RU2401783C2 - Cap - Google Patents

Abstract

FIELD: transport, package.

SUBSTANCE: proposed cap has cylindrical body to be press-fitted on flask neck and cover with screw thread for fitting on the body. Said body has central bore parallel to body axis to receive tube with lengthwise holes to axially move therein. Annular recesses with scalloped surface for scalloped band to be fitted thereon.

EFFECT: safe storage of dissolved substance and solvent and preparation of solution.

4 dwg

Description

The invention - the cap relates to the field of medical industry and can be used to seal vials for drugs.

Known glass bottles designed to store dry medicinal substance (1), and ampoules designed to store solvent (2). Their disadvantage is that in order to prepare an injection solution, it is necessary to open the ampoule with the solvent and transfer the solvent to the vial with the dry drug substance, which violates the isolation of the contents of the ampoule from the environment and there is a risk of loss of sterility of the solution.

The objective of the invention is to create conditions for the storage of the drug substance and the solvent "in one package" and the preparation of the solution while maintaining sterility. The problem is solved with the help of a cap, which, isolating the internal volume of the bottle from environmental influences, makes it possible to dissolve dry matter in a liquid, without violating the isolation of the contents from the environment.

The cap is illustrated by drawings:

Figure 1 - General view;

Figure 2 is a General view in section;

Figure 3 - in the assembled state in the context;

Figure 4 - in working condition in section.

General view of the cap - Figure 1, where the positions indicated:

1 - housing;

2 - a gear tape;

3 - cover;

4 - bottle.

A General view of the cap in the context - Figure 2, the positions indicated:

1 - case, solid product. The lower part of the housing 1 is pressed onto the neck of the bottle 4.

The upper part of the housing 1 is a cylinder, in the center of which, parallel to its axis, a through cylindrical hole passes, forming a tube of the central hole 5, which extends to the level of the end of the lower part of the housing. On the inner surface in the upper part of the Central hole of the housing there is an annular protrusion 8 for fixing the movable tube 15.

On the outer surface of the lower part of the housing there is an annular recess with a toothed surface 6, for laying the toothed belt 2. On the outer surface of the upper part of the housing there is a screw thread 12 for screwing the cover 3.

2 - a gear tape. The toothed belt has protrusions and depressions that correspond to depressions and protrusions on the toothed surface in the annular recesses on the housing 1 and the lid 3. The toothed tape is laid in annular recesses with a toothed surface on the housing and on the lid. Entering into engagement with the gear surface in the annular recess 6 of the housing 1 and with the gear surface in the annular recess 7 of the cover 3, prevents the rotation of the cover relative to the housing.

3 - cover. The lower part of the lid on the outside has an annular recess with a toothed surface 7 for laying the toothed belt 2. On the inner surface of the walls of the lid there is a screw thread for screwing onto the threaded part 12 of the housing 1. The inner surface of the bottom of the lid is a flat circle.

4 - bottle.

5 - tube of the central hole.

6 - an annular recess with a serrated surface on the housing.

7 - an annular recess with a serrated surface on the lid.

8 - an annular protrusion on the inner surface of the Central hole for fixing the movable tube 15.

9 - an annular recess on the surface of a movable tube for fixation in the "storage" position.

10 - an annular recess on the surface of a movable tube for fixation in the "dissolution" position.

11 is a stopper that closes the entrance to a movable tube of elastic material through which the syringe needle can easily penetrate.

12 - screw thread.

13 - freely protruding end of the gear tape for ease of removal.

14 - longitudinal holes in the movable tube 15.

15 - movable tube.

In the lower part of the tube there are longitudinal holes 14. On the outer surface of the upper part of the tube there are two annular recesses designed to fix the movable tube in positions: 9 - “storage” and 10 - “dissolution” located at a distance from each other equal to the distance to which the tube will move from the "storage" position to the "dissolution" position.

16 - metal foil or film of a polymeric material. By closing the entrance to the tube of the Central hole 5, provides maximum reliability of isolation of dry matter from the solvent. A metal foil or a film of polymer material is thermally soldered to the end of the tube of the Central hole 5.

In the assembled state in the context of the cap is illustrated in Fig.3.

The lower part of the housing 1 is pressed onto the neck of the vial 4. The movable tube 15 is inserted into the central hole of the housing 1 and is fixed by an annular protrusion 8 in the "storage" position. The tube is closed by a stopper 11. The cap 3 is screwed onto the threaded part of the case until the inner surface of the bottom of the cap comes into contact with the end of the movable tube 15. Toothed tape 2 is placed in the annular recesses with a toothed surface on the case and cap 2. The tube of the central hole 5 located in the neck of the bottle covers the bottom of the tube. The top of the tube is located in the center hole of the case. Thus, the longitudinal holes of the tube overlap with the inner surface of the central hole of the casing, and an enclosed space forms in the tube. To ensure maximum reliability of the isolation of dry matter from the solvent, the lower end of the central tube 5 is covered with a metal foil or a film of polymer material 16. The bottle 4 and the movable tube 15 are filled with the required amount of soluble substance and solvent, moreover, the solvent and the solute can occupy different positions: soluble the substance in the vial is the solvent in vitro or vice versa.

The operation of the cap is illustrated in FIG. 4 and proceeds as follows: to prepare the solution, remove the toothed belt 2. The cap 3 is screwed fully against the thread. When screwing, the inner surface of the bottom of the lid moves downward along the O-O axis. Sliding along the end of the movable tube 15, the inner surface of the bottom of the lid exerts increasing pressure on the movable tube, forcing it to translate along the O-O axis. Moving, a movable test tube destroys (tears) a metal foil or a film of a polymer material. The lines of destruction (rupture) of the metal foil or film of a polymer material can be set before soldering to the end of the tube of the Central hole. With further movement, the longitudinal openings of the movable tube partially come out of the tube coverage area with the inner surface of the tube of the central hole — the volumes of the tube and vial merge, and parts of the destroyed foil or film are bent to the vial wall. Moving the test tube will continue until the inner surface of the bottom of the lid adheres to the end surface of the housing. Further screwing of the cover will become impossible. The transferred tube is fixed by an annular protrusion 8 in the "dissolution" position. For the best mixing of the components, the vial is shaken.

The finished solution is isolated from the environment, sterility is maintained. To select the prepared solution, the cap is screwed up, the bottle is turned upside down and the tube plug is pierced with a syringe needle. Part of the longitudinal holes, continuing into the tube of the central hole of the housing, contributes to the most complete draining of the solution from the bottle into the tube.

The cap, isolating the internal volume of the vial from the environment, allows you to quickly prepare the solution while fully maintaining sterility. It eliminates a number of manipulations with the ampoule in the case of using separately stored components - in the ampoule and in the bottle. The entrance to the tube from the side of the tube is larger than the opening of the opened ampoule, and it is easier to get into it with a syringe needle. In this case, there is absolutely no contact of the soluble substance, solvent and the prepared solution with the environment, which cannot be avoided even when opening the ampoule, as well as when choosing a liquid in the syringe, when the released volume of the ampoule is filled with ambient air. According to the author, such qualities of the cap may be of value in emergency situations: in conditions of smoke, dust, or increased infectious danger.

Information sources

1. V.M. Gretsky, B.C. Khomenu. "Guide to practical exercises on drug technology." Moscow, "Medicine", 1984, pp. 30-33.

2. "Big Medical Encyclopedia", volume 1, third edition. Moscow, “Soviet Encyclopedia”, 1974, pp. 388-389.

Claims (1)

The cap contains a cylindrical body for pressing on the neck of the bottle and a screw cap for mounting on the body, characterized in that the body is made with a hole in the center located parallel to the axis of the body, where the tube is installed with longitudinal holes and with the possibility of axial movement, moreover, on the body and annular recesses with a toothed surface for installing a protective toothed tape are made on the lid.

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