of neurotransmitter systems. Madopar, which has neurotransmitter, neuromodulating properties, improves the condition of dopaminergic, catecholaminergic systems, accelerates neurotransmitter transmission, significantly improves targeted activity, promotes the formation of motivational mechanisms, improves attention, memory, changes the emotional state, provides a more stable effect.

For comparison, we present the results of patient correction without the use of madopar, carried out according to the standard treatment regimen (neurometabolic, nootropic, vascular, stimulating therapy, classes with a psychologist).

Patient A.P., 6 years old. The diagnosis: “Disorders of psychological development, children's autism of endogenous origin”, was treated at the clinic from July 3 to July 19, 2007. Complaints about developmental delay, lack of phrasal speech, detachment, low interest in the environment, in communication, a primitive monotonous game of manipulative character, motor stereotypes, fears, hysterical states during the ban, attachment to certain conditions.

Tables 7-11 show the research results: data on the dynamics of indicators of visual memory, auditory-speech memory, attention, thought processes, emotional sphere carried out according to the methods: hardly verifiable figures, 10-word technique, proof-reading tests, Koos cubes, fourth extra test, picture tests (home -tree-man). Table 12 shows a comparative analysis of the dynamics of the mental activity of children who underwent treatment according to the standard correction scheme.

Table 7 Data dynamics indicators of visual memory Indicators Before treatment After treatment Visual memory 2 figures (arithmetic mean) 2.25 figures (arithmetic mean)

From table 7 it is seen that the amount of visual memory increased 1.13 times.

Table 8 Data on the dynamics of indicators of auditory speech memory Indicators Before treatment After treatment The amount of auditory speech memory 3 words (arithmetic mean) 3.3 words (arithmetic mean)

From table 8 it is seen that the amount of auditory-speech memory increased 1.1 times.

Table 9 Attention Index Dynamics Data Indicators Before treatment After treatment Number of errors in 1 min. 8 (arithmetic mean) 6.90 (arithmetic mean)

From table 9 it is seen that arbitrary attention remained unstable, the number of errors decreased slightly (1.15 times).

Table 10 Data on the dynamics of indicators of productivity of thinking Indicators Before treatment After treatment Number of completed tasks 3.4 (arithmetic mean) 3.7 (arithmetic mean)

From table 10 it is seen that after the standard course of treatment, the child was able to complete an average of 0.3 more tasks.

Table 11 Data dynamics indicators of the emotional sphere Indicators Before treatment After treatment Phobias 7.9 7.0 Anxiety 7.3 6.1 Aggressive reactions 5.5 5,4

From table 11 it is seen that after the standard course of treatment the phobia decreased 1.13 times, anxiety decreased 1.2; aggressive reactions decreased insignificantly - 1.02.

According to the results of the studies, a comparative analysis of the dynamics of the mental activity of children who underwent treatment according to the standard scheme was carried out, the data are shown in table 12.

All children were divided into four groups:

1. 0 points - children who did not have the dynamics of mental activity; 2. 1 point - children who had a weak dynamics of mental activity and slight dynamics in one of the studied indicators; 3. 2 points - children who showed slight dynamics in all studied indicators; 4. 3 points - children who showed significant positive dynamics in all studied indicators.

Table 12 Analysis of indicators of the dynamics of mental activity of children Indicators 0 points - lack of dynamics 1 point - weak dynamics 2 points - moderate dynamics 3 points - pronounced dynamics Groups one 2 3 four Amount of children (%) 43 38 19 0

From table 12 it is seen that in children taking treatment according to the standard method, positive dynamics of a pronounced degree were not noted, the dynamics of cognitive activity of a moderate degree in 19% of cases in children (see indicators of group 3), in 38% - a weak degree (unreliable, ) in 43% of cases there is a lack of dynamics.

While taking this therapy, it was noted: a slight increase in visual and auditory-speech memory, voluntary attention remained unstable, and the productivity of thinking improved slightly.

The effect of the drug Madopar was studied in 58 patients aged 5 to 8 years who were treated in the clinic in 2001-2007. with a diagnosis of "Disorders of psychological development, childhood autism of endogenous origin."

Madopar, possessing neurotransmitter, neuromodulatory properties, changes the state of dopamine and catecholamine receptors [4], accelerates neurotransmitter transmission, has a positive effect on the formation of emotional reactions, regulation of complex motor functions, cognitive processes, significantly improves targeted activity, motivational mechanisms, attention, memory, changes the emotional state, provides the effectiveness of correction.

The use of madopar significantly increases the effectiveness of correction - in 81% of cases, there was an improvement in the indicators of visual memory, auditory-speech memory, attention, thought processes, the emotional sphere, which can significantly reduce hospitalization time and financial costs for treatment.

Information sources

1. RU №2000128654 / 14, А61К 31/195. Methods of treating neuropsychiatric disorders, 09/20/2002

2. M.D. Mashkovsky. Medicines M .: New wave, 1996. T.I., pp. 173-175 - prototype.

3. E.Yu. Misionzhik, R.D. Kogan, Yu.B. Balandina et al. Clinical and pathogenetic correlations in intellectual deficiency in premature infants. // Zh. Neuropathology and psychiatry. S.S. Korsakova. M .: Medicine, 1985. T.85, issue. 3, pp. 388-393.

4. E.F. Lavrenetskaya, M.M. Katz, G.N. Baldenkov. On the role of dopamine receptors in the mechanisms of action of antipsychotics. // Zh. Neuropathology and psychiatry. S.S. Korsakova. M .: Medicine, 1985. T.85, issue. 3, pp. 431-435.

Claims (1)

The use of madopar as a drug for the correction of cognitive, motivational, emotional disorders in children with autistic disorders.