RU2070051C1 - Agent for diarrhea treatment - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: invention involves preparing composition containing pomegranate fruit native juice, rowan melanocarpous native juice, pomegranate fruit peel decoction, food gelatin and 5% lactobacterin ferment taken at the definite ratio. EFFECT: enhanced effectiveness of treatment. 1 tbl

Description

 The invention relates to medicine, namely to gastroenterology.

 In medicine, means are known to normalize the intestinal motor function, these include astringents (tannin and other tannins of plant origin) = bismuth and aluminum salts, drugs that block neuromuscular conduction (opium and imodium derivatives), antibacterial drugs, and enzymes.

 All these drugs, except antibacterial ones, have a predominantly symptomatic effect, without affecting (or having little effect) on the triggers of the pathological process, such as lipid peroxidation disorders and dysbiotic changes, which certainly occur with diarrhea of any origin and are especially persistent in inflammatory diseases such as non-specific ulcerative colitis. In addition, astringent drugs reduce the natural production of mucus by coagulating its proteins. At the same time, a decrease in mucus production is one of the triggers for the development of an erosive process in ulcerative colitis. Milk-based therapeutic food products enriched with lactobacilli or bifidobacteria practically do not have antidiarrheal effects and cannot be used in cases of milk intolerance.

 To achieve the optimal therapeutic effect, a pathogenetic approach to eliminating the causes of diarrhea is necessary, especially in severe diseases such as ulcerative colitis.

 In folk medicine, the antidiarrheal effect of pomegranate juice is known, which has been prescribed since the time of Hippocrates for gastrointestinal disorders (T. A. Aseeva. Ts. A. Naydakova "Food plants in Tibetan medicine", Novosibirsk, "Science", 1991, p.100 ) Also, a similar effect of aronia juice and a decoction of pomegranate peels, which are used in folk medicine as astringents, is known (R.M.Seredin "Medicinal Plants of Dagestan", Makhachkala, 1961, p. 60; A.F. Hammerman, M. D.Shupinskaya, A.A. Yatsenko-Khmelevskaya "Healer Plants", M. 1963, p.380; A.D. Turova "Medicinal plants of the USSR and their use", M. 1967, p.336-339).

 It should be noted that the use of juices is usually seasonal in nature, since canned juices of industrial production contain a number of additives that adversely affect the digestive tract, sometimes leading to the opposite effect. In addition, industrial juices do not affect the dysbiosis present in diarrhea.

 The aim of the invention is to obtain a plant-based antidiarrheal food product with antimicrobial and antioxidant effects, capable of correcting impaired intestinal biocenosis.

 The product contains pomegranate and chokeberry juices, a decoction of pomegranate peels (1:50), edible gelatin, distilled sterile water and 5% sourdough lactebacterin with the following quantitative content of components, wt.

Native pomegranate juice 11-13
native aronia juice 24-26
Decoction of pomegranate peels 24-26
Edible gelatin 19-21
Ferment of lactobacterin 5% 4.9-5.1
The distilled water is sterile, the rest.

 These component ratios are selected experimentally, based on organoleptic properties. Ferment of lactobacterin is used in the volume of the standard permitted dose.

 The growth of lactobacilli in the presence of the drug is not suppressed.

Titration: control up to 10 ¹⁶ (row up to 10 ¹⁶ ) experience up to 10 ¹⁶ .

 Antimicrobial effect tested (in vitro) in the microbiological laboratory of the Institute. Bacteriostatic effect was revealed in relation to xebsiella, hemolytic, lactose-deficient and full-fledged Escherichia coli, Staphylococcus aureus and epidermal. The bactericidal effect is determined in relation to Proteus and sigemic bacillus (see table 1).

Antioxidant properties are the ability of pomegranate juice to reduce the potential ability of lipids to peroxidate (at a rate of 1 / C ₅₀ ):
finished product control
30-42 8-10
Indicator C ₅₀ represents the amount of substrate, the ability to reduce by 50% the chemiluminescence of the standard system based on lipoproteins of the yolk of chicken eggs.

 Preparation of funds is as follows.

Following the rules of asepsis, the individual components are introduced into a sterile container and mixed. The product container is kept in a thermostat at 37 ^o for 3 hours. Then, in a sterile box, the product is poured into sterile containers (baby food jars, etc.) of 50 ml each, cooled in a refrigerator to a jelly-like state and stored until sale. When controlling the sterility of the product (on a plate with blood agar), microflora growth was not detected.

 The consistency is jelly-like, homogeneous; color is dark lilac, pH - 4.3-4.5; the taste is sweet and sour.

 The tool is used as follows.

 For a child suffering from ulcerative colitis or diarrhea accompanied by milk intolerance, against the background of the hygiene and diet regimen and complex drug therapy, the agent "Gricolo" is prescribed 2-3 times a day between meals. A single dose for a child of school age 50 ml. The minimum duration of treatment is 2 weeks.

 Clinical example. Sveta T., 11 years old, medical history N 2209 was in the 2nd gastroenterological department of the Nizhny Novgorod Research Institute of Pediatric Gastroenterology from 29.10 to 12.12.91 with a diagnosis of ulcerative colitis, total, moderate, activity I-II Art. chronic course.

Upon receipt, the condition is satisfactory. An objective examination revealed abdominal tenderness along the large intestine. Stool 4 times a day, liquid with an admixture of dark blood and mucus. Endoscopically: total damage to the colon with activity of the process of I-II degree. Total an. blood: Er-4, 3 • 10 ¹² , HB 136 g / l L-8, 8 • 10 ⁹ p-4, s-48, l-42, M-6, ESR 18 mm / h. In the coprogram, a large number of fresh and changed red blood cells and Charcot-Leiden crystals was determined. Feces for dysbacteriosis: dysbacteriosis due to an increased content of protea and a deficiency of bifidobacteria was detected. Blood for lipid peroxidation: the level of malondialdehyde (MDA) is 44.1 μmol / L (normal 30.3 ± 1.4).

 Against the background of the hygiene and dietary regimen, she received treatment: salazopyridazine according to the scheme, vitamins A, B1, B2, B6, nicotinic, ascorbic, and folic acids. From the 5th day of stay in the hospital she received the Gricolo drug 50.0 2 times a day.

 On the 9th day of hospital stay (4th day of treatment with Gricolo), the frequency of stool decreased to 2 times a day. The stool remained mushy, an admixture of a small amount of blood was periodically preserved.

At the end of treatment, the patient's condition was satisfactory. There were no complaints, objectively on organs without features. Stool once a day, decorated, without impurities of blood. Endoscopically: activity of the process is 0-I degree. In general, an. blood ER-4.2 • 10 ¹² , HB 128 g / l, L-5.0 • 10 ⁹ , s-30, l-62, m-3, e-4, b = 1, ESR 9 mm / h . Coprogram without features. In the inoculation for dysbiosis, only a deficiency of bifidobacteria was detected. The level of MDA is 29.3 μmol / L.

Claims (1)

 An agent for treating diarrhea containing plant products and distilled water, characterized in that it contains pomegranate juice, native aronia juice, decoction of pomegranate fruit peels and additional edible gelatin and 5% lactobacterin yeast in the following ratio components, wt. Native juice of pomegranate fruit 11 13
Aronia juice 24 26
Pomegranate peel decoction (1:50) 24 26
Edible gelatin 1.9 2.1
5% fermentation of lactobactrin 4.9 5.1
Sterile distilled water

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