RU2080113C1 - Method of increase of safety and productivity of agriculture animals - Google Patents

Abstract

FIELD: veterinary science. SUBSTANCE: method involves the use of terpene-like preparation polyene-1 as 10% aqueous solution. Preparation is given orally at doses 0.1-0.5 ml/kg animal mass or as aerosol at air saturation 1-3 ml/$$$. Method is used for prophylaxis against gastroenteric and respiratory diseases in agriculture animals. EFFECT: enhanced effectiveness of method, increased resistance of animals. 2 tbl

Description

 The invention relates to veterinary medicine, in particular to methods for increasing the safety and productivity of farm animals by preventing gastrointestinal and respiratory diseases with strengthening the animals' resistance to infections.

 With the industrial content in modern livestock complexes of large numbers, due to the lack of natural factors, animals often experience stresses, their resistance decreases.

The most well-known methods of prevention, involving the use of antibiotics and chemotherapeutic drugs, do not increase resistance. When using them, one has to take into account the likelihood of allergic reactions and various contraindications. The effectiveness of these methods is reduced due to the emergence of resistant strains of pathogenic microorganisms, and sometimes with the irrational use of antibiotics, dysbacteriosis develops, especially in ruminants, and acute diseases turn into chronic ones [1]
It is known that resistance can increase terpenoid compositions and essential oils, including turpentine and pine, containing α-pinene as the main component [2 4]
Known methods for increasing the safety and productivity of farm animals by oral [3] or aerosol [4] use of terpenoid compositions and essential oils. But these methods are relatively unlikely and not widely used. The proposed complex, and sometimes deficient [4] compositions of oils, along with the necessary components, also contain harmful Karen; since the oils are practically insoluble in water, small doses of them are difficult to evenly mix with large volumes of feed or spray in the air, and point overdoses are fraught with an inadequate active principle, on the one hand, and increased toxicity on the other. In addition, terpenoid oils are chemically labile, flammable and toxic liquids, their transportation and storage are associated with certain difficulties.

The closest analogue of the invention is a method that provides for both oral and aerosol use of “Forest A Balm” [5] However, it is characterized by the already noted general disadvantages of the use of terpenoid compositions. Its effectiveness is also relatively low, for example, chickens are reduced by only 0.6%; daily weight gain is increased by 5.6%
The purpose of the invention is a more effective way of preventing gastrointestinal and respiratory diseases of farm animals, strengthening their resistance, using a terpenoid preparation, devoid of the disadvantages of the prototype.

To eliminate the disadvantages of the prototype, it is proposed to use a 10% aqueous solution of the terpenoid preparation "polyene-1" at the rate of 0.1-0.5 ml / kg body weight of the animal when administered orally, or 1 3 ml / m ^{3 of} air from the livestock building with aerosol spraying. The polyene-1 preparation used to stimulate calf growth consists (in parts by weight) of: a-pinene (0.5 0.6), benzyl alcohol (0.5 0.6) and block copolymer of ethylene oxide and propylene oxide (6.5 to 7.5) and, unlike other terpenoid formulations, can be solubilized.

 Dosages of the drug are justified theoretically, based on data on the consumption of essential oil by agricultural and wild animals along with the feed (or with such feed additives as coniferous foot), and then adjusted during experimental work. When administered orally, the dosed volume of the aqueous solution is added to the feed (for example, mixed with colostrum or milk, or given in the form of wet mixes with animal feed), or in drinking water, or in saline. Aerosol treatment of livestock buildings is carried out, after sealing, using aerosol generators (for example, type SAG 1), in accordance with the instructions for their use, with optimal exposures of 30 to 40 minutes.

 The invention, conditions and results of its application are illustrated by examples.

 Example 1, calves (see table. 1, exp. 1 3).

To increase the safety and weight gain of calves, a 10% aqueous solution of polyene-1 is prescribed 1 2 times a day at 0.2 0.3 ml / kg with food or with water. In the experimental groups, the calves are active, willingly eat food, get sick less, and the diseased recover quickly. At the end of the course, the increase in live weight relative to control up to 87%; 100% safety
Example 2, piglets (see table. 1, exp. 4 5 and table. 2, exp. 4). To increase the safety and weight gain of piglets, a 10% aqueous solution of polyene-1 is mixed with feed (for example, with feed) at the rate of 0.1 0.2 ml / kg body weight or sprayed in the form of an aerosol at the rate of 2.5 ml / m ^{3 of} air. In the first case (Table 1), the decrease in waste among sucking pigs reaches 73 weaners -100% weight gain sharply increases compared with the control. In the second case (Table 2), the waste decreased by 49.2%
Example 3, chickens (see table. 1, exp. 6 and table. 2, exp. 1 3).

To increase the safety and weight gain of chickens, a 10% aqueous solution of polyene-1 is given with food or with drinking water at the rate of a daily dose of 0.1 ml / kg of bird mass or sprayed at a rate of 1 1.5 ml / m ^{3 of the} room. In the first case (Table 1), the decrease in waste is 15 20% with an increase in average daily gain by 9 10 in the second (Table 2), respectively, 62.0 80.4 and 6.6 17.7
The proposed method has the following advantages:
1. In General, a significantly greater efficiency of the method.

 2. A more convenient form of the solubilized terpenoid preparation, which allows it to be mixed evenly with water and food and eliminating the risk of overdose.

 3. The positive role of water particles, contributing to the formation of useful, negatively charged air ions during aerosol spraying of the drug.

 4. The absence of the drug negatively affecting the organisms of Karen.

 5. Convenience and safety of transportation, storage and use.

 6. The possibility of expanding the range of technological and affordable terpenoid agents for oral and aerosol use.

Sources of information,
1. Petrukhin I.V. Feed and feed additives. Rosagropromizdat, M. 1989, p. 348.

 2. Gildemeister E, Fr. Hoffmann Die atherisehe Ole Akademie Verlag, B. 1956, B. I, s. 140.

3. Repyakh S. M. E. D. Levin. The use of essential oils and preparations based on them. V. Prince Feed additives from woody greens. Forest industry. M. 1988, p. 85
4. Joubert L. M. Gattefoss. Bactericidal properties of essential oils in veterinary prophylaxis and therapy. IV International Congress of Essential Oils. Tbilisi, 1968, p. 99
5. Ispenkov A. et al. The effect of forest balsam. J. Poultry, 1989, N 8, p. 34.7

Claims (1)

A method of increasing the safety and productivity of farm animals by oral or aerosol administration of terpenoid formulations, characterized in that polyene-1 is used as a terpenoid preparation in the form of a 10% aqueous solution orally at dosages of 0.1 to 0.5 ml / kg of animal weight or aerosol at saturation of air 1 3 ml / m ³ .

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