RU2353108C2 - Hot liquid fibrous product - Google Patents

Abstract

FIELD: chemistry, pharmacology. ^ SUBSTANCE: claimed invention relates to method of obtaining hot liquid fibrous product for enteral introduction, which can be successfully used for treatment and prevention of diet-sensitive disease states, for instance excessive body weight. Invention method includes mixing a. portion of recoverable composition, including (i) 0.1-75 g pectin, (ii) indigestible oligosaccharide with polymerisation degree more than 2 and fewer than 60 monose links and (iii) gas-excreting system, and b. liquid with temperature more than 35C. Product has low viscosity and does not contain aggregates (big lumps of fibrous material). Also described is product itself and its application. ^ EFFECT: improved taste characteristics. ^ 15 cl, 5 tbl, 9 ex

Description

FIELD OF THE INVENTION

The present invention relates to a method for producing a hot liquid fiber product, which can be used in a method for the treatment and / or prevention of diet-sensitive disease conditions, for example, overweight.

State of the art

Fiber-fortified drinks are used for several purposes, for example, for the treatment of diarrhea, obesity and as carriers of medications.

Stillman in US 6248390 describes a self-stabilizing, ready-to-use, practically tasteless and odorless liquid similar to water intended for human and animal consumption, consisting of safe water and a significant amount of one or more water-soluble dietary fibers. A mixture of water with fiber is intended for drinking or enteral nutrition, as such and / or in a mixture with other components. The liquid can be directly consumed in hot or cold condition, or at any temperature required to prepare / reconstitute drinks or a liquid food product from dry powder (for example, coffee, tea, concentrates such as “HAWALLAN PUNCH (R), frozen concentrates such like lemonade / orange juice, soups and pet food).

WO 02/096219 (Wolf et al.) Describes a method of attenuating a glycemic reaction caused by a meal by ingestion of a fibrous system whose viscosity is regulated by an acid. The first component of an induced viscosity fiber system is anionic soluble fiber. The second component of the fiber system with induced viscosity is water-insoluble, acid-soluble polyvalent cations.

Tarral et al. (WO 96/33694) describes pectin preparations containing at least one pectin associated with a complex composition that primarily contains an effervescent pair that readily disperses pectin in water, hydrates it and regulates the gel formation process regardless of the hardness of the water used as component of the suspension, and as a second component, the composition under consideration contains a mixture of compounds providing the presence of calcium ions necessary for gel formation in an acidic medium, as well as magnesium ions, Kinetic aspects of the availability of calcium.

WO 99/59542, Tarral et al. describes a pectin preparation used as a medicament for oral administration capable of gel formation in an acidic medium containing at least pectin with a methoxylation degree of more than 15% and calcium ions containing an inhibitor of the gelation process with a pH above 6.

The main disadvantage of the liquid fiber products described in the known publications is their unsatisfactory taste.

Summary of the invention

Known high fiber drinks can be prepared by the consumer by reconstituting a powder containing fibrous material in a suitable liquid, for example, water. However, the simple mixing of the fibrous powder is often associated with a number of problems, for example, the formation of aggregates (large pieces of material). Aggregate formation can be reduced by vigorous shaking or stirring. However, such an operation may lead to undesirable foaming of the beverage. In addition, the fiber drinks obtained by reconstitution with water often have undesirable taste properties, which, at least in part, may be associated with high viscosity and / or the presence of aggregates in this type of fiber-containing drinks.

The present inventors have found that palatability can be improved by incorporating a gas evolution system into a fiber-containing reconstitutable powder. However, it was found that in this case, the improvement of taste is not enough. Surprisingly, the inventors have found that the palatability (for example, the sensation in the mouth) of a fibrous beverage is significantly improved if the reconstituted mixture containing the fibrous material and effervescent additives is restored using hot water.

DETAILED DESCRIPTION OF THE INVENTION

In accordance with one aspect of the present invention relates to a method for producing a hot liquid fibrous product for enteral administration, comprising mixing:

but. means for restoring a composition comprising

(i) 0.1-75 g of fiber, and

(ii) gas evolution system

b. liquids with a temperature above 35 ° C

In accordance with another aspect, the present invention relates to a packaged reconstitutable composition provided with instructions for mixing the contents with a liquid having a temperature above 35 ° C, said composition comprising per unit dose:

(i) 0.1-75 g of fiber, and

(ii) gas evolution system

Terms

Used in the text of the invention, the term "fiber" or "ingested fiber" refers to carbohydrates that are digested by enzymes and acids present in the human digestive tract.

The term "soluble fiber" refers to fibers that are soluble in aqueous solutions, in particular to a fiber that is soluble in water.

The term “reconstitutable composition” is hereinafter abbreviated as RC. According to a preferred embodiment, the RCs are placed in a package, which is accompanied by instructions indicating the recipe for mixing RC with a liquid having a temperature above 35 ° C. The preferred package contains (written) instructions explaining the operation of mixing RC with a liquid having a temperature above 35 ° C.

Fiber

The preferred RC used in the method according to the invention contains 0.1-75 g of fiber per dosage. It has been found that a particularly good correlation between taste and functionality is achieved if the fiber is used in an amount of 0.25-35 g, especially in the case where the specified interval is 0.5-15 g, and especially in the case when the amount in question is 0.75-10 g per dose, particularly preferably 1-7 g.

A preferred fiber is a soluble material, more preferably a soluble, water-soluble material. A preferred fiber is selected from the group consisting of pectin, alginate, xanthan gum, carrageenan, mannan (robinia bean gum, cognac mannan, guar gum, tar tar), arabinan, xylan, galactan, β-glucan, chitosan, gelan gum, gum arabic sodium carboxymethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, tragant resin, low and high methoxylated pectin, psyllium and fructan; a more preferred group consists of low and high methoxylated pectin, xanthan gum, robinia bean gum, cognac mannan, guar gum, β-glucan and alginate. Pectin, especially low methoxylated pectin, is preferred. It is preferable to select a fiber from such a group that, when dissolved in an aqueous solution at pH 7, a high viscosity value is provided upon acidification of said liquid.

When one or more fibers selected from the group consisting of low- and high-methoxylated pectin, xanthan gum, robinia bean gum, cognac mannan, gaura gum, β-glucan and alginate are used, the packaging of the present liquid or reconstitutable composition preferably contains 0.1-25 g, more preferably 0.25-7 g, most preferably 0.5-4 g of the specified substance, or a combination of two or more of these fibers. Preferred RC contains 0.1-10 g, more preferably 0.25-5 g, most preferably 0.5-4 g of at least one resin selected from the group consisting of low and high methoxylated pectin, xanthan gum, bean gum robinia, cognac mannan, gaura resin, β-glucan and alginate, preferably pectin with a low degree of methoxylation.

A preferred RC contains 0.1-10 g, more preferably 0.2-7 g, most preferably 0.25-5 g of low methoxylated pectin and / or alginate per packaging.

A preferred fiber has an average molecular weight of at least 400 Da, most preferably at least 5000 Da, even more preferably at least 12000 Da, and most preferably at least 15000 Da.

Gas release system

In order to ensure proper fiber distribution in a hot liquid, not accompanied by significant aggregation, the reconstitutable system of the present invention includes a gas bubble emitting system. The content of such a system in RC is preferably limited in such a way as to prevent excessive release of gas bubbles.

The gas evolution system includes at least a carbon dioxide emitting base and / or an oxygen emitting base. A preferred gas evolution system includes a carbon dioxide emitting base when reacted with added hot water. The gas emitting system may be the only carbon dioxide emitting base. The preferred carbon dioxide emitting base is selected from the group consisting of potassium, lithium, sodium, calcium, ammonium carbonates, hemicarbonates, and hydrogen carbonates, L-lysine carbonates, arginine carbonates, sodium glycine carbonates, sodium amino acid carbonates, and combinations thereof. A preferred gas emitting system comprises a carbonate salt, more preferably a carbonate salt selected from the group consisting of sodium carbonate, potassium carbonate, calcium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, ammonium bicarbonate, sodium glycine carbonate, and combinations thereof. The use of only calcium carbonate may not provide a sufficient distribution of ingredients in hot water. Therefore, in accordance with a particularly preferred embodiment, the reconstituted composition of the invention comprises at least one salt selected from the group consisting of sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, ammonium bicarbonate, and sodium glycine carbonate; optionally mixed with calcium carbonate. The most preferred carbon dioxide emitting base comprises at least one bicarbonate salt, which is preferably selected from the group consisting of calcium bicarbonate, potassium bicarbonate and sodium bicarbonate.

The RC according to the invention preferably contains 0.05-10 g of base emitting carbon dioxide (preferably carbonate) per package, more preferably 0.1-5 g per package, even more preferably at least 0.2 g per package per package, most preferably 0.25-3 g per package.

The concentration of the base emitting carbon dioxide in RC is preferably 0.5-80 wt.%, More preferably 1-50 wt.%, Most preferably 2-40 wt.%.

Optimize the fiber: carbon dioxide base mass ratio is an important step to reduce foaming and agglomerate formation. According to a preferred embodiment, RC is characterized by a fiber: base weight ratio in the range of 100: 1-1: 10, more preferably 10: 1-1: 2, more preferably 10: 1-1: 1.

To facilitate distribution and further reduce aggregate formation, the composition of the present invention preferably comprises a carrier that prevents the formation of a gel mass from the fiber. Therefore, the preferred fiber content in the reconstitutable composition of the present invention is less than 90 wt.% Based on the dry weight of RC, more preferably less than 75 wt.%.

A preferred gas evolution system comprises a pair of effervescent elements including a carbon dioxide emitting base as well as an acid component. The term "acid component" refers to any compound or material that can serve as sources of proton and are capable of reacting with a base for releasing carbon dioxide.

The acid component can be characterized by more than one acid dissociation constant, i.e. contain several acidic functional groups. The acid component may be any organic or inorganic acid in its free form, in the form of an anhydride or an acid salt. According to a preferred embodiment of the invention, the acid component is a solid at room temperature, and the saturated solution of the acid component has a pH of 4.5 or lower at room temperature. The acid component may also be an alkali metal salt of the first acid component, which is a solid at room temperature (for example, sodium salt, potassium salt, etc.). As an acid component, it is desirable to use a compound that does not adversely affect animals, including humans.

As the acidic component, tartaric acid, citric acid, maleic acid, fumaric acid, malic acid, adipic acid, succinic acid, lactic acid, glycolic acid, alpha-hydroxy acids, ascorbic acid, amino acids and their alkali metal bicarbonates can be used. In the case of acidic substances such as phosphoric acid or pyrophosphoric acid, or other inorganic acids that are liquid substances at room temperature, alkali metal salts that are solids at room temperature can be used.

The acid component of the gas-emitting pair preferably contains a solid physiologically applicable acid selected from the group consisting of citric, tartaric, adipic, fumaric, maleic, malic, lactic and benzoic acid, as well as phosphonates, preferably phosphonates of citric, tartaric, adipic, fumaric or malic acid .

To reduce the degree of foaming in the present invention and to prevent the formation of a high viscosity liquid fibrous product when reacted with water, the gas evolution pair preferably contains limited amounts of an acid component, preferably less than 10 g, more preferably less than 5 g, even more preferably less than 2 g, and most preferably less than 1 g of the acid component in the package. A preferred RC of the present invention contains at least 0.025 g of an acid ingredient. The preferred content of the packaging of the acid component and the carbon dioxide emitting base is 0.05-10 g, preferably 0.1-5 g, more preferably 0.25-3 g of a carbon dioxide emitting base (eg, a bicarbonate salt); and 0.05-10 g, more preferably 0.1-5 g, even more preferably 0.5-3 g of an acid component (e.g. citric acid) per package.

Calcium

According to a particularly preferred embodiment of the invention, the RC comprises a calcium salt. The combination of calcium with a gel-forming fiber in the presence of calcium (e.g. low methoxylated pectin and / or alginate) provides good saturation, making the liquid fiber product particularly useful for treating and / or preventing diet-dependent conditions such as being overweight.

Typically, such fibrous products have a relatively high viscosity due to the gelling reaction between calcium and fiber. A known method of lowering the viscosity of a fibrous product is to use an insoluble calcium salt in a liquid with a neutral or high pH, wherein the insoluble calcium salt will dissolve as a result of a decrease in pH and / or increase in temperature. However, such products have an undesirable taste and, as a rule, high viscosity. In addition, fiber / calcium systems are not readily soluble. The use of hot water to improve solubility should be avoided, as this can lead to the formation of aggregates, possibly due to Ca-induced gelation.

The inventors of the present invention unexpectedly discovered that calcium / fiber systems can be used in the RC of the invention as a resulting fiber product having excellent mouthfeel and mouth feel. It has been found that the effervescent (gas-generating) system in RC extremely effectively prevents aggregate formation even when very hot water is used to dissolve the RC. According to a preferred embodiment, the present invention relates to an RC comprising low methoxylated pectin and / or alginate, a calcium salt and a second gas generating component. Mixing fiber, calcium and an additional gas-forming component with hot water leads to the formation of a fibrous product with an extremely low viscosity, which is possible due to the fact that the base emitting carbon dioxide neutralizes the acid component faster and disperses the fiber faster than when the water has room temperature.

The RC of the present invention contains a calcium salt, which is significantly less soluble in water at a temperature of 370 ° C and a pH value of the present composition than at a temperature of 370 ° C and a pH of less than 5. Consider the calcium salt present in the composition in an amount exceeding the maximum solubility, dissolves in the stomach as a result of an increase in pH and / or an increase in temperature. Thus, the concentration of calcium ions in the gastric environment increases, which automatically stimulates the gelation of pectin and / or alginate.

Due to the effect of induction of gelation under the influence of calcium ions, the concentration of the ions in the liquid mixture (at pH close to neutral) is preferably relatively low. The limited presence of (dissolved) calcium ions in the pH region close to neutral prevents the formation of a gel matrix, which can have a negative effect on the increase in viscosity. Thus, in accordance with a preferred embodiment of the invention, the solubility of calcium salts in the considered composition is less than 0.15, more preferably less than 0.1, even more preferably less than 0.06 g per 100 ml (demineralized water) at a temperature of 20 ° C. and pH 7.0.

Preferred calcium salts provide the dissolution of more than 0.05 g of calcium in 100 ml of water at a pH of less than 4 and at a temperature of 370 ° C, more preferably they provide the dissolution of 0.1 g of salts in 100 ml of water under these conditions. The solubility of calcium salt at pH less than 4 and at a temperature of 370 ° C is not limited to a specific value, however, it is usually 50 g of salt in 100 ml of water.

The calcium salt is preferably selected from the group consisting of calcium phosphate (e.g., tribasic, dibasic, monobasic or calcium pentatriphosphate), calcium carbonate, calcium sulfate, calcium oxide, calcium citrate (e.g. monocalcium citrate, or tricalcium citrate), calcium salt coated a substance having limited solubility in water at pH 7 and soluble at a pH below 5 (hereinafter referred to as such examples as “coated calcium salts”) or mixtures of these substances. Examples of coatings and methods for preparing coated calcium salts are described in WO 0038829, the full contents of this work being referred to in the present description.

More preferably, the calcium salt is selected from the group consisting of coated calcium salt, calcium carbonate, and mixtures thereof. Even more preferably, when 50 wt.% And 100 wt.% Of the calcium salt are calcium carbonate.

In order to ensure optimum gelling properties without significantly compromising the palatability of the liquid fiber product, RC preferably contains less than 10 wt.% Calcium salt, more preferably less than 5 wt.% Calcium salt, even more preferably less than 2.5 wt.% Calcium salt , most preferably less than 1 wt.% calcium salt based on the total weight of RC.

A single RC package preferably contains from 10 mg to 5 g, preferably from 25 mg to 2.5 g, even more preferably 0.50-1 g of calcium.

The liquid composition obtained by the method of the invention preferably contains at least 25 mg / L Ca. A preferred concentration of calcium exceeds 50 mg Ca / liter, a more preferred concentration exceeds 100 mg Ca / L, most preferably more than 150 mg Ca per liter. The preferred concentration of calcium in the composition should not exceed 15 g Ca / L, more preferably not higher than 5 g Ca / L, even more preferably not higher than 3 g Ca / L.

Liquid fiber product

The preferred viscosity of the liquid product obtained by the method according to the invention and / or from RC according to the present invention, providing advantages in the method for the treatment and / or prophylaxis of conditions depending on the diet, (for example, overweight) is less than 100 MPa, more preferably less than 50 MPa , even more preferably less than 25 MPa, even more preferably less than 10 MPa, most preferably less than 5 MPa at a shear rate of 10 ° C ^-1 . At pH 3 and a temperature of 370 ° C (at least part) of the product has a preferred viscosity of more than 200 MPa, more preferably higher than 500 MPa, most preferably more than 1000 MPa at a shear rate of 100 s ^-1 . The preferred viscosity of the composition at pH 3 and 370 ° C does not exceed 100,000 MPa at a shear rate of 10 ° C ^-1 .

The term “viscosity” as used herein refers to a physical parameter that can be determined using a Carri-Med rheometer. The test uses a conical geometric shape (6 cm acrylic cone, 2 °) with a gasket between the plate and a geometric configuration 55 microns thick. The linear speed of the continuous oblique shear was 0-200 s ^-1 for 30 seconds. The rheometer was thermostated at a given temperature value.

To determine the viscosity at acidic pH values (pH 3), a sufficient amount of a 1M HCl solution was homogeneously mixed (dropwise with very careful stirring for 20 seconds to prevent gel destruction) with the liquid composition in order to establish a pH of 3. After that, the composition was allowed to stand for about 10 minutes at 370 ° C. The composition thus obtained was used to determine the viscosity at pH 3, following the procedure described above.

The liquid fiber product obtained using RC is preferably used at a temperature above 35 ° C, even more preferably at a temperature of about 370 ° C or higher (for example, about 370 ° C).

The pH of the preferred liquid fiber product is greater than 3, more preferably greater than 4, even more preferably greater than 5, and most preferably greater than 6.

Recovery fluid

The present invention relates to a method comprising mixing a powder with a hot liquid. Used in the text, the term "hot" refers to a liquid with a temperature above 35 ° C, preferably to a liquid having a temperature of 370 ° C or higher. Preferably, the temperature of the liquid does not exceed its boiling point, i.e. for water, the temperature of the liquid should not exceed 100 ° C.

According to a preferred embodiment, the RC of the present invention is mixed with water having a temperature of 35-100 ° C, more preferably 50-100 ° C. The reconstituted packaged composition is provided with instructions for mixing the contents of the pack with a liquid having a temperature above 35 ° C, which does not necessarily indicate the exact temperature, and may refer to warm liquid, boiling water, boiling liquid, and the like. Such terminology usually refers to a liquid with a temperature of about 35 ° C or higher.

A preferred liquid miscible with RC has a pH above 3, more preferably above 4, even more preferably above 6. The liquid may be slightly salty since the gas emitting system is able to reduce the acidity of the liquid. The preferred pH of the reducing liquid is below 10, even more preferably below 8.

Oligosaccharide

If RC contains one of the above fibers, in particular a fiber selected from the group consisting of low or high methoxylated pectin, xanthan gum, robinia bean extract, cognac mannan, guar gum, β-glucan and alginate, it is preferable that the system additionally contained indigestible (non-digestible) oligosaccharide.

As used herein, the term “non-digestible oligosaccharide” refers to saccharides with a degree of polymerization of monose units exceeding 2, more preferably exceeding 3, most preferably exceeding 4, which are not digested or only partially digested in the intestine by the action of acids or digesting enzymes present in upper gastrointestinal tract (small intestines and stomach), but which are fermented by the intestinal flora.

The degree of polymerization of the oligosaccharide is less than 60 monose units, preferably less than 40, even more preferably less than 20, most preferably less than 10.

Suitable oligosaccharides are fermented by the intestinal flora. The oligosaccharides used in the composition of the present invention can significantly increase the content of cecal and / or colon intestinal SCFA.

Preferred oligosaccharides are selected from the group consisting of cellobiose (4-O-β-D-glucopyranosyl-D-glucose), cellodextrins ((4-O-β-D-glucopyranosyl) _n- D-glucose), B-cyclodextrins (cyclic molecules of α-1-4-linked D-glucose; α-cyclodextrin hexamer, β-cyclodextrin heptamer and γ-cyclodextrin octamer), indigestible dextrin, gentio-oligosaccharides (a mixture of β-1-6 linked glucose residues, and a certain amount of 1-4 bonds ), gluco-oligosaccharides (a mixture of α-D-glucose), isomaltooligosaccharides (linear α-1-6 linked glucose o stats with a certain amount of 1-4 bonds), isomaltose (6-O-α-D-glucopyranosyl-D-glucose); isomaltrioses (6-O-α-D-glucopyranosyl- (1-6) -α-D-glucopyranosyl-D-glucose), 6-O-α-D-glucopyranosyl- (1-6) -α-D-glucopyranosyl - (1-4) -D-glucose), leukemia (5-O-α-D-glucopyranosyl-D-fructopyranoside), palatinose or isomaltulose (6-O-α-D-glucopyranosyl-D-fructose), teanderoses ( O-α-D-glucopyranosyl- (1-6) -O-α-D-glucopyranosyl- (1-2) -B-D-fructofuranoside), D-agatose, D-lyxohexulose, lactosaccharose (O-β-D -galactopyranosyl (-1-4) -O-α-D-glucopyrazonyl- (1-2) -β-D-fructofuranoside), α-galactooligosaccharides, including raffinose, stachyose and other soy oligosaccharides (O-α-D-galactopyranosyl - (1-6) -α-D-g lucopyranosyl-β-D-fructofuranoside), β-galactooligosaccharides or transgalactooligosaccharides (β-D-galactopyranosyl- (1-6) - [β-D-glucopyranosyl] _n - (1-4) -α-D-glucose), lactulose (4-O-β-D-galactopyranosyl-D-fructose), 4'-galactosyllactose (OD-galactopyranosyl- (1-4) -O-β-D-glucopyranosyl- (1-4) -D-glucopyranose), synthetic galactooligosaccharide (neogalactobiosis, isogalactobiosis, galsurosis, isolactose I, II and III), Levant type fructans (β-D- (2 → 6) -fructofuranosyl) _n α-D-glucopyranoside), Iniline type fructans (β-D- ( (2 → 1) -fructofuranosyl) _n α-D-glucopyranoside),

1f-β-fructofuranosylnistose (β-D - ((2 → 1) -frutofuranosyl) _n BD-fructofuranoside), xyloligosaccharides (BD ((1 → 4) -xylose) _n , lactinoses, lactosaccharoses, arabinoligosaccharides and their combinations.

According to a preferred embodiment, the oligosaccharide is selected from the group consisting of fructans, fructooligosaccharides, indigestible dextrins, galactooligosaccharides, xylooligosaccharides, soy oligosaccharides, arabino oligosaccharides, gluco-oligosaccharides

RC preferably contains 0.1-100 g, more preferably 0.5-50, even more preferably 1-25 g of oligosaccharides per pack.

The liquid fiber product of the present invention comprises at least 0.1 wt.%, Preferably at least 0.2 wt.%, More preferably at least 0.5 wt.% And even more preferably at least 0.9 wt. % indigestible oligosaccharides. Although the use of significant amounts of oligosaccharides usually does not lead to undesirable effects, the composition of the present invention preferably contains oligosaccharides in an amount of less than 20 wt.%, More preferably less than 10 wt.%, Even more preferably less than 5 wt.%.

Taste qualities

Additional ingredients may be added to the formulation, for example, flavors, colorants, sweeteners, antioxidants, stabilizers and / or adjuvants.

Dosage

The term "dosage" refers to the part of the RC according to the invention, which (after recovery) is delivered or must be delivered to the body as a result of a single use. According to a particularly preferred embodiment, the RCs of the present invention are packaged as a set of dosages. RC can also be packaged in a tank containing several dosages, with instructions for separating a single dosage from the kit attached to the container. According to the present invention, to obtain an appropriate dosage, RC is preferably mixed with a liquid volume of 50-1000 ml, more preferably 100-500 ml, even more preferably 120-400 ml, most preferably 150-350 ml.

Liquid low calorie fiber product

According to a preferred embodiment, the present invention relates to a low calorie RC, whereby after mixing with hot water, a hot low calorie liquid fiber product is obtained. The fiber contained in the low calorie RC of the invention is preferably selected from the group consisting of low or high methyl pectin or alginate. Preferably, low methoxylated pectin is used.

One dose of low-calorie RC according to the invention preferably has an energy value of 0-200 kcal, more preferably 0-100 kcal, more preferably 0-50 kcal, most preferably 0-25 kcal, in particular 0-10 kcal.

The low calorie hot fiber fluid obtained by the method of the invention preferably contains 0-500 kcal / L. The liquid composition is characterized by a calorie content of less than 400 kcal / l, more preferably less than 250 kcal / l, most preferably less than 50 kcal / l, in particular less than 25 kcal / l.

The low calorie RC of the present invention preferably contains no more than a limited number of high-calorie ingredients. The composition of the present invention preferably contains:

- less than 5 wt.% protein based on the total weight of RC, preferably less than 1 wt.%, more preferably less than 0.1 wt.%; and / or

- less than 10 wt.% glycerides (i.e. tri-, di- and / or monoglycerides) and / or fatty acids based on the total weight of RC, preferably less than 1 wt.%, more preferably less than 0.1 wt.% ; and / or

- less than 50 wt.% digestible carbohydrates, preferably less than 5 wt.%, more preferably less than 0.5 wt.% based on the total weight of RC.

Hot drinks

It has been found that the RC of the invention can be used to prepare beverages that are usually consumed at elevated temperatures, such as, for example, tea, cocoa and coffee. Thus, RC may further include one ingredient selected from the group consisting of cocoa, recoverable coffee and recoverable tea. A preferred RC includes an ingredient selected from caffeine, theobromine and catechin.

Complete nutritional composition

The RC of the present invention can also be used in the form of powdered, reconstitutable, complete nutritional preparations, including carbohydrates and / or protein, optionally mixed with fat, used as baby food and medical food products. In this application, the RC is preferably mixed with a reducing liquid having a temperature of 35-370 ° C, more preferably 35-40 ° C.

According to a further preferred embodiment, the present invention relates to a composition comprising a protein in an amount of 1-25 g, preferably 2-15 g, more preferably 3-7 g per dose; digestible carbohydrates in an amount of 2-100 g, preferably 5-50 g, even more preferably 10-25 g per dose; fat in an amount of 1-25 g, preferably 2-20 g, more preferably 5-10 g; fiber and gas system.

The caloric content of one dose of the present composition is preferably 50-750 kcal, more preferably 75-500 kcal, even more preferably at least 100 kcal, more preferably 100-250 kcal.

Tasty food

Strengthening the beverage with fiber, in particular saturating fibers, does not improve the palatability of the product. In addition, the authors of the present invention found that some of the gas emitting agents have a salty aftertaste. At least part of these problems can be solved using the present invention. It was found that the taste of the product can be further improved if the product has a “salty” taste, for example, when the fiber-gas-emitting agent system is combined with soup or broth. Therefore, the present invention also provides a (packaged) reconstitutable salt product containing fiber and a gas evolution system, for example low methoxylated pectin and / or alginates; calcium and gas vapor.

According to a preferred embodiment, the present invention relates to a recoverable (e.g., low-calorie) soup or broth product comprising a system of the invention comprising a fiber and a gas-generating component. Thus, an additional aspect of the invention relates to RC, further comprising sodium chloride and / or glutamate. The preferred content of sodium chloride is 0.05-25 g, more preferably 0.1-10 g, even more preferably 0.4-5 g per dose; and / or 0.05-5 g, preferably 0.1-2 g glutamate per dose.

A preferred salt composition includes at least one component selected from the group consisting of meat flavoring (e.g., chicken, beef, pork), fish flavoring, vegetable flavoring (e.g., tomato, mushroom, carrot, onion for flavoring the soup) and yeast extract.

In addition, salty foods can be used in a method of reducing or preventing conditions associated with a diet such as being overweight.

Treatment

The present invention also relates to a method for treating or preventing a condition of a mammal associated with a reaction to a diet. The term “dietary condition” refers to any disease or physical condition that may be caused or result from the consumption of proteins, carbohydrates or fats. The RC of the invention can be used to produce a hot liquid product that can be used in a method of treating and / or preventing a condition selected from the group consisting of diabetes, overweight, high cholesterol (eg, hypercholesterolemia), diarrhea, and coronary heart disease .

The method according to the invention is particularly suitable for the (prophylactic) treatment of obesity, since a decrease in appetite associated with the use of a liquid fiber product obtained by the method according to the invention usually leads to a decrease in body weight, a decrease in weight gain or a decrease in fat production.

Another useful effect of this method is its use to suppress fluctuations in blood glucose levels, which is especially beneficial for patients with diabetes. Suppressing fluctuations in blood glucose, in particular “peaks” in glucose, is also very useful for obese people, since the gradual absorption of carbohydrates usually leads to less fat formation than with the rapid absorption of the same amount of carbohydrates.

Thus, a hot liquid fibrous product, in particular low-calorie, fiber-reinforced compositions containing low methoxylated pectin and / or alginates; calcium and a gas-releasing component can be successfully used in a method for the treatment and / or prevention of overweight and diabetes, the method comprising administering to a single-chamber stomach mammal a liquid fiber product that can be easily obtained from a reconstitutable powder and / or using invention.

The term "overweight" refers to body weight and / or adipose tissue mass that exceed the desired body weight and / or the desired adipose tissue mass. Obese mammals with a single chamber stomach are considered overweight. The method according to the invention can be particularly successfully used in people with a body mass index above 25. Thus, the method in question can be used to reduce adipose tissue mass or to prevent fat loss and increase the ratio between lean mass and fat mass and / or muscle mass and fat mass .

The method of the invention can be used to treat and prevent overweight in therapy and / or in cosmetic treatment or prophylaxis, i.e. to reduce weight.

The liquid fiber product obtained by the method of the invention and / or RC reduction can be successfully used in a method of reducing appetite in humans, the method being considered in humans using the above-described composition in an amount that reduces appetite. The method according to the invention is preferably used for the prevention or treatment of overweight people, especially when used on young men and children, for example, in the treatment and / or prevention of childhood obesity. The liquid fiber product of the present invention can be successfully used to induce a saturation state, and this method involves the use of the above composition in humans.

In addition, the liquid fiber product of the invention reduces the consumption of meat calories when the product in question is consumed immediately before or during meat consumption. Thus, the present invention also provides a method of reducing meat calorie intake in order to prevent excess calorie intake in meat consumption and / or regulate daily calorie intake, the method contemplated in humans using an effective amount of the above liquid fiber product immediately before or during meat consumption products (during breakfast, breakfast, replacing the first and second breakfast, lunch, hearty dinner with tea or lunch).

According to a further preferred embodiment, the RC is accompanied by instructions and / or instructions describing the use of the liquid composition in the case of a dietary condition. Directions or instructions can be given in any form, for example, in the form of a text indicating to the consumer the way to achieve the intended goal. In the case when the drug is intended to reduce weight, the product may have a name that indicates the way to achieve the goal, for example, “slim water”, “low-calorie drink”, “light soup”, “warm and light; warm & slim "," hot and lean "; hot & lean ”,“ lean drink ”, etc. In addition, pictures and drawings can be used that draw the consumer's attention to the purpose of the product, for example, “slim”, “figure”, “balance”. Preferred indications are selected from the group consisting of alphabetic indications, numerical indications, color indications, graphic indications and combinations thereof.

EXAMPLES

Example 1: Viscosity of Low Calcium Pectin-Calcium Beverage

The reconstitutable powder containing the ingredients shown in Table I (with flavoring and color additives) was mixed in 300 ml of water at a temperature of about 70 ° C or 20 ° C. After that, the viscosity of the resulting mixture was determined. The hot drink had a low viscosity and good taste (Table II).

Table I
Ingredients of Single Dosage of reconstituted powder Ingredient Weight Pectin Genu LM 2.0 g CaCO ₃ 0.25 g Dextrose 4.0 g Apple acid 0.4 g Lemon acid 0.30 g NaHCO ₃ 1.25 g KHCO ₃ 1.49 g Acesulfame-K 0.015 g Sucralose 0.04 g

Table II
Viscosity and pH of a liquid product prepared from a reconstitutable powder of Table I Temperature Viscosity pH 20 ° C 16.5 MPa 6.9 70 ° C 3.1 MPa 7.8

Example 2: Viscosity of Low Calorie Pectin Drink

The reconstitutable powder having the composition shown in Table III (with flavoring and color additives) was mixed in 300 ml of water at a temperature of about 70 ° C or 20 ° C. After that, the viscosity of the resulting mixture was determined. The hot drink had a low viscosity and good taste (Table IV).

Table III
Ingredients of a single dose of reconstituted powder: Ingredient Weight Pectin Genu LM 2.0 g CaCO ₃ 0.25 g Dextrose 4.0 g Apple acid 0.4 g Lemon acid 0.30 g NaHCO ₃ 0.68 g KHCO ₃ 0.98 g Acesulfame-K 0.015 g Sucralose 0.04 g Table IV
Viscosity and pH of a liquid product prepared from a reconstitutable powder of Table I Temperature Viscosity pH 20 ° C 40 MPa 6.7 70 ° C 3 MPa 7.2

Example 3: Viscosity of Low Calorie Pectin Drink

The gas formulation of Example 2, further containing 2 g of Fibersol 2 ^TM (Matsutani Chemical Industry Co., Japan).

Example 4: Gas-Release Baby Composition

The reconstitutable baby food powder was mixed with one liter of warm water at a temperature of about 370 ° C. Portions of 100-250 ml in volume can be taken from the recovered liquid.

Table v
The formula in accordance with the concentrations according to the invention per liter of nutritional composition Ingredient Amount / liter Protein 13.0-20.3 g Fat 24.0-38.2 g Carbohydrate 70.0-110 g Calcium 510-910 mg Phosphorus 390-600 mg Magnesium 50-100 mg Chloride 420-575 mg Iron 8-16 mg Zinc 5-8 mg Copper 500-1000 mcg Iodine 100-510 mcg Manganese 34-510 mcg Vitamin A 20000-3800 IU Vitamin D 400-500 IU Vitamin E 20-26 IU Vitamin K 55-200 mcg Vitamin C 60-200 mg Thiamine 405-4100 mcg Riboflavin 610-2000 mcg Pyridoxine 400-800 mcg Vitamin B _-12 1.7-6 mcg Niacin 7-15 mg Folic acid 100-275 mcg Pantothenic acid 3-7.5 mg Biotin 30-150 kg Taurine 45-70 mg Carnitine 35-60 mg Choline 50-202 mg Inositol 30-100 mg Low methoxyl pectin 0.5-10 g NaHCO ₃ 1-5 g Lemon acid 1-6 g KHCO ₃ 1-5 g

Example 5: Effervescent baby formula

The effervescent formula for children according to example 3, in which the low methoxylated pectin is replaced by 1-10 g of xanthan gum.

Example 6: Effervescent baby formula

The effervescent baby formula according to example 4, additionally containing 0.5-5 g of calcium carbonate.

Example 7: Low-calorie broth for weight loss (one serving)

A Bovril ^™ Instant Bouillon Powder sachet with instructions for mixing contents with boiling water, containing: edible salt, sodium monoglutamate, reconstituted beef powder, hydrolyzed vegetable protein, caramel, sugar, modified corn starch, yeast extract, spices, flavoring, mono- and diglycerides in combination with 2 g of Pectin Genu LM, 0.25 g of CaCO ₃ , 0.5 g of citric acid, 1.25 g of NaHCO ₃ and 1.49 g of KHCO ₃ .

Example 8: Low-calorie tea for weight loss (one serving)

Tea powder sachet, equipped with instructions for mixing with 200 ml of vaporous water, containing:

Calcium carbonate (125 mg), low methoxylated pectin (1000 mg), oligosaccharides (2000 mg), water-soluble extract of Ilex paraquariensis (400 mg), water-soluble black tea extract (300 mg), water-soluble Red Bush extract (400 mg), citric acid ( 50 mg), malic acid 350 mg, 0.11 g NaHCO ₃ and 0.17 g KHCO ₃ .

Example 9: Fiber Reinforced Food

A powder composition with instructions for mixing the contents with 200 ml of hot water, comprising:

10 g Stimulance ^TM (Nutricia, The Nederlands)

0.30 g of citric acid

1.25 g NaHCO ₃

1.49 g of KHCO ₃ .

Claims (15)

1. A method of obtaining a hot liquid fibrous product for enteral administration, comprising mixing:
a) servings of a reconstitutable composition comprising
(i) 0.1-75 g of pectin;
(ii) a non-digestible oligosaccharide with a degree of polymerization of more than 2 and less than 60 monose units and
(iii) a gas evolution system; and
b) liquids with a temperature above 35 ° C. 2. The method according to claim 1, wherein the non-digestible oligosaccharide is selected from the group consisting of fructans, fructo-oligosaccharides, non-digestible dextrins, galactooligosaccharides, xylooligosaccharides, soya oligosaccharides, mango-oligosaccharides, 3. The method according to claim 1 or 2, in which the restored composition further comprises a calcium salt. 4. The method according to claim 1 or 2, in which the volume of liquid is 50-1000 ml. 5. The method according to claim 1 or 2, in which the fiber is a low methoxylated pectin. 6. The method according to claim 1 or 2, in which the gas evolution system comprises at least one carbon dioxide emitting base selected from the group consisting of sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, ammonium bicarbonate and sodium glycine carbonate. 7. The method according to claim 6, further comprising an acidic ingredient selected from the group consisting of citric, tartaric, adipic, fumaric, malic, lactic, acetic, maleic and benzoic acids, as well as phosphates. 8. The method according to claim 1 or 2, in which the recoverable composition further comprises NaCl and / or glutamate. 9. The method according to claim 1 or 2, in which the resulting liquid fibrous product has a pH of more than 4. 10. The method according to claim 3, in which the reconstituted composition contains a calcium salt with a solubility of less than 0.15 g per 100 ml of water at 20 ° C and a pH of 7, which provides more than 0.05 g of dissolved calcium per 100 ml of water at a pH below 4 and a temperature of 370 ° C., wherein the obtained liquid product (i) has a viscosity below about 100 mPa · s and (ii) when acidified to pH 3, shows a viscosity above about 250 mPa · s. 11. A hot liquid fibrous product with a viscosity of less than 100 mPa · s, with a pH above 4 and a temperature of at least 35 ° C and a viscosity of at least 250 mPa · s when acidified to pH 3, said product comprising (i) calcium salt with a solubility of less than 0.15 g per 100 ml of water at 20 ° C and pH 7, which provides more than 0.05 g of dissolved calcium per 100 ml of water at a pH below 4 and a temperature of 37 ° C, (ii) 0 , 1-75 g of fiber per serving, (iii) indigestible oligosaccharide with a degree of polymerization of monose units of more than 2 and less than 60. 12. The use of the product according to claim 11 in the manufacture of a composition for the treatment and / or prophylaxis of a disease state, depending on the diet, in a mammal with a single chamber stomach. 13. The use according to claim 12, in which the disease state, depending on the diet, is overweight. 14. A packaged reconstitutable composition provided with instructions for mixing one or more doses of the reconstituted composition with a liquid having a temperature of more than 35 ° C, wherein a dose of said composition includes:
(i) 0.1-75 g of pectin;
(ii) a non-digestible oligosaccharide with a polymerization degree of monose units of more than 2 and less than 60; and
(iii) a gas evolution system. 15. The packaged reconstitutable composition of claim 14, wherein:
ingredient (i) contains 0.5-15 g of low methoxylated pectin;
ingredient (iii) contains 0.01-25 g of a carbon dioxide emitting base, preferably selected from the group consisting of sodium carbonate, potassium carbonate, calcium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, ammonium bicarbonate and sodium glycine carbonate;
and the composition further comprises
(iv) 0.025-5 g of an acidic ingredient, preferably selected from the group consisting of citric, tartaric, adipic, fumaric, malic, lactic, acetic, maleic and benzoic acids, as well as phosphates and (v) 0.05-5 g of calcium .