RU2231999C2 - Method for hyperthermic treatment of malignant neoplasms - Google Patents

Abstract

FIELD: medicine, oncology.

SUBSTANCE: one should affect body tissues in area of the tumor or its metastases with high-frequency electromagnetic field or with the light of infrared diapason at high-density power at increasing either local or total temperature up to 43-43.5 C. Before heating, the tissues of affected area should be infiltrated with an aqueous silver solution at 20-50 mg/l concentration at the quantity of 100-500 ml. Moreover. Solution should be affected with magnetic field at 200-1000 oersted intensity.

EFFECT: higher efficiency of therapy.

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Description

The invention relates to medicine and can be used to treat various types of malignant tumors, both limited and widespread (generalized).

Numerous studies have so far proved that in conditions of local or general (whole body) hyperthermia with an increase in tissue temperature to 42.5-43 ° C. conditions are being created for the selective death of pathologically altered cells.

A known method of hyperthermic treatment of malignant neoplasms, including the general irradiation of the human body with electromagnetic waves (EM). This is as follows. After preliminary preparation, the patient is placed on a thermostat, covered with a blanket and a protective blanket. Under general anesthesia, a HF EM hyperthermia session is performed. During the session, the body temperature is increased over a period of 48-116 minutes to 40.5-42.5 ° C and maintained for 114-224 minutes. Against this background, well-known chemotherapy regimens are carried out (V.F. Pugachev et al. Hyperthermia in Oncology ". Abstracts of the 2nd All-Union Symposium, Obninsk, NIIMR USSR Academy of Medical Sciences, 1990, book 1, p. 98-99).

Also known and is closest to the proposed method of increasing the destructive effect of hyperthermia on tumor tissue cells due to intravenous or interstitial administration of a suspension of ferromagnetic material (microparticles or colloidal solutions).

When using the known method, ferromagnetic particles under certain conditions (EM field characteristics) provide a higher degree of heating in the area of the tumor tissue, which causes an increase in the destruction process. However, it is necessary to apply additional measures to localize the introduced ferromagnetic particles (permanent magnet field), as well as to stop the negative consequences of the penetration of ferromagnetic particles outside the tumor propagation zone. The ingress of these particles into the vessels of vital organs (liver, kidneys, brain, etc.) provokes the development of a number of serious, life-threatening complications.

In the implementation of this method, a device is used that includes a thermostat and an installation for carrying out hyperthermia (F. Baluseuk et al. Controlled hyperthermia., St. Petersburg: Nevsky dialect, 2001, p. 72-73).

It is known that noble metal ions (silver, gold, platinum) have pronounced antitumor properties and are used as carcinostatic drugs (colloidal gold, platinum). All of them have a certain toxicity, but it is significant in platinum and significantly less pronounced in silver. There is an inverse relationship between the toxic and cytotoxic properties of precious metals; therefore, under normal conditions, silver preparations have not received practical application in oncology due to the weak effect on the viability of cancer cells.

The conditions of exposure to electromagnetic energy (light, HF EM fields) with manifestations of their thermal effect dramatically change the relationship of the cell with their environment. The cells of malignant neoplasms, due to the characteristics of the membrane and the near-membrane hydroionic medium, acquire the properties of selectively generating and concentrating thermal energy, as well as changing the processes of transport and utilization of metabolic products in the intracellular medium. As studies and clinical practice have shown, the action of cytotoxic agents, in particular silver ions, is significantly enhanced, while maintaining a selective character. Further enhances the above properties, the preliminary impact on aqueous solutions of silver magnetic field voltage of 200-1000 Oersted.

The proposed method of hyperthermic treatment of malignant neoplasms is as follows.

Before the start of the EM session or laser general or local hyperthermia, the surrounding tissue is infiltrated with an aqueous silver solution in a concentration of 20-50 mg / l in an amount of 100-500 ml through an injection needle with a syringe or other injection device into the tumor tissue (main node or metastases).

The solution is prepared immediately before administration in the chamber.

In this case, the solution is exposed to a magnetic field with a voltage of 200-100 Oersted.

Hyperthermia is carried out with an increase in temperature of 43-43.5 ° C by a known method.

Example 1 application of the method. Patient S-kaya I.V., 70 years old, medical history No. 911/216, was admitted to St. Petersburg Clinical Hospital of the Russian Academy of Sciences in March 2001 with a diagnosis of Cancer of the left breast (T-4, n-2, M +). An examination revealed a large (12 × 12 × 10 cm) tumor, occupying most of the left mammary gland, sprouting skin and the area of the nipple. In the axillary and subpectoral tissue there are conglomerates of dense lymph nodes. X-ray and ultrasound-metastatic lesions of liver and lung tissue. After an additional clinical examination - a session of general thermochemotherapy (apparatus "South ICH") with an increase in body temperature to 43.3 ° C for 55 minutes.

During the session, 0.4 g of cyclospamide and 0.01 doxirubicin were intravenously administered. In the posthyperthermic period, the size of the tumor decreased slightly, however, according to the biopsy of the tumor node there are sections of morphologically preserved adenocarcinoma cells. Unsuccessful changes in metastatic elements. After 3 months, in June 2001, a repeated session of high-frequency general hyperthermia, at the beginning of which 450 ml of an aqueous silver solution prepared according to the claimed method was interstitially injected into the tumor and axillary tissue area. The regimes and duration of the hyperthermia session, as well as the chemotherapy method, were similar.

In the post-hyperthermic period, the size of the main neoplasm node decreased more significantly, which allowed two weeks later, July 12, 2001, to excise the main affected part of the gland with a block of fiber (as an extended sectoral resection - sanitary amputation). According to a pathomorphological study (No. 2027-36 dated 07/20/01), the drug shows signs of scirrhosis of the tissue, tumor cells are detected in five lymph nodes, as well as along the edge of the skin incision. Healing by first intention. After a month, a biopsy from the edge of the skin wound at the incision site of the tumor cells did not reveal. Obvious regression of metastatic lesions in the liver and lung tissue. After six months, no signs of tumor changes in the wound, liver and lungs were detected. After a year and a half according to the examination, there are no signs of a tumor process.

Example 2. Patient S. va L.V., 62 years old, medical history No. 1027/346, in 1998 underwent surgery - sectoral resection of the right breast. Histological examination revealed signs of an adenocarcinomatous form of cancer. The patient refused from radical removal of the gland - she suffers from a severe form of allergy, including drug. Passed a course of immunochemotherapy. In February 2002, she applied for local tumor recurrence in the area of the postoperative scar, as well as for a larger node in the subareolar region. When mammography and echography of the formation correspond to the stage T-2, T-3. Lymphogenic metastases were not detected. In March 2002, a course of interstitial injections of aqueous silver solutions (25 mg / l) of 40-50 ml was started. With simultaneous transcutaneous irradiation of the tumor zone with a solid-state laser Alod-01 in the regime of 0.82 μm, 5 W, 2 kJ / cm 2 under the control of interstitial temperature. A total of 5 sessions were performed during March-April 2002. The procedure was easily transferred, the general reaction to the introduction of the solution was practically absent. Tightening of the tissue of the tumor nodes was noted, their borders became clearer. May 16, 2002 - operation: radical conservative mastectomy on the right. The postoperative period went smoothly, the wound healed by primary intention. When examining the drug in two independent histopathological institutions, the conclusions were drawn: 1. (No. 8679-8685) - fatty and fibrous tissues with foci of chronic inflammation, loose granulation tissue. Inflammation, edema 2. - (1766-72) The mammary gland is 15 × 10 × 5 cm. The tumor node with a diameter of 3 cm is star-shaped with cysts and hemorrhages. No lymph nodes found in fiber. Histologically, one can think of the presence of infiltrating lobular cancer with pronounced signs of therapeutic pathomorphism of the 2nd stage.

Claims (1)

A method of hyperthermic treatment of malignant neoplasms, including exposure to body tissues in the tumor zone or its metastases with a high frequency electromagnetic field or high power density infrared light with an increase in local or general temperature to 43-43.5 ° C, characterized in that before the start of warming the tissues of the affected area are infiltrated with an aqueous silver solution of a concentration of 20-50 mg / l in an amount of 100-500 ml, while the solution is exposed to a magnetic field with a voltage of 200-1000 E.