RU2319476C2 - Medicinal device - Google Patents

Abstract

FIELD: pharmacology.

SUBSTANCE: device has cap with capsule; preparations are placed inside case-envelope of cap. Bushing is put onto case. Second capsule is disposed in bushing. Second capsule contains preparation being poor compatible with preparations from first capsule. Both preparations are supposed to be taken together. Capsules with bushing are fastened to cases by fixing rings 10. Silver coating and marking are applied onto device from outside. A, C, E, B1, microelements as iodine, selenium, fluoride and probiotics or their spores are introduced into material of envelopes-cases, caps and bushing.

EFFECT: comfort at storage and simultaneous reception of poor compatible preparations.

2 cl, 6 dwg

Description

The medicinal device relates to the field of pharmacology.

The medicinal device is a capsule containing a shell - a container for powdered, granular, pasty or liquid medicinal substances. Capsules come with gelatin, polymer and starch membranes. Their main purpose when taken orally is to mask the unpleasant taste and smell of the medicine. Gelatin capsules have become popular because of the high accuracy of dosage of drugs in them, the latter are well protected from light, air, moisture. Capsules are well swallowed, aesthetic in appearance, quickly swell, dissolve and absorb in the gastrointestinal tract. The pharmacological effect of drugs appears within 4-5 minutes. Gelatin capsules may contain all substances that do not interact with glycerin and gelatin and do not dissolve gelatin. The disadvantage of gelatin capsules is their high sensitivity to moisture, an excellent medium for the reproduction of microorganisms. The latter is prevented by adding preservatives to the gelatin mass: nipagin (0.1%), nipazole (0.4%), sorbic acid (0.1-0.2%).

Gelatin capsules are flexible and can be filled with the necessary medication at the pharmacy at the request of a doctor. The polymer capsules are smaller, but solid, and the preparations in them are produced only by the factory. Now the factory production of encapsulated drugs is significantly predominant. If it is necessary to protect capsules (medicinal substances) from the effects of gastric acid or to dissolve and absorb the drug only in the intestine, they are impregnated with formaldehyde vapor (possibly in a pharmacy), or acid resistance and resistance to enzymes of the gastric juice are provided by factory technology. Encapsulation allows you to hide the unpleasant taste or smell of the drug, to remove or dramatically reduce the ulcerative effect of the drug on the gastric mucosa. Capsules with a multicomponent composition have a commercial name that is used when they are prescribed (nitroglycerin, essentiale, vitamin E), see the textbook, Vinogradov V.M., Katkova EB, Mukhin EA "Pharmacology with the recipe." SPb., SpetsLit, 2000, pp. 40-41.

The disadvantages of such devices are the inability to place drugs that are poorly compatible with each other in one capsule, such as analgesics with analeptics, the inconvenience of use in extreme conditions (at night, fighting for soldiers of extreme risk), and the insufficient therapeutic effect of the capsules.

The closest solution is the capsule device indicated in the textbook for students of medical institutes D. Kharkevich "Pharmacology", "Medicine", 1993, S. 521-523. The capsule is a shell for metered powdery, pasty, granular and liquid medicinal substances used inside. Capsules are divided into soft or elastic, hard, with caps. Soft and hard gelatin capsules have a spherical (pill), ovoid or oblong shape and contain 0.1-0.5 g of medicinal substances. Capsules with caps are cylinders open on one side and rounded from the closed end, freely entering one another, without forming gaps. To obtain gelatin capsules that are resistant to the action of gastric juice and disintegrating in the intestines, they are treated with vapors of a formaldehyde solution or its alcohol solution. The composition of the shell-case of gelatin capsules includes the following components: gelatin, glycerin, water - these are the main components. In addition, sugar syrup, sorbitol (plasticizer) can be introduced into the shell.

The disadvantages of the above devices are the lack of effectiveness of the therapeutic effect when using capsules with various drugs, the inconvenience of using them under extreme conditions, at night, military, climatic conditions, the inability to place drugs that are poorly compatible with each other, in the same package if they are taken inside.

The technical result of the proposed solution is to increase the effectiveness of therapeutic, protective and antiseptic properties when used in field, night, combat, i.e. in extreme conditions, increasing the effectiveness of the drug effect for severe injuries, injuries, infections by simultaneously taking several capsules with drugs that are poorly compatible with each other when stored in one place.

This result is achieved by the fact that in a medicinal device containing a capsule with a cap or a pill, provided with medicines inside the shells made in the form of shells, a sleeve is put on the capsule or pill housings with an additional capsule placed inside it with a cap or pill filled inside their bodies with other drugs that are poorly compatible during storage with drugs placed in the first capsule or pill, but used at the same time, while caps caps or part of the pill’s case renewed on the outside of the coupling and secured on their housings with locking rings in the joint with the coupling, on the outside the device is coated with a layer of silver and marked with a fluorescent substance on the coupling, and vitamins A 1500-6500 ME, E 2.5-200 are introduced into the material of the shells of the capsules or pills of the coupling ME, B1 - thiamine - 1.5 mg, C 10-100 mg, trace elements - iodine from 50 to 150 μg, selenium from 8 to 70 μg, fluorine from 0.2 to 1.0 mg and probiotics or their spores - up to 35 mg

The essence of the solution is expressed in the aggregate of essential features sufficient to achieve the technical result provided by the solution.

The essential features of the device, which coincide with the known features of the prototype, are: the presence in the medicinal device of a capsule with a cap or pill, provided inside their bodies, made in the form of shells, with drugs.

The salient features of the proposed solution are: A - a sleeve is put on the capsule or pill body with an additional capsule placed inside it with a cap or pill, filled with other drugs inside their bodies that are poorly compatible when stored together with the drugs placed in the first capsule or pill, but consumed simultaneously; B - capsule caps or a part of pill cases is installed outside the coupling and the latter is fixed to the cases with retaining rings in joint with caps; B - caps with a sleeve on the outside are covered with a layer of silver; G - on the coupling marked with a fluorescent substance; D - vitamins are introduced into the material of the shells of capsule cases or pills and couplings - A - 1500-6500 ME, E 2.5-200 ME, C 10-100 mg, B1 - thiamine 1.5 mg, microelements - iodine from 50 to 150 mcg, selenium from 8 to 70 mcg, fluorine from 0.2 to 1.0 mg and probiotics or their spores - up to 35 mg.

A particular distinguishing feature is E - one or more pills can be placed between the capsules or pills inside the sleeve.

The medicinal device contains a capsule 1, Fig. 1, with a cap 2, provided with a medicine 4 inside the case made in the form of a capsule 3 shell 3, a sleeve 5, a sleeve 5 is put on, inside which a second capsule 6 is placed, the case 7 of which with a cap 8 of such the same sizes as the previous case 3 and the lid 2 of the first capsule 1. In the case 7 of the second capsule 6 there are other drugs 9. The coupling 5 on the cases 3 and 7 is fixed in joint with the caps 2 and 8 with the help of fixing rings 10 - a melted gelatin tape or polyvinyl alcohol. On a single complex of sleeve 5 with caps 2 and 8, worn on the housings 3 and 7, a silver layer is applied on the outside 11. A sleeve 5 is also marked on the sleeve 5 with fluorescent substance 12, for example, sodium fluorescein, an orange dye that glows brightly in the dark when illuminated green color. Vitamins, for example, Vitamin A from 1500 to 6500 ME, E from 2.5 to 200 ME, C from 10 to 100 mg, B1 - thiamine 1.5 mg, trace elements such as iodine from 50 to 150 are introduced into the material of the shells of the capsule bodies and couplings mcg, selenium from 8 to 70 mcg, fluorine from 0.2 to 1.0 mg and probiotics or their spores - up to 35 mg.

The medicinal device can also be made in the form of two pills (spherical capsules) 13 and 14, figure 2, placed in the sleeve 15 and fastened on the outside also with fixing gelatin rings 16.

Depending on the amount of drugs and vitamins, the device can be supplemented with one or more pills 17, Figs. 3, 4, 5, 6, placed in their couplings 18, 19, 20, 21.

Cases made in the form of shells, capsules and pills, caps, couplings are made of one material - gelatin according to one technology on standard equipment. And because Since the coupling is the same shell as the covers, only without the back, the economic costs of its manufacture are very small. Such drug devices with capsules and pills are a single complex due to the locking rings connecting the capsule or pill housing with the sleeve.

When using such a combined capsule in extreme conditions (night, combat, climatic) for fighters of extreme risk, you need to choose a combination of capsules with certain medications. For example, in case of injuries, injuries, it is necessary to quickly reduce pain, i.e. take a narcotic analgesic, for example, morphine, and at the same time it is necessary to take analeptic (opiate antagonist), because the patient may be in serious condition, for example, a medicine such as naltrexone, in order to cause a stimulating effect on the central nervous system, as opposed to that obtained when taking analgesics (narcotic substances), which, on the contrary, inhibit the central nervous system. When analgesics and analeptics are in the same capsule or pill, it is undesirable, because when stored together, they are poorly compatible with each other. And since in extreme nighttime conditions it’s hard to figure out where a particular medicine is, then thanks to the labeling with a fluorescent substance that glows in the dark, you can accurately find the right combination of drugs. In extreme conditions (climatic), far from sterile, a combined medicinal device with several capsules or pills connected by their couplings, covered with a layer of silver, gives it the bactericidal property and reduces microbial effects.

In addition, for the prevention of the occurrence of infectious diseases with the long-term presence of injured people and rescuers in the centers of emergency situations, which are usually accompanied by massive human losses and, as a result, the occurrence of a focus of infection, antibiotics are used in medical practice, which (mainly of a wide spectrum of action) are part of first-aid kits for emergency medical care. So, an individual motorist’s first-aid kit includes a capsule with a doxycycline antibiotic. A single use of one capsule of such an antibiotic is guaranteed to ensure that people are even in the outbreak with pathogens of especially dangerous infections (for example, such as smallpox) for a day. However, the use of antibiotics for a long time gives a number of side effects, among which there is the occurrence of intestinal dysbiosis due to the suppression of the intestinal flora and, as a result, the activation of saprophytic infection, including fungal (Candida albicans). In addition, given the new terrorist acts, the use by terrorists as biological weapons of not only strains of especially dangerous infections, but also various types of especially pathogenic fungal crops, is not ruled out. Therefore, in extreme situations, to expand the preventive measures for the occurrence of infectious diseases, along with antibiotics of antimicrobial action, it is advisable to use an antifungal drug, such as Diflucan. To compensate for the suppression of a wide spectrum of action of the natural microbial flora of the intestine during the long-term use of antibiotics, the restoration of this flora by parallel saturation of the gastrointestinal tract with probiotics, i.e. as a measure for the prevention of antibiotic intestinal dysbiosis. For example, the use of doxycycline (an antimicrobial antibiotic) with encapsulated diflucan (an antifungal drug) and bactisubtil. The simultaneous presence of these drugs in the volume of one capsule or pill is unacceptable due to the possible negative effect of one group of components on others, for example, the weakening of virulence (therapeutic effect) of microbiological strains. The use of three capsules (one capsule of each of the above drugs) simultaneously under extreme conditions for a large number of people for a short period of time is impossible, and the time lost as a result of delay will cost an increase in the number of unjustified loss of human life. Therefore, it is advisable to connect an antimicrobial capsule and capsule with an antifungal drug in one device, as well as introducing their caps and probiotic couplings or their spores into the composition of the capsule walls, for example, such as Bifiform or Bactisubtil (B. Cereus IP 5832 spores - 1 billion) - 35 mg Probiotics maintain and regulate the physiological balance of the intestinal flora, ensure its physiological balance of the intestinal flora and physiological functions, create unfavorable conditions for the reproduction and vital activity of pathogenic microorganisms, and participate in the synthesis of vitamins. For example, the use of the probiotic Bifiform leads to the restoration of the body's natural and immune defenses. Probiotics are the means of choice in the treatment and prevention of intestinal dysbiosis, especially as a result of antibiotic treatment with a wide spectrum of action. The introduction of microelements and vitamins into the capsule shell of probiotics will result in rational modernization with the simultaneous use of two or more poorly compatible components during storage, reduce the time of distribution of these funds to the affected population, and the introduction of vitamins into the clutch and capsule shells will lead to the effect of a double (quick and delayed) saturation of the body with vitamins. The introduction of vitamin A (in the form of acetate) in a dose of 1500 to 6500 ME promotes the formation of visual pigments, improves the condition of bones and skin; vitamin E (tocopherol acetate) in a dose of from 2.5 to 200 ME - an antioxidant protects cell membranes from the effects of free radicals that can form in the human body located in a radioactively contaminated area. The introduction of vitamin B1 - thiamine (in the form of mononitrate) - 1.5 mg - an activator of carbohydrate metabolism improves the resistance of the nervous system to stress; Vitamin C (ascorbic acid) - in a dose of 10 to 100 mg - the main vitamin in the redox reactions that occur in the body improves immunity stimulation (under stress, the body's immunity lowers its protective functions). The doses of vitamins used depend on the degree of exposure to drugs used depending on the degree of human damage (injuries, injuries, infections, etc.), gas exposures. The stage of fast saturation is achieved due to the release of vitamins located in the capsule shell itself, the stage of delayed saturation will be due to the creation of natural vitamins synthesized by probiotics. Moreover, the device acquires, in addition to the protective function, the polytherapeutic, modular, and also the function of accelerating the breakdown of the gelatin (protein) membrane in the digestive tract, and the known properties of probiotics include the property of accelerating protein breakdown, saturation with microelements of the body and, as a result, increasing human immunity (especially located in the disaster area). The introduction of microdoses of microelements into the capsule shell will ensure the optimal supply of the missing microorganisms to humans in catastrophes in endemic areas, for example, with a lack of iodine, selenium, fluorine. The introduction of a microelement (mineral) of iodine with a dose of 50 to 150 μg, which is involved in the synthesis of thyroid hormones, provides the necessary speed of biochemical processes in the human body (especially in the radiation hazardous zone) and also has the property of bactericidal activity. The introduction of the trace element selenium with a dose of 8 to 70 μg helps to improve tissue metabolism; the introduction of fluorine in a dose of 0.2 to 1.0 mg improves the metabolism of bone tissue. Doses of vitamins, trace elements, probiotics or their spores contained in the capsule shell and clutch are given in amounts equivalent to the daily requirement.

So, the proposed drug device allows you to simultaneously provide assistance to a stressed person, support and stimulate his central nervous system, reduce pain and support his vitality with vitamins, microelements and probiotics, protect his body’s immune system.

The use of the solution “Medicinal device” in comparison with the known prototype solution allows to increase the effectiveness of medical use in extreme field (combat) conditions, reduces the time of medical care, increase the effectiveness of drug exposure in severe injuries and injuries in extreme conditions by simultaneously taking several capsules with drugs that are poorly compatible with each other when stored in one place, due to the fact that in the proposed device containing cap an ulu with a cap or a pill, provided with medicines inside their shell cases, a sleeve is put on the capsule or pill body with an additional capsule located in it with a cap filled with other medicines that are poorly compatible with medicines when stored in one place, placed in the first case, the coupling on the housings is fixed with locking rings in a joint with the covers, the covers with the coupling are coated with a layer of silver on the outside and the fluorescent substance is marked on the coupling, moreover, in the material of the coupling shell, caps l or pills and capsules, vitamins A, E, C, B1 are introduced, trace elements - iodine, selenium, fluorine and probiotics or their spores with specific doses, and one or more pills can be placed between the capsules or pills inside the sleeve. Capsules and pills of the device can include various combinations of medicinal substances, microelements (minerals), probiotics, depending on various extreme conditions and situations and tasks. But it is advisable to use a combination of drugs with vitamins, minerals and probiotics in situations of rapid response to technological disasters. The device allows anesthesia to a patient who is in extreme conditions, such as trauma, injury and other respiratory, nervous and bodily injuries while protecting and supporting his body. The proposed medicinal device is technologically advanced in production, manufactured on standard equipment for such products, and is economical. Due to its therapeutic, technological and economic properties, the proposed medicinal device will find its practical application.

Claims (2)

1. Medicinal device containing a capsule with a cap or pill, and an additional capsule with a cap or pill, provided with medications inside the shells that are poorly compatible when stored with medicines in one capsule or pill, but used simultaneously, characterized in that on the capsule body or a clutch is put on the pills, an additional capsule with a cap or a pill is placed inside the clutch, while the caps of the capsules or part of the pill cases are mounted outside the clutch and fixed to their shells cross-linking rings with the coupling, the device is coated with a layer of silver on the outside, the fluorescent substance is marked on the coupling, and vitamins are introduced into the material of capsule shells or pills and couplings in the following dosage: Vitamin A - 1500-6500 ME, Vitamin E - 2.5-200 IU, vitamin C 10-100 mg, vitamin B1-thiamine - 1.5 mg, trace elements in the following dosage: iodine from 50 to 150 μg, selenium from 8 to 70 μg, fluorine from 0.2 to 1.0 mg and probiotics or their spores in a dosage up to 35 mg. 2. The drug device according to claim 1, characterized in that one or more pills are additionally placed inside the sleeve between the capsules or pills.

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