RU2395565C2 - Lipase-containing composition and bleaching catalyst - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: present invention relates to a composition which contains lipase, and a bleaching catalyst which can accept an oxygen atom from a peroxy acid and transfer the oxygen atom to an oxidisable substrate.

EFFECT: less bad smell which arises when using lipase enzymes in detergents.

13 cl, 4 tbl, 3 ex

Description

Technical field

The present invention relates to a composition comprising a lipase and a whitening catalyst. More specifically, the present invention relates to a composition containing a lipase and a bleaching catalyst capable of accepting an oxygen atom from a peroxy acid and transferring an oxygen atom to an oxidizable substrate. The compositions of the present invention are typically suitable for use as detergent compositions for washing and have good cleaning efficiency and a reduced unpleasant odor profile, especially for problematic contamination with residues of dairy products.

Prior art

Contaminants causing untidiness such as body contamination and other hydrophobic contaminants, including dairy contamination, are very difficult to remove from the fabric during the washing process. The emergence in the 1980s of lipase enzymes suitable for use in detergents (for example, Lipolase and Lipolase Ultra, from Novo Nordisk - now Novozymes), creates new opportunities for developers to improve the removal of fats. Lipase enzymes catalyze the hydrolysis of triglycerides, which are the main component of many widespread fatty contaminants, such as sebum secretions, animal fats (e.g. lard, ghee, butter) and vegetable oils (e.g. olive oil, sunflower oil, peanut butter). However, these enzymes exhibit limited effectiveness in the first wash cycle (being effective primarily in the spin phase of the washing process) and cause an unpleasant odor after washing. Not wanting to be bound by theory, we indicate that the unpleasant odor is caused by fatty acids released during the hydrolysis of fats, and is especially noticeable when contaminated with dairy products such as milk, cream, butter and yogurt; milk fats contain triglycerides functionalized with short chain (e.g. C ₄ ) fatty acyl units that release unpleasantly smelling volatile fatty acids after lipolysis. A general overview of the use of lipases in solid laundry detergents is given in the following link: Enzymes in Detergency, ed. JH van Her et al., Vol.69, Marcel Dekker Surfactant Series, Marcel Dekker, New York, 1997, pp 93-132 (ISBN 0-8247-9995-X).

Recently, industrial production of the so-called "first wash cycle" lipases, such as Lipoprime ™ and Lipex ™ (Novozymes company), which are effective in the initial wash cycle, has been launched. The Lipex ™ enzyme is described in more detail in WO 00/60063 and US 6939702 B1 (Novozymes). Laundry detergent compositions containing the Lipex ™ enzyme are described in more detail at IP.com. publication IP 6443D (Novozymes). However, for the best use of lipase technology, there remains a need to improve both the odor profile for residual contamination with dairy products and the efficiency of cleaning from complex contaminants.

Detergent manufacturers have also tried to incorporate whitening catalysts, especially oxaziridinium or oxaziridinium-forming whitening catalysts, into their detergents in order to ensure good whitening performance. EP 0728181, EP 0728182, EP 0728183, EP 0775192, US 4678792, US 5045223, US 5047163, US 5360568, US 5360569, US 5370826, US 5442066, US 5478357, US 5482515, US 5550256, US 5653910, US 576001 , US 5785886, US 5952282, US 6042744, WO 95/13351, WO 95/13353, WO 97/10323, WO 98/16614, WO 00/42151, WO 00/42156, WO 01/16110, WO 01/16263, WO 01/16273, WO 01/16274, WO 01/16275, WO 01/16276, WO 01/16277 relate to detergent compositions containing oxaziridinium and / or oxaziridinium-forming whitening catalysts.

There remains a need for laundry detergent compositions that have a good overall cleaning profile, good bleaching efficiency in cold water, good cleaning of fatty contaminants, and a reduced unpleasant odor profile with residual fatty contaminants, especially dairy product contaminants.

The inventors have found that the use of lipase in combination with a whitening catalyst capable of accepting an oxygen atom from a peroxyacid and transferring an oxygen atom to an oxidizable substrate improves the washing efficiency of the detergent composition, while at the same time maintaining a reduced unpleasant odor profile with residual grease, especially milk products.

In another embodiment of the present invention, the inventors have found that a compatibility profile with a rubber hose for pumping out water is improved when the diacyl and / or tetraacyl peroxide materials are in combination with a lipase.

In a particularly preferred embodiment of the present invention, the inventors have found that using lipase in combination with (i) a whitening catalyst capable of accepting an oxygen atom from a peroxy acid and transferring an oxygen atom to an oxidizable substrate, and (ii) diacyl and / or tetraacyl peroxide materials significantly improves the detergent the effectiveness of the composition, reduces the profile of the odor of the composition and improves the compatibility profile of the composition with a rubber hose for pumping water.

SUMMARY OF THE INVENTION

In a first embodiment, the present invention provides a composition comprising: (i) a lipase and (ii) a bleaching catalyst capable of accepting an oxygen atom from a peroxy acid and transferring an oxygen atom to an oxidizable substrate.

In a second embodiment, the present invention provides a composition comprising: (i) a lipase and (ii) diacyl and / or tetraacyl peroxide materials.

DETAILED DESCRIPTION OF THE INVENTION

Composition

The composition includes: (i) a lipase and (ii) a bleaching catalyst capable of accepting an oxygen atom from a peroxy acid and transferring an oxygen atom to an oxidizable substrate. Lipase and whitening catalyst are described in more detail below.

The composition may be suitable for use as a detergent composition for a laundry detergent, a composition for a detergent, a composition for washing dishes or a composition for cleaning hard surfaces. The composition is typically a detergent composition. The composition may be a composition for treating tissue. Preferably, the composition is a laundry detergent composition.

The composition may be in any form, such as liquid or solid, although preferably the composition is in solid form. Typically, the composition is in dispersed form, such as agglomerate, spray-dried powder, extrudate, flakes, needle crystals, ribbon-like products, granules, or any combination thereof. The composition may be in the form of a compacted particulate material, such as a tablet or tile form. The composition may be in some other unit dosage form, such as a sachet form, where the composition is typically at least partially, preferably substantially completely, surrounded by a water-soluble film, such as polyvinyl alcohol. Preferably, the composition is in the form of a free flowing particulate material; under the form of a free-flowing dispersed material typically means that the composition is in the form of individual discrete particles. The composition may be made by any suitable method, including agglomeration, spray drying, extrusion, mixing, dry mixing, spraying, roller compaction, spheronization, tableting, or any combination thereof.

The composition typically has a bulk density of 450 to 1000 g / l, preferably detergent compositions with a low bulk density have a bulk density of 550 to 650 g / l, and preferably detergent compositions with a high bulk density have a bulk density of 750 to 900 g / l. The composition may also have a bulk density of 650 to 750 g / l. During the washing process, the composition is typically contacted with water to form a washing solution having a pH from above 7 to below 13, preferably from above 7 to below 10.5. This is the optimum pH to ensure good cleaning while also providing a good tissue care profile.

Preferably, the composition comprises: (i) from 0% to less than 10%, preferably up to 7% or 4%, or 1%, or 1.5%, by weight of the composition, tetraacetylethylenediamine and / or hydroxybenzenesulfonate bleaching activators. Most preferably, the composition is substantially free of tetraacetylethylenediamine and / or hydroxybenzenesulfonate bleaching activators. "Essentially does not contain" typically means "does not contain specially included." Maintaining minimum levels of these types of bleach activators maintains a good safety profile for dye formulations.

Preferably, upon contact with water, the composition forms a washing solution having a pH of from 7 to 10.5. Compositions having such an alkalinity reserve profile and a pH profile exhibit a good lipase stability profile.

Preferably, the composition comprises from 0%, or from 1%, or from 2%, or from 3%, or from 4%, or from 5% and up to 30%, or up to 20%, or up to 10%, by weight of the composition, carbonate anion source. The carbonate anion source levels described above provide the composition with good overall washing efficiency and good whitening efficiency.

Preferably, the composition comprises a dye transfer inhibitor. Suitable dye transfer inhibitors are selected from the group consisting of polyvinylpyrrolidone, preferably having a weight average molecular weight of from 40,000 to 80,000 Da, preferably from 50,000 to 70,000 Da; polyvinylimidazole, preferably having a weight average molecular weight of from 10,000 to 40,000 Da, preferably from 15,000 to 25,000 Da; polyvinylpyridine-N-oxide polymer, preferably having a weight average molecular weight of from 30,000 to 70,000 Da, preferably from 40,000 to 60,000 Da; a copolymer of polyvinylpyrrolidone and vinylimidazole, preferably having a weight average molecular weight of from 30,000 to 70,000 Da, preferably from 40,000 to 60,000 Da; and any combination thereof. Compositions containing a dye transfer inhibitor exhibit an additionally improved dye safety profile.

The composition may include from 0% to less than 5%, preferably up to 4%, or up to 3%, or up to 2%, or even up to 1%, by weight of the composition, of the zeolite main component. Although the composition may include a zeolite main component at the level of 5% wt. or more, preferably the composition comprises less than 5% wt. zeolite main component. It may be preferable for the composition to be substantially free of a zeolite main component. "Essentially free of zeolite main component" typically implies that the composition does not contain a specially incorporated zeolite main component. This is especially preferred when the composition is a solid detergent composition for washing and it is desirable for the composition to have very high solubility to minimize the amount of water-insoluble residues (which, for example, can be deposited on the surface of the fabric), and also when it is very desirable to obtain a clear detergent solution . Suitable zeolite main components include zeolite A, zeolite X, zeolite R and zeolite MAP.

The composition may include from 0% to less than 10% or less than 5%, preferably up to 4%, or up to 3%, or up to 2%, or even up to 1%, by weight of the composition, of the phosphate base component. Although the composition may include a phosphate base component at a level of 10% wt. or more, preferably the composition contains less than 10% wt. phosphate core component. It may even be preferable for the composition to be substantially free of a phosphate base component. "Substantially free of a phosphate base component" typically implies that the composition does not contain a specially added phosphate base component. This is especially preferred if it is desirable for the composition to have a very good environmental safety profile. Suitable phosphate base components include sodium tripolyphosphate.

The composition may include from 0% to less than 5%, or preferably up to 4%, or up to 3%, or even up to 2%, or up to 1%, by weight of the composition, silicate salt. Although the composition may include a silicate salt at the level of 5% wt. or more, preferably the composition comprises less than 5% wt. silicate salt. It may even be preferable for the composition to be substantially free of silicate salt. "Substantially free of silicate salt" typically implies that the composition does not contain specially added silicate salt. This is especially preferred when the composition is a solid detergent composition for washing and it is desirable to ensure that the composition has very good dispersibility and solubility profiles and to ensure that the composition gives a clear detergent solution when dissolved in water. Silicate salts include water insoluble silicate salts. Silicate salts also include amorphous silicate salts and crystalline layered silicate salts (e.g., SKS-6). Silicate salts include sodium silicate.

The composition typically includes auxiliary ingredients. These auxiliary ingredients include detergent surfactants, such as anionic detergent surfactants, nonionic detergent surfactants, cationic detergent surfactants, zwitterionic detergent surfactants, amphoteric detergent surfactants; preferred anionic detergent surfactants are alkoxylated anionic detergent surfactants such as linear or branched, substituted or unsubstituted C _12-18 alkyl alkoxylated sulfates having an average degree of alkoxylation of from 1 to 30, preferably from 1 to 10, preferably linear or branched, substituted or unsubstituted C _12-18 -alkiletoksilirovannye sulphates having an average degree of ethoxylation of from 1 to 10, most preferably unsubstituted linear C _12-18 -alkiletoksilirovannye sulphates having an average degree of ethoxylation of from 3 to 7, other preferred anionic detersive surfactants are alkyl sulfates, alkyl sulfonates, alkyl phosphates, alkyl phosphonates, alkyl carboxylates or any mixture thereof, preferred alkyl sulphates include linear or branched, substituted or unsubstituted C _10-18 alkyl sulfates; another preferred anionic detergent surfactant is C _10-13 linear alkyl benzene sulfonate; preferred nonionic detergent surfactants are C _8-18 alkyl alkoxylated alcohols having an average degree of alkoxylation of 1 to 20, preferably 3 to 10, most preferred are C _12-18 alkyl ethoxylated alcohols having an average degree of alkoxylation of 3 to 10 ; preferred cationic detergent surfactants are mono-C _6-18 alkyl monohydroxyethyl dimethyl quaternary ammonium chlorides, more preferred is mono C _8-10 alkyl monohydroxyethyl dimethyl quaternary ammonium chloride, mono-C _10-12 alkyl monohydroxyethyl ethyl dimethyl dimethyl mono-C ₁₀ -alkyl monohydroxyethyl dimethyl quaternary ammonium chloride; a peroxide oxygen source such as percarbonate salts and / or perborate salts, preferably sodium percarbonate, the peroxide oxygen source preferably at least partially coated, preferably completely coated with a coating ingredient such as a carbonate salt, sulfate salt, silicate salt, borosilicate or mixtures, including their mixed salts; bleaching activators such as tetraacetylethylenediamine, hydroxybenzenesulfonate bleaching activators such as nonanoyloxybenzenesulfonate, caprolactam bleaching activators, imide bleaching activators such as N-nonanoyl-N-methylacetamide; enzymes such as amylases, arabinases, xylanases, galactanases, glucanases, carbohydrases, cellulases, laccases, oxidases, peroxidases, proteases, glucanases, pectatliases and mannanases, proteases are particularly preferred; antifoam systems, such as silicone-based defoamers; fluorescent whitening agents; photobleach; filler salts such as sulfate salts, preferably sodium sulfate; fabric softening agents such as clay, silicone, and / or quaternary ammonium compounds, montmorillonite clay, optionally in combination with silicone, is particularly preferred; flocculants such as polyethylene oxide; dye transfer inhibitors such as polyvinylpyrrolidone, poly-4-vinylpyridine-N-oxide and / or a copolymer of vinylpyrrolidone and vinylimidazole; tissue integrity components such as hydrophobically modified cellulose and oligomers obtained by condensation of imidazole and epichlorohydrin; contaminant dispersants and aids to prevent redeposition of contaminants, such as alkoxylated polyamines and ethoxylated ethyleneimine polymers; anti-re-deposition components such as carboxymethyl cellulose and polyesters; perfumes; sulfamic acid or its salts; citric acid or its salts; carbonate salts, sodium carbonate is particularly preferred; and dyes such as orange dye, blue dye, green dye, purple dye, pink dye, or any mixture thereof.

A second embodiment of the present invention relates to a composition comprising: (i) a lipase, for example, a first cycle wash lipase; and (ii) diacyl peroxide.

Lipase

The composition includes a lipase. The inclusion of lipase in the composition improves the washing efficiency. In addition, the combination of lipase with a whitening catalyst significantly reduces the odor profile of the composition.

Typically, lipase is numbered 3.1.1 by the Classification of Enzymes (EU), especially 3.1.1.3, as defined by the EU classification, IUPAC-IUBMB.

Preferably, the composition comprises a lipase in an amount of at least 0.5 mg, preferably at least 0.7 mg, or at least 1.0 mg, or at least 1.5 mg, or at least 2.0 mg, or even at least 3.0 mg, or at least 5.0 mg, or even at least 10 mg of active lipase, per 100 g of composition. Lipase may include a calcium binding site. Lipase may also exhibit improved stability and / or activity, especially activity in the presence of high levels of free calcium cations, which may be present in the washing solution. This is especially preferred when the composition contains low levels of a zeolite main component and a phosphate main component.

Typical EU lipases 3.1.1.3 include those described in WO 00/60063, WO 99/42566, WO 97/04078, WO 97/04079, US 5869438 and US 6939702 B1. Preferred lipases are produced by Absidia reflexa. Absidia corymbefera, Rhizmucor miehei, Rhizopus delemar, Aspergillus niger, Aspergillus tubigensis, Fusarium oxysporum, Fusarium heterosporum, Aspergillus oryzea, Penicilium camemberiniiominomomaergomomaergomomaergomomapergumompergom Preferred are lipases sold by Novozymes under the trademarks Lipolase®, Lipolase Ultra®, Lipoprime® and Lipex® (registered trademarks of Novozymes), and LIPASE P "AMANO®" available from Areario Pharmaceutical Co. Ltd., Nagoya, Japan, AMANO-CES®, commercially available from Touo Jozo Co., Tagata, Japan; and further Chromobacter viscosum lipase from US Biochemical Corp., USA. and Diosynth Co., Netherlands, and other lipases such as Pseudomonas gladioli. Other suitable lipases are described in WO 02062973, WO 2004/101759, WO 2004/101760 and WO 2004/101763.

Preferably, the lipase is a polypeptide having an amino acid sequence that: (a) has at least 90% identity with wild-type lipase isolated from strain Humicola lanuginosa DSM 4109; (b) in comparison with said wild-type lipase, comprises replacing an electrically neutral or negatively charged amino acid on a surface of a three-dimensional structure located at a distance of not more than 15 from E1 or Q249 by a positively charged amino acid; and / or (c) includes an additional peptide at the C-terminus; and / or (d) includes an additional peptide at the N-terminus; and / or (e) satisfies the following restrictions: (i) includes a negatively charged amino acid at position E210 of said wild-type lipase; (ii) includes a negatively charged amino acid in the region corresponding to positions 90-101 of said wild-type lipase; and (iii) includes a neutral or negatively charged amino acid at a position corresponding to N94 of said wild-type lipase, and / or has a negative or neutral total electric charge in a region corresponding to positions 90-101 of said wild-type lipase. The peptide sequence of wild-type lipase is shown below (sequence ID NO: 2).

In one embodiment, suitable lipases include “first cycle lipases” described in WO 00/60063 and US Pat. No. 6,939,702 B1, preferably SEQ ID NO: 2, more preferably SEQ ID NO: 2, having at least 90% homology with SEQ ID NO: 2, containing the substitution of an electrically neutral or negatively charged amino acid for R or K in any of the positions 3, 224, 229, 231 and 233, the most preferred option containing mutations T231R and N233R, and this most preferred option is sold under the trademark Lipex®.

Other suitable lipases are cutinases and esterases.

Typically, the composition comprises lipase in an amount of from 10 to 20,000 LU / g, or from 100 to 10,000 LU / g, or even from 500 LU / g or from 750 LU / g and up to 3,000 LU / g, or up to 1,500 LU / g, or up to 1250 LU / g.

Whitening catalyst

The whitening catalyst is capable of accepting an oxygen atom from a peroxy acid and / or its salt and transferring an oxygen atom to an oxidizable substrate. Suitable whitening catalysts include, but are not limited to: iminium cations and polyions; iminium zwitterions; modified amines; modified amine oxides; N-sulfonylimines; N-phosphonylimines; N-acylimins; thiadiazole dioxides; perfluorimines; cyclic ketosugar and mixtures thereof.

Suitable iminium cations and polyions include, but are not limited to, N-methyl-3,4-dihydroisoquinolinium tetrafluoroborate prepared as described in Tetrahedron (1992), 49 (2), 423-38 (see, for example, compound 4, p. 433); N-methyl-3,4-dihydroisoquinolinium p-toluenesulfonate prepared as described in US Pat. No. 5,360,569 (see, for example, column 11, Example 1); and N-octyl-3,4-dihydroisoquinolinium p-toluenesulfonate prepared as described in US Pat. No. 5,360,568 (see, for example, column 10, Example 3).

Suitable iminium zwitterions include, but are not limited to, N- (3-sulfopropyl) -3,4-dihydroisoquinolinium, an internal salt prepared as described in US Pat. No. 5,576,282 (see, for example, column 31, Example II); N- [2- (sulfooxy) dodecyl] -3,4-dihydroisoquinolinium, an internal salt prepared as described in US Pat. No. 5,817,614 (see, for example, column 32, Example V); 2- [3 - [(2-ethylhexyl) oxy] -2- (sulfooxy) propyl] -3,4-dihydroisoquinolinium, an internal salt prepared as described in WO 05/047264 (see, for example, page 18, Example 8) and 2- [3 - [(2-butyl octyl) oxy] -2- (sulfooxy) propyl] -3,4-dihydroisoquinolinium, an internal salt.

Suitable oxygen transfer catalysts of the modified amine type include, but are not limited to, 1,2,3,4-tetrahydro-2-methyl-1-isoquinolinol, which can be made according to the procedures described in Tetrahedron Letters (1987), 28 (48 ), 6061-6064. Suitable oxygen transfer catalysts of the modified amine oxide type include, but are not limited to, 1-hydroxy-N-hydroxy-N- [2- (sulfooxy) decyl] -1,2,3,4-tetrahydroisoquinoline sodium.

Suitable N-sulfonylimine oxygen transfer catalysts include, but are not limited to, 3-methyl-1,2-benzisothiazole-1,1-dioxide, prepared in accordance with the procedure described in Journal of Organic Chemistry (1990), 55 (4), 1254 -61.

Suitable N-phosphonylimine oxygen transfer catalysts include, but are not limited to, the amide [R- (E)] - N - [(2-chloro-5-nitrophenyl) methylene] -P-phenyl-P- (2,4,6-trimethylphenyl ) phosphinic acid, which can be manufactured in accordance with the procedures described in Journal of Chemical Society, Chemical Communications (1994), (22), 2569-70.

Suitable N-acylimine oxygen transfer catalysts include, but are not limited to, [N (E)] - N- (phenylmethylene) acetamide, which can be made in accordance with the procedures described in Polish Journal of Chemistry (2003), 77 (5), 577-590.

Suitable thiadiazole dioxide oxygen transfer catalysts include, but are not limited to, 3-methyl-4-phenyl-1,2,5-thiadiazole-1,1-dioxide, which can be made in accordance with the procedures described in US patent 5753599 (column 9, Example 2).

Suitable perfluorimine oxygen transfer catalysts include, but are not limited to, (Z) -2,2,3,3,4,4,4-heptafluoro-N- (nonafluorobutyl) butanimidoyl fluoride, which can be made according to the procedures described in Tetrahedron Letters (1994), 35 (34), 6329-30.

Suitable oxygen transfer catalysts of the cyclic ketosugar type include, but are not limited to, 1,2: 4,5-di-O-isopropylidene-D-erythro-2,3-hexodiuro-2,6-pyranose, made in accordance with US patent 6649085 ( column 12, Example 1).

Preferably, the whitening catalyst comprises an imine and / or carbonyl functional group and is typically capable of forming an oxaziridinium and / or dioxirane functional group upon acceptance of an oxygen atom, especially when accepting an oxygen atom from a peroxy acid and / or its salt. Preferably, the whitening catalyst comprises an oxaziridinium functional group and / or is capable of forming an oxaziridinium functional group upon accepting an oxygen atom, especially when accepting an oxygen atom from a peroxy acid and / or its salt. Preferably, the whitening catalyst comprises a cyclic iminium functional group, preferably in which the cyclic moiety has a ring size of five to eight atoms (including a nitrogen atom), preferably six atoms. Preferably, the whitening catalyst comprises an aryliminium functional group, preferably a bicyclic aryliminium functional group, preferably a 3,4-dihydroisoquinolinium functional group. A typically imine functional group is a quaternary imine functional group and is typically capable of forming a quaternary oxaziridinium functional group upon accepting an oxygen atom, especially when accepting an oxygen atom from a peroxy acid and / or its salt. Preferably, the whitening catalyst has a chemical structure corresponding to the following chemical formula

in which n and m independently have values from 0 to 4, preferably n and m are both equal to 0; each R ^{1 is} independently selected from a substituted or unsubstituted radical selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, condensed aryl, heterocyclic ring, condensed heterocyclic ring, nitro, halogen, cyano, sulfonato, alkoxy, keto, carboxyl and carboalkoxy radicals; and any two vicinal R ¹ substituents may combine to form a fused aryl, fused carbocyclic or fused heterocyclic ring; each R ^{2 is} independently selected from a substituted or unsubstituted radical independently selected from the group consisting of hydrogen, hydroxy, alkyl, cycloalkyl, alkaryl, aryl, aralkyl, alkylene, heterocyclic ring, alkoxy, arylcarbonyl groups, carboxyalkyl groups and amide groups; any R ² can be combined with any other R ² to form part of a common ring; any geminal R ² may combine to form a carbonyl; and any two R ² may combine to form a substituted or unsubstituted fused unsaturated moiety; R ³ is C ₁ -C ₂₀ substituted or unsubstituted alkyl; R ⁴ is hydrogen or a Q _t -A moiety, where: Q is a branched or unbranched alkylene, t = 0 or 1, and A is an anionic group selected from the group consisting of OSO ₃ ^- , SO ₃ ^- , CO ₂ ^- , OCO ₂ ^- , ORO ₃ ^2- , ORO ₃ H ^- , and ORO ₂ ^- ; R ⁵ is hydrogen or a —CR ¹¹ R ¹² —YG _b —Y _c - [(CR ⁹ R ¹⁰ ) _y —O] _k —R ⁸ fragment in which each Y is independently selected from the group consisting of O, S, NH or NR ⁸ ; and each R ^{8 is} independently selected from the group consisting of alkyl, aryl and heteroaryl, wherein said fragments are substituted or unsubstituted, and regardless of whether they are substituted or unsubstituted, said fragments contain less than 21 carbon atoms; each G is independently selected from the group consisting of CO, SO ₂ , SO, PO, and PO ₂ ; R ⁹ and R ^{10 are} independently selected from the group consisting of H and C ₁ -C ₄ alkyl; R ¹¹ and R ^{12 are} independently selected from the group consisting of H and alkyl, or taken together may combine to form carbonyl; b is 0 or 1; c can be = 0 or 1, but c must be = 0 if b = 0; y is an integer from 1 to 6; k is an integer from 0 to 20; R ⁶ is H or an alkyl, aryl or heteroaryl moiety; moreover, these fragments are substituted or unsubstituted; and X, if present, is a suitable charge balancing counterion, preferably X is present when R ⁴ is hydrogen, and suitable X include, without limitation, chloride, bromide, sulfate, methosulfate, sulfonate, p-toluenesulfonate, borotetrafluoride and phosphate.

In one embodiment of the present invention, the whitening catalyst has a structure corresponding to the general formula below:

where R is a branched alkyl group containing from three to 24 carbon atoms (including branched carbon atoms) or a linear alkyl group containing from one to 24 carbon atoms; preferably R ¹³ is a branched alkyl group containing from eight to 18 carbon atoms, or a linear alkyl group containing from eight to eighteen carbon atoms; preferably R ^{13 is} selected from the group consisting of 2-propylheptyl, 2-butyl octyl, 2-pentylnonyl, 2-hexyldecyl, n-dodecyl, n-tetradecyl, n-hexadecyl, n-octadecyl, isononyl, isodecyl, isotridecyl and isopentyl; preferably R ^{13 is} selected from the group consisting of 2-butyl octyl, 2-pentylnonyl, 2-hexyldecyl, isotridecyl and isopentadecyl.

Oxybenzenesulfonate and / or oxybenzoic whitening activators

The composition preferably includes (i) oxybenzenesulfonate bleaching activators and / or oxybenzoic bleaching activators and (ii) a source of peroxide oxygen. Typically, an oxybenzoic acid based bleach activator is in salt form. Preferred oxybenzenesulfonate whitening activators include whitening activators having the general formula:

R- (C = O) -L

where R denotes an optionally branched alkyl group containing, when the bleach activator is hydrophobic, from 6 to 14 carbon atoms or from 8 to 12 carbon atoms, and L is a leaving group. Examples of suitable leaving groups are benzoic acid and its derivatives, especially its salts. Another particularly preferred leaving group is oxybenzenesulfonate. Suitable whitening activators include dodecanoyloxybenzenesulfonate, decanoyloxybenzenesulfonate, decanoyloxybenzoic acid salt, 3,5,5-trimethylhexanoyloxybenzenesulfonate, nonanoylamidocaproyloxybenzenesulfonate and nonanoyloxybenzenesulfonate (Nanoyloxybenzenesulfonate). Suitable whitening activators are also disclosed in WO 98/17767. The inclusion of these whitening activators in the composition is particularly preferred when the composition contains low levels of a zeolite main component and a phosphate main component. The inventors have found that combining these bleaching activators with a peroxide oxygen source and a bleaching catalyst, as described in more detail above, and a lipase, especially in a detergent composition with a reduced content of the main detergent component (such as a detergent composition comprising low levels of a zeolite main component and phosphate main component), improves the overall washing efficiency, improves the compatibility profile with a rubber hose for pumping water and reduces the profile of iyatnogo odor composition.

Diacyl peroxide

In another embodiment, the composition comprises: (i) a lipase; and (ii) diacyl and / or tetraacyl peroxide materials. The inventors have found that these compositions exhibit marvelous compatibility with a rubber hose. Diacyl peroxides, as well as tetraacyl peroxides, are known to destroy rubber, such as rubber hoses for pumping water from automatic washing machines, and this can lead to failure of the rubber hose for pumping water over many washing cycles. The inventors have found that combining diacyl peroxides and / or tetraacyl peroxides with lipase solves this incompatibility problem with a rubber hose for pumping water.

The diacyl peroxide whitening materials are preferably selected from diacyl peroxides of the general formula:

R ¹ -C (O) -OO- (O) CR ²

where R ¹ denotes a C ₆ -C ₁₂ -alkyl, preferably a C ₆ -C ₁₂ -alkyl group containing a linear chain with at least 5 carbon atoms, and optionally containing one or more substituents (for example, -N ⁺ (CH ₃ ) ₃ , —COOH or —CN) and / or one or more inserted fragments (for example, —CONH or —CH = CH—) located between adjacent carbon atoms of the alkyl radical, and R ² is an aliphatic group compatible with the peroxide fragment, such such that R ¹ and R ² together contain a total of 8 to 30 carbon atoms. In one preferred aspect, R ¹ and R ² are linear unsubstituted C ₆ -C ₁₂ alkyl chains. Most preferably, R ¹ and R ² are identical. Diacyl peroxides in which R ¹ and R ^{2 are} both C ₆ -C ₁₂ alkyl groups are particularly preferred. Preferably at least one of, most preferably only one of, the R groups (R ¹ and R ² ) does not contain side chains or side ring groups in the alpha position, or preferably in either the alpha or beta position, or most preferably in none of the alpha, or beta, or gamma positions. In yet another preferred embodiment, the DAP may be asymmetric, so that preferably the hydrolysis of the acyl group of R ¹ proceeds quickly to form a peracid, but the hydrolysis of the acyl group of R ² proceeds slowly.

Tetraacyl peroxide whitening materials are preferably selected from tetraacyl peroxides of the general formula:

R ³ -C (O) -OO-C (O) - (CH ₂ ) _n -C (O) -OO-C (O) -R ³

where R ³ is a C ₁ -C ₉ , preferably a C ₃ -C ₇ alkyl group, and n is an integer from 2 to 12, preferably from 4 to 10, inclusive.

Preferably, diacyl- and / or tetraatsilperoksidnye bleaching materials are present in an amount sufficient to provide at least 0.5 million ^-1, preferably at least 10 million ^-1 and more preferably at least 50 million ^- 1, by weight of the detergent solution. In a preferred embodiment, bleaching materials are present in an amount sufficient to provide from about 0.5 to about 300 million ^-1, more preferably from about 30 to about 150 million ^-1, by weight of the detergent solution.

Pre-prepared Peroxy Acids

The pre-prepared peroxyacids or salts thereof are typically peroxycarboxylic acid or a salt thereof or peroxy sulfonic acid or a salt thereof.

Pre-prepared peroxyacids or their salts are preferably peroxycarboxylic acid or its salt, typically having a chemical structure corresponding to the following chemical formula:

in which R ^{14 is} selected from an alkyl, aralkyl, cycloalkyl, aryl or heterocyclic group; the group R ¹⁴ may be linear or branched, substituted or unsubstituted; and Y is any suitable counterion which provides electroneutrality, preferably Y is selected from hydrogen, sodium or potassium. Preferably R ¹⁴ is linear or branched, substituted or unsubstituted C _6-9 -alkyl. Preferably, the peroxyacid or its salt is selected from peroxyhexanoic acid, peroxyheptanoic acid, peroxyoctanoic acid, peroxynonanoic acid, peroxydecanoic acid, any salt thereof or any combination thereof. Preferably, the peroxyacid or its salt has a melting point in the range of 30 to 60 ° C.

The pre-prepared peroxyacid or its salt may also be peroxysulfonic acid or its salt, typically having a chemical structure corresponding to the following chemical formula:

in which R ^{15 is} selected from an alkyl, aralkyl, cycloalkyl, aryl or heterocyclic group; the group R ¹⁵ may be linear or branched, substituted or unsubstituted; and Z is any suitable counterion which provides electroneutrality, preferably Z is selected from hydrogen, sodium or potassium. Preferably, R ¹⁵ is linear or branched, substituted or unsubstituted C _6-9 alkyl.

EXAMPLES

Example 1: Synthesis of complex mono- [2- (3,4-dihydroisoquinolin-2-yl) -1- (2-ethylhexyloxymethyl) ethyl] sulfuric acid ester, internal salt

Synthesis of 2-ethylhexylglycidyl ether: In a flame-dried round-bottomed flask of 500 ml equipped with a dropping funnel charged with epichlorohydrin (15.62 g, 0.17 mol), 2-ethylhexanol (16.5 g, 0.127 mol) and chloride are added tin (4) (0.20 g, 0.001 mol). The reaction is kept under argon atmosphere and heated to 90 ° C in an oil bath. Epichlorohydrin is added dropwise to the stirred solution over 60 minutes, followed by stirring at 90 ° C. for 18 hours. The reaction was equipped with a vacuum distillation nozzle and 1-chloro-3- (2-ethylhexyloxy) propan-2-ol was distilled off at a pressure of 0.2 mm Hg. 1-Chloro-3- (2-ethylhexyloxy) propan-2-ol (4.46 g, 0.020 mol) was dissolved in tetrahydrofuran (50 ml) and stirred at room temperature under argon. Potassium tert-butoxide (2.52 g, 0.022 mol) was added to the stirred solution, and the suspension was stirred at room temperature for 18 hours. The reaction was then evaporated to a dry residue, the residue was dissolved in hexanes and washed with water (100 ml). The hexane phase is separated, dried with Na ₂ SO ₄ , filtered and evaporated to a dry residue, obtaining crude 2-ethylhexylglycidyl ether, which can be further purified by vacuum distillation.

Synthesis of mono- [2- (3,4-dihydroisoquinolin-2-yl) -1- (2-ethylhexyloxymethyl) ethyl] ester of sulfuric acid, internal salt: Into a flame-dried 250 ml three-neck round bottom flask equipped with a refrigerator 3,4-dihydroisoquinoline (0.40 mol; prepared as described in Example 1, US 5576282), 2-ethylhexyl glycidyl ether (0.38 mol) is added to the dry argon feed inlet, a magnetic stir bar, a thermometer and a heating bath. , obtained as described above), a complex of SO ₃ -DMF (0.38 mol) and acetonitrile (500 ml). The reaction is heated to 80 ° C and stirred at this temperature for 72 hours. The reaction was cooled to room temperature, evaporated to a dry residue, and the residue was recrystallized from ethyl acetate and / or ethanol to give the desired product. The acetonitrile solvent may be replaced by other solvents, including, but not limited to, 1,2-dichloroethane.

Example 2: Synthesis of complex mono- [2- (3,4-dihydroisoquinolin-2-yl) -1- (2-butyloctyloxymethyl) ethyl] sulfuric acid ester, internal salt

The desired product is obtained in accordance with Example 1, but replacing 2-butyloctanol with 2-hexyloctanol.

Example 3: Laundry Detergent Compositions

The following laundry detergent compositions — A, B, C, and D — are suitable for use with the present invention. Typically, these compositions are metered into water at a concentration of 80 to 120 g / L during the washing process.

Table 1 Ingredient BUT AT FROM D The whitening catalyst prepared in accordance with example 1 or 2 0.1% wt. 0.05% wt. 0.03% wt. 0.05% wt. Lipase (9 mg / g of active substance) 0.15% wt. 0.2% wt. 0.3% wt. 0.2% wt. Linear C _12-13 Sodium Alkylbenzene Sulfonate (LAS) 9.0% wt. 8% wt. 7.5% wt. 7.0% wt. Tallowalkyl Sulphate (TAS) 1.0% wt. 1.0% wt. Alkyl ethoxylated C _14-15 alcohol with an average degree of ethoxylation of 7 (AE7) 2.5% wt. Alkyl ethoxylated C _14-15 alcohol sulfate with an average degree of ethoxylation of 3 (AE ₃ S) 4% wt. 3.0% wt. 2.5% wt. Mono-C _12-14 -alkyl monohydroxy-ethyl dimethyl quaternary ammonium chloride 1.5% wt. 1.0% wt. Zeolite 4A 15% wt. 12.5% wt. Lemon acid 3.0% wt. 2.0% wt. 3.0% wt. 3.0% wt. Sodium percarbonate 20% wt. 15% wt. 17.5% wt. 14% wt. TAED (tetraacetylethylenediamine) 2.5% wt. 3% wt. 2.3% wt. 1.6% wt. NOBS (nonanoyloxybenzenesulfonate) 0,0% 1.0% wt. 0.0% wt. 1.5% wt. Sodium carbonate 20% wt. 25% wt. 20% wt. 25% wt. Polymer carboxylate 2.0% wt. 1.5% wt. 3.0% wt. 2.5% wt. A compound having the following general structure: bis ((C ₂ H ₅ O) (C ₂ H ₄ O) _n ) (CH ₃ ) —N ⁺ —C _x H _2x —N ⁺ - (CH ₃ ) bis ((C ₂ H ₅ O) - (C ₂ H ₄ CO) _n ), where n = 20 to 30 and x = 3 to 8, or its sulfonated or sulfonated variants 1.0% wt. 0.5% wt. 0.75% wt. 1.0% wt. Carboxymethyl cellulose 1.5% wt. 1.0% wt. Other enzymes 1.0% wt. 0.5% wt. 0.75% wt. 0.5% wt. Ethylenediamino-succinic acid 0.5% wt. 0.1% wt. 0.2% wt. 0.25% wt. Magnesium sulfate 0.75% wt. 0.5% wt. 1.0% wt. 0.5% wt. Hydroxyethanedi (methylene phosphonic acid) 0.5% wt. 0.25% wt. 0.2% wt. 0.4% wt. Fluorescent whitening agent 0.2% wt. 0.1% wt. 0.15% wt. 0.25% wt. Silicone antifoaming agent 0.1% wt. 0.05% wt. 0.1% wt. 0.1% wt. Soap 0.5% wt. 0.25% wt. 0.0% wt. 0.3% wt. Photo bleach 0.01% wt. 0.0001% wt. 0,0005% wt. 0.0015% wt. Flavoring 1.0% wt. 0.5% wt. 0.75% wt. 0.5% wt. Sodium sulfate 13% wt. 15% wt. 30% wt. 30% wt. Water and more up to 100% wt. up to 100% wt. up to 100% wt. up to 100% wt.

The following laundry detergent compositions — E, F, G, and H — are suitable for use with the present invention. Typically, these compositions are metered into water at a concentration of 80 to 120 g / L during the washing process.

table 2 Ingredient E F G N The whitening catalyst prepared in accordance with example 1 or 2 0.01% wt. 0.05% wt. Diacyl peroxide 2% wt. 1% wt. 0.5% wt. 1% wt. Lipase (9 mg / g of active enzyme) 0.5% wt. 0.3% wt. 0.2% wt. 0.1% wt. Linear C _12-13 Sodium Alkylbenzene Sulfonate (LAS) 8.0% wt. 5.0% wt. 7.5% wt. 7.0% wt. Sulphate of C _14-15 alkyl ethoxylated alcohol with an average degree of ethoxylation of 3 (AE ₃ S) 5.0% wt. 2.5% wt. 3.5% wt. 6.0% wt. Lemon acid 3.0% wt. 2.0% wt. 5.0% wt. 2.5% wt. Sodium carbonate 20% wt. 25% wt. 22.5% wt. 25% wt. Polymer carboxylate 2.0% wt. 3.5% wt. 3.5% wt. 2.5% wt. A compound having the following general structure: bis ((C ₂ H ₅ O) (C ₂ H ₄ O) _n ) (CH ₃ ) —N ⁺ —C _x H _2x —N ⁺ - (CH ₃ ) bis ((C ₂ H ₅ O) - (C ₂ H ₄ CO) _n ), where n = 20 to 30 and x = 3 to 8 or its sulfonated or sulfonated variants 1.0% wt. 0.5% wt. 0.75% wt. 1.0% wt. Sodium percarbonate 0% wt. 15% wt. 17.5% wt. 14% wt. TAED (tetraacetylethylenediamine) 0% wt. 3% wt. 2.3% wt. 1.6% wt. Carboxymethyl cellulose 0.5% wt. 1.0% wt. 1.5% wt. 1.0% wt. Other enzymes 1.0% wt. 0.5% wt. 0.2% wt. 0.5% wt. Ethylenediamino-succinic acid 0.05% wt. 0.1% wt. 0.2% wt. 0.15% wt. Magnesium sulfate 0.35% wt. 0.1% wt. 1.0% wt. 0.25% wt. Hydroxyethanedi (methylene phosphonic acid) 0.1% wt. 0.25% wt. 0.2% wt. 0.5% wt. Fluorescent whitening agent 0.2% wt. 0.1% wt. 0.15% wt. 0.25% wt. Silicone antifoaming agent 0.1% wt. 0.05% wt. 0.1% wt. 0.2% wt. Soap 0.5% wt. 0.25% wt. 1.0% wt. 0.5% wt. Photo bleach 0.01% wt. 0.0001% wt. 0,0005% wt. 0.0015% wt. Flavoring 1.0% wt. 0.5% wt. 0.75% wt. 0.5% wt. Sodium sulfate 45% wt. 30% wt. 20% wt. 22% wt. Water and more up to 100% wt. up to 100% wt. up to 100% wt. up to 100% wt.

The following laundry detergent compositions — I, J, K, and L — are suitable for use with the present invention. Typically, these compositions are metered into water at a concentration of from 20 to 60 g / l during the washing process.

Table 3 Ingredient I J TO L The whitening catalyst prepared in accordance with example 1 or 2 0.15% wt. 0.10% wt. 0.1% wt. 0.15% wt. Diacyl peroxide 1% wt. 0.5% wt. Lipase 0.5% wt. 0.3% wt. 0.1% wt. 0.2% wt. Linear C _12-13 Sodium Alkylbenzene Sulfonate (LAS) 15% wt. 17.5% wt. 20% wt. 10.0% wt. Sulphate of C _14-15 alkyl ethoxylated alcohol with an average degree of ethoxylation of 3 (AE ₃ S) 7.0% wt. 7.5% wt. 5.0% wt. 5.0% wt. Lemon acid 7.0% wt. 5.0% wt. 7.5% wt. 3.0% wt. Sodium percarbonate 20% wt. 15% wt. 0% wt. 14% wt. TAED (tetraacetylethylenediamine) 2.5% wt. 3% wt. 0% wt. 1.6% wt. NOBS (nonanoyloxybenzenesulfonate) 0.0% wt. 2.0% wt. 0.0% wt. 0% wt. Sodium carbonate 22.5% wt. 25% wt. 20% wt. 10% wt. Polymer carboxylate 7.0% wt. 7.5% wt. 5.0% wt. 3.0% wt. A compound having the following general structure: bis ((C ₂ H ₅ O) (C ₂ H ₄ O) _n ) (CH ₃ ) —N ⁺ —C _x H _2x —N ⁺ - (CH ₃ ) bis ((C ₂ H ₅ O) - (C ₂ H ₄ CO) _n ), where n = 20 to 30 and x = 3 to 8 or its sulfonated or sulfonated variants 2.5% wt. 1.5% wt. 3.0% wt. 1.0% wt. Carboxymethyl cellulose 2.5% wt. 3.0% wt. 1.5% wt. 1.0% wt. Other enzymes 2.5% wt. 1.5% wt. 3.0% wt. 0.75% wt. Ethylenediamino-succinic acid 0.25% wt. 0.1% wt. 0.5% wt. 0.15% wt. Hydroxyethanedi (methylene phosphonic acid) 0.5% wt. 0.75% wt. 0.25% wt. 0.2% wt. Fluorescent whitening agent 0.5% wt. 0.75% wt. 0.25% wt. 0.15% wt. Silicone antifoaming agent 0.05% wt. 0.10% wt. 0.02% wt. 0.02% wt. Photo bleach 0.025% wt. 0.050% wt. 0.02% wt. 0.0015% wt. Water, filler (including sodium sulfate) and more up to 100% wt. up to 100% wt. up to 100% wt. up to 100% wt.

The bleaching detergent compositions in the form of granular laundry detergents are represented by the following formulations. Any of the following compositions are used for washing fabrics at a concentration of 600-10000 mn ^-1 in water, with typical median conditions of 2500 mn ^-1, 25 ° C. and a ratio of water: cloth 25: 1. A typical pH is about 10, but can be adjusted by changing the ratio of acid to Na salt of alkylbenzenesulfonate.

Table 4 M N O R Q R Linear alkylbenzenesulfonate twenty 22 twenty fifteen twenty twenty C ₁₂ -Dimetilgidroksietil ammonium chloride 0.7 one 0,0 0.6 0,0 0.7 AE3S 0.9 0,0 0.9 0,0 0,0 0.9 AE7 0,0 0.5 0,0 one 3 one Sodium Tripolyphosphate 23 thirty 23 17 12 23 Zeolite A 0,0 0,0 0,0 0,0 10 0,0 1.6R Silicate 7 7 7 7 7 7 Sodium carbonate fifteen fourteen fifteen eighteen fifteen fifteen Polyacrylate MW 4500 one 0,0 one one 1,5 one Carboxymethyl cellulose one one one one one one Savinase 32.89 mg / g 0.1 0,07 0.1 0.1 0.1 0.1 Natalase 8.65 mg / g 0.1 0.1 0.1 0,0 0.1 0.1 Lipase 18 mg / g * 0,03 0,07 0.3 0.1 0,07 0.1 Tinopal AMS (Ciba) 0.06 0,0 0.06 0.18 0.06 0.06 Tinopal CBS-X (Ciba) 0.1 0.06 0.1 0,0 0.1 0.1 Diethylene triamine penta acetic acid 0.6 0.3 0.6 0.25 0.6 0.6 MgSO ₄ one one one 0.5 one one Sodium percarbonate 0,0 5.2 0.1 0,0 0,0 0,0 Photo bleach 0.0030 0.0015 0.0015 0.0020 0.0045 0.0010 Sodium Perborate Monohydrate 4.4 0,0 3.85 2.09 0.78 3.63 NOBS 1.9 0,0 1,66 0,0 0.33 0.75 TAED 0.58 1,2 0.51 0,0 0.015 0.28 Organic catalyst ^** 0.0185 0.0185 0.0162 0 0.0111 0.0074 Diacyl peroxide ^*** 0.5 one Sulphate / Moisture Up to 100% Up to 100% Up to 100% Up to 100% Up to 100% Up to 100% ^* Lipase is preferably Lipex®. ^** Organic catalyst prepared in accordance with Examples 1 or 2, or mixtures thereof. ^{*** The} diacyl peroxide is preferably dinonanoyl peroxide.

Sequence I.D No. 2

All documents cited in the detailed description of the invention, in their relevant part, are incorporated into the present invention by reference; reference to any document should not be construed as an assumption that it is a prior art in relation to the present invention. To the extent that any meaning or definition of a term in this document contradicts any meaning or definition of the same term in a document incorporated by reference, the meaning or definition given to that term in this document should be given priority.

Although specific embodiments of the present invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications can be made without violating the spirit and scope of the invention. Therefore, it is intended that the appended claims cover all such changes and modifications that fall within the scope of the present invention.

Claims (13)

1. A composition comprising:
(a) lipase; and
(b) a bleaching catalyst capable of accepting an oxygen atom from a peroxyacid and transferring an oxygen atom to an oxidizable substrate, said whitening catalyst comprising an imine functional group and
wherein the lipase is a polypeptide having an amino acid sequence that:
(a) has at least 90% identity with wild-type lipase isolated from strain Humicola lanuginosa DSM 4109;
(b) in comparison with said wild-type lipase, comprises replacing an electrically neutral or negatively charged amino acid on the surface of a three-dimensional structure at a distance of not more than 15 Å from E1 or Q249 by a positively charged amino acid; and / or
(c) includes an additional peptide at the C-terminus; and / or
(d) includes an additional peptide at the N-terminus; and / or
(e) satisfies the following restrictions:
(i) includes a negatively charged amino acid at position E210 of said wild-type lipase;
(ii) includes a negatively charged amino acid in the region corresponding to positions 90-101 of said wild-type lipase; and
(iii) includes a neutral or negatively charged amino acid at a position corresponding to N94 of said wild-type lipase, and / or has a negative or neutral total electric charge in the region corresponding to positions 90-101 of said wild-type lipase. 2. The composition according to claim 1, characterized in that the whitening catalyst comprises an oxaziridinium and / or dioxiran functional group and / or is capable of forming an oxaziridinium and / or dioxiran functional group upon acceptance of an oxygen atom. 3. The composition according to claim 1, characterized in that the whitening catalyst has a chemical structure corresponding to the chemical formula:

in which n and m independently have values from 0 to 4; each R ^{1 is} independently selected from a substituted or unsubstituted radical selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, condensed aryl, heterocyclic ring group, condensed heterocyclic ring group, nitro, halogen, cyano, sulfonato, alkoxy, keto, carboxyl and carboalkoxyl radicals, and any two vicinal substituents R ¹ may combine to form fused aryl, fused carbocyclic or fused heterocyclic ring; each R ^{2 is} independently selected from a substituted or unsubstituted radical independently selected from the group consisting of hydrogen, hydroxy, alkyl, cycloalkyl, alkaryl, aryl, aralkyl, alkylenes, heterocyclic ring groups, alkoxy, arylcarbonyl groups, carboxyalkyl groups and amide groups; any R ² can be combined with any other R ² to form part of a common ring; any geminal R ² may combine to form a carbonyl; and where any two R ² may combine to form a substituted or unsubstituted fused unsaturated moiety; R ³ is C ₁ -C ₂₀ substituted or unsubstituted alkyl; R ⁴ is hydrogen or a Q _t -A moiety in which Q is branched or unbranched alkylene, t = 0 or 1, and A is an anionic group selected from the group consisting of OSO ₃ ^- , SO ₂ ^- , CO ₂ ^- , OCO ₂ ^- , ORO ₃ ^2- , ORO ₃ H ^- and ORO ₂ ^- ; R ⁵ is hydrogen or a —CR ¹¹ R ¹² —YG _b —Y _c - [(CR ⁹ R ¹⁰ ) _y —O] _k —R ⁸ fragment in which each Y is independently selected from the group consisting of O, S, NH or NR ⁸ ; and each R ^{8 is} independently selected from the group consisting of alkyl, aryl, and heteroaryl, wherein said fragments are substituted or unsubstituted, and regardless of whether they are substituted or unsubstituted, said fragments contain less than 21 carbon atoms; each G is independently selected from the group consisting of CO, SO ₂ , SO, PO and PO ₂ ^- , R ⁹ and R ^{10 are} independently selected from the group consisting of hydrogen and C ₁ -C ₄ alkyl; R ¹¹ and R ^{12 are} independently selected from the group consisting of hydrogen and alkyl, or, taken together, may combine to form carbonyl; b is 0 or 1; c can be = 0 or 1, but c must be = 0 if b = 0; y is an integer from 1 to 6; k is an integer from 0 to 20; R ⁶ is H or an alkyl, aryl or heteroaryl moiety; where these fragments are substituted or unsubstituted; and X, if present, indicates a counterion suitable for charge balancing. 4. The composition according to claim 1, characterized in that the whitening catalyst has a chemical structure corresponding to the chemical formula:

where R ¹³ denotes a branched alkyl group containing from 3 to 24 carbon atoms or a linear alkyl group containing from 1 to 24 carbon atoms. 5. The composition according to claim 1, characterized in that the whitening catalyst has a chemical structure corresponding to the chemical formula:

where R ^{13 is} selected from the group consisting of 2-butyl octyl, 2-pentylnonyl, 2-hexyldecyl, isotridecyl and isopentadecyl. 6. The composition according to claim 1, characterized in that the lipase is a variant of Humicola lanuginos lipase with mutations T231R and N233R. 7. The composition according to claim 1, characterized in that it contains less than 5% by weight of the composition of the source of peroxide oxygen. 8. The composition according to claim 1, characterized in that it contains from 5 to 10% by weight of the composition, a carbonate anion source. 9. The composition according to claim 1, characterized in that it contains a dye transfer inhibitor. 10. The composition according to claim 1, characterized in that it contains:
(a) less than 5% by weight of the composition of the zeolite main component;
(b) optionally, less than 5% by weight of the phosphate base component composition; and
(c) optionally, less than 5% by weight of the silicate salt composition. 11. The composition according to claim 1, characterized in that it contains diacyl and / or tetraacyl peroxide materials. 12. The composition according to claim 1, characterized in that it contains an oxybenzenesulfonate bleach activator and a source of peroxide oxygen. 13. The composition according to claim 1, characterized in that it contains a pre-prepared peroxyacid.