RU2354364C1 - Method of preventing disease recurrence in patients with herpes simplex - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to infectious diseases and can be used for prevention of herpes simplex disease recurrence. For this purpose patients in intra-recurrence period are administered complex of measures aimed at reduction of skin and mucosa acidity: special diet, favouring shift of pH of tissues and biological fluids toward alkali side, consumption of 3-4 litres of drinking water a day, limiting consumption of products possessing "acidifying" properties, salt and pickles, exclusion of food vinegar and containing it products from diet. During period of high risk of disease recurrence development additionally perorally administered is 0.25% solution of sodium citrate 100 ml per hour during 10 hours daily. After each two weeks of carrying our anti-recurrence measures 5-7 day recess is administered.

EFFECT: invention allows to increase efficiency of anti-recurrence prophylaxis due to suppression of retraction of herpes simplex viruses and their leaving ganglia nerve cells by reducing skin and mucosa acidity.

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Description

The invention relates to medicine, namely to infectious diseases, and is intended to prevent relapse of the disease in patients with herpes simplex. Herpes simplex (PG), being the most common human viral infection, is characterized by a chronic recurrent course. Initially intruding into the mucous membranes of the mouth or genitals, the pathogens of PG penetrate further into the ganglion nerve cells, persisting in them for life. Periodically, they can leave the above cells and, reaching the nearest areas of the skin and mucous membranes, begin to multiply in them. This creates a pathogenetic basis for the development of relapses of the disease.

As you know, the use of modern antiherpetic drugs does not provide a radical destruction of persistent PG viruses in the nerve ganglia. Only with the manifestation of infection, penetrating the skin and mucous pathogens become vulnerable to chemotherapeutic effects. Therefore, to prevent recurrence of GHG, the most frequent use is the constant (over many months and years) intake of antiherpetic drugs such as acyclovir, famciclovir, valacyclovir, etc. - M. Radar, - 2005). However, this is associated with a large number of side effects, and patients are psychologically perceived very negatively.

Methods are also proposed for the prevention of recurrence of herpetic infection, based on the permanent use of drugs that stimulate the immune system. We are talking about such drugs as neovir, cycloferon, allokin-alpha, taktivin, thymalin, thymogen, etc. (M.S. Tishchenko / Herpes simplex: clinical and immunological features in HIV-infected people, improvement of treatment and prevention methods. Abstract . ... doctor of medical sciences - M., 2005). However, all of these methods are not effective enough (M.S. Tishchenko, 2005), and long-term use of immunotropic drugs is either impossible or is accompanied by severe side effects.

There is a way to prevent recurrence of GHG, based on the preventive use of antiherpetic vaccines (Internal diseases according to Tinsley R. Harrison. Edited by E. Faugi et al. Volume 1. Transl. From English - M., Practice-Grow-Hill, 2002. - S.1326). However, the effectiveness of this method also remains very low (M.S. Tishchenko, 2005).

Such a method of treating chronic recurrent herpes virus infection is known from the patent literature. According to this method, during a period of exacerbation, a combination of valtrex with polyoxidonium, neovir and derinate is prescribed. At the end of the relapse treatment, cycloferon is prescribed in combination with alpizarin, B vitamins and a biostimulator - Moskovia balm. The method provides a treatment effect due to the complex effect on the causative agent of the disease and the body's immune system (see Russian Patent 2197969, publ. 02/10/2003, MKI A61K 31/447).

A known method for the diagnosis and prevention of frequent relapses of herpes simplex. In accordance with this method, if patients have three or more signs out of five possible: dry skin, constipation, body temperature less than 36.4 ° C, low blood pressure, burdened history of the thyroid gland, thyroid hormones are administered. The method allows to eliminate immunological disorders. This increases the effectiveness of disease prevention (see Russian Patent 2159632, publ. 20.04.99, MKI A61K 38/22).

An indirect disadvantage of this method is the appointment of hormonal drugs that cause unwanted side effects.

The above analogues are in various ways aimed at increasing immunity as a prophylactic against relapses of herpes simplex. Among them, it is difficult to choose any one technical solution as a prototype, since our proposed method does not contain common features with the given analogues.

As our studies showed, the recurrence of the disease in patients with PG can be due to the development of tissue acidosis under the influence of various factors (hypothermia, overheating, colds and intestinal diseases, menstruation, stress, etc.) (I.I. Vasilieva et al. - “Determination of pH of affected skin and mucous membranes in patients with herpes simplex in the dynamics of the infectious process” // 61st final scientific conference of young scientists: Annotations of reports and materials for science of Rostov State Medical University. - Rostov-on-Don, 2007. - P.47-48 ) Based on this, we attempted to suppress the reactivation of PG viruses and their exit from the ganglia nerve cells by leveling the “acidification” of the skin and mucous membranes that naturally develops during relapses, which formed the basis of the method we developed.

The purpose of the invention is the development of a more effective and devoid of side effects way to prevent relapse of the disease in patients with PG.

The technical result of the invention is to reduce the acidity of the skin and mucous membranes in patients with recurrent herpes simplex.

The problem is achieved in that according to the method of preventing relapse of the disease in patients with herpes simplex, patients in the inter-relapse period of the disease are prescribed a set of measures aimed at reducing the acidity of the skin and mucous membranes, namely, a special diet that promotes a shift in the pH of tissues and biological fluids to the alkaline side, consumption a large amount of drinking water (up to 3-4 liters per day), limiting the consumption of products with “acidifying” properties, salt and pickles, excluding pi chewing vinegar and products containing it (mayonnaise, marinades), as well as at a high risk of developing relapses of the disease, an additional daily oral administration of a 0.25% solution of citric acid sodium at 100 ml per hour for 10 hours is prescribed. At the same time, every two weeks of anti-relapse measures, a break of 5-7 days is prescribed.

Thus, the prescribed set of measures contributes to the achievement of a technical result, namely, a decrease in the pH of the skin and mucous membranes in patients with recurrent herpes simplex, due to which it is possible to effectively prevent disease recurrence in patients with PG without any side effects.

A method for preventing relapse of the disease in patients with herpes simplex is as follows.

Patients with a recurring form of GHG are prescribed in the inter-relapse period of the disease: 1) a special diet that promotes a shift in the pH of tissues and body fluids to the alkaline side: vegetables (potatoes, legumes, beets, carrots, cucumbers, celery, cauliflower, peas, lettuce, greens, radishes, turnips, swede), fruits and berries (oranges, lemons, raisins, apples, bananas, nutmegs, peaches), nuts (almonds), chestnuts, dairy products (cow's milk, sour cream, cream), with the consumption of large quantities of drinking water (up to 3-4 liters per day). Limit the consumption of products with “acidifying” properties: white whole wheat bread, oatmeal, rice and other cereals, cheeses, eggs, meat (chicken, beef, pork, rabbit meat) and fish products (pike, cod), some berries, fruits and nuts (lingonberries, plums, prunes, peanuts, pears), salts (sodium chloride) and pickles. Food vinegar and products containing it (mayonnaise, pickled vegetables and fruits) are excluded from food.

Additionally, during a high risk of developing relapses of the disease (febrile illness, respiratory and intestinal infections, stressful situations, menstruation, hypothermia, etc.), an oral daily intake of 0.25% citric acid sodium solution is prescribed at 100 ml per hour for 10 hours (based on 30-40 mg of sodium citrate per 1 kg of patient weight).

At the same time, every two weeks of anti-relapse measures, a break of 5-7 days is prescribed. This is due to the fact that the continuous use of “alkalizing” diets is less effective due to the compensatory effect of the body's buffer systems.

The inventive method is based on the actual material obtained by us in the treatment of 142 patients with recurrent GHG course. The studies were carried out in the conditions of the 5th infectious ward and clinic of the MLPUZ "City Hospital No. 1 named after N. A. Semashko ”, Rostov-on-Don. Using the alphabetical randomization method, two groups of patients suffering from recurrent herpes of the face and genitals were formed. Patients of the first of them (n = 73) in the inter-relapse period of the disease were assigned a list of prophylactic measures proposed by the present method. Patients of the second group (n = 69), which was considered by us as a control, did not carry out these measures.

As shown by our clinical observations over 6 months, the use of the proposed method allows to increase the number of people with no recurrence of the disease by more than 6 times (table 1). Moreover, even in those patients in whom recurrences of GHG did occur, their frequency was significantly lower than in the comparison group (table 2).

Side effects when using the proposed method were not identified.

The invention is illustrated by the following clinical examples.

Patient S., 34 years old, was observed in the 5th infectious ward of GB No. 1 named after N.A.Semashko, Rostov-on-Don (IB No. 13232-06) regarding recurrent herpes of the face. Sick for 15 years. The recurrence rate of the disease is at least 10-12 per year. Their occurrence occurs during the development of acute respiratory viral infections, hypothermia, overheating, and the intake of products containing acetic acid (5% solution of food vinegar, mayonnaise, pickled vegetables, etc.). He received all anti-relapse drugs that exist today, but to no avail. For 6 months, the patient underwent the preventive measures recommended by us according to the claimed method, which he rigorously carried out. Over the entire period of observation, recurrence of GHG was not noted. Side effects were absent.

Patient K., 36 years old, was observed in the clinic of GB No. 1 named after N.A.Semashko, Rostov-on-Don (outpatient map No. 612-07) for recurrent genital herpes, which has been suffering for more than 20 years. Relapses occurred regularly immediately before the onset of menstruation and with hypothermia. Their frequency reached 2-3 times a month. The standard anti-relapse therapy conducted by the patient did not give any stable effect. Only the use of preventive measures according to the claimed method made it possible for the first time in many years that within 5 months of preventive treatment, not a single relapse was registered in the patient. Side effects were not observed.

Table 1 The comparative number of patients with PG without relapse, receiving standard anti-relapse treatment according to the present method and in the control group No. / No. Groups of patients with PG The number of people with PG who have not had a relapse of the disease within 6 months R one. Received preventive therapeutic measures by the present method (n = 73) 40 (54.8 ± 5.8%) <0.001 2. Control Group (n = 69) 6 (8.7 ± 3.4%)

table 2 The distribution of patients with PG receiving anti-relapse treatment according to the present method and in the control group, depending on the presence and frequency of relapse of the disease Relapse rate Groups of patients with PG R Received preventive measures according to the claimed method (n = 73) Control Group (n = 69) 0 40 (54.8 ± 5.8%) 6 (8.7 ± 3.4%) <0.001 1-2 28 (38.4 ± 5.7%) 21 (30.4 ± 5.5%) > 0.05 3-6 5 (6.8 ± 2.9%) 33 (47.8 ± 6.0%) <0.001 > 6 0 (0 + 1.4%) 9 (13.0 ± 4.0%) <0.01

Claims (1)

A method for the prevention of relapse of the disease in patients with herpes simplex, which prescribes to patients in the inter-relapse period of the disease a complex of measures aimed at reducing the acidity of the skin and mucous membranes, including: a special diet that helps shift the pH of tissues and body fluids to the alkaline side, consumption of large amounts of drinking water - up to 3-4 liters per day, limiting the consumption of products with “acidifying” properties, salt and pickles, the exclusion of food vinegar and its products from holders, and also at a time of high risk of developing relapses of the disease, an additional daily oral administration of a 0.25% solution of citric acid sodium is added at 100 ml per hour for 10 hours, and every two weeks of anti-relapse measures, a break is prescribed for a duration of 5-7 days.