RU2164132C2 - Suppository with radon of medical designation - Google Patents

Abstract

FIELD: medicine, particularly, medical preparation with radon. SUBSTANCE: invention proposes replacement of filler containing cacao butter in the amount of 2 g for medical suppository in sealed vessel of 10-ml volume with 8 ml of aqueous concentrate of radon with activity of 0.05-0.5 mc of oxygen utilization factor for saturation of suppository up to activity of 0.1-1.0 mc of oxygen utilization factor. The invention excludes radon losses, simplifies the application procedures and due to increased time of radon retention in organism, quantity of daily procedures is reduced and their efficiency are increased. EFFECT: increased efficiency of procedures. 2 ex

Description

 The present invention relates to medicine, in particular to medicines, and can be used for the treatment and prevention of various diseases in medical institutions equipped with radon laboratories.

 An analogue of the invention can serve as candles from cocoa butter with various medicinal products. For example, therapeutic candles with voltaren, methyluracil, belladonna (Vidal Drug Reference, 1996).

 The prototype of the proposed candles can be microclysters with an aqueous concentrate of radon used for treatment (I. I. Gusarov "Radonotherapy", 1974). To carry out the procedure, about 100 ml of an aqueous solution of radon is injected into the rectum using a Jeanne syringe.

 The disadvantage of perrectal administration of an aqueous solution of radon is the loss of radon from the water when it is taken into the syringe and during the procedure, as well as the fact that this procedure must be carried out three times a day, which is inconvenient for the patient and is actually only possible under stationary conditions.

 The technical result of the invention is a longer delay of radon in the rectum, reduction of the volume of the treatment medium introduced into the rectum, exclusion of radon losses, simplification of the procedure, reduction of the number of daily procedures to one due to saturation of the filler for the treatment candle with radon.

 The specified technical result is achieved by the fact that in a sealed vessel with a capacity of 10 ml with 8 ml of an aqueous concentrate of radon with an activity of 0.05-0.5 μCi / ml, a filler for a therapeutic candle, consisting of cocoa butter, is placed in an amount of 2 g per 23-25 h, to saturate the candles to an activity of 0.1-1.0 μCi.

 Measurements on a gamma counter showed that cocoa butter saturates with radon 30 times better than water, and firmly holds radon in a hermetically enclosed space (for example, a bottle with a ground stopper).

 A saturation time of 23-25 hours is necessary for the most complete transition of radon from an aqueous concentrate into a filler for a therapeutic candle. A time of less than 23 hours is not enough for saturation, an increase in time of more than 25 hours increases losses due to the natural decay of radon.

 Description of the candle.

 In a 10 ml flask filled with 8 ml of an aqueous radon concentrate with an activity of 0.05-0.5 µCi / ml, a filler of cocoa butter weighing 2 g is placed, after which the flask is hermetically closed. After 24 hours, 25% of the radon from the water passes into the candle (with a ratio of the volume of water and cocoa butter 4: 1) and is firmly held in it. The activity of the aqueous radon concentrate is selected so that the radon content in the candle matches the specified value (from 0.1 to 1.0 μCi). The patient injects 1-3 candles per day into his rectum, depending on the medical purpose.

 Example 1. To obtain a candle containing 0.1 μCi, 8 ml of an aqueous radon concentrate with a specific activity of 0.05 μCi / ml was poured into a hermetically sealed vial and a candle made of cocoa butter weighing 2 g for 24 hours was placed in it.

 Example 2. To obtain a candle containing 1 μCi, 8 ml of an aqueous radon concentrate with a specific activity of 0.5 μCi / ml is poured into a hermetically sealed vial and a candle made of cocoa butter weighing 2 g for 24 hours is placed in it.

 It was found that radon from a candle is practically not lost during storage in an aqueous solution in a sealed vessel (only natural decay of radon occurs (half-life of 3.825 days). A candle saturated with radon is wrapped in foil and stored in the refrigerator’s freezer. there is practically no loss of radon from the candle into the environment, and there are practically no losses of radon from the candle during the procedure.

 Using a candle, an increase in the effectiveness of the procedure is achieved due to prolongation of the content of radon in the rectum and its slower removal from the pelvic organs, a significant reduction in the volume of the radon-containing medium for one procedure, the exclusion of radon losses during the procedure, the possibility of the procedure even for patients on an outpatient basis .

 In the rectum, radon from cocoa butter is absorbed into the blood and is completely eliminated from the body through the lungs in about 6-8 hours, and from water in 2-3 hours.

 The technical and economic efficiency of a candle with radon is that it is simple to manufacture, convenient to use. Almost safe for staff, as it is introduced by the patient himself. The use of this candle is possible both in stationary and on an outpatient basis in medical institutions where radon procedures are dispensed.

 The method of preparing a candle with radon was tested in the radiobiology laboratory of the Russian Scientific Center for Reconstructive Medicine and Balneology of the Ministry of Health of the Russian Federation, tested in an animal experiment, tested on patients at the RSCVMiK clinic and is recommended for implementation in medical practice.

Claims (1)

 Candle with radon for therapeutic use, consisting of cocoa butter weighing 2 g, characterized in that it is saturated with radon from an aqueous concentrate of radon for 23 - 25 hours to an activity of 0.1 - 1.0 μCi.