RU2046606C1 - Surgery commissure thread - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: surgery commissure thread is obtained from high-molecular poly-[bis-(trifluoroethoxy)phosphazenes] with molecular mass 1000000-1500000 and 15000000-27000000 taken at the ratio (0.1-5.0):(95.0-99.9), respectively. EFFECT: enhanced quality of thread.

Description

 The invention relates to medicine, in particular to surgery, and relates to synthetic absorbable suture threads.

 Resorbable suture threads of biological nature (catgut, collagen) and synthetic suture threads based on polyglycolide are known.

 However, these suture threads do not have an adjustable dispersion rate, antimicrobial action, and have poor physical and mechanical properties.

 The objective of the invention is the creation of a surgical suture thread, devoid of the above disadvantages.

 The problem is solved by creating a suture thread from a mixture of high molecular weight polyphosphazenes of poly- [bis- (trifluoroethoxy) phosphazenes] with a molecular weight of 1,000,000-1,500,000 and with a molecular weight of 1,500,000-27,000,000, taken in quantitative proportions (0.1-5.0) :( 95 , 0-99.9), respectively.

 Surgical suture threads are obtained in two ways.

According to the first method, 0.1-5.0 wt.% Are added to the molten poly- [bis- (trifluoroethoxy) phosphazene] with a molecular weight of 15000000-27000000. poly- [bis- (trifluoroethoxy) phosphazene] with a molecular weight of 1,000,000 to 1,500,000. The resulting mixture was subjected to extrusion apparatus for fiberizing molten at the following regime: Temperature 245-250 ^{° C} Speed expiration through a die orifice diameter of 0.5 mm 0.02 ms spunbonded hood 100-500 finished fiber diameter (monoliths) 0.02- 0.10 mm
According to the second method, a fiber of poly- [bis- (trifluoroethoxy) phosphazene] with a molecular weight of 1,500,000-27,000,000 obtained by the wet spinning process (SU 1506954 A1, class D 01 F 7/76, 1989) is passed through 1-10% solution of poly [bis (trifluoroethoxy) phosphazene] 1000000-1500000 with a molecular weight in acetone, methyl ethyl ketone, tetrahydrofuran, hexafluorobenzene et al., followed by drying at 50-60 ^{° C} for 1-3 hours.

Example 1. To the melt 114.40 g (95.0 wt.) Poly- [bis- (trifluoroethoxy) phosphazene] with a molecular weight of 14800000 was added 5.60 g (5.0 wt.) Poly- [ bis- (trifluoroethoxy) phosphazene] with a molecular weight of 1,000,000. The resulting mixture was subjected to molding according to the procedure described above. Monofilament with a diameter of 0.05 mm. Breaking strength of 19.7 kg / mm ² , elongation of 15% strength in the node 63%
PRI me R 2. In the melt of 149.85 g (99.9 wt.) Poly- [bis- (trifluoroethoxy) phosphazene] with a molecular weight of 27000000 was added 0.15 g (0.1 wt.) Poly- [ bis- (trifluoroethoxy) phosphazene] with a molecular weight of 1,500,000. The mode of spinning is the same as described above. Monofilament with a diameter of 0,026 mm. Breaking strength 29.8 kg / mm ² , elongation 32%, knot strength 68%. The thread does not cause inflammation in the tissues of living organisms and maintains strength characteristics after 6 months.

PRI me R 3. A fiber from poly- [bis- (trifluoroethoxy) phosphazene] with a molecular weight of 14975000, obtained by wet method, for 5 s pass through a 5% solution of poly- [bis- (trifluoroethoxy) phosphazene] with a molecular weight of 1,500,000 in ethyl acetate and dried at 50 ^about C for 2 hours. Filament yarn with a diameter of 0.05 mm Breaking strength of 50 kg / mm ² , elongation of 30%, strength in a knot of 70%. The thread has an antimicrobial effect and completely resolves in the tissues of a living organism within 1 month.

 Suture threads exhibit antimicrobial activity throughout the entire time the suture is in contact with a living organism.

Claims (1)

 SURGICAL SEWING THREAD based on a synthetic polymer, characterized in that poly- [bis- (trifluoroethoxy) phosphazenes] with a mol.m are used as a polymer. 1,000,000 1,500,000 and 1,500,000,270,000,000 with their ratio of (0.1 - 5.0) (95.0 99.9), respectively.