RU2120280C1 - Homeopathic agent "atsenamet" for treatment of alcohol addiction - Google Patents

Abstract

FIELD: medicine, in particular, narcology; may be used for treatment and prophylaxis of alcohol addiction, abstinent and alcohol withdrawal syndrome. SUBSTANCE: agent contains three components in homeopathically balanced potencies. 100 g of agent includes 1.0 g of mixture of equal parts of potentiated solutions in 45-deg alcohol: acetic acid, 30c; sodium sulfate, 39c; hydrochloride methoclopramide, 36c; 1.0 g of 70-deg alcohol; 98.0 g of sugar granules. For treatment of alcohol addiction, agent is administered by 7-9 granules 3 times a day before or during meals. After 7-day administration of agent, interval for 1-3 days takes place. EFFECT: improved efficiency; reduced treatment time of alcoholism of various severity. 3 cl, 3 ex

Description

 The invention relates to medicine, namely to narcology, and can be used for the prevention and treatment of alcoholism of varying severity.

 In the existing literature, analogues of the proposed Acenamet are homeopathic medicines used to treat alcoholism. In accordance with the presented claims, from the used homeopathic remedies, it is possible to isolate acids: acetic acid (Acidum aceticum) and sulfuric acid (Acidum sulfuricum), which are used separately in various homeopathic dilutions (Treatment of alcoholism with homeopathic remedies, Atlas, 1993). Separate and complex use of these acids without specially selected substances does not give the necessary results. Other homeopathic remedies are described in the same source: Agaricus 200, Arsenicum album 200, Asarium 30, Capsicum 30, Causticum 200, Conium 30 and others. The wide spectrum of action of these drugs also does not allow to achieve sufficient treatment effectiveness. Many of the proposed products are rare, and the raw materials for their manufacture are not standardized. This makes it difficult to evaluate the results of treatment and limits the availability of the method.

 The prototype of the proposed tool "Acenamet" should be considered the patent of Russia N 2039561 for the invention: "Homeopathic remedy for the prevention and treatment of alcoholism." Patent holder Yamchenko A.O., 1995. Application N 94040297 of November 22, 1994. The preparation "Acidum C" (Acidum sulfuricum comp.) Includes 5 ingredients: Acidum sulfuricum 3x, Arsenicum ald. 8x, Lyсopodium 12x, Nux vomica 6x, Sulfur 12x).

 A significant drawback of this drug is the presence of poorly compatible and highly toxic substances in low dilutions (in high concentrations). The drug contains substances poorly soluble in water and alcohol, Lycopodium and Sulfur. Its manufacture is very time-consuming and dangerous for pharmacists, and the presence of various highly active substances in one solution contributes to unpredictable interference of drug exposure, which affects the effectiveness of the drug and causes undesirable and uncontrolled reactions in patients. This drug does not affect the motivation and conditioned reflex component of alcohol dependence, but only has a metabolic effect.

 An analogue of the proposed method of treatment is the use of homeopathic medicines for the treatment of alcoholism, which avoid the main disadvantages of traditional pharmacological methods of treatment (high toxicity, a large number of side effects, and the high cost of treatment). The use of homeopathic remedies for the treatment of alcoholism is described in books (Treatment of alcoholism with homeopathic remedies, "Atlas", 1993 HK Allen. The main indications for the purpose and characteristics of leading homeopathic remedies. "Homeopathic medicine", Smolensk, 1996).

 The prototype of the proposed method of treatment can be considered the patent of Russia N 2039561 for the invention: "Homeopathic remedy for the prevention and treatment of alcoholism." Patent holder Yamchenko AO, 1995. Application N 94040297 of November 22, 1994.

 According to the prototype, the method of treatment of alcoholism is as follows: the drug "Acidum C" take 5 to 8 drops 2 to 3 times a day; 3 days to take, 3 days break, etc. The drug is diluted in water (about 1/4 cup) and drunk in small sips, without swallowing longer; the drug can be dripped directly into the mouth; in case of acute binge, it is allowed to add 1 teaspoon of the drug to half a glass of vodka. Food weakens the effect, therefore, if possible, take it half an hour before meals and half an hour or more after meals.

 The disadvantage of the prototype should be considered an undifferentiated approach to prescribing the drug to patients with varying degrees of severity of the disease and the subjective nature of determining the dosage and frequency of administration.

 The prototype of the proposed method of treatment according to paragraph 3 of the formula can be considered the use of homeopathic medicines using constitutional homeopathic medicines, described in the book (G. Keller Homeopathy. M .: "Medicine" 1989). However, this method is not suitable for the treatment of patients with alcoholism.

 Throughout the world, the problem of alcoholism is becoming increasingly important. Despite the large number of proposed methods of treatment, to date there is no universally recognized and sufficiently effective method. The most common pharmacotherapeutic methods of treatment. A modern characterization of these methods is given in (Shen W. W. Pharmacotherapy of alcoholusm: the American current status (Review). Keio Journal of Medicine 40 (1); 1991, p. 9-12). However, the applied formological preparations are nonspecific, have no selective effect, have high toxicity and a large number of side effects. Due to these shortcomings, a long and complete course of treatment is almost impossible.

 The problem to which the invention is directed is to increase the efficiency and reduce the time of treatment of alcoholism of varying severity.

 The problem is achieved in that in the known method of treatment, including the use of a homeopathic remedy, according to the invention, the patient receives a basic homeopathic remedy as a homeopathic remedy, and in severe cases of the disease, an additional test preparation and an individual treatment complex.

The proposed homeopathic remedy "Acenamet" includes 3 components in homeopathically balanced potencies: acetic acid (Acidum aceticum) 30, sodium sulfate (Natrium sulfuricum) 39, metoclopromide hydrochloride (Metoclopramidum hydrochloricum) 36 in equal proportions. These components in the form of a 45 ^o alcohol solution together with 70 ^o alcohol are applied to sugar granules. The basic homeopathic remedy is prepared in accordance with the rules adopted in the Guide to the manufacture of homeopathic medicines. W. Schwabe, 1950, ed. V.I. Rybaka, Moscow, 1967.

In this case, 100 g of the basic homeopathic remedy contains
1.0 g of a mixture of equal parts of potentiated solutions at 45 ^o alcohol:
Acetic acid 30 s (30th dilution)
Sodium sulfate 39 s (39th hundredth dilution)
Metoclopramide hydrochloride 36 s (36th hundredth dilution)
1.0 g of 70 ^o alcohol.

 988.0 g sugar granules.

 The name of the product includes the first letters of its constituent chemical components.

 Obtaining a positive result through the use of this homeopathic remedy is guaranteed by the fact that it is composed of a minimum amount of complementary substances in balanced homeopathic dilutions. The ingredients of Metoclopramidum hydrochloricum in the indicated homeopathic dilution have an effect on the supporting mechanisms of the conditioned reflex component of alcohol dependence. Two other chemicals that make up the complex stabilize its action and minimize the influence of provoking factors from the environment.

 A method for the treatment of alcohol dependence, including the use of the homeopathic remedy "Acenamet", provides for a differentiated purpose depending on the severity of the disease and other characteristics of the patient. At the same time, the applied doses, the frequency and duration of administration, as well as the concomitant drugs used differ.

 Distinctive features of the proposed method for the treatment of alcohol dependence are that before taking the Acenamet homeopathic remedy in severe cases of the disease, as well as in the case of prolonged and unsuccessful treatment with other methods, a test drug is prescribed, and the Acenamet homeopathic remedy is taken with an individual treatment complex, including psychotypic or constitutional drugs.

 A comparative analysis of the proposed method with the prototype method indicates significant distinctive features, namely, that increases efficiency and reduces treatment time. Improving the efficiency and reducing the treatment time is achieved due to the fact that the proposed method of treatment takes into account the patient’s psychotype, uses a fundamentally new triple approach in the use of drugs (a new basic drug, a test drug and an individual treatment complex are used), which allows simultaneous exposure on the internal and external mechanisms of the pathological process.

 The novelty of the method is confirmed by the above features. The advantage of the proposed method is also that it is suitable for the prevention and treatment of alcohol dependence, withdrawal symptoms and hangover. The medicines used have no contraindications and side effects; they have both anti-alcohol, anti-toxic and somatic therapeutic effects.

 The basic homeopathic remedy "Acenamet" and the individual treatment complex eliminate positive motivations after drinking alcohol, block the supporting mechanisms of the conditioned reflex component of alcohol dependence and minimize the influence of provocative factors from the external environment.

 The method is as follows: after a conversation with the patient or his relatives, the form and severity of the disease is determined. In chronic alcoholism I and II stages, as well as for the treatment of withdrawal symptoms or a hangover syndrome, only the basic homeopathic remedy "Acenamet" is used. For the treatment of chronic alcoholism of stage III, as well as in cases of previous unsuccessful treatment of stage I and II, a test drug, a basic food supplement and an individual treatment complex are used. For the treatment of stage I chronic alcoholism take 7 granules of the basic homeopathic remedy "Acenamet" 3 times a day, before meals, under the tongue until resorption. After a seven-day treatment, they take a 3-day break. The course of treatment is carried out until the clinical indications are normalized. After achieving the clinical effect, one month after the end of treatment, a two-week preventive course of treatment with the basic homeopathic remedy "Acenamet" is carried out, 3 granules 1 time per day, before meals, under the tongue until resorption.

 In the case of treatment without the knowledge of the patient, the granules are crushed into powder and added to any not very hot or acidic food.

 In the treatment of chronic alcoholism of stage II, 9 granules of the basic homeopathic remedy "Acenamet" are prescribed 3 times a day, before meals, under the tongue until resorption. After a 7-day treatment, a one-day break is taken. The course of treatment is to normalize the clinical indications.

 For the treatment of chronic alcoholism of the III stage, as well as in the case of unsuccessful previous treatment of the I and II stages, the patient or his relatives receive a testing homeopathic medicine, which is selected according to the general rules of classical homeopathy with a special assessment technique. 15 days after the start of treatment, the patient or his relatives fill out a special questionnaire, which is analyzed by the attending physician or computer program. The questionnaire determines the effect of the test drug, the patient’s psychotype, and the component of the individual treatment complex is selected. An individual complex includes a constitutional homeopathic preparation and a preparation corresponding to the patient’s psychotype (psychotypic preparation). This drug is determined by the analytical repertory of symptoms of psyche and intelligence of Goering (Analytical Repertory of the Symptoms of the Mind. C. Hering, 1995).

 In the treatment of withdrawal symptoms, the drug is taken in 7 granules after 2 hours the first week, after 3 hours the second week, after 4 hours the third week, after 6 hours the fourth week. If necessary, the course of treatment is repeated without interruption.

 According to the claimed method of treatment treated 150 patients.

 Treatment was monitored throughout the course of treatment.

 The possibility of carrying out the invention is confirmed by the following examples.

 Example No. 1. Patient L. 32 years. Suffers from chronic alcoholism for 2 years. Clinically: chronic stage I alcoholism. There is no sedative effect of alcohol, according to relatives, there is a loss of memory of certain events of the past evening, but the general course of events is remembered. Actively looking for the slightest reason to drink. On this basis, there are constant conflicts in the family. The treatment took place without the knowledge of the patient. Mother gave the basic homeopathic remedy "Acenamet" in food for 2 months, 7 granules 3 times a day. After 7 days of taking the drug, I took a break of 3 days. After the first month of treatment, the patient ceased to feel the need for alcohol, but drank at the suggestion of old friends. After drinking alcohol, I felt bad. Feeling unwell was accompanied by severe nausea, vomiting, and intermittent palpitations with flushing of the face. The day after drinking, I felt pain and heaviness in my stomach after eating. The feeling of heaviness did not pass within 3 to 5 days. There was an aversion to alcohol. 2 months after treatment, he completely stopped drinking alcohol, as there was no attraction to alcohol, and after taking it, there was a fear of some kind of disease. I completely refused alcohol because of the fear of getting sick.

 Example No. 2. Patient S. 35 years. He applied for treatment after leaving his job. Clinically chronic stage II alcoholism.

 Severe withdrawal symptoms and complete amnesia of intoxication. Drinks since 17 years. Earlier treatment did not pass. Taking the basic homeopathic remedy "Acenamet" for 2 months, 9 granules 3 times a day with a break of 1 day after every 7 days of admission. After 1 month after taking began to notice a deterioration after drinking alcohol. There was severe nausea, vomiting, salivation, palpitations, and a feeling of lack of air. After eating, there is a feeling of heaviness in the stomach and intestines, loss of appetite, aversion to certain foods (porridge, mashed potatoes and milk). Symptoms worsened after taking alcohol. The patient turned to the attending physician, as he believed that the medicine caused some new disease. Treatment was discontinued, but the condition did not improve. He was hospitalized in the gastroenterological department, where the diagnosis was made: chronic hyperacid gastritis. After discharge from the hospital, the condition improved significantly and the patient began to take alcohol. After drinking alcohol, my health was good, but the next day the general condition worsened, nausea, headache, urging to vomit, trembling throughout the body appeared. This condition was regarded as the need for hangover. For this purpose, the patient took 100 g of vodka. 1 hour after drinking alcohol, nausea intensified, vomiting and a feeling of lack of air appeared. After inhaling ammonia, the condition improved, but nausea, vomiting, and heaviness in the stomach soon appeared. This condition was assessed as a hangover syndrome, and the patient, following the instructions, began to take “Acenamet" 3 granules in 15 minutes. After the 4th dose, all symptoms disappeared and my health returned to normal. The patient again resumed taking the medicine 9 granules under the tongue 3 times a day with a break of 1 day every 7 days of administration. After 2 months of treatment, the need for alcohol no longer arose. No deterioration of health was noted anymore. Gradually, the dosage of the drug was reduced to 3 granules per day. At this dose, the drug was taken for another 1 month. Currently does not drink alcohol.

 Example No. 3. Patient N. 43 years. Chronic alcoholism of the III stage, severe form. The patient is exhausted, crying, an asthenic type of personality psychopathization is noted. Often in a depressed state. There were two suicidal attempts. He was treated three times for alcoholism. Six months ago, subcutaneous implantation of Esperal was performed. After that, somatoneurological disorders appeared. The patient has chronic gastritis, accompanied by anorexia, does not feel taste sensations, has an aversion to food, constant headaches, dizziness, and pain in the liver. The skin is icteric, on the nose and cheeks of telangiectasia. Notes constant pain in the heart. HELL 150/110 mm RT. Art. A patient of medium height, pale with sunken eyes and swelling around the eyes. The skin is dry with a tendency to peeling, profuse dandruff on the head. It feels burning throughout the body, which is reduced by heat. Poor appetite with anorexia, thirst with a need for cold water. Nausea, vomiting, belching, abdominal pain. Sensation of a stone lying in the stomach and right hypochondrium. A particularly strong burning sensation in the stomach and intestines. Loose stool in the middle of the night, often at 2-4 hours, gums bleeding, tongue numb. Headache eases in the fresh air. Wakes up at night from suffocation and coughing. Feels a contracting burning pain in the heart, often at night. When walking, cramps occur in the calf muscles, aggravated by cold. The patient often has complete prostration, suicidal thoughts, general fear, suspicion, anxiety, insomnia, terrible dreams.

 Based on an analysis of symptomatology, Arsenicum alb was selected as the test drug. 6 two are glad in a day on 5 granules. Two weeks later, the patient noted an increase in physical and mental anxiety, nightly attacks of hiccups, a sensation of lengthening of the teeth. Based on the analysis of the questionnaire and the analytical repertory of mental symptoms, Arsenicum alb 30 was selected 1 time per week for 5 granules. Thus, an individual treatment complex includes.

 1. The constitutional psychotypic drug Arsenicum album 30, 5 granules once a week (in this case, the constitutional and psychotypic drug are the same, but in other cases they can be different).

 2. Basic homeopathic remedy ("Acenamet") 9 granules 3 times a day, take 7 days, 1 day break. On the day of taking Arsenicum album 30, a basic food supplement is taken 3 hours after taking the first drug. After a month of treatment, there is a significant improvement in well-being. Withdrawal syndrome is clearly expressed. After 2 months of treatment, a significant decrease in withdrawal symptoms was noted. The basic homeopathic remedy is taken 7 granules 2 times a day without a break. After 3 months of treatment, the need for alcohol is not felt. The basic homeopathic remedy is taken for prophylactic purposes for another two weeks, 5 granules 1 time per day.

 Thus, the proposed method effectively suppresses addiction to alcohol, provides an individual approach to treatment and reduces its time.

Claims (3)

1. An agent for the treatment of alcohol dependence, containing ingredients in homeopathic dilution, including acid and alcohol, characterized in that the agent contains acetic acid and additionally sodium sulfate, metoclopramide hydrochloride, while 100 g of the agent contain
1.0 g of a mixture of equal parts of potentiated solutions at 45 ^o alcohol:
Acetic acid - 30 s
Sodium sulfate - 39 s
Metoclopramide Hydrochloride - 36 sec
1.0 g of 70 ^o alcohol,
98.0 g sugar granules. 2. A method of treating alcohol dependence, comprising administering a homeopathic remedy, characterized in that the “Acenamate" agent is administered, 100 g of which contains
1.0 g of a mixture of equal parts of potentiated solutions at 45 ^o alcohol;
Acetic acid - 30 s. Sodium sulfate sulfate - 39 s,
Metoclopramide Hydrochloride - 36 sec
1.0 g of 70 ^o alcohol,
98.0 g sugar granules,
the drug is administered 7 to 9 granules 3 times a day before or during meals, after a seven-day intake, take a break of 1-3 days.  3. The method according to p. 2, characterized in that the test drug is preliminarily administered and the individual patient complex is determined, including constitutional and psychotypic homeopathic preparations, and the agent according to claim 1 is administered three hours after the administration of the individual complex.