RU2307642C1 - Method and device for carrying out thermal-contrasting non-invasive therapy - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves treating skin with substances of cosmetic and medical activity. Subdermal skin treatment is carried out at the first stage by applying contact-mode low-frequency ultrasonic peeling to skin via peeling solution covering the skin surface using ultrasonic oscillations having frequency of 25.6-44.0 kHz and ultrasonic applicator oscillation amplitude of 5-30 mcm with radiating applicator end face having disintegrating notches. Skin vaporization is carried out at the second stage by heating it with vapor to a temperature not less than 60°C, and subsequent cooling it to a temperature 25-30°C using ozone/NO-containing air mixture. Thermal-contrasting impregnation at the third stage with ozone/NO-containing air mixture containing of medicinal substance introduced into skin blood- and lymphatic system and into underlying tissues first by means of thermal applicator, having Peltier element, heating skin to temperature not higher than 50°C and supporting this state, and then cooling the skin area with the thermal applicator to a temperature of 5-10°C via intermediate capillary-porous lining saturated by medicinal substance. Thermal-contrasting massage of skin is carried out at the fourth stage by cyclic heating skin to a temperature not exceeding 40°C, and then sharp cooling with thermal applicator is applied to reach temperature of 5-10°C. Subdermal ultrasonic massage is carried out at the fifth stage of treatment by applying low-frequency ultrasonic skin treatment with ultrasonic oscillations in frequency range of 25.6-44.0 kHz with ultrasonic applicator oscillation amplitude emitted by smooth radiating end face being equal to 5-30 mcm. The treatment is performed through intermediate capillary-porous lining saturated with medicinal substance and in contact mode. General treatment session duration is 45-60 min long. Device has contrasting thermocycling unit, ultrasonic oscillator, unit for producing air mixture and pressure chamber. Thermal applicators having Peltier elements and the attached contact plate are additionally connected to the contrasting thermocycling unit. Contact plate of one of thermal applicators is attached to replaceable contact element by means of threaded connection. The ultrasonic oscillator is connected to ultrasonic applicators, one of which has replaceable radiating element connectable via threaded connection. The unit for producing ozone/NO-containing air mixture and the vaporizer are connected to the pressure chamber cavity.

EFFECT: high quality of cosmetic treatment results.

9 cl, 13 dwg

Description

The invention relates to medicine and can be used for thermal contrast effects on the skin during the implementation of non-invasive subdermal therapy in cosmetology and aesthetic surgery, as well as in dermatology.

The search for beauty is part of human nature. Beautiful and physically attractive people have great potential for their success and self-realization in various fields of activity of the modern world. The elimination and masking of physical defects or shortcomings of a person, achieved in various ways, dramatically increase the level of self-esteem, psycho-emotional state, and the quality of his life.

The media daily overwhelms the public with various kinds of information about the success of people in politics, cinema and theater, show business, entrepreneurship, etc., which meet high standards of beauty, and there is no limit to discussions regarding the appearance and its importance for career and family well-being. The current situation has generated enormous demand and, accordingly, the emergence of many areas of the provision of various kinds of services for maintaining or acquiring beauty, ensuring the enormous profitability of this business sector. Currently, the service market offers diverse cosmetology and massage rooms, gyms and gyms, as well as the possibilities of aesthetic surgery.

Known methods for the treatment of cosmetic defects of the skin, which include exposure to the skin with substances of a cosmetic and therapeutic nature [1].

However, these methods, when used in various types of cosmetic procedures that affect the skin of problem areas of the body, do not allow for deep skin cleansing, micromassage and full restoration of the skin.

A device for cryomassage is known that provides contrast thermal cycling of the skin of the face by using a contrast thermal cycling unit and a massage unit including a body in which a Peltier thermocouple with an attached contact plate is installed, means for cooling or heating the contact plate, including a direct current source connected via a switching unit to Peltier thermocouple [2].

However, this device has limited use, associated only with contrast thermal cycling of the skin of the face, which does not allow their use in various types of cosmetic procedures that affect the skin of problem areas of the body, as well as the implementation of a wide range of modern cosmetic methods associated with the implementation of deep skin cleansing, micromassage and restoration of the skin of the face, neck, hands, chest, hips, etc., the greatest effect of which can be achieved only when using ultrasound, especially high-amplitude low-frequency ultrasound. In addition, this device does not allow exposure of the skin to ozone / NO-containing medicinal substances that provide pronounced bactericidal, fungicidal, virucidal, immunocorrective, detoxifying, oxygenating, vasodilating and other effects and contributing to the achievement of a pronounced cosmetic result.

Closest to the technical nature of the claimed invention is a device for the treatment of baldness, comprising a contrast thermal cycling unit, an ultrasonic oscillation generator, an ozone-containing air mixture generator and a pressure chamber [3].

However, this device is intended only to implement a method of affecting the scalp in the treatment of baldness and cannot be used, in a single technological cycle, in the implementation of modern cosmetic methods related to the multifunctional effect on the patient's skin with a pronounced cosmetic effect. This is due to the impossibility of providing a comprehensive effect on the skin of the problem areas of the body: contrast thermal cycling, high-amplitude ultrasound of the low frequency range, as well as ozone / NO-containing drugs with bactericidal, fungicidal, virucidal, immunocorrective, detoxifying, oxygenating, vasodilating effects skin cleansing and the implementation of lymphogenic thermocontrast and ultrasonic micromassage and restoration of the skin of the face, neck, p uk, breasts, hips, etc., as well as stimulating the impregnation of ozone / NO-containing medicinal substances deep into the skin of the problem areas of the body.

The objective of the invention is the provision in a single technological cycle of the implementation of modern cosmetic techniques related to the multifunctional effect on the patient's skin, contributing to deep skin cleansing, the implementation of lymphogenic thermocontrast and ultrasonic micromassage, as well as stimulating the impregnation of ozone / NO-containing substances deep into the skin with achieving pronounced cosmetic effect.

The objective of the invention in terms of the method is achieved by the fact that in the method of complex thermal contrast non-invasive subdermal therapy, which consists in exposing the skin to substances of a cosmetic and therapeutic nature, while:

- at the first stage, subdermal skin sanitation is carried out by contact low-frequency ultrasonic peeling of the skin with ultrasonic vibrations with a frequency of 25.6 ... 44.0 kHz with an oscillation amplitude of the ultrasonic applicator with a radiating end having disintegrating notches, 5-30 microns, through a peeling solution applied to the skin;

- at the second stage, vaporization of the skin is carried out by heating it with steam to a temperature of at least 60 ° C, and then cooling it to a temperature of 25 ... 30 ° C with ozone / NO-containing air mixture;

- at the third stage, thermo-contrast impregnation of the ozone / NO-containing medicinal substance into the blood and lymph system of the skin and underlying tissues is carried out by first heating the skin with a thermal applicator including a Peltier thermocouple to a temperature of not more than 50 ° C and then maintaining it, and then cooling it skin area with a thermal applicator to a temperature of 5 ... 10 ° C through an intermediate capillary-porous pad saturated with a medicinal substance;

- at the fourth stage, a contact thermal contrast massage of the skin is carried out by cyclic heating with a thermal applicator, including a Peltier thermocouple, of the skin to a temperature of not more than 40 ° C, and then its sharp cooling with a thermal applicator to a temperature of 5 ... 10 ° C;

- at the fifth stage, a subdermal ultrasound massage is performed by low-frequency ultrasonic treatment of the skin with ultrasonic vibrations with a frequency of 25.6 ... 44.0 kHz with an oscillation amplitude of the ultrasonic applicator with a smooth emitting end-face - 5-30 microns as through an intermediate capillary-porous pad saturated with a medicinal substance, and contact, while the total duration of the treatment session is 45-60 minutes

At the same time, ozone / NO-containing saline solution is used as a peeling solution and a medicinal substance. In addition, 5-10% ozonide / NO-containing oil-in-water oil emulsion is used as a drug substance.

The objective of the invention in terms of a device for implementing the method is achieved by the fact that in a device for complex thermal contrast non-invasive subdermal therapy containing a contrast thermal cycling unit, an ultrasonic oscillation generator, an ozone-air mixture generator and a pressure chamber, thermal applicators are connected to the contrast thermal cycling unit, including a Peltier thermocouple with an attached contact plate while the contact plate of one of the thermal applicators is made with the possibility of attaching to the thread of the interchangeable contact element, the ultrasonic oscillation generator connected to ultrasonic applicators, one of which is configured to attach a replaceable radiating element to the thread, and the ozone / NO-containing air mixture generator and the vaporizer are connected to the pressure chamber cavity. In this case, the replaceable contact element of the thermal applicator is made with a generatrix, for example, in the form of a hemisphere, cone, truncated cone, cone with a rounded apex.

In addition, the radiating end face of the replaceable radiating element of the ultrasonic applicator is made, for example, in the form of a hemisphere, cone, truncated cone, cone with a rounded apex. In this case, the radiating end is made smooth. In this case, the radiating end face is made with disintegrating notches of different geometries.

An analysis of the known technical solutions shows that at the filing date of the application for the invention, there is no known method for complex thermocontrast noninvasive subdermal therapy and a device for its implementation with the indicated distinctive features, which allows providing in the single technological cycle the implementation of modern cosmetic techniques related to multifunctional exposure to the patient’s skin by deep skin cleansing, lymphogenous thermocontrast and ultrasonic micromassage as well as stimulating the impregnation of ozone / NO-containing substances that contribute to the achievement of a pronounced cosmetic effect.

The advantages of the method of complex thermocontrast noninvasive subdermal therapy and devices for its implementation are justified by the fact that the proposed technical solution provides the possibility of multifunctional application of the method due to the complex or separately use (during cosmetic procedures) of physical and physico-chemical factors affecting the patient’s skin . In this case, it is possible to carry out a number of cyclograms using various types of effects using different physicochemical factors and providing not only cosmetic, but also therapeutic effects: sanitizing, tonic, decongestant, bactericidal, fungicidal, virucidal, anti-inflammatory, biostimulating, reparative and regenerative, metabolic, trophic, immunomodulating, defibrosing, etc. The present invention has the ability to affect the skin and the body as a whole, using:

- the disintegrating property of low-frequency ultrasound, which is realized due to high-amplitude ultrasonic deformation (without using an intermediate solution) and cavitation (using an intermediate solution) with disintegrating notches of the emitting end of the ultrasonic applicator, the destruction and removal of dead epithelium flakes, comedones, acne, reducing the amount of skin sebum (surface peeling );

- the gas-fusion property of the heated coolant (steam) and ozone / NO-containing air mixture, which, along with deep heating of the skin, leads to vapor-air vaporization (steaming) of the skin surface, pronounced hyperemia and sweating, as well as providing pathogenic pathogens in the surface and deep layers of the skin microorganisms, lipolysis, the removal of toxins from the deep subcutaneous layers, increased microcirculation (lymph and blood flow), etc .;

- thermocontrast absorption, which implements cyclically carried out hyper- and hypothermic effects on the surface of the skin and contributes to the improvement of skin permeability for highly active ozone / NO-containing substances (ozone / NO-containing physiological saline, 5-10% ozonide / NO-containing oil emulsion type “oil in water”), as well as cosmetics generally accepted in cosmetology with active involvement along with the circulatory system and lymphatic system, as one of the most important sanogenic-potent functional systems of the body (Yu.I. Borodin, 1 986), which can intensify:

- oxygenating, immunocorrecting, detoxifying, mass transfer and other processes in the treatment of blood-lymphocapillary disorders and correction of structural changes in the microvasculature, as well as lesions characteristic of problem skin;

- thermocontrast massage, which implements cyclically performed hyper- and hypothermic effects on the surface of the skin and helps to enhance microcirculation, stimulate the elastic fibers of the skin, relax muscles, including facial muscles, reduce wrinkles (toning and lifting), etc .;

- extracting and impregnating properties of low-frequency ultrasound, which realize due to cavitation, acoustic currents, variable sound pressure, as well as “direct” and “reverse” sound-capillary effects arising in the medium of the intermediate solution under the action of ultrasonic vibrations of the smooth radiating end face of the ultrasonic applicator, fat extraction, residues of microorganisms, various contaminants, toxins, as well as pronounced impregnation of ozone / NO-containing skin into the cleaned capillary-porous skin system eschestv conventional in cosmetics and means (deep peeling);

- ultrasonic massage, which implements a high-amplitude vibro-microwave effect on the surface of the skin and contributes to the excrement, defibrosing, lymphatic drainage, anti-inflammatory and analgesic effects, enhancing microcirculation, permeability of the skin and cell membranes, activating regeneration processes (toning and lifting);

- highly active ozone / NO-containing substances that implement the therapeutic effects of ozone (O3) and exogenous nitric oxide (NO) both in the form of an ozone / NO-containing air mixture, and in its complex with drug solutions, for example, ozone / NO- containing saline solution, 5-10% ozonide / NO-containing oil-in-water oil emulsion, simultaneously affecting many pathogenetic links of problem skin associated with circulatory and lymphatic disorders at the microcirculatory level, leading to diffuse hypoxia, anaerobic abolizmu, accumulation of toxic oxygenated radicals, hyperpigmentation, etc., concludes:

- in initiating local and general bactericidal, fungicidal and virucidal effects;

- in the activation of oxygen-dependent processes in the body, in increasing the number of energy substrates, normalizing lipid peroxidation, the acid-base state and potential of the antioxidant system, leading to an increase in the deformability of red blood cells, the oxygen-transporting function of the blood;

- normalization of the rheological properties of blood and lymph, vasodilation and improvement and normalization of microcirculatory disorders in the blood and lymph systems, improving vascular trophism and tissue metabolism;

- to increase the synthetic activity of the body by enhancing peroxisomal oxidation and the functioning of glutathione-dependent systems that protect cells from toxins;

- in the correction and stimulation of the general detoxification, immunocorrecting, vasodilating, oxygenation, antihypoxic and analgesic effects, etc.

Ozone (O3) and exogenous nitric oxide (NO), in ozone / NO-containing air mixture and ozone / NO-containing substances (in therapeutic doses), have several important advantages for use in cosmetology:

- they are azeotropic with respect to the body, i.e. behave as pure and biologically compatible substances with the body;

- their therapeutic doses do not cause side effects and do not have a negative effect on the body (with the exception of the ingress of ozone into the respiratory tract);

- they exclude the development of resistance to them of pathogenic microflora;

- they act on a biological object regardless of the initial etiological factor that caused the skin disease;

- they enhance the utilization of oxygen by tissues, stabilize cell membranes, increase the body's defenses;

- they correct violations of the synthesis of endogenous vasodilator - nitric oxide (NO);

- they are immunomodulators, etc .;

- they have a positive effect (at the body level) on the central nervous system, endocrine, respiratory, hematopoietic, immune, excretory and reproductive systems, etc.

The invention is illustrated by drawings, where:

- figure 1 shows a diagram of a contact low-frequency ultrasonic peeling of the skin;

- figure 2 shows a scheme for vaporization of the skin by steam heating and its subsequent cooling by ozone / NO-containing air mixture;

- figure 3 shows a diagram of the thermopaque impregnation of ozone / NO-containing medicinal substance into the blood and lymph system of the skin and underlying tissue with a thermal applicator through an intermediate capillary-porous pad saturated with ozone / NO-containing substance;

- figure 4 shows a diagram of the contact thermal contrast massage of the skin with a thermal applicator;

- figure 5 shows a diagram of a subdermal ultrasound massage of the skin with an ultrasonic applicator with a smooth emitting end through a capillary-porous intermediate pad saturated with ozone / NO-containing substance;

- figure 6 shows a diagram of a subdermal contact ultrasound massage of the skin with an ultrasonic applicator with a smooth emitting end (without capillary-porous intermediate strip);

- Fig.7 shows a diagram of an ultrasonic applicator with a flat emitting end;

- Fig. 8 shows a diagram of an ultrasonic applicator with a set of replaceable radiating elements of various configurations with and without disintegrating notches on the radiating end;

- figure 9 shows a diagram of a thermal applicator with a flat contact element;

- figure 10 shows a diagram of a thermal applicator with a set of interchangeable contact elements of different configurations;

- figure 11 shows an exemplary sequence diagram of the process of vaporizing the skin by heating with steam and then cooling it with an ozone / NO-containing air mixture;

- Fig. 12 shows an exemplary cyclogram of thermocontrast noninvasive therapy by cyclic thermocontrast exposure to the skin with a thermal applicator through an intermediate capillary-porous pad saturated with ozone / NO-containing substance (hyperthermia-temperature maintenance-hypothermia);

- Fig. 13 shows an exemplary cyclogram of thermocontrast noninvasive therapy by cyclic thermocontrast exposure to the skin with a thermal applicator through an intermediate capillary-porous pad saturated with ozone / NO-containing substance (hyperthermia-hypothermia).

A device for implementing the method of complex thermal contrast non-invasive subdermal therapy contains (Figs. 1-10): a pressure chamber 1, consisting of a hemispherical polymer body 1.1, a gasket 1.2, a heat transfer medium (steam), a nozzle 1.3, and an ozone / NO-containing air mixture of a nozzle 1.4 , a throttle fitting 1.5 with a disposable nozzle attached to it with a mouthpiece 1.6. The hemispherical body 1.1 is mounted with the possibility of angular displacements in space on a rack 1.7 connected to a support 1.8. In addition, the device is equipped with a device complex "Prolong-MM-Cosmeton" 2, which includes the following main instrument units: vaporizer 2.1, connected to the cavity of the hemispherical body 1.1 through a supply pipe 2.1.1; a generator of ozone / NO-containing air mixture 2.2, connected to the cavity of the hemispherical body 1.1 through a supply pipe 2.2.1; generator of ultrasonic vibrations 2.3 with attached ultrasonic applicators 2.3.1 and 2.3.2; block contrast thermal cycling 2.4 with attached thermal applicators 2.4.1 and 2.4.2.

In this case, the ultrasonic applicators 2.3.1 and 2.3.2 consist of a supporting body 2.3.3, annular piezoceramic elements 2.3.4, reflective plates 2.3.5 and an oscillation transformer 2.3.6 in the form of a tightening bolt acting as a waveguide tool.

For the multifunctional use of ultrasonic applicators at different stages of the cosmetology procedure, the oscillation transformer 2.3.6 of the ultrasonic applicator 2.3.1 is equipped with a flat smooth radiating end face 2.3.6.1, used, for example, for contact low-frequency ultrasonic exposure when performing procedures of subdermal ultrasonic massage on the skin of problem areas bodies (arms, chest, hips, etc.) having a topographically simple relief, and an oscillation transformer 2.3.6 of the ultrasonic applicator 2.3.2 it is fitted with a central threaded hole 2.3.6.2 for connecting (depending on the technological stage of the cosmetology procedure) removable radiating elements with a threaded rod having different configurations of radiating ends, for example, in the form of a hemisphere 2.3.7, a cone 2.3.8, a truncated cone 2.3.9 , a cone with a rounded apex 2.3.10, used, for example, for contact low-frequency ultrasonic exposure when performing procedures of subdermal ultrasonic massage on the skin of problem areas of the body (face, neck, hands, gru q, etc.) having a topographically complex relief. Moreover, the above radiating ends of the replaceable radiating elements are made smooth. In addition, to perform contact low-frequency ultrasonic peeling when performing procedures on the skin of problem areas of the body (arms, chest, hips, etc.) having a topographically simple relief, to the vibration transformer 2.3.6 of the ultrasonic applicator 2.3.2, equipped with a central threaded hole 2.3.6.2, connect through a threaded rod (depending on the technological stage of the cosmetology procedure) removable radiating elements: a hemisphere 2.3.11 or a truncated cone 2.3.13 with disintegrating notches of different g geometries. When performing procedures on the skin of problem areas of the body (face, neck, hands, etc.), having a topographically complex relief, to the vibration transformer 2.3.6 of the ultrasonic applicator 2.3.2 equipped with a central threaded hole 2.3.6.2, connect it through a threaded rod (depending on the technological stage of the cosmetology procedure) replaceable radiating elements: cone 2.3.12 or cone with a rounded apex 2.3.14 with disintegrating notches of different geometries.

In turn, the thermal applicators 2.4.1 and 2.4.2 consist of a supporting body 2.4.3, as well as a Peltier 2.4.4 thermocouple, coupled through a thermal paste 2.4.5 with a radiator 2.4.6, screwed into a polymer support sleeve 2.4.7 and providing hypo - and hyperthermic effects in contact thermal cycling of the skin. In addition, the Peltier thermocouple 2.4.4, also through the thermal paste 2.4.5 is connected to the contact plate 2.4.8, in which the temperature sensor 2.4.9 is fixed through the thermal paste 2.4.5. In this case, the difference between the thermal applicator 2.4.2 and the thermal applicator 2.4.1 consists in the execution of a threaded rod 2.4.8.1 on the contact plate 2.4.8, which makes it possible to attach interchangeable contact elements to the contact plate 2.4.8 with different configurations, for example, in the form of a hemisphere 2.4 .10, cone 2.4.11, truncated cone 2.4.12, cone with a rounded apex 2.4.13, used when performing cosmetic procedures on the skin of problem areas of the body (face, neck, hands, chest, hips, etc.) having topographically difficult terrain.

For example, when performing the cosmetic applicator 2.4.2 cosmetic procedures on the skin of problem areas of the face in the nose, contact elements with the configuration of the generators in the form of a cone 2.4.11 or a cone with a rounded apex 2.4.13 are used, and in the forehead, neck, chin, hands , breasts, hips, etc., use contact elements with the configuration of generators in the form of a hemisphere 2.4.10, a truncated cone 2.4.12, and also to the contact plate 2.4.8 of the thermal applicator 2.4.1.

The above expands the functionality of the device, where thermal applicators 2.4.1 and 2.4.2 realize the possibility of performing many cosmetic procedures on the skin of problem areas of the body (face, neck, hands, chest, hips, etc.) associated with contrast thermal cycling, thermal contrast impregnation of drugs substances, contact thermal contrast massage, etc.

The method is as follows.

Before carrying out the procedures, a generally accepted preliminary preparation protocol is carried out, which includes a hypocaloric diet, physical exercises, massage or self-massage aimed at normalizing the patient’s psychological mood, developing a healthy eating habits, preventing toxicosis with intense fat breakdown, as well as improving macro- and microcirculation blood and lymphatic systems of the body as a whole. Subsequently, the treatment procedures are carried out in the patient's "lying" or "reclining" position.

At the first stage of treatment (Fig. 1), subdermal skin sanitation is performed by contact low-frequency ultrasound peeling of the skin with low-frequency ultrasonic vibrations with a frequency of 25.6 ... 44.0 kHz with an oscillation amplitude of the ultrasonic applicator of 5-30 μm (depending from the anatomical site of the skin) through a peeling solution (for example, ozone / NO-containing saline solution) applied to the skin. In this case, the effect on the surface of the skin is carried out by means of the oscillating end face of the removable element of the ultrasonic applicator 2.3.2 (hemisphere 2.3.11, cone 2.3.12, truncated cone 2.3.13 or cone with a rounded apex 2.3.14) with a surface unevenness in the form of disintegrating notches of different geometry, the configuration of which is selected depending on the complexity of the topographic relief of the problem areas of the body.

Subdermal skin sanitation is achieved due to the effects of high-amplitude low-frequency ultrasound (LCH): cavitation, alternating sound pressure, acoustic currents, etc., initiated at the interface “notching of the emitting end-solution-surface of the skin”, as well as due to high-amplitude cyclic deformation of the cutting the edge of the notch of the stratum corneum of the skin and surface contaminants in the form of a conglomerate of fat, dirt and cosmetic residues. In connection with the surface unevenness of the relief of the skin of a particular part of the patient’s body, replaceable radiating elements are used with the configuration of the radiating end corresponding to the best conditions for its contact with the relief of the skin region subjected to subdermal sanitation (sanitation of the forehead, nose, cheeks, neck, and hands, chest, hips, etc.).

At the second stage of treatment (figure 2), subdermal skin sanitation is performed by vaporization of the skin when it is heated with steam to a temperature of at least 60 ° C, followed by cooling to body temperature with an ozone / NO-containing air mixture with the exception of damage to lung surfactant by ozone due to use by the patient of a replaceable branch pipe with a mouthpiece communicating with the environment.

In this case, the cyclogram depicted in Fig. 11 is implemented, which allows for the implementation of thermotherapy at the first stage of the cyclogram, leading to deep heating of the skin with simultaneous steam exposure, causing vapor-air vaporization (steaming) of the skin, severe hyperemia and sweating, elimination of toxins from the subcutaneous layers, increased microcirculation (lymph and blood flow), etc. At the second stage of the cyclogram, gas fusion therapy is implemented that provides (both in a mixture with steam and separately) impregnation exogenously introduced (in biotropic doses) vasoactive ozone / NO-containing gas component (ozone / NO-containing air mixture) into the vaporized skin and, further, into the deeper tissue structures of the body.

At the third stage of treatment (Fig. 3 and Fig. 12), a subdermal thermocontrast non-invasive therapy is carried out by non-invasive thermocontrast impregnation of ozone / NO-containing medicinal substance into the blood and lymph system of the skin and the underlying tissues by contact through an intermediate capillary-porous pad 3 saturated for example, ozone / NO-containing physiological saline or 5-10% ozonide / NO-containing oil-in-water emulsion for a problem area of the skin. First, the skin is heated with a thermal applicator 2.4.1 or 2.4.2, including a Peltier thermocouple, to a temperature of not more than 50 ° C and the time that is prescribed by the cosmetologist depending on the degree of damage to the skin, with its subsequent maintenance, and then this area is cooldown skin with a thermal applicator 2.4.1 or 2.4.2 to a temperature of 5 ... 10 ° C.

In this case, the impact on the surface of the skin is carried out by means of a removable contact element with a different configuration of the generators (hemisphere 2.4.10, cone 2.4.11, truncated cone 2.4.12 or cone with a rounded peak 2.4.13) of the thermal applicator 2.4.2 or through the contact plate 2.4 .8 thermal applicator 2.4.1, the configuration of which is selected depending on the complexity of the topographic relief of the problem areas of the body (forehead, nose, cheeks, neck, hands, chest, hips, etc.). The contact action of the thermal applicator 2.4.1 or 2.4.2 is carried out by its reciprocating or circular movement (under its own weight) in the area of the problem area of the skin.

In the implementation of the cyclogram of Fig. 12, which implements a process of non-invasive thermocontrast impregnation of ozone / NO-containing medicinal substance into the blood and lymph system of the skin and underlying tissues, the introduction of ozone / NO-containing medicinal substances into the skin to a greater depth through the intact skin due to the effect of enhancing the permeability of the skin barrier during sequential excitation and inhibition of sweating in this area by exposure to a complex of physico-chemical factors, including the use of contrasting temperatures and highly active ozone / NO-containing medicinal substance introduced through an intermediate technological pad saturated with it 3. The aforementioned helps to increase the permeability of the skin due to the intensification of rheological and diffusion processes at the interfaces: "water-soluble drug substance-skin surface-surface of the excretory duct wall sweat gland - the surface of the wall of the outer root vagina of the hair follicle. "

The physiological meaning of the proposed complex effect on the skin with thermal contrast temperatures (“warming-cooling”) and a highly active drug substance is to enhance its impregnation to a greater depth from the surface of the skin over the problem area of the skin, down to the sebaceous glands and hair follicle and saturating the tissues of the outer and internal root vaginas of the hair follicle, hair bag, sebaceous and sweat glands, the muscle tissue around them, the blood and lymphocapillary network surrounding the matrix elk follicle, sebaceous and sweat glands, plasma, interstitial fluid with the creation of a long-term depot of ozone / NO-containing medicinal substance in the affected area of the skin, in changing metabolic processes in the tissues, in providing directly in the depth of the dermis (in the area of the hair follicle, sebaceous and sweat glands and in their vicinity) enhancing the bactericidal and fungicidal effects of the drug substance, as well as the forced oxygenation and oxidation of these tissue structures by the ozone / NO-containing drug substance. In this case, the kinetics of impregnation of a drug substance to a greater depth includes the mechanisms of rheological and diffusion penetration provided by cyclical stimulation of the following processes:

- progressive return movement of sweat and drug substance in the excretory duct of the sweat gland and root vagina of the hair follicle;

- enhancing blood supply to tissue structures as a response to the exogenous dilating effect of ozone / NO-containing drug substance;

- enhancing the interaction between the elements of the biosystem in the area of the hair follicle, sebaceous and sweat glands and ozone / NO-containing medicinal substance.

At the same time, a transglandular (rheological) pathway for the penetration of ozone / NO-containing medicinal substance into the internal environment of the problem area of the skin through the excretory ducts of the sweat glands and root sheaths of the hair follicles and hair bags is provided due to the gradual hyperthermic effect on the skin surface in this area until developed hyperemia and sweating of the order of 50 ° C, maintaining this temperature and subsequent sharp cooling to a temperature of about 5 ... 10 ° C. The consequent contraction and relaxation of the contractile parts of the sweat glands (P.P.Slynko, 1976) and the corresponding departments of the hair follicles that arise in this way cause the progressive-return movement of the sweat mixture with ozone / NO-containing medicinal substance in the excretory ducts of the sweat glands, hair root root sheaths the follicle and hair bags, which are channels through which the drug bypasses the skin barrier into the depths of these ducts and through their walls penetrates into the intercellular space in intercellular fluid accumulating in the interior, the distal portions of the sweat ducts, root sheath of hair follicles and hair bags, densely wrapped blood and lymphatic capillaries. At the same time, diffusion penetration into the lymph and blood capillaries of ozone / NO-containing medicinal substance accumulated in the area of sweat ducts, sebaceous glands and hair follicles at the stage of exposure to the skin surface with contrasting temperatures is accelerated. Further, through the capillary network of the blood and lymph system with blood and lymph flow, the ozone / NO-containing drug substance is carried deep into the skin, saturating the hair follicles, sebaceous glands and other skin derivatives affected by pathogenic microflora, providing not only pronounced bactericidal and fungicidal effects, but also the creation of They have a long-term depot of a medicine containing nitrogen oxide (NO), an allotropic modification of oxygen - ozone (O ₃ ), and also its decomposition products - highly active groups of substances: atomic O and molecular O ₂ oxygen, ozonides with a high redox potential and a powerful disinfecting property, which can effectively destroy bacteria (especially anaerobes), fungi, viruses and their toxins. In addition, penetrating into the deep zones of the problem area of the skin with impaired trophism and, as a rule, elements of local hypoxia, highly active ozone / NO-containing substance provides forced oxygenation of this area, which, in turn, stimulates microcirculation with increased blood supply, and therefore and mass transfer, immunomodulatory, trophic and reparative processes in the zone of its impact. All this also enhances the permeability of the skin, walls of the sweat ducts and cavities of the sebaceous glands and hair follicles for ions and molecules of ozone / NO-containing substances, and also affects their chemical activity, causing increased intermolecular interaction and further penetration of the drug into the body tissues.

In the fourth stage of treatment (Fig. 4 and Fig. 13), a subdermal thermocontrast noninvasive therapy is carried out by contact thermocontrast massage of the skin. In this case, a cyclic effect on the skin is carried out, first by heating it to a temperature of no more than 40 ° C, and then drastically cooling this area to a temperature of 5 ... 10 ° C by means of a removable contact element with different configuration of generators (hemisphere 2.4.10, cone 2.4 .11, a truncated cone 2.4.12 or a cone with a rounded apex 2.4.13) of the thermal applicator 2.4.2 or through the contact plate 2.4.8 of the thermal applicator 2.4.1, the configuration of which is selected depending on the complexity of the topographic relief of the problem areas of the body (forehead, n wasp, cheeks, 19 neck, arms, chest, hips, etc.). The contact action of the thermal applicator 2.4.1 or 2.4.1 is carried out by reciprocating or circular movement of it (under its own weight) in the area of the problem area of the skin.

In the implementation of the cyclogram of Fig. 13, which implements the process of contact thermal contrast massage of the skin, contrast thermal cycling is provided, accompanied by periodic stretching (during heating) and compression (when cooling) of the problem area of the skin under the contact plate of the thermal applicator 2.4.1 or 2.4.1. The above improves the permeability of the skin, enhances the mass transfer processes in relation to the impregnation of the drug substance, as well as the physiological metabolic processes in this area of the skin and its subcutaneous layers, which contributes to the prolonged effect of the treatment.

At the fifth stage of treatment (Fig. 5, Fig. 6 and Fig. 8), a subdermal ultrasound massage is performed by contacting low-frequency ultrasound exposure to the skin with ultrasonic vibrations with a frequency of 25.6 ... 44.0 kHz with an oscillation amplitude of a smooth emitting end - 5-30 microns of a replaceable element with a different configuration of generators (hemisphere 2.3.7, cone 2.3.8, truncated cone 2.3.9 or cone with a rounded apex 2.3.10) of an ultrasonic applicator 2.3.2 or a flat smooth developed radiating end face 2.3.6.1 ultrasonic applicator 2.3.1, conf uracil which is selected depending on the complexity of the topographic relief problematic areas of the body (forehead, nose, cheeks, neck, arms, chest, thighs and so forth.). In this case, the contact low-frequency ultrasonic treatment of the skin with ultrasonic vibrations is carried out both through an intermediate capillary-porous pad 3 (FIG. 5) saturated with ozone / NO-containing physiological saline or 5-10% ozonide / NO-containing oil emulsion water ", and contact (Fig.6). Contact action is carried out by reciprocating or circular movement (under its own weight) of the ultrasonic applicator 2.3.1 or 2.3.2. in the area of the problem area of the skin.

A device for implementing the method of integrated thermocontrast noninvasive subdermal therapy works as follows. Before the implementation of the first stage of treatment (Fig. 1, Fig. 7 and Fig. 8), for example, one replaceable radiating element with disintegrating notches 2.3.11-2.3.14 is screwed onto the ultrasonic applicator 2.3.2 (depending on the anatomical site of the skin where it is necessary to produce ultrasonic peeling). After applying a peeling solution to the skin area (for example, ozone / NO-containing physiological saline), an ultrasonic generator 2.3 is turned on. After that, a removable radiating element oscillating with an ultrasonic frequency with disintegrating notches is brought into contact with the surface layer of the skin to be peeled, contact the reciprocating, circular or angular movement of the radiating element (depending on the anatomical part of the skin), change its pressure to skin, irrigate this area with a peeling solution, performing disintegration, as well as mechanical and acoustic removal of dead skin from the skin surface GOVERNMENTAL cells, grease, cosmetic residues and so forth. After ultrasonic peeling 2.3.2 ultrasonic applicator is withdrawn from the skin surface, and the generator is switched off 2.3.

After ultrasonic peeling, which is implemented at the first stage of treatment, at the second stage of treatment (Fig. 2), a pressure chamber 1 is installed on the cleaned skin surface so that the sealing pad 12 provides complete sealing of the internal volume of the pressure chamber 1 from the environment, and the patient's breathing is ensured through the pipe with a 1.6 mouthpiece inserted into his oral cavity. After that, the vaporizer 2.1 is turned on and the heat carrier (steam) is supplied into the pressure chamber through the supply pipe 2.1.1 and the nozzle 1.3 to heat the patient's skin to the required temperature during the heating exposure determined by the cosmetologist. Upon reaching the required level of hyperemia and sweating, the vaporizer 2.1 is turned off, and the ozone / NO-containing air mixture generator 2.2 is turned on. At the same time, ozone / NO-containing air mixture with ambient temperature is supplied through a pipe 2.2.1 and a nozzle 1.4 into the pressure chamber, ensuring the implementation of gas-fusion therapy of previously cleansed skin during the exposure determined by the cosmetologist. At the end of gas-fusion therapy, the generator of ozone / NO-containing air mixture 2.2 is turned off, the pressure chamber is removed from the skin of the patient, the nozzle with the mouthpiece 1.6 is removed.

In the third stage of treatment (Fig. 3, Fig. 9 and Fig. 10), non-invasive thermocontrast impregnation of ozone / NO-containing medicinal substance is carried out into the blood and lymph system of the skin and underlying tissues. For this, a technological capillary-porous pad 3, impregnated with, for example, ozone / NO-containing physiological saline or 5-10% ozonide / NO-containing oil-in-water oil emulsion, is placed on the skin site treated at the first and second stages of treatment. and install on it a thermal applicator 2.4.1 or 2.4.2 with a removable contact element attached to it with the generatrix configuration necessary for processing a particular area of the skin cover (pos. 2.4.8, 2.4.10-2.4.13). Then turn on the contrast thermal cycling unit 2.4. Reciprocal, circular or angular movements of the thermal applicator 2.4.1 or 2.4.2 (depending on the anatomical site of the skin) initiate non-invasive thermocontrast impregnation of ozone / NO-containing drug into the blood and lymph system of the skin and underlying tissues. In this case, in automatic mode: hyperthermic effect on the skin, soaking of the heating temperature and sharp hypothermal (cryo) effect are carried out by means of automatic contrast thermal cycling implemented by block 2.4 (non-invasive thermocontrast impregnation of ozone / NO-containing medicinal substance). At the end of the subdermal thermocontrast noninvasive therapy, the thermal applicator 2.4.1 or 2.4.2 is removed from the process capillary-porous pad 3, and the contrast thermal cycling unit 2.4 is turned off, the process capillary-porous pad 3 is removed. The total time of non-invasive thermocontrast impregnation of ozone / NO-containing medicinal substance is determined by the cosmetologist.

In the fourth stage of treatment (Fig. 4 and Fig. 10), a contact thermal contrast massage of the skin is performed. Techniques for working with the thermal applicators 2.4.1 or 2.4.2, as well as with the contrast thermal cycling unit 2.4 are similar to the above. In this case, the following are carried out in automatic mode: contact cyclic hyperthermal and sharp hypothermic (cryo) effects on the skin (in the absence of a technological capillary-porous pad 3) by means of automatic contrast thermal cycling implemented by block 2.4 (thermal contrast massage mode). The total time for thermal contrast massage of the skin is determined by the cosmetologist.

In the fifth stage of treatment (Fig. 5-Fig. 8), a subdermal ultrasound massage is performed. For this purpose, a technological capillary-porous pad 3, impregnated with, for example, ozone / NO-containing physiological saline or 5-10% ozonide / NO-containing oil-in-water oil emulsion, is placed on the skin area treated at the previous stages of treatment, and install an ultrasonic applicator 2.3.1 on it with a flat smooth developed radiating end face 2.3.6.1 or 2.3.2 with one of the replaceable radiating elements attached to it with a smooth generatrix of the radiating end face 2.3.7-2.3.10 (depending on the anatomical site of the skin cover where it is necessary to produce ultrasonic massage). It is possible to conduct ultrasonic massage by excluding from the process a technological capillary-porous gasket 3 (Fig.6). After that, the ultrasonic generator 2.3 is turned on and the skin is contacted by reciprocal or circular movement (under its own weight) of the ultrasonic applicator. The total ultrasound massage time is determined by the beautician. At the end of the ultrasound massage stage, the ultrasonic generator 2.3 is turned off, the ultrasonic applicator 2.3.1 or 2.3.2 is removed from the skin surface, the technological capillary-porous pad 3 (if any) is removed.

The total duration of the treatment session is 45-60 minutes. The total number of sessions is determined by the cosmetologist depending on the nosology and duration of the disease of the skin and the dynamics of the therapeutic effect of the proposed method of treatment. In this case, variations in the sequence of execution of the individual steps of the complex thermocontrast noninvasive subdermal therapy method are possible, as well as the use of the individual steps of this method with the exception of steps that are not advisable to achieve the therapeutic result of a skin disease.

The method of complex thermal contrast non-invasive subdermal therapy of the skin, which implements peeling, vaporization associated with exposure to an ozone / NO-air mixture, prelimfatichesky thermocontrast absorption of ozone / NO-containing substances, thermocontrast and ultrasonic toning, thermocontrast and ultrasonic lifting: it is possible to apply problems skin with the presence of comedones, acne and post-acne; rough keratinized skin; cicatricial changes in the skin; subacute and chronic skin diseases; hyperpigmentation; lymphostasis; hypotonic dehydrated skin; small- and large-wrinkled type of skin aging; rosacea; cellulite; removal of tattoos (detailing) and correction of errors of performing permanent makeup, etc.

In addition, the method and its constituent treatment steps can be used for cosmetic defects caused by injuries.

Information sources

1. Handbook of medical cosmetics. - M.: Medicine, 1975 .-- pp. 11-109.

2. RF patent 2047298, cl. A61H 7/00, 1995.

3. RF patent 2191558, cl. A61F 7/00, 2002.

Claims (9)

1. The method of complex thermocontrast noninvasive subdermal therapy, which consists in exposure to the skin with substances of a cosmetic and therapeutic nature, while at the first stage, subdermal skin sanitation is carried out by means of contact low-frequency ultrasonic peeling of the skin with ultrasonic vibrations with a frequency of 25.6-44.0 kHz with an oscillation amplitude of an ultrasonic applicator with a radiating end face having disintegrating notches of 5-30 μm through a peeling solution applied to skin covering; at the second stage, vaporization of the skin is carried out with steam heating to a temperature of at least 60 ° C, and then cooling it to a temperature of 25-30 ° C with an ozone / NO-containing air mixture; at the third stage, thermo-contrast impregnation of the ozone / NO-containing medicinal substance into the blood and lymph system of the skin and underlying tissues is carried out by first heating the skin with a thermal applicator including a Peltier thermocouple to a temperature of not more than 50 ° C and then maintaining it, and then cooling this area skin with a thermal applicator to a temperature of 5-10 ° C through an intermediate capillary-porous pad saturated with a drug substance; at the fourth stage, a contact thermal contrast massage of the skin is carried out by cyclic heating with a thermal applicator, including a Peltier thermocouple, of the skin to a temperature of not more than 40 ° C, and then its sharp cooling with a thermal applicator to a temperature of 5-10 ° C; at the fifth stage of treatment, a subdermal ultrasound massage is performed by low-frequency ultrasonic treatment of the skin with ultrasonic vibrations with a frequency of 25.6-44.0 kHz with an oscillation amplitude of the ultrasonic applicator with a smooth emitting end face 5-30 μm as through an intermediate capillary-porous pad saturated medicinal substance, and contact, while the total duration of the treatment session is 45-60 minutes 2. The method according to claim 1, characterized in that the ozone / NO-containing saline solution is used as the peeling solution. 3. The method according to claim 1, characterized in that the ozone / NO-containing saline solution is used as a drug substance. 4. The method according to claim 1, characterized in that as a medicinal substance use 5-10% ozonide / NO-containing oil emulsion of the type "oil in water". 5. Device for thermocontrast noninvasive subdermal therapy, comprising a contrast thermal cycling unit, an ultrasonic oscillation generator, an air mixture generator and a pressure chamber, characterized in that thermal applicators are connected to the contrast thermal cycling unit, including a Peltier thermocouple with an attached contact plate, and a contact plate of one of the thermal applicators made with the possibility of attaching a replaceable contact element on the thread, the generator of ultrasonic vibrations dinene with ultrasonic applicators, one of which is made with the possibility of attaching a replaceable radiating element on the thread, and an ozone / NO-containing air mixture generator and a vaporizer are connected to the pressure chamber cavity. 6. The device according to claim 5, characterized in that the interchangeable contact element is made with a generatrix, for example, in the form of a hemisphere, cone, truncated cone, cone with a rounded apex. 7. The device according to claim 5, characterized in that the radiating end face of the replaceable radiating element is made, for example, in the form of a hemisphere, cone, truncated cone, cone with a rounded apex. 8. The device according to claim 7, characterized in that the radiating end face is made smooth. 9. The device according to claim 7, characterized in that the radiating end face is made with disintegrating notches of different geometries.

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