RU2391958C1 - Surgical pad - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention belongs to medicine, notably, to gauze products of surgical use, e.g. pads, bandages developed with absorbed radiation dose 1000-1300 kGy.

EFFECT: products are bioresorptive in post-operative site of patient's organism.

2 cl, 1 ex, 3 tbl

Description

The present invention relates to the field of medicine and medical technology and relates to gauze products for surgical purposes, such as wipes or bandages, which have the property of bioresorption in the postoperative field in the patient's body.

Known medical gauze made from cotton yarn of low density [1]. Gauze has a high breathability and is easily modeled in napkins, tampons, etc.

There is a method of improving the absorbency of gauze while maintaining its wound healing properties by activating it with an aqueous solution of an oxidizing agent - sodium dichloroisocyanurate at 45-50 ° C, followed by sizing with a foamy composition containing water, polyglucan microbial polysaccharide and surfactant [2].

However, in surgical practice there are cases when surgical gauze products, such as wipes, bandages or tampons, are left in the patient’s body after surgery, which leads to undesirable serious consequences.

Even special surgical wipes with detectable x-ray irradiation material have been developed that provide the ability to indicate the presence of a surgical wipe in the body [3].

The objective of the present invention is to develop gauze products for surgical use, such as wipes or bandages, which have the property of bioresorption in the postoperative field in the patient's body.

In accordance with the invention, gauze products of a surgical purpose are described having the bioresorption property, characterized in that they are treated with radiation or made of medical gauze treated with radiation at an absorbed dose of 1000-1300 kGy.

At the same time, gauze products for surgical use can be gauze napkins, bandages, tampons, etc.

The gauze products and gauze described in accordance with the invention do not lose their operational properties, have good absorbency and, if left inadvertently in the surgical field in the patient’s body, undergo bioresorption without any complications for the patient’s body.

The invention is illustrated by the following examples.

Example 1

Radiation processing of medical gauze products is carried out on a radiation-technological installation consisting of linear electron accelerators "Electronics-10-10" (a tandem of sequentially installed accelerators on one beam conveyor located vertically with respect to the irradiated objects) in the transport system. The required dose is collected fractionally (in cycles), passing samples of gauze or gauze through the beam sweep zone, the speed of movement in the irradiation zone is 2-4 cm / s. The absorbed dose rate in the material in the irradiation zone is 4-5 kGy / s, the absorbed dose per cycle is 10-15 kGy. The electron energy in the beam is 8–9 MeV, the beam current is 600–700 μA, and the beam power is 5–6 kW. Irradiation is carried out under normal atmospheric conditions. Samples of gauze or gauze were heated under a beam of electrons no more than 2-3 ° C. The absorbed dose was determined using certified DPD (F) -30/190 dosimeters with an accuracy of at least 15%.

Table 1 shows the conditions of radiation exposure.

The resulting samples were tested. The experiment was carried out at a constant temperature of 21-22 ° C. Fresh blood was taken from a donor calf (150 ml) on the day of the experiment (0.5 hours before the experiment).

Sterile samples of gauze or gauze 2 × 2 cm in size were placed in glass tubes and placed in groups. 5 ml of physiological saline solution was added to samples of group I, and 5 ml of blood to samples of group II, after which time was timed. After three hours, the experiments were stopped. The research results are presented in table 2.

table 2 Sample Number Wednesday Time Experiment Results Medical gauze bandage The control 0.9% NaCl
blood > 3 hours No visible changes > 3 hours No visible changes I 0.9% NaCl
blood > 3 hours No visible changes > 3 hours No visible changes II 0.9% NaCl
blood > 3 hours No visible changes > 3 hours No visible changes III 0.9% NaCl
blood > 3 hours No visible changes > 3 hours No visible changes IV 0.9% NaCl
blood 73 ' Partial lysis 32 ' Partial lysis Medical gauze napkins The control 0.9% NaCl
blood > 3 hours No visible changes > 3 hours No visible changes I 0.9% NaCl
blood > 3 hours No visible changes > 3 hours No visible changes II 0.9% NaCl
blood 70 ' Partial lysis 28 ' Partial lysis III 0.9% NaCl
blood 32 ' Lysis 15'30 '' Lysis

Table 3 shows the results of the experiment on adult rats with a live weight of 250-300 g. Gauze products were left in the abdominal cavity of the rat.

Table 3 Sample Number Time Absorbed Dose, kGy Experiment Results The control 7 days Medical gauze bandage All fibers of the bandage are surrounded by powerful lymphocytic infiltrates without a purulent-inflammatory process. I 7 days 90 All fibers of the bandage are surrounded by powerful lymphocytic infiltrates without a purulent-inflammatory process. II 14 days 320 All fibers of the bandage are surrounded by powerful lymphocytic infiltrates without a purulent-inflammatory process. III 21 days 500 All fibers of the bandage are surrounded by powerful lymphocytic infiltrates without a purulent-inflammatory process. IV 30 days 1000 Less pronounced infiltration around the bandage without purulent-inflammatory process Medical gauze napkin The control 7 days to All fibers of the bandage are surrounded by powerful lymphocytic infiltrates without a purulent-inflammatory process.

Table 3 (continued) I 7 days 550 Lymphocytic infiltration of tissue around the napkin is less pronounced II 14 days 1000 Lymphocytic infiltration of tissue around the napkin is less pronounced III 21 days 1300 Granulation tissue is less pronounced than in previous experiments. The same applies to lymphocytic infiltration. Purulent-inflammatory process is not detected

Literature

1. RU 2194534, C1, 12.20.2002.

2. SU 1697831, A, 12.15.1991.

3. RU 2004134300, F, 05/10/2006.

Claims (2)

1. A gauze product for surgical use, having the property of bioresorption, characterized in that it is treated with radiation or made of medical gauze treated with radiation, with an absorbed dose of 1000-1300 kGy. 2. A surgical gauze product according to claim 1, which is a gauze napkin, bandage or tampon.