RU2307655C2 - Combined method for treating central nerve system malignant tumor cases - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves exposing hypothalamus area to alternating magnetic field in ultra-low frequency bandwidth and operation field to permanent magnetic field in postoperative period in combination with adjuvant chemo radiation therapy in ablatable central nerve system tumor cases. The hypothalamus area is treated in the same way and the tumor is treated with permanent magnetic field in applying palliative chemo radiation therapy in nonablatable central nerve system tumor cases.

EFFECT: reduced risk of adverse side effects; reduced tumor size; prolonged survival period.

Description

The invention relates to medicine, namely to oncology, and can be used in adjuvant or palliative chemoradiotherapy of malignant tumors of the central nervous system.

There is a method of treating experimental tumors by selecting certain biotropic parameters of an ultra-low-frequency alternating magnetic field, adequate to the frequency of natural vibrations of various structural sublevels (subcellular, cellular, tissue), while the synchronization of processes was purposefully triggered at the level of the whole organism - an activation reaction with its inherent high non-specific and antitumor resistance, and regression and complete resorption of experimental tumors was obtained (Garkavi L. ., Kvakina EB, Shihlyarova AI, "National Oncology - the main way of development", Moscow, 2001, str.526).

A known method of treating cancer of the lower lip and facial skin with a constant magnetic field without the use of specific antitumor therapy (ed. Certificate No. 522688, Pankov AK, Garkavi L.Kh., Ukolova MA, Kvakina EB, Salatov R .N., 1976), and a complete tumor regression was obtained.

A known method of treating malignant brain tumors by combining remote gamma therapy (DHT) with systemic chemotherapy (nitrosomethylurea preparations, temodal) (Minesh Mehta, USA, “Combined therapy for malignant gliomas”, Materials of the 12th Oncology Conference, Denmark, 21- September 25, 2003, p. 5), selected by us as a prototype. The disadvantages of the method of treatment of malignant tumors of the central nervous system (CNS) is the low efficiency and high toxicity of chemotherapy.

The aim of the invention is to increase the efficiency and reduce the toxicity of the method of treatment of malignant tumors of the central nervous system.

This goal is achieved by the fact that in adjuvant complex chemoradiotherapy of removable malignant tumors of the central nervous system or in palliative chemoradiotherapy of unremovable malignant tumors of the central nervous system, the effect of an alternating magnetic field of ultra-low frequencies on the hypothalamic region and a constant magnetic field on the tumor or surgery area is used.

The invention "A method for the complex treatment of malignant tumors of the central nervous system" is new, as it is unknown from the level of medicine in the field of complex treatment of malignant tumors of the central nervous system.

The invention is industrially applicable, as it can be used in healthcare, in medical institutions involved in the treatment of patients with central nervous system tumors, in cancer research institutes, oncology dispensaries and other clinical institutions.

“A method for the complex treatment of central nervous system malignant tumors” is performed as follows: in the postoperative period with adjuvant complex chemoradiotherapy of removable central nervous system malignancies or palliative chemoradiotherapy of unremovable central nervous system malignancies, an ultralow-frequency alternating magnetic field is applied to the hypothalamic region (VLF exposition) changes exponentially, and by a constant magnetic field (PMF) to the tumor or area of operation according to the scheme:

1st day of the emergency medical care in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 5 5 5 exposure (min) 7 one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min 2nd day of the emergency medical care in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 3,5 3,5 3,5 exposure (min) 6 one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min 3rd day of the emergency medical care in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 2.5 2.5 2.5 exposure (min) 5 one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min 4th day of the emergency medical care in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 1.8 1.8 1.8 exposure (min) four one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min 5th day of the emergency medical care in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 1.3 1.3 1.3 exposure (min) 3 one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min 8th day of the NPSF in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 3,5 3,5 3,5 exposure (min) 7 one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min 9th day of the NPSF in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 2.5 2.5 2.5 exposure (min) 6 one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min 10th day of the NPSF in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 1.8 1.8 1.8 exposure (min) 5 one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min 11th day of the emergency medical care in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 1.3 1.3 1.3 exposure (min) four one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min 12th day of the NPSF in the region hypothalamus: frequency (Hz) 0,03 3 9 induction (mTl) 0.8 0.8 0.8 exposure (min) 3 one one after 2 hours PMP in the region. Tumors: induction 20 mT, exposure 20 min

An example of a specific implementation of the "Method of complex therapy of malignant tumors of the central nervous system"

Patient Eliseev N.P., 46 years old, medical history 8287 / t. Received in Dep. OTSNS RNII on 04.29.04 with a diagnosis of Inoperable glioma of the left parietal region. Goal. brain. Epi Syndrome. On an MRI goal. brain from 04/23/2003 - a glial tumor of the left parietal lobe up to 56 by 45 by 52 mm of irregular shape, with fuzzy contours, with a slight deformation of the rights. lateral ventricle. Neurologically - right-sided spastic hemiparesis up to 4 points, frequent attacks of motor Jackson epilepsy in the right limbs. From April 29, 2004 to January 31, 2005, palliative chemoradiotherapy (a course of remote gamma-therapy in a total focal dose of 60 Gy and 4 courses of systemic polychemotherapy with cyclophosphamum in a total dose of 2000 mg, doxorubicin in a total dose of 200 mg) was carried out in the department of OTsNS RNIIII mg and cisplatin in a total dose of 200 mg, in parallel, an exposure was made to the hypothalamic region of an alternating magnetic field of ultra-low frequencies and a constant magnetic field on a tumor according to the above scheme), during chemoradiotherapy of side effects and manifestations chemotherapy drug toxicity (headaches, nausea, vomiting) was not observed.

On an MRI goal. brain from 01/12/2005, there is a decrease in the tumor to 22 by 16 by 20 mm, the heterogeneity of its structure with foci of calcification, regression of perifocal edema and compression of the lateral ventricle. Clinically - a regression of right-sided hemiparesis, the epi-syndrome was stopped.

Feasibility study.

“A method for the complex treatment of central nervous system malignant tumors” consists in the fact that exposure to the hypothalamic region with an alternating magnetic field of ultra-low frequencies and a constant magnetic field on the tumor or area of surgery can reduce toxicity, the frequency of side effects and thereby increase the effectiveness of adjuvant complex chemoradiotherapy of removable malignant tumors CNS or palliative chemoradiotherapy of undecided malignant tumors of the central nervous system.

Claims (1)

A method for the complex treatment of malignant tumors of the central nervous system, including chemoradiotherapy, characterized in that in the postoperative period with adjuvant chemoradiotherapy of removable malignant tumors of the central nervous system or in palliative chemoradiotherapy of unremovable malignant tumors of the central nervous system, an effect on the area of hypothalamic magnetic field is applied over the area of hypothalamus frequencies and the tumor or area of operation with a constant magnetic field.