RU2210377C1 - Method for increasing human and animal sexual activity (potency) - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: one should orally intake biologically active additives obtained out of cucumaria (sea cucumber) as "Tingol-2" at the quantity of 0.05-0.25 ml/kg body weight or "Erogol" at the quantity of 0.03-0.06 g/kg body weight daily for 20-40 d. Result is achieved due to higher libido, stimulation of spermiogenesis and increased number and mobility of spermatozoa. EFFECT: increased sexual activity.

Description

 The invention relates to medicine and can be used as a means to increase sexual activity in men of any age category and in warm-blooded animals.

 Known plant restorative agents exhibiting non-specific immunomodulating properties, used as agents that stimulate the nervous system in asthenic conditions, overwork, such as tinctures of ginseng, lure, aralia, safflower levzea, eleutherococcus, etc. (Mashkovsky M.D. Medicines 1. - M.: New Wave LLC: Publisher SB Divov, 2001. - S. 133-135).

 Known general strengthening agents obtained from raw materials of animal origin: pantocrine and Rantarin from antlers of sika deer (Mashkovsky M.D. Medicines, vol. 1. - M .: New Wave LLC: Publisher SB Divov, 2001. - S.136), pantogem from sika deer blood (TU 429-021-001-92).

 Compositional agents of a wide spectrum of action are known, consisting of sources of plant and animal origin, such as Herbamarin and Vitagen balms (TU 9169-010-20785204-94) containing extracts from ginseng, eleutherococcus, lemongrass, salmon milk , mummy.

 These funds are used in the rehabilitation of patients after various diseases, a decrease in the functions of the central nervous system, and a deterioration in muscle and mental performance.

 Known funds from cucumaria for the treatment of diseases of the musculoskeletal system (in particular, osteochondrosis and osteoporosis) of people of the older age category (40 years and above), described in US patent 5770205 (1998) and 5876762 (1999). The feedstocks are mainly Cucumaria japonica and Cucumaria frondosa.

 A method of treating inflammatory diseases is to use effective doses of compositions consisting of active ingredients isolated mechanically from the cucumaria membrane (body wall) - epithelial layer and corolla. The mechanical separation of the epithelial layer, corolla or inner wall of the body is carried out without and using heat treatment, the resulting mass is crushed and dried to an amount of water of 3-4%. For treatment, products are used that are obtained from the epithelial layer and corollas and the body wall itself separately, or making up various compositions from them.

 Cucumaria japonica holoturia triterpene glycosides are known to have antifungal, antitumor, cytolytic activity and exhibit immuno-modulating properties (Stonik VA, Elyakov GB Structure and Biological Activities of Sponge and Sea Cucumber Toxins. - Handbook of Natural Toxins and Venoms. - Ed. Tu. A. Marcel Dekker Inc., NY, 1988 .-- P. 107-120). The effects of triterpene glycosides on immunocompetent cells are known (Popov A.M., Atopkina L.N., Samoshina N.F., Uvarova N.I. Study of the immunomodulating activity of tetracyclic triterpene glycosides of the dammaran and holostane series. - Antibiotics and chemotherapy. -1994. - 39 (9-10), - S. 19-25). It is known that triterpene glycosides isolated from Cucumaria japonica have a modulating effect on stage III of the phagocytic reaction and stimulate low respiratory metabolism in the experiment on patients with chronic nonspecific inflammatory processes (osteoarthritis and bronchitis) of different age categories (Gerasimenko T.P., Stonik, Stonik V. A., Potapov VN Triterpene holosuria glycosides of Cucumaria-japonica as modulators of the functional activity of human blood neutrophils in vitro - New biomedical technologies using dietary supplements. - Collection of materials of the Russian scientific conference. - Vladivostok, June 24-25, 1998 - S. 1-4).

 There is a method of increasing the reproductive function by applying tincture of ginseng during sexual impotence of men (Ya. E. Ginzburg. Experience in treating ginseng in patients with functional disorders of sexual activity. - V. collection of materials for the study of stimulant and tonics. Means ginseng root Schisandra. - Issue 1, Vladivostok, 1951. - S.137-141).

 A known method of increasing the fertility of cows during the summer monsoon (RF patent 2148907 from 09/29/1998). During the summer monsoon, cows are fed with prickly Eleutherococcus extract. At the very beginning of estrus, 150 ml of prickly Eleutherococcus extract are given to the cows once, bringing the volume to 500 ml with water. The method allows to remove heat stress and has a positive effect on the results of insemination.

 Known means used in animal husbandry to stimulate the reproductive function of cows with endometritis (RF patent 2013950 from 06.15.1994), by two, three times injection of tissue extract from trepang. According to the description of the invention, the use of the drug increases the fertility of cows, and also helps to increase the live weight of calves, chickens and white mice. The analysis of this patent shows that the drug from trepang reduces the inflammatory process in diseases of the genital organs of cows, which indicates its possible anti-inflammatory effect.

 The closest to the achieved effect are funds from plant materials, in particular eleutherococcus. At the Khabarovsk artificial insemination station, an experiment was conducted to study the effect of eleutherococcus on the rearing function of bulls (Maksimov Yu.A. Eleutherococcus is a plant stimulant of the reproductive functions of cattle. - Materials for the study of ginseng and other medicinal products of the Far East. - Vladivostok, 1966. - Issue 8). Animals of the experimental group received 20 g of milled roots of Eleutherococcus for 15 days. It was found that Eleutherococcus increased sexual activity during the period of admission. The total number of sperm in the ejaculate while taking the roots increased by 24% compared with the control, and in the next month by 50%. Tincture of the roots of Eleutherococcus, used in small doses for feeding chickens and roosters for 20 days, allowed to reduce the number of unfertilized eggs by 3.8% (Lyapustina T.K. Use of Eleutherococcus in poultry and cattle breeding. - V. Sat. Results of the study of Eleutherococcus in Soviet Union .-- Vladivostok, 1966. - S. 85-87).

 The objective of the invention is the expansion of the arsenal of tools that increase the function of reproduction by increasing the mobility of sperm in the ejaculate, increasing sexual activity and increasing physical and mental performance.

 The problem is solved in that to stimulate spermatogenesis and increase sexual activity, biologically active additives TINGOL-2 or Erogol are used in an amount of 0.03 to 0.25 g (ml) per 1 kg of body weight.

 The essence of the invention is as follows: to stimulate spermatogenesis and increase sexual activity, TINGOL-2 or Erogol are used. In particular, per 1 kg of the mass of a person or animal "TINGOL-2" - from 0.05 to 0.25 ml. "Erogol" from 0.03 to 0.06 g.

 TINGOL-2 dietary supplement is a yellowish-golden solution obtained from the entrails of holothurians (Cucumaria japonica, Cucumaria frondosa), containing triterpene glycosides in an amount of 700-3500 μg / ml, with an alcohol content of 10-50% and lipids 0 , 5-4%.

 Dietary supplement "Erogol" is a powder obtained after processing the entrails of holothuria (Сucumaria-japonica, Cucumaria frondosa) with a water content of 3 - 12%, triterpene glycosides - 800-4500 μg / g, protein - 35-45%, manganese - 13 , 5-24.5 mg / kg, zinc - 44.0-82.0 mg / kg, iron - 481.2-893.5 mg / kg, copper - 5.6-10.4 mg / kg, nickel - 2.4-4.2 mg / kg, as well as the sum of the elements (calcium, magnesium, potassium) that regulate the water-salt balance of the body 6500-12000 mg / kg.

 The use of these biologically active additives as a means to increase sexual activity was discovered by the authors for the first time. The new function of the drugs does not obviously follow from their properties and composition.

 As a result of the tests, the stimulation of spermatogenesis was revealed for the first time both in experimental animals (mice) and in male volunteers who turned to the andrologist.

 Example 1

The effect of TINGOL-2 on the reproductive system of mammals was studied at the Department of Biology of VSMU
All animals from birth were kept under standard vivarium conditions. Studies were conducted on four groups of non-linear male mice:
Group 1 (control, adults) received a normative food mixture;
2nd group - adult males received "TINGOL-2" in the form of one daily supplement to the main feed in the amount of 0.03 ml per 1 kg of body weight;
3rd group (control, young) received a normative food mixture;
4th group - young males received "TINGOL-2" in the form of a daily individual supplement to the main feed of 0.03 ml per 1 kg of body weight;
During the entire period of the experiment, the animals were kept under normal light and temperature conditions, dynamic monitoring of the condition and behavior of animals was carried out. After 2 months, all animals were killed by decapitation and carried out morphometric, morphological and biochemical tests. A study of the testes of experimental animals, both adults and young, treated with TINGOL-2 revealed an increase in mitotically dividing spermatogonia in comparison with the control by 15% (in young animals) and by 26% (in adult animals). In males, the number of seminiferous tubules with mature spermatids (stage 12 of spermatogenesis) as a result of taking TINGOL-2 significantly increases compared with the control.

 There were no deviations in the behavior of adult and young animals treated with TINGOL-2 compared with the control.

 Morphometric parameters of adult and young mice (body weight, liver, spleen, testes) after taking "TINGOL-2" did not differ from those in the control groups.

 Example 2

 Studies on the use of "TINGOL-2" in the treatment of patients suffering from impaired sexual function were carried out on the basis of the clinic of the Internal Affairs Directorate of Primorsky Krai and the Center for Family Planning and Reproduction of Vladivostok.

 The selection criterion was men (10 people) with functional disturbances in the erection component, decreased libido, oligozoospermia of the 1st and 2nd degree and asthenozoospermia of the 1st and 2nd degree. The age of patients ranged from 24 to 55 years. All subjects filled out anonymous questionnaires about the development of the disease, were tested.

 The following preliminary laboratory tests were carried out: clinical blood test, general urine test, blood protein test, cholesterol, spermogram study, testosterone level determination.

 After a preliminary laboratory study, the subjects used TINGOL-2 in a dose of 5 ml 3 times a day for 21 days. The specified dose is 0.15 ml per 1 kg of human weight daily. The general condition of the subjects was monitored daily (mood, sleep, performance, libido, etc.). After using TINGOL-2, repeated laboratory tests were carried out: a general analysis of blood, cholesterol, blood proteins, spermogram, and the level of testosterone in the blood was determined.

 After treatment, it was found that “TINGOL-2” has a pronounced biological activity, which consists in improving the physical activity of the subjects, working capacity, mood, increasing libido, spontaneous and adequate erection, increasing the number of sexual intercourse, and improving sleep. The subjects increased the number of sperm in 1 ml of sperm by 80.3%, sperm motility increased by 61.0%, the level of motionless sperm decreased by 2 times. Blood testosterone levels increased by 18.3%.

 Example 3

 Studies on the use of "TINGOL-2" in the treatment of patients suffering from impaired sexual function were carried out on the basis of the clinic of the Internal Affairs Directorate of Primorsky Krai and the Center for Family Planning and Reproduction of Vladivostok.

 The selection criterion was men (15 people) with functional disturbances in the erection component, decreased libido, oligozoospermia of the 1st and 2nd degree and asthenozoospermia of the 1st and 2nd degree. The age of patients ranged from 23 to 61 years. All subjects filled out anonymous questionnaires about the development of the disease, were tested.

 A blood test, a general urine test, a study of blood proteins, the amount of cholesterol, testosterone, and a spermogram were performed.

 After a preliminary laboratory study, patients (5 people) used TINGOL-2, 0.05 ml per 1 kg of body weight daily for 42 days (1 teaspoon of the drug 1 time per day. The general condition of the subjects was monitored daily (mood, physical and mental performance, libido, etc.).

 It was established that "TINGOL-2" has activity, which consists in increasing physical and mental performance, increasing libido, spontaneous and adequate erection, increasing the number of sexual intercourse. The level of testosterone in the blood increased by 7.7%, the number of spermatozoa with rapid translational movement increased by 22.3%.

 Patients (10 people) receiving “TINGOL-2” 5 teaspoons daily (0.25 ml per 1 kg of a person’s weight) noted in some cases (3rd person) a slight overexcitation in the evening, which was sometimes expressed in difficulty falling asleep. After 20 days of treatment, the testosterone level in these patients increased by 20.1% compared with the control indicators, the number of sperm with the absence of translational motion decreased by 40%, the number of sperm with a slow translational motion decreased by 49%, the number of sperm with a rapid translational motion increased 1.5 times, the total amount of ejaculate increased by 63%.

 Example 4

 The use of "Erogol" as a therapeutic and prophylactic supplement in the treatment of patients suffering from impaired sexual function, decreased libido, oligozoospermia of the 1st and 2nd degree and asthenozoospermia of the 1st and 2nd degree.

 A group of patients (15 people) was formed on the basis of the clinic of the Internal Affairs Directorate of Primorsky Krai and the Center for Family Planning and Reproduction of Vladivostok. All subjects filled out anonymous questionnaires about the development of the disease, were tested. The following preliminary laboratory studies were carried out: a clinical blood test, a general urinalysis, a study of blood proteins, cholesterol, a spermogram study, determination of the level of testosterone, prolactin, FSH, hypertension. After a preliminary laboratory study, the subjects used Erogol at a dose of 2 capsules 2 times a day to 3 capsules 3 times a day, i.e. from 0.03 to 0.06 g per 1 kg of body weight for 21 days. The general condition of the subjects was monitored daily (mood, sleep, performance, libido, etc.). After the use of Erogol, repeated laboratory tests were carried out: a general analysis of blood, cholesterol, blood proteins, urine, the level of testosterone, prolactin, FSH, hypertension in serum, and spermogram were determined.

 There was an improvement in physical activity, performance, mood, spontaneous and adequate erection, increased libido, increased number of sexual intercourse, improved sleep. Sperm motility increased by 78%, the number of motionless sperm decreased by 2.3 times; the total sperm count in 1 ml of sperm increased from 146.4 million to 164.7 million. The level of testosterone in the blood increased by an average of 38.9%.

Claims (1)

 A method of increasing the sexual activity of humans and animals, including the intake of biologically active food supplements, characterized in that biologically active additives obtained from cucumaria are taken orally per 1 kg of body weight as a biologically active supplement stimulating spermatogenesis: "TINGOL-2" in an amount of from 0.05 to 0.25 ml or "Erogol" in an amount of from 0.03 ml to 0.06 g daily for 20-40 days.