RU2218926C2 - Method for treating patients for spinal cord injuries - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves per os administering a medicament at a dose of 70 mg/kg three times a day with 6 h long pauses. Six treatment courses are given with 30 days long pauses. The first course is given 20 days long, the second one 10 days long, the third one 10 days long, the fourth one 15 days long and the fifth one 20 days long. Forced movement modeling is administered using device for imitating walking beginning from the second biotherapy course for recovering nervous tissue. Training lessons are administered twice a day for 2.5 h. EFFECT: enhanced effectiveness of treatment. 4 dwg, 1 tbl

Description

 The invention relates to the field of medicine, namely biotherapy and physiotherapy.

Known drug against viral and bacterial infections, including a mixture of biomass of strains of the bacteria Bacillus subtillis and Bacillus licheniformis in equal proportions, in addition, it contains starch and sugar, and as the biomass of strains of the bacteria Bacillus subtilis and Bacillus licheniformis uses the biomass of strains of the bacterium Bacillus subtillis Bactillus subtillis bacteria -7092, VKPM B-7048 and Bacillus licheniformis VKPM B-7038 in spore form with a titer of at least 3 10 spores / g in the following quantitative ratio of components, wt.%:
A mixture of bacterial spores Bacillus subtillis and Bacillus licheniformis in equal proportions - 0.1 - 1.0
Starch - 1.0 - 3.0
Sugar - Else
(Patent 2142287, A 61 K 35/74, C 12 N 1/20 (C 12 N 1/20, C 12 R 1/07, 1/10, 1/125)). The research and production company "Research Center Koltsovo" named these drugs of the Vetom series (Certificate of Conformity ROSS RU ФВ 01 В 03089, Registration Certificate РО35-2.2064), which are used in veterinary medicine for the prevention and treatment of gastrointestinal diseases with the syndrome of diarrhea, viral and bacterial infections, as well as for the correction of immunodeficiency in calves, piglets, dogs, birds, stimulating the growth and development of young animals. It was established that the therapeutic effect of the drug in acute forms of infection depends on the frequency of administration of the drug - the more often it is used, the higher the therapeutic effect.

 Closer to the technical solution of this application is a method of regeneration of the central nervous system by the neurotrophic factor AF-1 (RU 2157223, 10.10.2000).

 A device for walking is known, containing a frame, wheels, palm rests, a base welded from pipes of various sizes, a wooden platform, clamps, spacers (AS USSR 1805943 from 03.30.1993).

 The aim of this invention is the restoration of regenerative processes and the conductive system in nerve tissues, the normalization of the patient's motor activity. This goal is achieved by using Vetom 7048, taking it three times a day per os with an interval of 6 hours at 70 mg / kg (table 1), conducting six courses of treatment with an interval between courses of 30 days, the first course is carried out for 20 days, the second - 10 days, the third - 10 days, the fifth - 15 days, the fifth - 20 days and the sixth - 20 days, while from the 2nd course of biotherapy for the regeneration of nerve tissue, a forced motion simulation is carried out using a device to simulate walking, classes are carried out on 2.5 hours twice a day. The patient is fixed in the simulator in an upright position. The simulator is placed on wheels in the classroom. The doctor gives the command: step right forward and moves the right foot forward (forced movement), gives the command: left forward, the left moves forward, the simulator moves. Movement stress is created by moving the patient, step distance is the length of the foot. Classes are held 1/3 of the daytime, i.e. 2.5 hours twice a day for five courses of treatment with biotherapy.

 This goal is achieved by the fact that the simulator (Fig. 1, 2) for simulating walking consists of a base welded of four pipes, the length of the base consists of two pipes of different sizes, the pipe in the pipe and is fixed with bolts to adjust the step length to the base up four pipes are attached, two pipes are attached from the corners of the base, two pipes to the center of the base, the pipes have a smaller diameter, a frame with larger pipes welded down is put on top of the pipe, the pipe is attached to the pipe and fixed by the patient’s height with bolts, onto the frame a wooden platform covered with foam rubber is pulled, two vertical metal blanks are fastened to the frame on both sides at a distance of 1/3 of the frame from the working side, metal blanks have different diameters - the bottom is larger, the top is smaller, from the working part of the simulator it is put on a vertical metal blank a sleeve welded to the supporting frame for the pelvis and hands, having a U-shaped shape, two internal arcs for the armrests are additionally welded to the supporting frame, the upper vertical arc is attached to the metal blanks from above, consisting of a U-shaped pipe, the diameter of the vertical arc is larger than the diameter of the metal ingot, but smaller than the diameter of the sleeve, the pipe is fixed in the pipe with bolts, a knee brace is fastened between the two vertical pipes, consisting of a wooden shield and three plates, the wheels are attached to the base as needed , a back cuff is attached to the support frame, consisting of two canvas belts fastened together with a dense fabric.

 The simulator (Fig. 1, 2) to simulate the walking of patients with spinal cord injuries consists of a base welded from four pipes (1, 2, 3, 4,). In length, the base (2, 3) consists of two pipes of different sizes, the pipe in the pipe and is fixed with bolts (5, 6), to control the length of the step, four pipes are attached up to the base (1, 2, 3, 4) (7, 8 , 9, 10), two pipes (9, 10) are attached from the corners of the base, two pipes (7, 8) are attached to the center of the base, pipes (7, 8, 9, 10) have a smaller diameter, on top of the pipes (7, 8, 9, 10) a frame (11) is put on with larger pipes welded down, the pipe is fixed in the pipe and, according to the patient’s growth, is fixed with bolts (12, 13, 14, 15). A wooden platform (16) covered with foam rubber is superimposed on the frame (11), two vertical metal bars (17, 18) are fastened to the frame (11) at a distance of 1/3 of the frame (11) from the working side, metal bars (17, 18) have different diameters - from the bottom large, small from above, from the working part of the simulator onto a vertical metal blank (17, 18) a sleeve (19, 20) is put on, welded to the support frame for the pelvis and hands, having a U-shaped (21). Two internal arcs (22, 23) for armrests are additionally welded to the support frame (21), upper vertical arc (24), consisting of a U-shaped pipe, diameter of the vertical arc (24) is mounted on top of metal bars (17, 18) more than the diameter of the metal disc (17, 18), but less than the diameter of the sleeve (19, 20), pipe fasteners in the pipe are bolted (25, 26). Between two vertical pipes (7, 8), a knee brace is fastened, consisting of a wooden shield (27) and three blanks (28, 29, 30), the wheels (31, 32, 33, 34) are attached to the base (1, 2, 3 , 4) if necessary, a back bracket (35) is attached to the support frame (21), consisting of two canvas belts fastened together with a dense fabric.

 The patient is fixed in the simulator vertically according to the model of movement. The body is fixed with a support frame (21), dorsal cuff (35), knees are fixed with a knee cuff (27), shoes are necessarily worn to preserve the anatomical model of the arch of the foot. The doctor who deals with the patient teaches you to simulate the movement of walking. He asks to close his eyes and visually imagine walking in place, gives the command: step with his left foot, step with his right foot. Simulation of walking movement will play quickly. Corresponding reactions will go in the body (fatigue, sweating, palpitations, rapid breathing, pulse). The development of the motion model should occupy a third of the patient's daytime.

 Rise - 7 am, hang up - 22 pm.

5 hours is the time of wakefulness;
5 hours is 1/3 of the daytime;
5 hours must be broken during the day for 2.5 hours.

Concrete example
Khakhulin Aleksey Sergeevich born in 1979, living at: Amur region, Blagoveshchensk, st. Vasilenko, 7, apt. 100, got into a car accident. Delivered to the neurosurgical department of the regional hospital with a diagnosis of comminuted fracture of the C6 body with a displacement of fragments of 1 cm in the front and 0.5 cm in the back. Axial displacement of the C5 vertebra in the back by 0.5 cm.

Neurological status upon admission:
Lack of movement in the legs, weakness in the arms, numbness of the trunk and legs. Cranial nerves do not suffer. A deep cut in the arms to the shoulder. In the hands of the lower conductor paraplegia. Violation of all types of sensitivity from level C7. Conductive dysfunction of the pelvic organs (urinary retention). Spondylography of the cervical spine in 2 projections from 09/28/98: comminuted fracture of the C6 body with a shift of the anterior fragments by 1 cm, posterior - by 0.5 cm. On 09/28/98, the patient was operated on: C6 vertebroectomy with anterior spinal fusion C5-C7 autograft . Control spondiolography of the cervical spine from 09/28/98 - condition after surgery: spinal column statics are satisfactory, compression of the spinal canal with bone fragments was not noted.

 In the early postoperative period, dynamics in neurological status were not observed. 10.21.98, appeared spinal automatism in the legs with hypertonicity. Urination according to type 4-5 times a day with residual urine of 50-60 ml.

 He received treatment - antibiotics (penicillin), cefazolin, hormone therapy, proserin, aloe, nicotinic acid.

Neurological status at discharge:
A deep cut in the arms to the shoulders, atrophy of the muscles of the hands, a cut in the legs with the phenomenon of hypertonicity, spinal automatism, bilateral Babinsky reflexes, impaired function of the pelvic organs with automatic emptying of the bladder. In March and September 1999 - rehabilitation treatment at the resort "Garden City" of Vladivostok. There are no speakers in neurological status.

 For the first time he took rehabilitation rehabilitation treatment using the new method using Vetom-7048 in November 1999. The first course of treatment is 20 days, he takes the drug 3 times a day per os with an interval of 6 hours at 70 mg / kg weight (table attached). At the same time, the patient imitates a model of walking in place using a simulator. On January 19, 2000, they passed the 2nd course of treatment - 10 days took the drug three times a day per os with an interval of 6 hours of 70 mg / kg of body weight.

 For the first time I stood in the simulator in an upright position with a knee stop and pelvic support. Towards the end of January 2000, resistance appeared in the muscles of the back and neck, and a sensation of abdominal muscles appeared. Since March, I started forced walking in the simulator. In April - the third course of treatment with bacteria: 10 days took three times a day per os with an interval of 6 hours at 70 mg / kg of body weight. Independently knelt in a prone position. In May 2000, they put on crutches. The fourth course of treatment was completed after two months within 15 days, taking the drug three times a day per os with an interval of 6 hours at 70 mg / kg, the fifth and sixth course were repeated after a month, but the exercises in the simulator continued.

 Description of pathological reflexes: after the third cycle of treatment, the Babinsky, Oppenheim, Rossolimo reflex are negative. The reflex of special automatism (triple bending), the protective reflex of Marie Foix-Bechterew are negative.

 Thus, the results of the clinical use of the bacterial preparation showed that VETOM-7048 stimulates the nerve growth factor, and at the same time stimulates the growth of nerve processes and the multiplication of neurons. The fact that neurons are able to divide and multiply with the help of the bacterial preparation VETOM-7048 is obvious (Fig. 3, 4).

Claims (1)

A method of treating patients with spinal cord injuries, including the use of a medicinal biological product, characterized in that they use Vetom-7048, take it three times a day per os with an interval of 6 hours at 70 mg / kg, six courses of treatment are carried out with an interval between courses of 30 days, the first course is 20 days, the second is 10 days, the third is 10 days, the fourth is 15 days, the fifth is 20 days and the sixth course is 20 days, while from the second course of biotherapy for the regeneration of nerve tissue, a forced motion simulation is performed using devices for simulate walking lessons are conducted for 2.5 hours, twice a day.

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