RU2337679C1 - Method of endothelial vessel recovery in persons with arterial hypertension associated with metabolic syndrome - Google Patents

Abstract

FIELD: medicine; haematology.

SUBSTANCE: for endotheliocytemia correction patient with arterial hypertension (AH) and metabolic syndrome (MS) is prescribed with long-term (not less than four months) multimodality therapy consisting of low-calorie diet, graduated static and dynamic physical activity and medicines Lisinopril dosed 10 mg in the morning, Rosuvastatin dosed 20 mg in the evening and Oligovit dosed 1 pill 3 times a day.

EFFECT: method allows for normalisation of endothelial vessel lining in patients with arterial hypertension associated with metabolic syndrome.

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Description

The invention relates to medicine, namely to hematology, cardiology and endocrinology.

As a prototype of the application, we can consider a method of restoring the endothelial lining of blood vessels in the treatment of arterial hypertension in patients with metabolic syndrome, including an individually selected hypocaloric diet and administration of an ACE inhibitor (Chazova I.E. et al. Metabolic syndrome. - M .: Media Medica, 2004, part 53-55, 121-127).

In preparing the application, the applicant authors found that patients with arterial hypertension with metabolic syndrome (n = 215) have pronounced endotheliocythemia on average 29.1 ± 0.15 cells / μl as a result of exfoliation of endotheliocytes from the vessel wall and exposure of subendothelial structures (elastin fibers collagen, fibronectin, etc.). This is largely due to the weakening of DNA repair in endotheliocytes (repair index 0.78 ± 0.07) - the correlation coefficient between endotheliocythemia and the repair index r = -0.68 and an increase in fragility of chromosomes in the endotheliocytes secreted from the bloodstream - the number of cells with chromosomal aberrations 2 , 57 ± 0.02 per 100 cells, the number of chromosomal aberrations 2.73 ± 0.04 per 100 cells, the number of chromosomal fragments 1.99 ± 0.02 per 100 cells, the number of exchanges 0.38 ± 0.07 per 100 cells , the number of single chromosome fragments 0.99 ± 0.07 per 100 cells, the number of paired fra genes 0.99 ± 0.05 per 100 cells, the number of chromosome exchanges 0.21 ± 0.02 per 100 cells, the number of chromatid exchanges 0.20 ± 0.02 per 100 cells (the correlation coefficient between the level of endotheliocythemia and fragility indices of chromosomes in endotheliocytes from 0.63 to 0.71).

Some positive effect of physical training and statins on vascular endothelium is known in patients with coronary heart disease (Galenko N.I. et al. Methods of non-pharmacological and pharmacological correction of endothelial dysfunction. // PHARMindeks-Praktic. - 2006, No. 10, website: www. pharmindex.ru/practic/10_cardio.html).

Patients of different categories are often prescribed multivitamin preparations.

However, never before a treatment complex consisting of a hypocaloric diet, dosed physical activity and drugs lisinopril, rosuvastatin and oligovit was not used in patients with arterial hypertension (AH) with metabolic syndrome (MS) in order to normalize the endothelial lining of blood vessels.

The aim of the invention is to develop a method of stabilizing the endothelial lining of blood vessels in patients with arterial hypertension in the metabolic syndrome.

The essence of the proposed method is that for the correction of endotheliocythemia in patients with hypertension with MS, a treatment complex is prescribed for a long period of time (at least four months), consisting of a hypocaloric diet, dosed static and dynamic physical activity, and lisinopril 10 mg in the morning, rosuvastatin 20 mg in the evening and oligovit 1 tablet 3 times a day.

The inventive method is as follows.

Determination of the level of endotheliocythemia in patients with hypertension in MS is carried out according to M. (1999) (Zaynulina M. S. Determination of blood endotheliocytes. In the book. Hemostasis. Physiological mechanisms, principles for the diagnosis of the main forms of hemorrhagic diseases. St. Petersburg, 1999. - pp. 72-73). The principle of the method is based on the isolation of endothelial cells together with platelets, followed by their precipitation by ADP. Venous blood in volumes of 4-5 ml is collected in test tubes. As a stabilizer, a 3.8% sodium citrate solution is used at a ratio of 1: 9. Platelet plasma is obtained by centrifugation (1000 rpm / min, 10 min). Platelets are precipitated by adding ADP (at the rate of 0.4 ml of a solution of 1 mg / ml ADP per 1 ml of supernatan), stirring the mixture for 10 min, followed by centrifugation (1000 rpm, 10-15 min). The platelet-free plasma is carefully separated from the deposited platelets and re-centrifuged (1000 rpm, 20 min). The resulting supernatant is drained and 0.1 ml of 0.9% NaCl is added to the precipitate, the precipitate is carefully separated with a glass rod from the walls and bottom of the tube. Counting the number of endothelial cells is carried out in two grids of the Goryaev chamber. The normative values are 1-2 cells / μl. With an increase in endotheliocythemia, patients with MS are prescribed the proposed treatment complex.

To create a negative energy balance in the body of patients, they are recommended an individually selected hypocaloric diet.

The caloric content of the daily diet individually for each patient with MS is calculated in kcal according to the formula:

for women 18-30 years old (0.0621 × body weight, kg + 2.0357) × 240,

31 years - 60 years (0.0342 × body weight, kg + 3.5377) × 240,

over 60 years old (0.0377 × body weight, kg + 2.7545) × 240,

for men 18-30 years old (0.0630 × body weight, kg + 2.8957) × 240,

31 years - 60 years (0.0484 × body weight, kg + 3.6534) × 240,

over 60 years old (0.0491 × body weight, kg + 2.4587) × 240.

The resulting coefficient remains unchanged with minimal physical activity, multiplied by 1.3 for moderate and 1.5 for high physical activity (as a rule, in patients with MS the level of physical activity is low).

3 main meals and 2 intermediate meals are recommended. With the regular skipping of one of the main meals, the frequency of obesity increases significantly, a positive correlation between obesity and skipping breakfast is also revealed. The following daily calorie distribution is recommended: breakfast - 25%, 2nd breakfast - 10%, lunch - 35%, afternoon tea - 10%, dinner - 20%.

To compile the patient’s menu, special tables are used with indications of the chemical composition and calorie content of the products, given that the main sources of energy are proteins (1 g contains 4 kcal), fats (9 kcal), carbohydrates (4 kcal) and alcohol (7 kcal).

The second component of the proposed method is feasible regular physical training.

In real life conditions, it is possible to carry out three forms of physical activity: 1) morning hygienic gymnastics (exercise); 2) therapeutic and preventive gymnastics; 3) fractional physical exercises throughout the day.

1. Morning hygienic gymnastics (exercise).

Morning exercises should be done after sleep before breakfast in a ventilated room. Under the influence of classes, the body is freed from the state of inhibition of physiological processes that occurs during sleep.

The sequence of exercises involves alternating the load on various muscle groups (arms, legs, body). Exercises are performed with a gradually increasing excursion of breathing, stretching, limited use of force conditions. The breathing during exercises should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhalation (inhalation 2-3 s, exhale 3-5 s).

With good health, the load can be strengthened by the number of repetitions, speeding up the pace, increasing the amplitude of movements and reducing pauses between exercises.

With fatigue, you should reduce the load, increase the duration of pauses between exercises, fill them with calm breathing.

After gymnastics, you need to go to a wipe or take a shower.

Morning exercises should cause a sense of vitality, increased activity, better health and performance.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum, you should temporarily interrupt classes and consult a doctor.

During the day, patients with MS are recommended preventive gymnastics. Depending on the initial training, it is possible to use at the beginning of a lightened version of physical activity, and subsequently a strengthened version.

2. Complexes of therapeutic and preventive gymnastics for persons suffering from MS.

2.1. A lightweight version of therapeutic gymnastics.

Exercise 1. Standing. Walking is calm with a gradual acceleration and deceleration of 1-2 minutes. During the exercise, a gradual deepening of breathing.

Exercise 2. Circular movements in the shoulder joints. When breeding - inhale, while mixing - exhale with a slight tilt of the body and retraction of the abdominal wall - 6-8 times. Fingers touch shoulders, elbows pressed to the body.

Exercise 3. Standing, hands on the belt. Alternately transferring the severity of the body from one leg to the other with slight bending of the legs in the knee joint, without taking the feet off the floor. Do the exercise 10-16 times with muscle tension in the legs.

Exercise 4. Standing, legs spaced shoulder width apart, hands on the belt. Torso forward, touch left sock with your right hand. 4-6 times alternately. When the position is straightened, inhale; when tilted, exhale. Looking forward.

Exercise 5. Standing, arms along the torso. At the same time, take straight arms and one leg to the sides with alternating leg abductions. 4-6 times in each direction alternately. A wave of arms and legs, breathing free, do not hold.

Exercise 6. Standing, legs to the sides, hands in front of the chest, palms down. With the turn of the body, spread your arms to the sides with the turn of the palms up - inhale. Return to the starting position with a slight tilt of the body forward - exhale. 3-5 times in each direction alternately. Coordinate breathing with the movement of the body and hands. By the end of the exhalation, retract the wall of the abdomen.

Exercise 7. Standing, hands free. Walking freely - 1 min, then with high flexion of the hips - 10-20 movements, followed by a transition to a quiet walk - 1-2 minutes. Rhythmic breathing, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. Bending back and bending forward of the body. Repeat 6-10 times. Do not hold your breath.

Exercise 9. Sitting on the edge of the chair, focus with tassels on the edge of the chair, and with your feet somewhat in front of the chair. Squats with an emphasis on the edge of the chair - 4-6 times. When squatting, exhale.

Exercise 10. Standing sideways to the back of the chair, hold on to it with one hand. Swing your free straight arm with your legs back. Return to starting position. Repeat 4-6 times with each hand and foot. Do not hold your breath.

Exercise 11. Standing, legs apart, arms at the waist. Turns the body to the right and left - 6-10 times alternately. Do not turn your head, look forward.

Exercise 12. Standing, legs together, arms down. To spread your arms to the sides - inhale, bend your leg at the knee and press your hands to your stomach - exhale. 3-5 times each leg in turn. Strive to maintain balance; as you exhale, draw in your stomach.

Exercise 13. Standing, legs together, arms down. Lateral slopes of the body with bending of the opposite arm ("pump"). Do not hold your breath, strive for a greater excursion of movement.

Exercise 14. Standing. Walking is calm with uniform breathing of medium depth, 1-2 minutes.

Exercise 15. Lying on a rug with a pillow placed under the head. Go to the half-sitting position and hug the bent hips - exhale, return to the starting position - inhale. Do not hold your breath. Strive in a half-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying, arms to the sides, legs apart. Semicircular movements with the right straight leg to the left with the turn of the pelvis - exhale - return to the starting position - inhale. 3-5 times in each direction. Alternately left and right with the greatest possible excursion of the leg movement, while maintaining the emphasis of the hands on the floor.

Exercise 17. Sitting on the floor; a) get on all fours; b) move to a kneeling position; c) raise your hands up - inhale, tilt the body, and take your hands back - exhale. When tilting, belly retract. Repeat 4-6 times; e) move to a standing position, and the son-in-law to a lying position; f) self-massage of the abdomen with small semicircular movements in a clockwise direction - 1-2 minutes. Rest 2 min; g) calm breathing; h) exercise in protruding (calm) and retracting (active) the abdominal wall. Combine abdominal retraction with expiration through the mouth. Repeat 4-6 times.

Exercise 18. Standing, arms bent. Vigorous walking on the spot or in a room with high flexion of the hips and waved arms - 20-30 steps. Do not hold your breath.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of the chair. Circular movements of the pelvis with retraction of the abdomen when the pelvis is brought back. 4-6 times in each direction.

Exercise 20. Standing. Calm walking with breathing of an average depth of 2-3 minutes.

With the initial sufficient training or exercise tolerance arising during the classes, the following set of exercises can be used.

2.2. A reinforced version of therapeutic gymnastics.

Exercise 1. Standing. Walking calm with rubbing the palms of the chest, abdomen, lower back. It takes 1-2 minutes.

Exercise 2. Standing, arms down. Simultaneous bending with tension and free “throwing” of arms forward, to the sides and up 12-16 times. When bending, exhale; when leveling, inhale.

Exercise 3. Standing, arms at the waist, legs shoulder width apart. Lateral movements of the pelvis to the right and left, back and forth. It is performed 6-10 times alternately. Breathing is free.

Exercise 4. Standing, feet shoulder width apart, arms down. Circular movements of straight arms in the shoulder joints, 6-10 times with maximum excursion, do not hold your breath.

Exercise 5. Standing, arms in front of the chest, bent at the elbows. Walking with high flexion of the hips, with the touch of hands. 6-10 times each leg in turn. The movements are vigorous, while flexing the thigh - exhale through the mouth.

Exercise 6. Walking calm 1-2 minutes.

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bending of the body. The exercise is performed 8-10 times. The movements are energetic. When straightening, inhale; when bent, exhale.

Exercise 8. Standing sideways to a chair, hold on to the back, the other hand at the waist. Alternating swings with a straight leg forward with the greatest possible excursion. Leg sweep combined with exhalation. It is carried out 4-6 times.

Exercise 9. Standing, legs apart, arms to the sides. Tilts the body forward with a touch of the right brush of the left toe of the foot, the other hand is pulled up. Return to starting position. Combine the slope with the exhale, while straightening, inhale 4-6 times.

Exercise 10. Walking calm with breathing of medium depth, 1-2 minutes.

Exercise 11. Standing, hands in a fist and lowered: a) bending the arms at the elbows with force and unbending them with the back, with the greatest possible straightening and tension and a delay in tension for 2-3 seconds. Standing, hands on the waist; b) half-squats, followed by lifting on toes and straining the legs. The exercise is performed 4-6 times with the greatest possible rectification and tension and a delay in the stress state for 2-3 seconds.

Exercise 12. Sitting on the edge of a chair. In the position of the leg raised and bent at the knee joint, alternately shake the tibia and thigh muscles with the hands. Reduce muscle tension, 1-2 minutes.

Exercise 13. Sitting on the edge of the chair, straight legs divorced. Breeding and mixing straight arms and legs. When breeding, inhale, while mixing, exhale. It is carried out 4-8 times.

Exercise 14. Standing. Walking is calm with the transition to a rhythmic calm run (jogging) in place or with movement. If tired, go for a walk with moderate breathing, 2-5 minutes.

Exercise 15. Lying on the mat. Simultaneous lifting of the body and legs on the exhale, 4-6 times. Arms and legs straightened, keep balance.

Exercise 16. Lying on the mat, emphasis with brushes on the floor. Cross movement with straight legs - “scissors”, 4-8 times. Do not hold your breath.

Exercise 17. With a quick straightening of the legs, move to a sitting position, then lie down. You can help with a wave, 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breath 4-6 times.

Exercise 19. Lying on your back, arms spread apart with the emphasis of the hands on the floor. With a turn of the pelvis to the left, bend the legs, turn the pelvis with crossed legs to the right and stretch the legs. Repeat such circular movements with legs 3-6 times in each direction alternately. Do not tear your hands off the floor. Do not hold your breath.

Exercise 20. Lying on your back, arms and legs apart. Alternate turns of the body to the right and left with the laying of one hand on the other. Do not move your legs. With arms apart, inhale, while turning, exhale. It is carried out 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) turn on the right side; c) go to the supine position; d) get on your knees; e) move to a standing position; f) walking in a place with high hip flexion and arm movement - 20-30 steps; g) sit on the mat; h) lie on your back, calm breathing. Repeat the whole complex 3-4 times.

Exercise 22. Standing. Walking calm with breathing of medium depth - 1-2 minutes.

Exercise 23. Standing, legs spaced the width of the foot, hands on the waist. Circular motion of the pelvis to the right and left 6-8 times. Do not hold your breath.

Exercise 24. Standing with legs wide apart, hands in front of the chest. Alternately bending the leg with the transfer of body weight to it with stretching the arms to the toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - inhale, while tilting - exhale.

Exercise 25. Standing, legs spaced shoulder width apart, arms at the waist. Circular head movements 4-10 times in each direction.

Exercise 26. Standing, legs spaced shoulder-width apart, arms at the waist. Tilt the body to the right, pulling the left hand up - inhale. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same, arms to shoulders. Circular movements of the hands with a maximum excursion in the shoulder joints, when breeding - inhale, while reducing and retracting the walls of the abdomen - exhale. The breath is deep.

Exercise 28. Standing. Calm walking and breathing of medium depth. Decrease in the general load, 1-2 min.

3. Fractional exercise throughout the day.

A patient with MS is a patient with a number of concomitant disorders and, above all, the cardiovascular system. This circumstance limits the simultaneous use of great physical activity in the process of morning gymnastics, as well as in the main occupation of therapeutic and prophylactic gymnastics. That is why an increase in the physical activity of people suffering from MS should be carried out by distributing physical activity in small doses throughout the day. This method of increasing the physical activity of patients with MS should be considered as a fractional load method.

Depending on the real life conditions of patients with MS suffering from various degrees of abdominal obesity, various exemplary fractions of various loads can be recommended to increase physical (motor) activity throughout the day.

Option 1.

Exercise 1. Sitting - spread your elbows to the sides - inhale, stretch your arms forward with tension - exhale, 4-6 times.

Exercise 2. Sitting - stand up with the deflection of the body and sit down - 8-10 times.

Exercise 3. Sitting - an imitation of the movements of a boxer with a possibly large rotation of the body - 10-12 times.

Option 2

Exercise 1. Standing - walking with high hip flexion - 16-30 times.

Exercise 2. Standing - circular movements of the head to the right and left - 3-8 times in each direction.

Exercise 3. Standing - legs spread apart - imitation of the movement of the pigtail - 10-12 times.

Exercise 4. Sitting - transition to a standing position - 10-12 times.

Option 3

Exercise 1. Walking is calm - 1 min.

Exercise 2. Walking accelerated - 1 min.

Exercise 3. Walking with a high flexion of the hips and alternate wave of hands 20-30 times.

Exercise 4. Walking calm with breathing - 1-2 minutes; the run is calm on the spot or with movement around the room - 2-5 minutes.

Option 4

Walking walk of various extent.

Option 5

Physical labor in various versions and of various durations depending on the conditions (cleaning the premises, home maintenance, work on cleaning the territory, garden works, etc.).

In addition to individually selected non-drug treatment, hypertensive patients with MS should be prescribed lisinopril 10 mg in the morning, rosuvastatin 20 mg in the evening and oligovit 1 tablet 3 times a day.

The method allows to normalize the stabilization of the endothelial lining of blood vessels in patients with MS for four months, translating it to a level characteristic of healthy people. Subject to the subsequent recommendations of the proposed method, it is possible to maintain stabilization of the endothelial lining of the vessels in optimal mode, which will significantly reduce the risk of thrombotic complications, reduce the number of cases of temporary disability, speed up and improve the quality of inpatient treatment, reduce disability, and also extend the life and reduce mortality of patients with MS from heart attack and stroke.

Example 1. Patient T., 50 years old, with metabolic syndrome 5 years. During the examination, blood was taken and revealed high endotheliocythemia (36 cells / μl), indicating a risk of hemostasis activation and the development of thrombosis. In a patient with endothelial cells, DNA repair (repair index 0.77) was reduced with an increase in the fragility of chromosomes in the endothelial cells released from the bloodstream - the number of cells with chromosome aberrations of 2.59 per 100 cells, the number of chromosomal aberrations of 2.74 per 100 cells, the number of chromosomal fragments 1.99 per 100 cells, the number of exchanges 0.39 per 100 cells, the number of single chromosome fragments 0.99 per 100 cells, the number of paired fragments 1.02 per 100 cells, the number of chromosomal exchanges 0.22 per 100 cells, the number of chromatid exchanges 0.22 per 100 cells OK.

For stopping endotheliocythemia and stabilizing the endothelial lining of the vessels in a patient with hypertension with MS for 4 months. a complex of an individually selected hypocaloric diet, dosed physical activity, lisinopril 10 mg in the morning, rosuvastatin 20 mg in the evening and oligovita 1 tablet 3 times a day was prescribed. After 4 months the patient is examined again. The level of endotheliocythemia was 2 cells / μl, which indicated the stabilization of vascular endothelium and the exclusion of the risk of thrombosis. At the same time, the level of DNA repair in endotheliocytes was normalized (a repair index of 0.94 with normalization of the level of chromosomal aberrations, the number of cells with chromosomal aberrations of 1.03 per 100 cells, the number of chromosomal aberrations of 1.02 per 100 cells, the number of fragments of 1.37 per 100 cells , the number of exchanges of 0.13 per 100 cells, the number of single fragments of 0.52 per 100 cells, the number of paired fragments of 0.42 per 100 cells, the number of chromosome exchanges of 0.07 per 100 cells, the number of chromatid exchanges of 0.06 per 100 cells) . The patient was recommended to follow these recommendations.

Observation of the patient subsequently did not reveal a recurrence of increased endotheliocythemia.

Example 2. Patient F., 59 years old, with a metabolic syndrome of 12 years. During the examination, blood was taken and revealed high endotheliocythemia (25 cells / μl), indicating a risk of hemostasis activation and the development of thrombosis. In a patient with endotheliocytes, DNA repair was weakened (repair index 0.76) and chromosome fragility was increased - the number of cells with chromosomal aberrations of 2.58 per 100 cells, the number of chromosome aberrations of 2.80 per 100 cells, the number of chromosome fragments of 2.02 per 100 cells, the number of exchanges 0.42 per 100 cells, the number of single chromosome fragments 1.05 per 100 cells, the number of paired fragments 1.00 per 100 cells, the number of chromosome exchanges 0.24 per 100 cells, the number of chromatid exchanges 0.25 per 100 cells.

For stopping endotheliocythemia and stabilizing the endothelial lining of the vessels of a patient with hypertension with MS for 4 months. a complex of an individually selected hypocaloric diet, dosed physical activity, lisinopril 10 mg in the morning, rosuvastatin 20 mg in the evening and oligovit 1 tablet 3 times a day are prescribed. After 4 months the patient was examined again. The level of endotheliocythemia was 1 cell / μl, which indicated the stabilization of vascular endothelium and the exclusion of the risk of thrombosis. The DNA normalization index was 0.96 in the patient and the number of endotheliocytes with chromosomal aberrations of 1.03 per 100 cells, the number of chromosomal aberrations of 1.09 per 100 cells, the number of fragments of 1.36 per 100 cells, the number of exchanges of 0.11 per 100 cells, the number of single fragments of 0.52 per 100 cells, the number of paired fragments of 0.43 per 100 cells, the number of chromosomal exchanges of 0.07 per 100 cells, the number of chromatid exchanges of 0.05 per 100 cells. The patient is recommended to adhere to these recommendations and further.

Observation of the patient subsequently did not reveal a recurrence of increased endotheliocythemia.

Claims (1)

A method of restoring the endothelial lining of blood vessels in individuals with arterial hypertension with a metabolic syndrome, characterized by the use of an individually selected hypocaloric diet, rationally dosed static and dynamic physical activities and drugs lisinopril 10 mg in the morning, rosuvastatin 20 mg in the evening and oligovit 1 tablet 3 times a day for 4 months.