RU2063771C1 - Method of sterilization of medical instruments - Google Patents

Abstract

FIELD: medicine, in particular, chemical sterilization. SUBSTANCE: a mixture of water-soluble polymer and bactericide is prepared. Instruments are immersed in the obtained mixture, taken out, dried in the open air and placed in a hermetically sealed package. EFFECT: reduced time of sterilization, increased time of storing of sterile medical instrument. 1 tbl

Description

 The alleged invention relates to medicine, namely to chemical sterilization, and can be used to process surgical instruments in the field, during natural disasters, in expeditions.

A known method of sterilization of medical instruments using an aqueous solution of hydrogen / Order of the Ministry of Health of the USSR N 408 dated June 12, 1989 /. The use of a 6% aqueous solution of H ₂ O ₂ for sterilization involves a 6-hour exposure of the instruments in the sterilizing solution and subsequent immersion in sterile water for 5 minutes.

 Preparation of the working solution should be carried out in a pharmacy, the shelf life is 7 days, and it is necessary: constant monitoring of the content of the active principle. Storage utensils must have a ground stopper; storage is carried out in a cool place.

 The aim of the invention is to reduce sterilization time, increase the duration of storage of sterile medical instruments.

The sterilization method is as follows:
A water-soluble bactericide is added to the water-soluble polymer / bactericidal preparations must be taken in effective concentrations on microorganisms / the processed tools are immersed in the resulting mixture, removed, dried in the open air and placed in an airtight container.

To prepare the polymer bactericidal mixture, we used a water-soluble polymer oligomeric sulfonyl pyrrolidium chloride / OSPH / 98 parts and a water-soluble bactericide-chloride three chlorall hexamethylene tetramine / ХТХ ГМТА / 2 parts
ХТХ ГМТА synthesized by a branch of the Ufa Petroleum Institute and proposed to protect surfactants from biodeterioration.

Вещество представляет собой порошок желтого цвета, хорошо растворим в воде и нерастворим в органических растворителях. Мол. масса 241, тем-ра плавления 173^oC.

The substance is a yellow powder, soluble in water and insoluble in organic solvents. Like weight 241, melting point 173 ^o C.

DL 50 dm white mice 1850 ± 382 mg / kg
DL 50 dm of white rats 5200 ± 848.5 mg / kg
DL 50 dm guinea pigs 1500 mg / kg.

 Cumulative properties of the compounds are not expressed; according to G.N.Krasnovsky's classification, it is assigned to the 3–4 hazard class.

 Oligomeric sulfonyl pyrrolidium chloride / OSPH /. Copyright certificate N 1530631, 1989

Логарифмическое число вязкости 0,2 0,24 ОСПХ растворим в воде, не растворим в органических растворителях. В-во малотоксичное (LD при введении в желудок крысам 17000 мг/кг, для мышей 6200 мг/кг) не раздражает слизистые оболочки и кожу, не изменяет деятельности сердечно-сосудистой системы, не оказывает депрессирующего действия на ц.н.с. не изменяет гематологические показатели периферической крови, не всасывается через неповрежденную кожу. На основании постановления Гос. комитета стандартов ОСПХ относится к 4-му классу малоопасных веществ.

Logarithmic viscosity number 0.2 0.24 OSPH soluble in water, insoluble in organic solvents. Low toxicity (LD when injected into the stomach of rats 17,000 mg / kg, for mice 6,200 mg / kg) does not irritate the mucous membranes and skin, does not alter the activity of the cardiovascular system, does not have a depressing effect on the central nervous system does not change the hematological parameters of peripheral blood, is not absorbed through intact skin. Based on the decision of the State. The OSHP Standards Committee belongs to the 4th class of low-hazard substances.

 We take control washes from non-sterile medical instruments and inoculate on AGV medium to determine bacterial contamination. Processed items, immerses the bactericidal mixture in the polymer, after 20 - 30 seconds, remove and dry in the open air.

 10-15 minutes after processing, the tools can be used for their intended purpose, for this it is necessary to wipe the treated items with a clean dressing moistened in any sterile solution to remove the polymer bactericidal film.

 The results of the study are shown in the table.

 For long-term storage, the processed tools are placed in hermetic packaging.

 Example 1

 To prepare the polymer of the bactericidal mixture, 2 g of ХТХ ГМТА was dissolved in the water-soluble OSPH polymer, bringing the volume to 100 ml.

 Surgical instruments were immersed in the resulting mixture, after 15 seconds they were removed, dried in air, and after 30 minutes, the treated objects were sterile.

 Studies show that the proposed method of sterilization of medical instruments using a polymer bactericidal mixture is effective, as it reduces the sterilization time, increases the storage time of sterile instruments, does not require additional costs. TTT1

Claims (1)

 A method of sterilizing medical instruments including chemical treatment, characterized in that the instruments are immersed for 15-30 seconds in a mixture of a water-soluble bactericide of chloride, trichlorall hexamethylene tetramine and water-soluble polymer oligomer sulfonyl pyrrolidium chloride, taken in a ratio of 1:49, then dried and sealed.

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