RU2146540C1 - Method and device for affecting pathogenic microorganisms - Google Patents

Abstract

FIELD: medicine; medical engineering. SUBSTANCE: method involves inhibiting metabolism activity of sample cells by injuring them to a state enabling full-scale cell activity restoration to be impossible. The state is recorded by exposing the carrier to extremely high frequency radiation in its direct interaction with the cells. Then the information carrier is enclosed into biologically inert material envelope and set into a device applied for acting upon the organism. The device has carrier with stored information that concerns metabolism activity of the injured sample cells prior to a state enabling full-scale cell activity restoration to be impossible. The carrier is mounted in screening casing with cover. The casing also has magnetic field source for acting upon the information carrier, manufactured as permanent magnet or solenoid. The information carrier is semiconductor crystal like semiconductor diode or transistor crystal connected to power supply source and having links to commutation and indication units. All units of the device are provided with screening partitions. The screening partitions and the screening casing enclose some protection volume protecting the information carrier from parasite self-recording during device operation time. EFFECT: excluded external noise influence; high accuracy in building structure of frequency-and-wave analog of the injured cells; enhanced effectiveness of treatment. 7 cl, 2 dwg

Description

 The invention relates to information-wave medicine and medical equipment and can be used for therapeutic effects in pathological conditions of humans or animals caused by pathogenic microorganisms, including bacteria, protozoa, viruses, fungi and prions.

 Known means using information-wave effects on the human body or animals. The principle of action of such funds is based on the organization of an external control action on the information field of the body. As you know, this external control action is an electromagnetic field of low intensity, which imitates the body's own information signals during the period when violations of the conditions of their normal functioning occur.

 A known method of therapy and diagnosis and its implementing system according to the application EA N 960039, MKI (6) A 61 B 5/04, publ. 06/30/97. The known method consists in organizing the external control loop of the body’s information field, for which the information field, which controls the body and which also reflects its interaction with the external environment, is removed from the body, processed and returned to the same or another body. One of the processing tasks is to isolate physiological and pathological vibrations that return to the human body with certain amplitudes and spectral ratios, in order to restore normal homeostasis of the biophysical and biochemical levels of its functioning.

 A system that implements this method contains a number of spatially separated sensors (electrodes). The recorded electromagnetic oscillations are subjected to adaptive spatio-temporal and frequency processing, nonlinear filtering, separation in the corresponding blocks and returned to the same or another system of spatially spaced electrodes located on the same or another organism.

 The introduction into the external control loop of additional information fields from other organisms, nosodes, organ preparations, etc., as well as natural and pathological secretions (blood, saliva, urine, tears, pieces of tissue, pus, etc.) allows solving diagnostic problems and increase the effectiveness of therapy.

 However, the known method and system are complex and can only be implemented in a hospital. Meanwhile, as often happens in practice, the diagnosis is not difficult, as, for example, in the case of diagnosing diseases caused by pathogenic microorganisms. In these cases, it is advisable to have a simple portable device for the implementation of therapeutic effects on pathogenic microorganisms.

 The closest method and device to the present invention is a technical solution according to the patent of the Russian Federation N 2055604 from 09/13/93, MKI A 61 M 37/00.

 A known method of influencing pathogenic microorganisms involves suppressing the metabolic activity of exemplary cells of a pathogenic microorganism, followed by recording their own electromagnetic radiation on a storage medium that provides a therapeutic effect on pathogenic microorganisms.

 A device that implements this method contains a carrier with information about the metabolic activity of pathogenic microorganisms installed in a shielding housing with a cover. The specified storage medium performs the functions of reception, transmission and storage and includes a receiver, a generator and a memory unit, made in the form of a single element. In addition, the device contains a temperature change unit connected to a single element, made in the simplest case in the form of an electric energy source. The storage medium through the switching unit is connected to a source of electrical energy. Information recording (during reception) and information reading (during transmission) are carried out during a full cycle of changing the temperature of the carrier material using the temperature change unit. As a result of the therapeutic effect, the metabolic activity of the cells of the pathogenic microorganism is established similar to the activity of model cells.

 Since in the process of implementing the method only the suppression of the metabolic activity of exemplary cells is performed, the process of restoring the metabolic activity of the cells of the pathogenic microorganism after the cessation of the treatment effect is possible, which reduces the efficiency of the method and the device that implements it.

 Since both recording and reading information are carried out as a single element, when recording along with useful information about the metabolic activity of sample cells, it is possible to record information fields of objects surrounding the device, and when reading (affecting an object), it is possible to simultaneously record complex information-wave effects as an organism in whole (human, animal), and its individual cells, as well as objects surrounding the device, which negatively affects the effectiveness of the method and device, because to recognize the control action in this complex signal and to adequately respond to it is almost impossible. In addition, as a result of exposure to electromagnetic fields excited by individual nodes of the device, it is possible to record information about the state of the materials from which these nodes are made. This "spurious" information is superimposed on the useful information, which also reduces the efficiency of the device.

 Low efficiency is a significant disadvantage of the known method and its implementing device.

 The problem to which the invention is directed, is to create an effective way of influencing pathogenic microorganisms that would not have an effect on autoflora and the body’s own cells, as well as to create a portable highly specialized device for therapeutically effective effect on a particular type of pathogenic microorganism and, in addition, in the creation of a unified range of devices characterized by built-in storage media, which are frequency-wave analogues of real types of damaged pathogenic microorganisms.

 The specified technical result is achieved in that in a device for influencing pathogenic microorganisms containing a carrier with information about the metabolic activity of pathogenic microorganisms installed in a shielding housing with a lid, according to the invention, the carrier includes information about the metabolic activity of damaged sample cells to a state in which the recovery process cell activity becomes impossible, a magnetic field source is installed in the housing to act on the information carrier .

 The specified result is also achieved by the fact that the magnetic field source can be made in the form of a permanent magnet of a rectangular, round or circular shape, as well as in the form of a solenoid.

 The information carrier in the proposed device can be made in the form of a semiconductor crystal. As a semiconductor crystal, a crystal of a semiconductor diode or transistor can be used, which is connected to a current source and connected to switching and indicating units.

 The specified technical result is also achieved by the fact that all nodes of the device are separated from each other by shielding partitions.

 With regard to the method, the technical result is achieved in that in the method for influencing pathogenic microorganisms, including suppressing the metabolic activity of sample cells, followed by recording their own electromagnetic radiation on a storage medium, according to the invention, the metabolic activity of sample cells is suppressed by damaging them to a state in which the process full restoration of cell activity becomes impossible, and information is recorded by exposure EHF radiation on the carrier during its direct contact with cells, after which the carrier is packed with biologically neutral material and installed in a device for influencing microorganisms.

 The essence of the proposed method lies in the fact that they suppress the metabolic activity of sample cells of a certain type and damage their structural and physiological state by any damaging factor, for example, exposure to chloramine, EHF exposure, UV exposure. Moreover, the choice of a damaging factor depends on the type of pathogenic microorganism. The degree of damage is judged by any known method, for example, by the degree of leakage of UV absorbing substances from the cell before and after exposure to the dose of damage. It was experimentally established that at the maximum possible degree of leakage of UV absorbing substances from the cell of the pathogenic microorganism, the membrane and the shell of the nucleus of the pathogenic microorganism are disrupted, which is accompanied by the release of nucleic acids, amino acids, nucleotides, etc. into the surrounding space, i.e. . a conformational isometric change in biomolecules occurs. In this case, the process of restoring the metabolic activity of exemplary cells in full becomes impossible.

 Then, in the laboratory, they record their own electromagnetic radiation of damaged cells by exposing the carrier to EHF radiation when it is in direct contact with the cells, and the recorded information is enhanced, after which the information carrier, a frequency-wave analogue of the damaged cells of a pathogenic microorganism, is placed in a device that carry out effects on the human or animal body. To increase the efficiency of the method, the storage medium is placed in a magnetic field.

 Recording in laboratory conditions (outside the exposure device) allows you to exclude when recording the effect of various bioenergy information on the storage medium. Strengthening bioenergy information during recording allows you to get a clearer structure of the frequency-wave analogue of damaged cells, as well as to increase the stability and reproducibility of recorded information. When an electromagnetic field of such a structure acts on the electromagnetic field of a pathogenic microorganism of a human or animal, a resonant interaction occurs between them, as a result of which the cells of the pathogenic microorganism acquire a state similar to that of the damaged microorganism recorded on the carrier. Since the frequency-wave analogue acquired a certain structure under the influence of the electromagnetic field of the sample cells, its interaction with the electromagnetic fields of the biological object is also selective, i.e. its field will interact only with the electromagnetic fields of a pathogenic microorganism of this type.

 The presence of a magnetic field source for acting on the information carrier allows one to significantly exceed the field strength of sample cells over the field strength of a pathogenic microorganism, and also creates an orientation in the space of information-wave action, which, in turn, allows to increase the efficiency of exposure to a pathogenic microorganism. It was established experimentally that a magnet of any shape can be used as a source of a magnetic field: rectangular, round, circular, etc., as well as a solenoid.

 All nodes of the device are separated from each other by shielding partitions.

 The shielding partitions in combination with a shielding case and a cover made of plastic coated with a layer of shielding material form a protective volume that allows you to protect the storage medium from “spurious” self-recording during operation of the device, thereby increasing its efficiency and eliminating negative effects on the body .

 The storage medium may be made of any material capable of efficiently recording, storing and transmitting information. A preferred embodiment for the present invention is a crystal of a semiconductor device, which makes it possible to create a compact portable device for influencing pathogenic microorganisms.

 In FIG. 1 shows a block diagram of the proposed device, in FIG. 2 shows the location of the storage medium inside the housing.

 The device for influencing pathogenic microorganisms contains a sequentially connected storage medium 1, a switching unit 2, an electric energy source 3. For convenience, a display unit 4 can be included in the circuit. The storage medium 1 is a frequency-wave analogue of damaged sample cells of a pathogenic microorganism of a certain type. As a carrier capable of forming a frequency-wave analog, a crystal of a semiconductor device is used: a diode or a transistor. In the example of FIG. 1 shows the inclusion of a diode. The storage medium 1 is placed in the field of a source of constant magnetic field 5, which can be made in the form of a permanent magnet of any shape: rectangular, round, circular, as well as in the form of a solenoid. In the case of a constant magnetic field source 5 in the form of a solenoid, its winding is connected to the circuit between blocks 1-2 or 1-4.

 All nodes of the device are separated from each other by shielding partitions 6 to protect the recorded information from extraneous influences. The device is equipped with a shielding housing 7 and a cover 8 made of plastic coated with a layer of shielding material. The switching unit 2 in the simplest case can be made in the form of a time relay, and the display unit 4 in the form of an LED, which is advisable to place on the same axis with the storage medium 1 (see Fig. 2).

 The method is carried out using the device as follows.

 A suspension of a pathogenic microorganism, such as Pseudomonas aeruginosa, is divided into separate portions and irradiated at different EHF frequencies using an EHF generator that generates oscillations in the frequency range allowed for use in medicine, equipped with an external emitter (not shown in the drawing) .

 After irradiation, individual portions of the suspension are precipitated at 6000 J in a centrifuge (Hitachi) and UV absorption is determined in the supernatant (supernatant). Optical density measurements are carried out on an Ultraspect-2 spectrophotometer (not shown in the drawing).

 By selecting the frequency of the EHF radiation, the maximum possible degree of leakage of UV absorbing substances from the cell (maximum radiation) is determined and it is used to judge the degree of damage to the sample cells. As a control, a portion of the suspension not exposed to the EHF radiation is used.

 Next, the bioenergy information of the sample cells is recorded on the information carrier 1. For this, a crystal of a semiconductor device with preformed terminals is attached to the external emitter of the EHF generator. The emitter is connected to the power supply of the EHF generator, bring it into contact with the sample cells and turn on the power supply for a short time (for 1-2 s). In this case, due to the high speed of the phase transition of the carrier material from one stable state to another at the moment of contact with the sample cells, the crystal of the semiconductor device forms a frequency-wave analogue of the model damaged cells with the inclusion of the EHF frequency range in its spectral characteristic.

 Due to the EHF effect, when information is recorded on the medium, it is amplified, which allows to obtain a more clear structure of the frequency-wave analogue. The prepared storage medium 1 is disconnected from the emitter of the EHF generator, packaged with a biologically neutral material and installed in the exposure device. In a similar way, a bank of information carriers is created, each of which is a frequency-wave analogue of model cells of a certain type of pathogenic microorganism. In the process of therapeutic exposure, the device is located in the immediate vicinity of the patient. By switching on the switching unit 2, the time counting mode is set to about 30 s, after which the device turns off.

 In the process of exposure, the electromagnetic field of the information carrier 1 (reference cells) interacts with the electromagnetic field of the pathogenic microorganism of a person or animal. As a result of the resonant interaction of these fields, the cells of the pathogenic microorganism acquire a state similar to that of the damaged microorganism recorded on the carrier. In this case, due to the action of the magnetic field, the radiated exposure signal has a higher total electromagnetic field strength. As a result of the superposition of electromagnetic signals from the “right” part (damaged sample cells) and pathology (from the bio-object), information exchange signals are corrected in the pathology-normal direction, since the signal from the “normal” field is predominant. In view of this, there is a restructuring of potential fields and, as a result, a restructuring of molecular cellular systems, leading to the disappearance of pathology.

 The impact of the device on the viability of pathogenic microorganisms was assessed using the example of Pseudomonas aeruginosa, by counting colony forming units of microorganisms exposed to the device and not exposed to it. As experiments have shown, the proposed device inhibits the viability of pathogenic microorganisms by 10-15 times.

Example 1
Patient T., 28 years old. He became ill sharply after cooling, there was weakness, chills, the temperature rose to 38.7, pain when swallowing, examination of the pharynx showed hyperemia, swelling of the palatine arches, tongue and tonsils. On the tonsils, festering follicles were visible through the hyperemic mucous membrane. Was diagnosed with follicular tonsillitis. When sowing from the throat, Staphylococcus aureus was sown in an amount of 2x10 CFU / ml. Conducted traditional drug treatment for seven days had no effect. After the treatment sessions with the proposed device, the patient felt better, the sore throat disappeared, the temperature returned to normal. With repeated sowing, Staphylococcus aureus was not detected.

Example 2
Patient D., 36 years old. He complained of frequent and painful urges to urinate at night, pain in the urethra and rectum during ejaculation. A study through the rectum indicated that the surface of the prostate is uneven, the consistency of the gland is slightly pasty, and palpation is very painful. Macroscopic examination of urine with a three-glass test shows purulent short filaments, which are "casts" of the excretory ducts from the prostate gland. Microscopic examination of the secretion of the prostate gland revealed an increase in the number of white blood cells, while the white blood cells were located in the form of clusters of greater or lesser magnitude. The number of cell elements in the counting chamber reached five million in one milliliter. A decrease in the number of lipoid grains was also noted. In bacteriological and serological studies, a diagnosis of chronic chlamydial prostatitis was made. After an unsuccessful treatment with two courses, the patient showed chlamydia. After using the proposed device for three weeks (total number of sessions - 24), the patient did not show chlamydia with repeated research for three months. The general condition improved, the signs of chronic prostatitis disappeared.

 The proposed method is universal, in terms of exposure to pathogenic microorganisms, including bacteria, protozoa, viruses, fungi and prions, and at the same time, selective, that is, narrowly specific, inactive on specific microorganisms, without exerting negative effects on autoflora and the body’s own cells.

 On the basis of the proposed device, a whole series of portable highly specialized devices can be created that differ from each other only in the type of information carrier for treating various diseases caused by pathogenic microorganisms.

 Experimental studies have shown that when exposed to the indicated device on patients without pathologies or pathologies caused by other reasons, negative effects on the body were not observed.

 The proposed method and device for its implementation can be used for the prevention and control of pathogenic microorganisms that affect domestic and wild animals, birds, fish, invertebrates, cultivated and wild plants, microbiological material and cultures used in industry and scientific research, to protect from microbiological damage to various objects and volumes of space, to protect various goods, devices, semi-finished products and materials from biological corrosion.

Claims (7)

 1. A device for influencing pathogenic microorganisms, containing a carrier with information about the metabolic activity of pathogenic microorganisms, installed in a shielding housing with a cover, characterized in that the carrier includes information on the metabolic activity of damaged sample cells to a state in which the process of restoration of cell activity becomes impossible , a magnetic field source is installed in the housing to act on the information carrier.  2. The device according to claim 1, characterized in that the magnetic field source is made in the form of a permanent magnet of a rectangular, round or circular shape.  3. The device according to claim 1, characterized in that the magnetic field source is made in the form of a solenoid.  4. The device according to paragraphs. 1 to 3, characterized in that the storage medium is made in the form of a semiconductor crystal.  5. The device according to paragraphs. 1 to 4, characterized in that as the information carrier, a crystal of a semiconductor diode or transistor is used, which is connected to a current source and connected to communication and indication units.  6. The device according to claim 5, characterized in that all the nodes of the device are separated from each other by shielding partitions.  7. A method of influencing pathogenic microorganisms, including suppressing the metabolic activity of exemplary cells, followed by recording their own electromagnetic radiation on a storage medium, characterized in that the suppression of the metabolic activity of exemplary cells is carried out by damaging them to a state in which the process of restoration of cell activity in full becomes impossible, and the recording of information is carried out by exposure to EHF radiation on the carrier with its direct contact with cells, after which the carrier is packed with biologically neutral material and installed in the device according to claims 1-6 for exposure to microorganisms.

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