RU2177799C1 - Species of medicinal plants for treatment of abstinent and postabstinent syndrome in drug addict patients (variants) - Google Patents

Abstract

FIELD: medicine, narcology, phytotherapy. SUBSTANCE: invention proposes 4 species for treatment of abstinent and postabstinent syndromes in patients suffering with drug addiction. The proposed species eliminate depression symptoms, enhanced excitability and sleep disturbance. Medicinal plants as components of species show interenhancing effect and prolong effect of each component that ensures to exclude intake of medicinal agents which deteriorate the impaired liver function as the main detoxificating organ in humans. Investigations showed good tolerance of species, absence of complications and adverse effects. The proposed species of medicinal plants can be used as a phytocomponent to biologically active supplements and tea. EFFECT: enhanced effectiveness of species, valuable medicinal properties, absence of adverse effects. 4 cl

Description

 The invention relates to medicine, namely to the creation of collections of medicinal plants that can be used to treat withdrawal and post-withdrawal syndromes in drug addicts.

 Known collection of herbs for the prevention and treatment of drug addiction (Medvedev V.M., Ponomareva A.G. Patent of the Russian Federation 2136302 "Collection" Tale "," H1 "," H2 "," H3 "herbs for the prevention and treatment of drug addiction (it options) ", (IPC A 61 K 35/78, published in BI 25 on 09/10/99).

 Harvesting H1 (cleansing) helps to reduce increasing depression and poor health by cleansing the gastrointestinal tract during the acute period of drug withdrawal. The collection contains motherwort, licorice, shepherd’s bag, immortelle, chamomile, mint, St. John’s wort, oak, yarrow, initial letter, clover, nettle, dogrose, hawthorn, lewze, eleutherococcus, valerian, caraway seeds, milk thistle and orange zest. The collection is the closest analogue to our collection 1.

 The collection of H2 (corrective) is aimed at correcting functional disorders in patients with drug addiction with a set of anti-inflammatory, soothing herbs. The collection contains motherwort, sage, calendula, nettle, oak, St. John's wort, yarrow, caraway seeds, coriander, celandine, eleutherococcus, leuzea, mint, bearberry, eucalyptus, valerian, tansy, licorice, calamus, rosehip, hawthorn, sweet clover, sweet clover, donnik . The fee is the closest analogue to our proposed fees 2-4.

 The principle of compiling the fees presented in the patent is based on an analysis of the stages of contamination of adolescents and the correction of the resulting violations of the gastrointestinal tract, immune system, allergic tissue damage in the form of liver cirrhosis, non-infectious hepatitis. The collections of H1 and H2 contain medicinal plants that reduce and remove the pathological manifestations of withdrawal symptoms.

 However, the authors did not take into account modern views on the biological basis for the development of drug addiction as an imbalance in neurotransmitter systems caused by chronic intoxication with drugs (I.P. Anokhina. Biological mechanisms of dependence on psychoactive substances. In the book: Lectures on narcology, under the editorship of prof.Ivanets N.N., M., 2000 .-- S. 16-40). The proposed fees are not effective enough to relieve the phenomena of depression, increased irritability, sleep disturbances and other phenomena that accompany withdrawal and post-withdrawal syndromes.

 The objective of the invention is to develop effective compositions of plant origin for the treatment of withdrawal and post-withdrawal syndromes in patients with opium addiction.

 The problem is solved by the following compositions.

Collection of medicinal plants 1
The collection is used for the predominance of depression, sleep disturbance, irritability in the withdrawal and post-withdrawal periods, and asthenia in the post-withdrawal period. The collection contains medicinal plants that relieve vegetative-somatic disorders that improve the activity of the gastrointestinal tract, general and coronary circulation, plant analgesics and other components in the following ratio, weight. hours:
Hypericum perforatum grass - 1.0 - 3.0
Grass meadowsweet - 1.0 - 3.0
Flowers of medicinal marigolds - 1.0 - 2.0
Plowed clover grass - 3.0 - 5.0
The grass of the white walnut - 1.0 - 3.0
Herb initial letters - 1.0 - 3.0
Yarrow grass - 1.0 - 3.0
Leaf of plantain large - 1.0 - 3.0
Melissa officinalis herb - 1.0 - 2.0
Licorice root naked - 1.0 - 2.0
Oregano grass - 1.0 - 3.0
Lungwort officinalis herb - 1.0 - 3.0
Cinnamon rose hips - 1.0 - 3.0
Common chicory herb - 1.0 - 2.0
Herb grass of the Common Arborea - 1.0 - 2.0
Herb smoky officinalis - 1.0 - 2.0
Swamp saber grass - 1.0 - 2.0
Blackberry leaf with gray - 1.0 - 2.0
Blood Red Hawthorn Fruits - 1.0 - 3.0
Cones of ordinary hop - 1.0 - 3.0
Collection of medicinal plants 2
The collection is used in the prevalence of increased irritability in the clinical picture, sleep disturbances up to insomnia, the collection corrects vegetative-somatic disorders, contains herbal analgesics and other components in the following ratio, weight. hours:
The grass of the white walnut - 1.0 - 3.0
Yarrow grass - 1.0 - 3.0
Melilotus officinalis herb - 1.0 - 3.0
Oregano grass - 1.0 - 3.0
Melissa officinalis herb - 1.0 - 2.0
Cones of ordinary hop - 1.0 - 3.0
Fragrant woodruff herb - 4.0 - 6.0
Grass of the bedstraw of the present - 1.0 - 3.0
Marsh Cinquefoil Grass - 4.0 - 6.0
Heartwort herb - 4.0 - 6.0
White Acacia Flowers - 1.0 - 3.0
Heather grass - 3.0 - 5.0
Grass river gravel - 1.0 - 3.0
Grass meadowsweet - 1.0 - 3.0
The method of preparation of the infusion from fees 1 and 2:
1 tablespoon of the brew is brewed with 500 ml of boiling water, insisted for 2 hours, filtered. Take an infusion of 0.5 cup 4-5 times a day and at night in the form of heat.

 Collection of medicinal plants 3 - detoxifying, improving the activity of the cardiovascular system, calming, relieving depression and improving sleep, correcting somatic-vegetative disorders.

Contains the following plant components, weight. hours:
Spring primrose grass - 1.0 - 3.0
Herb of medicinal plants - 1.0 - 3.0
Highlander's Grass - 1.0 - 3.0
Sowing oats grass - 1.0 - 2.0
Small Periwinkle Grass - 1.0 - 2.0
Common chicory herb - 1.0 - 2.0
Grass of loosestrife loosestrife - 1.0 - 2.0
Fragrant woodruff herb - 1.0 - 2.0
Flowers of medicinal marigolds - 1.0 - 3.0
Melilotus officinalis herb - 1.0 - 3.0
Yarrow grass - 1.0 - 3.0
Hypericum perforatum herb - 1.0 - 2.0
Stony bony grass - 1.0 - 2.0
Grass of a bedstraw of the present - 1.0 - 2.0
Plowed clover grass - 1.0 - 2.0
Licorice root naked - 1,0
Cones of ordinary hop - 1.0 - 2.0
Tricolor violet grass - 1.0 - 2.0
Oregano grass - 1.0 - 2.0
Grass shepherd's purse - 1.0 - 2.0
Grass bell bell crowded - 1.0 - 2.0
Heartwort herb - 1.0 - 3.0
Lungwort officinalis herb - 1.0 - 3.0
Grass Korostavista field - 1.0 - 3.0
Cinnamon rose hips - 1.0 - 3.0
Collection of medicinal plants 4
The main indication for use is the presence of chronic persistent hepatitis of viral origin. The collection is aimed at improving the activity of the gastrointestinal tract, the function of the liver, pancreas, taking into account the pathogenetic mechanisms - antiviral, cholelithic, activation of interferonogenesis, antioxidant. In addition, the collection contains medicinal plants, antidepressants, sedatives that improve sleep, general and cerebral circulation, tonic in the following ratio of components, weight. hours:
Cinnamon rose hips - 1.0 - 3.0
Peppermint herb - 1.0 - 3.0
Hypericum perforatum grass - 1.0 - 3.0
Stinging nettle herb - 1.0 - 3.0
Melilotus officinalis herb - 1.0 - 3.0
Flowers of medicinal marigolds - 1.0 - 3.0
Cross gentian grass - 1.0 - 2.0
Licorice root naked - 1.0 - 2.0
Dandelion Root - 1.0 - 2.0
The grass of the white walnut - 1.0 - 3.0
Herb of medicinal plants - 1.0 - 3.0
Marsh Cinquefoil grass - 1.0 - 3.0
Herb initial letters - 1.0 - 3.0
Raspberry leaf - 1.0 - 3.0
Leaf of plantain large - 1.0 - 3.0
Plowed clover grass - 1.0 - 2.0
Grass of loosestrife loosestrife - 1.0 - 2.0
Scepter-like Mullein Grass - 1.0 - 2.0
Veronica Dubrava grass - 1.0 - 2.0
Silver cinquefoil grass - 1.0 - 2.0
Grass Korostavista field - 1.0 - 2.0
Grass of a bedstraw of the present - 1.0 - 2.0
Common cuff grass - 1.0 - 3.0
Lungwort officinalis herb - 1.0 - 3.0
Common Dreams Grass - 1.0 - 3.0
Fees were applied in the form of a freshly prepared infusion in various combinations, depending on the prevalence of withdrawal and post-withdrawal syndromes of certain complaints in the clinical picture.

The method of preparation of the infusion from fees 3 and 4:
1 teaspoon of the brew is brewed with 500 ml of boiling water, insisted for 2 hours, filtered. Take an infusion of 1/3 cup 3 times a day 15 minutes before meals in a warm form.

 Treatment with collections was carried out in 100 patients with opium (heroin) drug addiction aged 15 to 36 years on the basis of the Counseling Center of the Krutitsky Patriarchal Compound (head hieromonk, Prof. Dr. med. Anatoly Berestov).

 The clinical picture of withdrawal symptoms was dominated by psychopathological disorders. The post-withdrawal condition was characterized by depression to one degree or another, anxiety, anergy, vegetative-somatic disorders, and a pathological attraction to heroin.

 A quantitative assessment of the severity of the condition of patients was carried out on a 4-point scale developed at the Research Institute of Narcology, where 0 is the absence of a symptom, 1 is its weak severity, 2 is moderate severity, 3 is severe severity (N. N. Ivanets, M. A. Vinnikova // Heroin addiction. - M.: 2000 - 122 p.).

 Mild severity of withdrawal and post-withdrawal syndromes was diagnosed in 68 patients, moderate - in 32 patients.

 Treatment of patients with the above infusions from fees reduced and eliminated pathological symptoms within 12-20 days, further maintenance therapy was carried out, given the duration of the course of post-withdrawal syndrome - from 15-20 days to 1-2 months (N.V. Strelets, S. I. Utkin, E. Yu. Grigoryeva // Issues of narcology. - M.: 2000 - p. 30-39).

 There were no complications during treatment.

We give specific examples.
Example 1
B. P., 19 years old. Complaints of poor sleep, irritability. Currently not studying, not working.

 Heroin is consumed throughout the year (intravenous administration of up to 0.1 g per day, daily). Before that, there was a sample of tobacco, marijuana for 3 months. Not treated. Spontaneous remissions - up to 7 days. Last use 7 days ago. A mild withdrawal syndrome with psychopathological manifestations was diagnosed (1 point).

 Charges 2 and 3 were assigned. On the 5th day of treatment, my health improved, I began to sleep more calmly, and my irritability was less.

 There are no complaints on the 12th day of treatment. The infusions from the collection tolerates well.

Example 2
Boy R., 26 years old. Complaints of poor sleep, low mood, feeling of anxiety. Secondary education, currently not studying, not working. Heroin consumes 1.5 years, daily, 2 times a day, intravenously, a dose of 0.1 g per day. Spontaneous remissions 3-4 days. He was treated by private practitioners-narcologists. Therapeutic remission up to 10 days. Last use 2 days ago. Diagnosis: opium (heroin) addiction. Mild withdrawal syndrome (psychopathological manifestations 2 points).

 Assigned infusions from fees 1 and 3. Improvement on the 8th day. Infusions well tolerates. The complete disappearance of all pathological symptoms was noted on the 14th day.

Example 3
B. P., 23 years old, higher education, does not work. He uses heroin for about a year, immediately intravenously, daily, 3-4 times a day. The daily dose is 1 g. Repeatedly treated in a hospital. In August 1999, hepatitis B was diagnosed and was not treated. Suffers from bronchial asthma.

 He addressed on April 17, 2000 with complaints of poor sleep, irritability, depression, pain in the muscles of the legs, back, sweating. Last drug use 3 days ago. On examination, the patient is anxious, hyperhidrosis, severe irritability.

 Diagnosis: opium (heroin) addiction. Abstinence syndrome of moderate severity with psychopathological (2 points) and somato-vegetative (2 points) manifestations.

 Prescribing infusions from fees 1 and 3 before and after meals, alternating every other day from 2 and 3. On the 6th day, the state of health improved, muscle pains, no sweating. He became calmer. On the 12th day of treatment, sleep returned to normal, mood improved. After 3 weeks, no complaints. Considering the moderate severity of withdrawal symptoms, it is recommended to continue taking infusion from collection 3 for a month, and also due to the presence of viral hepatitis, infusions from collection 4. Further examination and treatment by an infectious disease doctor are necessary.

 The results of dynamic observation during the year showed a lasting therapeutic effect.

Example 4
B. S., 21 years old, incomplete higher education, works as a worker. Heroin use history is 3 years, almost daily, 1 g or more per day. Spontaneous remissions up to 4 months. 3 years ago hepatitis "C" was diagnosed. He was treated in the hospital. Botkin. A month ago, a biochemical blood test was done: Al AT-56.3 units. , AsAT - 43.1 units. Last heroin use 3 days ago.

 Complaints of sleep disturbance, sometimes insomnia, severe irritability, depression, sweating, back pain, leg muscles.

 Withdrawal syndrome is defined as moderate with somatovegetative (2 points) and psychopathological (3 points) disorders. Chronic persistent hepatitis.

 Assigned infusions from fees 2 and 3 (alternating during the day before and after meals). On the 8th day of treatment, irritability, sweating, and muscle pain decreased. The mood background remains lowered. An infusion from collection 1 was added to the treatment. One week after that, she feels well and has no complaints. Infusions well tolerates.

 Given the presence of viral hepatitis and an increase in blood enzymes, an infusion from collection 4 was added. A control blood test after 3 weeks, the parameters of the enzymes AlAT and AsAT were normal.

 Studies have shown good tolerance fees according to the invention, the absence of complications and side effects.

 In the proposed collections, a large place is given to the removal of the phenomena of depression, increased irritability, and sleep disturbance. Medicinal plants taken in their composition, mutually reinforce and prolong the action of each other, which allows you to do without taking medications that worsen the already impaired liver function as the main detoxifying organ in humans.

 The proposed collections of medicinal plants can be used as a phytocomponent to biologically active additives and teas.

Claims (1)

1. Collection for the treatment of withdrawal and post-withdrawal syndromes in patients with drug addiction, containing St. John's wort, clover, yarrow, initial letter, licorice, rosehip, hawthorn, characterized in that it additionally contains grass of the meadowswort, medicinal marigold flowers, white calendula grass, large plantain leaf , Melissa officinalis herb, Origanum vulgaris herb, Medicinal herbs of Lungwort, Chicory vulgaris grass, Common arboretum grass, Medicinal haze grass, Marsh cinquefoil grass, Blackberry leaf and mew, hop cones ordinary at the following component ratio, wt. hours:
Hypericum perforatum grass - 1.0 - 3.0
Grass meadowsweet - 1.0 - 3.0
Flowers of medicinal marigolds - 1.0 - 2.0
Plowed clover grass - 3.0 - 5.0
The grass of the white walnut - 1.0 - 3.0
Herb initial letters - 1.0 - 3.0
Yarrow grass - 1.0 - 3.0
Leaf of plantain large - 1.0 - 3.0
Melissa officinalis herb - 1.0 - 2.0
Licorice root naked - 1.0 - 2.0
Oregano grass - 1.0 - 3.0
Lungwort officinalis herb - 1.0 - 3.0
Cinnamon rose hips - 1.0 - 3.0
Common chicory herb - 1.0 - 2.0
Herb grass of the Common Arborea - 1.0 - 2.0
Herb smoky officinalis - 1.0 - 2.0
Swamp saber grass - 1.0 - 2.0
Blackberry leaf with gray - 1.0 - 2.0
Blood Red Hawthorn Fruits - 1.0 - 3.0
Cones of ordinary hop - 1.0 - 3.0
2. A collection for the treatment of withdrawal and post-withdrawal syndromes in patients with drug addiction, containing yarrow, clover, motherwort, characterized in that it additionally contains white cucumber grass, common oregano grass, medicinal lemon balm grass, common hop cones, sweet woodruff grass, real grass sack grass , grass of saber-eared marsh, white acacia flowers, grass of heather ordinary, grass of river gravilate, grass of meadowsweet in the following ratio of components, weight. hours:
The grass of the white walnut - 1.0 - 3.0
Yarrow grass - 1.0 - 3.0
Melilotus officinalis herb - 1.0 - 3.0
Oregano grass - 1.0 - 3.0
Melissa officinalis herb - 1.0 - 2.0
Cones of ordinary hop - 1.0 - 3.0
Fragrant woodruff herb - 4.0 - 6.0
Grass of the bedstraw of the present - 1.0 - 3.0
Marsh Cinquefoil Grass - 4.0 - 6.0
Heartwort herb - 4.0 - 6.0
White Acacia Flowers - 1.0 - 3.0
Heather grass - 3.0 - 5.0
Grass river gravel - 1.0 - 3.0
Grass meadowsweet - 1.0 - 3.0
3. A collection for the treatment of withdrawal and post-withdrawal syndromes in patients with drug addiction, containing yarrow, marigolds, licorice, St. John's wort, rosehip, sweet clover, characterized in that it additionally contains spring primrose grass, medicinal herb, bird of highlander, grass of oat sowing, grass small periwinkle, common chicory grass, loosestrife grass, loosestrife grass, sweet woodruff grass, stony grass grass, real bedstraw grass, plowed clover grass, ordinary hop cones, violet grass tricolor, oregano grass, shepherd’s grass grass, bell bell grass, heartwort grass, medicinal lungwort grass, field bark grass in the following ratio of components, weight. hours:
Spring primrose grass - 1.0 - 3.0
Herb of medicinal plants - 1.0 - 3.0
Highlander's Grass - 1.0 - 3.0
Sowing oats grass - 1.0 - 2.0
Small Periwinkle Grass - 1.0 - 2.0
Common chicory herb - 1.0 - 2.0
Grass of loosestrife loosestrife - 1.0 - 2.0
Fragrant woodruff herb - 1.0 - 2.0
Flowers of medicinal marigolds - 1.0 - 3.0
Melilotus officinalis herb - 1.0 - 3.0
Yarrow grass - 1.0 - 3.0
Hypericum perforatum herb - 1.0 - 2.0
Stony bony grass - 1.0 - 2.0
Grass of a bedstraw of the present - 1.0 - 2.0
Plowed clover grass - 1.0 - 2.0
Licorice root naked - 1,0
Cones of ordinary hop - 1.0 - 2.0
Tricolor violet grass - 1.0 - 2.0
Oregano grass - 1.0 - 2.0
Grass shepherd's purse - 1.0 - 2.0
Grass bell bell crowded - 1.0 - 2.0
Heartwort herb - 1.0 - 3.0
Lungwort officinalis herb - 1.0 - 3.0
Grass Korostavista field - 1.0 - 3.0
Cinnamon rose hips - 1.0 - 3.0
4. A collection for the treatment of withdrawal and post-withdrawal syndromes in patients with drug addiction, containing rosehip, mint, St. John's wort, nettle, sweet clover, marigolds, licorice, clover, characterized in that it additionally contains gentian grass, crucifix root, dandelion root, white lamb grass, grass repesica officinalis, grass of the marsh cinquefoil, grass of the capercaillie medicinal, leaf of raspberry vulgaris, leaf of the large plantain, grass of the loosestrife loosestrifera, grass of the mullein scepter, grass of veronica oak, grass of the cinquefoil silver, grass knautia arvensis, Galium verum grass, grass, lady's mantle, lungwort medicinal herb and grass ground elder at the following component ratio, wt. hours:
Cinnamon rose hips - 1.0 - 3.0
Peppermint herb - 1.0 - 3.0
Hypericum perforatum grass - 1.0 - 3.0
Stinging nettle herb - 1.0 - 3.0
Melilotus officinalis herb - 1.0 - 3.0
Flowers of medicinal marigolds - 1.0 - 3.0
Cross gentian grass - 1.0 - 2.0
Licorice root naked - 1.0 - 2.0
Dandelion Root - 1.0 - 2.0
The grass of the white walnut - 1.0 - 3.0
Herb of medicinal plants - 1.0 - 3.0
Marsh Cinquefoil grass - 1.0 - 3.0
Herb initial letters - 1.0 - 3.0
Raspberry leaf - 1.0 - 3.0
Leaf of plantain large - 1.0 - 3.0
Plowed clover grass - 1.0 - 2.0
Grass of loosestrife loosestrife - 1.0 - 2.0
Scepter-like Mullein Grass - 1.0 - 2.0
Veronica Dubrava grass - 1.0 - 2.0
Silver cinquefoil grass - 1.0 - 2.0
Grass Korostavista field - 1.0 - 2.0
Grass of a bedstraw of the present - 1.0 - 2.0
Common cuff grass - 1.0 - 3.0
Lungwort officinalis herb - 1.0 - 3.0
Common Dreams Grass - 1.0 - 3.0