RU2072239C1 - Method and remedy for correcting metabolic alcohol dependence - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves administering preparation of the following composition: glucose 1.0-2.0, sodium piruvate 40-50 mg, calcium lactate 360-500 mg, thiamine bromide 50-60 mg, ascorbic acid 100-150 mg, magnesium sulfate 500-700 mg. The preparation is taken once or multiple times a day between meals during the first several days, then it is taken once a day until the treatment is over. During the following period, a patient takes the preparation independently when needed. EFFECT: enhanced effectiveness of treatment course. 2 cl

Description

 The invention relates to medicine, more specifically to narcology, and is intended for the treatment of patients with alcoholism. In addition, the proposed drug can be used to study the mechanisms of formation of endogenous ethanol (EE) in the body, the effect of the latter on metabolism and its recirculation.

 A known method for the treatment of chronic alcoholism (ed. St. N 1591217, A 61 K 31/00, 1989), which consists in the fact that the patient is injected intravenously with 10 ml of 25% glucose solution, 5 ml of 5% ascorbic acid solution and, in addition to in addition, thiamine in an amount of 40-60 mg, magnesium sulfate 680 720 mg, sodium pyruvate 40 60 mg and calcium lactate 350 370 mg per day are orally administered.

 The disadvantage of this method in relation to the proposed method and drug is a less pronounced therapeutic effect. This is expressed by the fact that in order to maintain a state of stable remission, it is necessary to conduct more often treatment courses with additional use of the drug in between. An undesirable sign is also the development of the effect of addiction to the drug and a decrease over time of its therapeutic effect.

 The aim of the invention is the enhancement of the therapeutic effect of the drug associated with obtaining stable remission (more than 10 months; in the prototype 6 months) after a single course of treatment (in the prototype after two courses), the absence of withdrawal symptoms even if alcohol intake is necessary (anniversaries, holidays, etc.) e.), maintaining long-term self-control in a provocative environment, forming psychological confidence in the possibility of extraction in the absence of fear of alcohol, maintaining a pronounced therapeutic effect with repeated use Laziness of the drug (lack of addiction).

 The essence of the proposed method and drug for the correction of metabolic dependence on alcohol is that the patient receives a course of treatment for 10 days or more with a drug containing glucose in the amount of 1.0 2.0 g, ascorbic acid 100 150 mg, magnesium sulfate 600 700 mg, calcium lactate 360 500 mg, sodium pyruvate 30 50 mg and thiamine bromide 50 60 mg.

Distinctive features of the prototype are the following:
all components of the prescription are introduced simultaneously in one official form;
the ratio of pyruvate to lactate in the recipe is 1 10.

The drug was tested on the basis of the drug treatment room (Novosibirsk) and the district hospital (Taimyr Peninsula). The test was conducted on individuals with an alcohol history who voluntarily agreed to take part in the examination. Two groups stood out:
Persons with abstinence
faces in the "bright" gap.

Two patients were allowed to drink during and after treatment. After taking vodka, patients noted the following:
there was no craving for alcohol provoked by his intake;
patients could stop themselves even after taking 300,400 g of vodka;
the phenomena of "hangover" after taking vodka was not observed.

 In both groups, no side effects were noted both during the treatment period and after it. The drug is safe for the treatment of alcoholism at any stage.

 Example 1. 16.04.90. Patient Mr. I turned into a state of withdrawal. After taking the drug, I did not notice any special changes. I felt good. The dream became deeper and calmer. Craving for alcohol has passed.

 04/30/90. I went to the village for an anniversary. On the first day I drank approximately 300,400 g of vodka, although I did not experience cravings. I didn’t want to talk to my relatives about what was being treated. He himself refused to take vodka without any effort. "Oddly enough, the patient’s words didn’t attract alcohol the next day." The next day I drank about 200 g with friends. "Stopped drinking alcohol easily." I felt good, did not feel cravings for alcohol.

 September 1990. Sometimes he began to drink on birthdays with friends. The next day, I did not get sober. He refused to take alcohol himself.

 Example 2. 04/23/90. Patient Zh. Appealed to the narcological office in a state of abstinence. Complained of a headache, a feeling of pressure in the temples and head. He had nightmares at night, “pounding everything”. After treatment, he noted a significant improvement in general condition, improved appetite, sleep, and performance. He does not feel cravings for alcohol. 10/04/90. Craving for alcohol is absent. There are no absenteeism at work. There are no violations of labor discipline.

 Example 3. 04/23/90. Patient S. suffers from chronic alcoholism (periodic binges). On examination, complained of headaches, sleep disturbance. Status of withdrawal. There is no installation for treatment. He underwent treatment with a new drug. Well-being immediately improved, craving for alcohol is absent.

 Ten months later, dreams appeared with an alcoholic theme, a desire to drink. He took the drug twice. The indifference to alcohol and the belief that attachment to it can be overcome again reappeared.

Claims (2)

 1. The method of correction of the metabolic dependence on alcohol, including the introduction of glucose, ascorbic acid sodium pyruvate, calcium lactate, thiamine bromide in an amount of 50 to 60 mg, magnesium sulfate 500 to 700 mg, one or more times a day in between meals, characterized in that the components are simultaneously administered orally, glucose in an amount of 1000-2000 mg, ascorbic acid 100 150 mg, sodium pyruvate 30 50 mg, calcium lactate 360 500 mg. 2. Means for the correction of metabolic dependence on alcohol, containing thiamine bromide, magnesium sulfate, sodium pyruvate, calcium lactate, characterized in that it additionally contains glucose and ascorbic acid with the following components, mg:
Thiamine Bromide 50 60
Magnesium Sulphate 500 700
Ascorbic acid 100 150
Glucose 1000 2000
Pyruvate Sodium 40 50
Calcium Lactate 360 500 °