RU2339045C2 - Method of prediction and estimation of state of health of human body - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: carry out the analysis of biochemical indicators of blood serum on aspartattransaminase (AST), alaninetransaminase (ALT), to level of the general protein, urea, a glucose and cholesterol, gammaglutamiletransferase (GGT) in metabolic communication between them. At first estimate level AST, then - ALT, on their parity define metabolism type. Comparison to level of the general fiber defines intensity of synthesis or disintegration of substances of an organism. On urea level define a limit of processes of disintegration of substances in an organism or its safety factor. On protein/urea parity define depth of catabolic shifts, on level of GGT define deficiency of amino acids of an organism, on glucose level characterise depth of pathological and physiological disturbances, definition of level of cholesterol supplements an estimation of a state of health and characterises all metabolism as a whole. On the sum of concentration of cholesterol and glucose define degree of a harmony of changes and convertibility of shifts as a whole an organism.

EFFECT: increase of accuracy of statement of the diagnosis; forecasting and an estimation of a state of health of a human body.

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Description

FIELD OF THE INVENTION

The invention relates to medicine and veterinary medicine, in particular to methods for predicting and assessing the state of the human and animal organism and can be used in assessing blood biochemical parameters.

State of the art

A known method for predicting human health, in which the period of change in health is defined as the product of time from the moment of collection of urine or blood to the moment of a sharp change in the dependence of the content (concentration) of ammonia in it, multiplied by a coefficient from 1 to 1000 depending on the storage temperature of urine or blood and a method of compensating for an evaporating liquid with prediction of an early period (T ₁ - a slow increase in the concentration of ammonia in a biologically active liquid), significant (T ₂ - a sharp p skeleton of concentration) and a sharp deterioration (T ₃ - decrease in concentration to 0) of the state of health (see RF patent No. 2140634, class G01N 33/48).

The disadvantage of this method for predicting human health is the inaccuracy of prediction.

There is a method for predicting the development of delta-virus superinfection in patients with chronic diffuse liver diseases, which consists in predicting the possibility of the development of delta-virus superinfection by examining peripheral blood lymphocytes of tissue antigens of the HLA system and the presence of HLA-B8, B35 or their combinations , and in the presence of HLA - B 18 - resistance to it (see RF patent No. 20066863, CL GO1N 33/53).

The disadvantage of this forecasting method is the inaccuracy of forecasting and diagnosis.

The closest in technical essence to the achieved positive effect and adopted by the authors for the prototype is a method for predicting and assessing the health status of the human body, including the analysis of biochemical parameters of blood serum by aspartate transaminase (ACT), alanine transaminase (ALT), the level of total protein, urea, glucose and cholesterol , gamma-glutamyltransferase (GGT), with the ACT norm ranging from 0 to 40 IU / L, ALT from 0 to 20 IU / L, the level of total protein from 65 to 86 g / L, urea from 5.0 to 6, 0 mmol / l, cold sterol from 5.0 to 5.5 mmol / l and GGT from 0 to 100 IU / l (see Norm in medical practice (reference guide), compiled by Litvinov A.V. M: Medpress, 1999, p.1 -144).

The disadvantage of this forecasting method is the inaccuracy of forecasting.

Disclosure of invention

The objective of the invention is to develop a method for predicting and assessing the health status of the human body, with an accurate diagnosis and assessment of the health status of the human body, which consists in assessing the biochemical parameters of blood serum in the metabolic relationship between them.

The technical result that can be obtained using the present invention is reduced to the accuracy of diagnosis, prediction and assessment of the health status of the human body.

The technical result is achieved using a method for predicting and evaluating the health status of a human body, including the analysis of biochemical parameters of blood serum by aspartate transaminase (ACT), alanine transaminase (ALT), total protein, urea, glucose and cholesterol, gamma glutamyl transferase (GGT), and the norm is ACT located in the range from 0 to 40 IU / l, ALT - from 0 to 20 ME / l, the level of total protein from 75 to 86 g / l, urea - from 5.0 to 6.0 mmol / l, glucose from 5, 0 to 5.5 mmol / l, cholesterol from 5.0 to 5.5 mmol / l and GGT from 0 to 100 IU / l, at This prediction and assessment of health is carried out according to the biochemical parameters of blood serum in a metabolic relationship between them, and the type of metabolism, substances are determined by the ACT / ALT ratio, and in combination with the level of total protein, the rate of synthesis or decomposition of the body’s substances is determined, the limit of processes is determined by the urea the breakdown of substances in the body, the level of GGT determines the deficiency of amino acids in the body, and the level of metabolism is determined by the level of glucose in combination with cholesterol, the degree of harmony is changed and reversibility of shifts in the whole organism.

The essence of the method for predicting and assessing the health status of the human body is to analyze the biochemical parameters of blood serum by aspartate transaminase (ACT), alanine transaminase (ALT), total protein, urea, glucose and cholesterol, gamma glutamyl transferase (GGT), and the ACT norm is in the range from 0 to 40 IU / l, ALT - from 0 to 20 IU / l, total protein level from 75 to 86 g / l, urea - from 5.0 to 6.0 mmol / l, glucose - from 5.0 to 5.5 mmol / L, cholesterol from 5.0 to 5.5 mmol / L and GGT from 0 to 100 IU / L, with prediction and assessment of Health is carried out according to the biochemical parameters of blood serum in a metabolic relationship between them, the stages of which are as follows:

- Ranking of parameters according to the level of activity of LBF: LBF is a serum enzyme whose values are in the range from 0 to 2500 IU / L under various conditions. It characterizes the thermogenesis and febrile state of the body.

- Determination of the ratio of AST / ALT to establish the type of metabolism. The ratio of the two enzymes allows us to assess the state of the processes of decay and synthesis in the whole organism.

- Assessment of the level of total protein (hard range from 75 to 86 g / l): a change in the above enzymes is necessary to maintain the level of total protein as it is the main parameter of physical and physiological well-being. The body is trying in various ways to compensate for the decrease in any parameter. Total protein along with glucose is one of its most important indicators, but not urgent, but delayed in nature. Two transamipases are involved in maintaining the level of total protein: (AST and ALT) and GTT. At the cellular level, each of these enzymes plays a coordinating role in metabolism, and therefore in maintaining the optimal level of total protein.

- The level of urea (5.0-6.0 mmol / L) is necessary to assess the intensity of catabolism and depends on the ratio of transaminase activity (AST / ALT)

- Calculation of the ratio of protein / urea allows you to calculate the depth of catabolic shifts.

- Comparison with the level of GGT activity (0-1500 IU / L) allows us to determine the intensity of tissue borrowing of proteins.

- Determination of glucose level (5.0-5.5 mmol / l) characterizes the depth of pathological and physiological disorders.

- Determining the level of cholesterol (5.0-5.5 mmol / l) supplements the assessment of the state of health and characterizes the entire metabolism as a whole.

- The summation of glucose and cholesterol is necessary to determine the degree of harmony of changes and reversibility of shifts.

- Conclusion.

The implementation of the invention

Examples of specific performance of the method for predicting and assessing the health status of the human body.

Example. An analysis of the biochemical parameters of blood serum of 9 patients.

The usual single analysis is not a prognostic indicator, since it is fragmentary, not algorithmized according to the laws of metabolic relations, arbitrary due to various technical equipment, material security and professional readiness.

According to the invention, the determination of biochemical parameters of blood serum (hereinafter blood) in the metabolic relationship between them is as follows.

- ACT (asparttransaminase) is an enzyme defined in the blood. The doctor who prescribed a biochemical blood test for ACT, based on the activity of this enzyme alone (in IU / L), currently only judges the presence of pathology - heart damage. In accordance with the invention, increased ACT activity is not only a marker of heart damage, but in 99% of cases it indicates the degree of catabolism of healthy people, the level of thermogenesis of healthy people, and also the presence of a febrile state of diverse origin (far from only cardiac). Therefore, the assessment of ACT in the blood (in combination with other biochemical parameters, also prescribed by the doctor) during the implementation of the method contributes to 1) the removal of false diagnoses; 2) getting rid of iatrogenic; 3) a judgment on the real level of the patient’s metabolism and its protective and compensatory forces; 4) the possible cancellation of a number of expensive potent pharmacological drugs.

It is proposed (as the first stage of the analysis) the ranking of parameters according to the ACT activity level: ACT is an enzyme of blood serum whose values are in the range from 0 to 2500 IU / L under various conditions. - ALT (alanine transaminase) is an enzyme defined in the blood. Doctor. who prescribed a biochemical blood test for ALT, according to the activity of this enzyme alone (in IU / L), at present, it only judges the presence of pathology - liver damage. In accordance with the invention, the increased ALT activity is not only a marker of liver damage, but in 99% of cases it indicates the degree of anabolism of practically healthy people, the level of gluconeogenesis (normal glucose synthesis from non-carbohydrates) in practically healthy people. Therefore, the assessment of ALT in the blood (in combination with other biochemical parameters, for example, ACT, also prescribed by a doctor) when implementing the proposed method contributes to: 1) the removal of false diagnoses (for example, toxicosis); 2) getting rid of iatrogenic; 3) a judgment on the body's ability to maintain glucose levels - the most important vital indicator; 4) the possible abolition of a number of expensive and potent pharmacological drugs.

They use (as the 2nd stage of the analysis) the obligatory determination of the ALT activity level: ALT is a serum enzyme whose values fall within the range from 0 to 3500 IU / l under various conditions.

- Determination of the ratio of AST / ALT to establish the type of metabolism. The ratio of the two enzymes allows us to assess the state of the processes of decay and synthesis in the whole organism.

- Assessment of the level of total protein (hard range from 75 to 86 g / l): a change in the above enzymes is necessary to maintain the level of total protein, since it is the main parameter of physical and physiological well-being. The body is trying in various ways to compensate for the decrease in any parameter. Total protein along with glucose is one of its most important indicators, but not urgent, but delayed in nature. Two transaminases (ACT and ALT), as well as GGT, are involved in maintaining the level of total protein. At the cellular level, each of these enzymes plays a coordinating role in metabolism, and therefore in maintaining the optimal level of total protein.

- The level of urea (5.0-6.0 mmol / l) is necessary to assess the intensity of catabolism and depends on the ratio of transaminase activity.

- Calculation of the ratio of protein / urea allows you to calculate the depth of catabolic shifts.

- GGT (gammaglutamyltransferase) is an enzyme detected in the blood. The doctor who prescribed a biochemical blood test for GGT by the activity of this enzyme alone (in IU / L) currently only judges the presence of pathology - cholestasis or alcoholism (alcoholic cirrhosis of the liver). In accordance with the invention, increased GGT activity is not only a marker of cholestasis or alcoholic liver damage, and in 99% of cases it indicates the degree of amino acid deficiency in tissues sometimes in healthy people, as well as the intensity of interorganic transport of amino acids in healthy and sick people ( not only with hepatic pathology or a defect in the biliary tract). Therefore, the evaluation of GGT in the blood (in combination with other biochemical parameters, also prescribed by a doctor), when implementing our approach, will contribute to: 1) the removal of false diagnoses; 2) getting rid of iatrogenic; 3) a judgment on the real level of the patient's protein metabolism and its protective-compensatory forces; 4) the possible abolition of a number of expensive potent pharmacological drugs; 5) qualified non-pharmacological correction of conditions of almost any genesis. The range of GGT activity is 0-1500 IU / L. The indicator allows you to find out the intensity of tissue borrowing of proteins (amino acids) with a decrease in the level of protein and glucose in the blood.

- Determination of glucose level (5.0-5.5 mmol / l) characterizes the depth of pathological and physiological disorders.

- Determining the level of cholesterol (5.0-5.5 mmol / l) supplements the assessment of the state of health and characterizes the entire metabolism as a whole. The normal cholesterol level is 5-6 mmol / l, not more, but not less, or 120-160 mg%. The sum of the two terms: “cholesterol concentration” and “glucose content” in the blood is a rigid biological constant. In healthy people, it is 10 mmol / L. Under conditions of the most powerful energy deficiency (for example, with alcoholism or prolonged fever), reciprocity (conjugation) of these two terms is triggered: a decrease in glucose leads to an increase in cholesterol or vice versa, but subject to a constant dozen. In traditional clinical practice, increased attention is paid only to high cholesterol, primarily because of fear of atherosclerosis. A deficient cholesterol is not even considered, moreover, it is considered a prognostically favorable factor. In fact, low cholesterol is no less dangerous and indicates serious metabolic disturbances.

- The summation of glucose and cholesterol is necessary to determine the degree of harmony of changes and reversibility of shifts.

- Conclusion.

Table 1 gives an example of sets of biochemical analysis of blood serum of 9 patients, in table 2 - a differentiated approach to the analysis of biochemical parameters of blood serum in the metabolic relationship between them, and in table 3 - analysis of biochemical parameters in alcoholism.

Table 1 Patient number ACT ALT Coeff. de Ritis GGT Urea Total Protein / Albumin Cholesterol Glucose Cholesterol + Glucose Creatinine one 447 297 1.51 300 4.05 60/41 53 3.5 8.8 79 2 114 56 2.01 204 3,55 66/40 5.3 3.2 8.5 70 3 196 137 1.43 435 2.27 62/43 5.0 3.7 8.7 72 four 319 168 1.78 Q9 4.14 74/47 3.7 4.5 8.2 77 5 266 93 2.86 681 3.96 89/36 3,1 4,5 7.6 58 6 193 77 2,5 377 2.67 80/33 2.9 6.1 9.0 64 7 191 one hundred 1.91 191 4.72 62/35 5.4 5.0 10.4 71 8 165 143 1.15 350 1.01 72/43 5,4 5,0 10,4 71 9 125 85 1.47 95 4.82 77/47 5,4 5,0 10,4 79 table 2 Patient number ACT ALT Coeff. de Ritis GGT Urea Total Protein / Albumin Cholesterol Glucose Cholesterol + Glucose Creatinine Patients "deficient" in glucose one 447 297 1.51 300 4.05 60/41 5.3 3.5 8.8 79 2 114 56 2.01 204 3,55 66/40 5.3 3.2 8.5 70 3 196 137 1.43 435 2.27 62/43 5.0 3.7 8.7 72 Patients "deficient" in cholesterol four 319 168 1.78 749 4.14 74/47 3.7 4.5 8.2 77 5 266 93 2.86 681 3.96 89/36 3,1 4,5 7.6 58 6 193 77 2.5 377 2.67 80/33 2.9 6.1 8.7 64 Patients with normal cholesterol glucose 7 191 one hundred 1.91 191 4.72 62/35 5.4 5.0 10.4 71 8 165 143 1.15 350 1.01 72/43 5,4 5,0 10,4 71 9 125 85 1.47 95 4.82 77/47 5,4 5,0 10,4 79

The total level of cholesterol and glucose in the blood of the first six patients (No. 1, 2, 3, 4, 5, 6) is reduced, it is less than 10. In patients No. 1, No. 2 and No. 3, the decrease was due to glucose: it is below normal (below 5.0 mmol / l), and cholesterol is within normal limits (5.0-5.3 mmol / l). And in patients No. 4, No. 5 and No. 6, the low total value is mainly associated with low cholesterol (2.9-3.7 mmol / L in comparison with the norm of 5-6 mmol / L). And only in patients No. 7, No. 8 and No. 9 that “ten” (10.4 mmol / L) was obtained as a result of summing the cholesterol and glucose content. An analysis of their blood shows that both of these indicators individually are also within normal limits.

Thus, three groups of patients emerged:

As can be seen from the table divided into three parts, clinically almost “identical” patients differ significantly in their biochemical parameters. The first three patients (No. 1-3) are characterized by severe hypoglycemia, which means the need for therapy to increase (normalize) glucose levels: intravenous administration of glucose with insulin. In this case, hypoglycemia is one of the links in the entire pathogenetic chain of a particular disease.

The second three patients (No. 4-6) with hypocholesterolemia need: 1) an additional study in the form of a detailed clinical blood test with a leukocyte formula, since this condition should be accompanied by a decrease in lymphocytes and other white blood cells, as well as red blood cells; 2) careful monitoring of symptoms of hypocorticism - a lack of stress hormones produced by the adrenal cortex, as an indicator of the phase of exhaustion.

And only the third group of patients (No. 7-9) is not the object of great concern for the highest priority biochemical indicators due to the sufficiency of glucose and cholesterol levels in the optimal combination (10.4 mmol / l). Although it should be remembered that these patients remain ill, the pathogenesis of their disease is different from that of the first two groups. It is possible that they are in a phase of resistance to the stress factor that caused the disease. Therefore, patients No. 7-9 are most adapted and their condition is more favorable prognostically.

Algorithm for biochemical analysis performed by a physician.

When a doctor receives a complete biochemical analysis from the laboratory, he should be able to read it, that is, analyze it from the point of view of the specific metabolism of a particular patient, and not with the help of a template of generally accepted standards. And of course, do not rush to make a diagnosis of "a lesion based on enzyme diagnostics." The presence and variability of enzymes in the blood was created by nature not to indicate the affected area, and not to make a diagnosis by a doctor, but, first of all, to maintain a person’s health, to maintain homeostasis, to ensure the best adaptation to the conditions of existence, to create optimal conditions for development. In other words, fermentemia is biologically feasible precisely because of its functional variability.

ACT METABOLISM INTEGRATOR MARKER OF THE CENTRAL CATABOLISM ZONE INDICATOR OF POLITICAL MECHANISM OF CYTOLYSIS ALT Glucose-Alanine Shunt Component MARKER OF THE PERIPHERAL ZONE OF CATABOLISM AST / ALT METABOLIC ADAPTATION INDICATOR STREAMS GGT MARKER OF MALIGNIZATION Intoxication Marker ALLERGIZATION MARKER ONTOGENETIC MATURITY MARKER AMINO ACID PUMP IN CELLS ANTIGENIC COMPONENT

The normal cholesterol level is 5-6 mmol / L, not more, but not less. Or 120-160 mg%. The sum of the two terms: “cholesterol concentration” and “glucose content” in the blood is a rigid biological constant. In healthy people, it is 10 mmol / L. Under conditions of the most powerful energy deficiency (for example, with alcoholism or prolonged fever), reciprocity (conjugation) of these two terms is triggered: a decrease in glucose leads to an increase in cholesterol or vice versa, but subject to a constant dozen. In traditional clinical practice, increased attention is paid only to high cholesterol, primarily because of fear of atherosclerosis. A deficient cholesterol is not even considered, moreover, it is considered a prognostically favorable factor. In fact, low cholesterol is no less dangerous and indicates serious metabolic disturbances.

The invention in comparison with the prototype and other known technical solutions has the following advantages:

- accuracy of diagnosis;

- prediction and assessment of the health status of the human body, is to assess the biochemical parameters of blood serum in the metabolic relationship between them.

Claims (1)

A method for predicting and assessing the health status of a human body, including the analysis of serum biochemical parameters for aspartate transaminase (ACT), alanine transaminase (ALT), total protein, urea, glucose and cholesterol, gamma glutamyl transferase (GGT), characterized in that predicting and evaluating health carried out on the biochemical parameters of blood serum in a metabolic relationship between them, while first assessing the level of ACT, then ALT, then by their ratio determine the type of metabolism, Moreover, the AST / ALT ratio of more than 1.2 indicates a catabolic type of enzyme, from 0.8 to 1.2 - an intermediate type of enzyme, and less than 0.8 - an anabolic type of enzyme, a comparison with the level of total protein determines the intensity of synthesis or decomposition of substances of the body, considering the optimal level of total protein from 75 to 86 g / l, and the level of urea determines the limit of the processes of decomposition of substances in the body or its margin of safety, the ratio of protein / urea determines the depth of catabolic shifts, the level of GGT is determined by the amino acid cyt of the body, according to the glucose level, characterizes the depth of pathological and physiological disorders, determining the level of cholesterol complements the assessment of the state of health and characterizes the entire metabolism as a whole, while the sum of the concentrations of cholesterol and glucose, which in the blood of healthy people is 10 mmol / l, is determined degree of harmony of changes and reversibility of shifts in the whole organism.