RU2085206C1 - Agent for treatment of paroxysmal tachycardia and angioneurosis - Google Patents

Abstract

FIELD: medicine, pharmacy. SUBSTANCE: agent is tablet preparation based on hawthorn fruits. Agent is dosed by 1 tablet (0.5 g) three times per a day for 20 day. Use of the proposed agent ensures to avoid overdosing. EFFECT: enhanced effectiveness of agent.

Description

 The invention relates to medicine, in particular to agents for the treatment of cardiovascular diseases.

 Known use for the treatment of paroxysmal tachycardia and angioneurosis of preparations of plant origin, in particular aymalin, extract and tincture of hawthorn fruit, a decoction of hawthorn fruit.

 A decoction of the fruits of hawthorn is prescribed 1 / 3-1 / 2 cup 2-3 times a day before meals.

 The disadvantages of this dosage form are: the duration of manufacture, the variability of the composition, chemical instability and a tendency to microbial contamination during storage, the lack of standardization methods for active substances.

 Tincture is prescribed 20 drops 3 times a day. The extract is prescribed for 20-30 drops 3-4 times a day. The disadvantages of treatment with extract and tincture of hawthorn fruits are: the use of a dosage form with an inconvenient dosage method, the use of ethanol.

 The purpose of the invention is the creation of a dosage form that allows you to: maximize the use of the amount of biologically active substances; rational and comprehensive use of raw materials; standardize for various groups of biologically active substances.

 The goal is achieved using tablets of hawthorn fruit, used in 1 tablet of 0.5 g 3 times a day for 20 days.

 Tablets were obtained by direct compression without auxiliary substances of hawthorn fruit powder in a manual hydraulic press at a pressure of 80-100 MPa.

 Example 1. The tool was prepared as follows. The pharmacy mixture of hawthorn fruit was ground in a meat grinder without residue to a powder passing through a sieve with a hole size of 1 mm. A portion of the powder weighing 0.5 g was pressed in a matrix with a hole diameter of 12 mm on a manual hydraulic press at a pressure of 80-100 MPa. The tablets are round in shape with biconvex surfaces and even edges. The surface of the tablets is smooth. Color - sandy brown with dark spots, odorless, sweet taste. The average tablet weight is 0.5 ± 4.8%; strength; 98.7%; disintegration 12 min; i.e. tablets meet the requirements of GF XI (1).

 Tablets from hawthorn fruit were used in complex therapy in 13 patients suffering from various heart diseases: paroxysmal tachycardia, angioneurosis, coronary heart disease of functional class II and III, cardiac arrhythmias of paroxysmal and persistent atrial fibrillation. The age of the patients was 55-82 years. The criteria for evaluating the effectiveness of treatment were the results of an objective study of the patient, clinical and biochemical examination, instrumental examination (ECHO-KG, ECG, stress tests).

 In complex therapy, as a rule, no more than 3-4 drugs were used, including tablets of hawthorn fruit. The preparation of hawthorn was prescribed 1 tablet 3 times a day 30 minutes before meals for 20 days.

 All patients studied the drug was well tolerated. In no case have any clinically or laboratory side effects or complications been identified.

 In patients taking hawthorn, a more rapid decrease in pain attacks, a more persistent effect from the use of antiarrhythmic drugs, an improvement in the serum lipid spectrum (a decrease in the atherogenic fraction of lipids and cholesterol) were noted.

 Thus, the drug can be recommended as a tool used in complex therapy for paroxysmal tachycardia, in patients with atherosclerosis, and in patients with atrial fibrillation as an additional drug.

 Example 2. Patient L., born in 1944 Diagnosis: Post-myocardial cardiosclerosis. Paroxysmal tachycardia. Osteoarthrosis of the spine with a primary lesion of the cervicothoracic region. She received complex therapy, including vasodilators, anti-inflammatory drugs, beta-AB (the usual therapeutic doses did not give a lasting effect when obzidan was prescribed at a dose of 1/4 tablet per day, and higher doses caused a rhythm decrease to 42 beats per minute, in connection with which the drug was canceled). After a course of treatment for 20 days. a drug from the fruits of hawthorn noted a decrease in pain attacks, normalized lipid profile of the blood, there were no attacks of palpitations.

 Example 3. Patient J. 58 years. Diagnosis: ischemic heart disease, angina pectoris 11 f, cells. Arterial hypertension, sympathetic adrenal crisis. Since January 1990, the patient’s blood pressure ranged from 140/80 to 230/120 mm Hg. Art. He took various antihypertensive drugs without significant effect. After treatment with pyroxane and defenin, which were canceled after stopping the attacks. With daily monitoring of the ECG, episodes of AU blockade of the second stage were revealed. type Mebica, periods of sinus tachycardia up to 100 beats. per minute, rare atrial extrasystoles. A biochemical blood test revealed: cholesterol 7.02 mmol / L, triglycerides 2.63 mmol / L. After treatment with tablets of hawthorn fruit, an improvement was observed in the general condition of the patient, pulse normalization, with a biochemical blood test: cholesterol 6.1 mmol / L, triglycerides 1.23 mmol / L.

 As a result of the studies, it was found that hawthorn fruit tablets have a good therapeutic effect in the treatment of paroxysmal tachycardia, angioneurosis during complex therapy. The drug can be used as an adjuvant for dose adjustment of cardiac glycosides in the constant form of atrial fibrillation. A positive effect on the lipid composition of the blood was revealed.

 The proposed drug is the only dosage form of hawthorn, and it is known that an overdose of hawthorn preparations entails the occurrence of arrhythmias. Hawthorn fruit tablets are convenient to use both in the hospital and in outpatient treatment, especially in the prevention and treatment of cardiovascular diseases in the elderly.

 In the technology for producing tablets of hawthorn fruit, auxiliary substances are not used (as well as in the manufacture of briquettes from crushed medicinal plant material), which makes this dosage form more economical. But unlike briquettes of other types of raw materials, which are used to obtain water extracts, while the whole amount of hydrophobic biologically active substances and some of the active hydrophilic substances remain in the raw materials, hawthorn fruit tablets used directly inside allow rational and comprehensive use of raw materials.

Sources of information
1. The State Pharmacopoeia of the USSR: Issue 2. General methods of analysis. Medicinal plant material. / MH USSR / M. Medicine, 1989, p. 154-160.

 2. Mashkovsky M. D. Drugs. M. Medicine, 1993, v. 1, p. 478.

 3. Mashkovsky M. D. Drugs. M. Medicine, 1993, v. 1, p. 533-534.

 4. Sokolov S.Ya. Zamotaev I.P. Handbook of medicinal plants. Phytotherapy. M. Metallurgy, 1989, p. 92-94.

Claims (1)

 An agent for treating paroxysmal tachycardia and angioeurosis based on hawthorn, characterized in that it is made in tablet form from powder of hawthorn fruit.