RU2022129311A - METHOD FOR PRODUCING TWO 4-{[(2S)-2-{4-[5-CHLORO-2-(1H-1,2,3-TRIAZOL-1-YL)PHENYL]-5-METHOXY-2-OXOPYRIDIN-1 (2H)-IL} BUTANOYL]AMINO}-2-FLUOROBENZAMIDE DERIVATIVES - Google Patents

METHOD FOR PRODUCING TWO 4-{[(2S)-2-{4-[5-CHLORO-2-(1H-1,2,3-TRIAZOL-1-YL)PHENYL]-5-METHOXY-2-OXOPYRIDIN-1 (2H)-IL} BUTANOYL]AMINO}-2-FLUOROBENZAMIDE DERIVATIVES Download PDF

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RU2022129311A
RU2022129311A RU2022129311A RU2022129311A RU2022129311A RU 2022129311 A RU2022129311 A RU 2022129311A RU 2022129311 A RU2022129311 A RU 2022129311A RU 2022129311 A RU2022129311 A RU 2022129311A RU 2022129311 A RU2022129311 A RU 2022129311A
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oxopyridin
butanoyl
triazol
chloro
methoxy
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RU2022129311A
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Russian (ru)
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Юлиан ЭГГЕР
Даниель ГЁТЦ
Михаль ЗОВА
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Байер Акциенгезельшафт
Байер Фарма Акциенгезельшафт
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1. 4-({(2S)-2-[4-{5-Хлор-2-[4-(трифторметил)-1H-1,2,3-триазол-1-ил]фенил}-5-метокси-2-оксопиридин-1(2H)-ил]бутаноил}-амино)-2-фторбензамид ацетон, имеющий формулу1. 4-({(2S)-2-[4-{5-Chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}-5-methoxy- 2-oxopyridin-1(2H)-yl]butanoyl}-amino)-2-fluorobenzamide acetone having the formula
Figure 00000001
Figure 00000001
2. Способ получения 4-({(2S)-2-[4-{5-хлор-2-[4-(трифторметил)-1H-1,2,3-триазол-1-ил]фенил}-5-метокси-2-оксопиридин-1(2H)-ил]бутаноил}-амино)-2-фторбензамида (II), имеющего формулу (II)2. Method for obtaining 4-({(2S)-2-[4-{5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}-5- methoxy-2-oxopyridin-1(2H)-yl]butanoyl}-amino)-2-fluorobenzamide (II) having the formula (II)
Figure 00000002
Figure 00000002
отличающийся тем, что 4-({(2S)-2-[4-{5-хлор-2-[4-(трифторметил)-1H-1,2,3-триазол-1-ил]фенил}-5-метокси-2-оксопиридин-1(2H)-ил]бутаноил}-амино)-2-фторбензамид ацетон (IIc) изолируют и превращают в 4-({(2S)-2-[4-{5-хлор-2-[4-(трифторметил)-1H-1,2,3-триазол-1-ил]фенил}-5-метокси-2-оксопиридин-1(2H)-ил]бутаноил}-амино)-2-фторбензамид (II).characterized in that 4-({(2S)-2-[4-{5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}-5- methoxy-2-oxopyridin-1(2H)-yl]butanoyl}-amino)-2-fluorobenzamide acetone (IIc) is isolated and converted to 4-({(2S)-2-[4-{5-chloro-2- [4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}-5-methoxy-2-oxopyridin-1(2H)-yl]butanoyl}-amino)-2-fluorobenzamide (II ).
RU2022129311A 2018-03-15 2019-03-08 METHOD FOR PRODUCING TWO 4-{[(2S)-2-{4-[5-CHLORO-2-(1H-1,2,3-TRIAZOL-1-YL)PHENYL]-5-METHOXY-2-OXOPYRIDIN-1 (2H)-IL} BUTANOYL]AMINO}-2-FLUOROBENZAMIDE DERIVATIVES RU2022129311A (en)

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EP18161983.4 2018-03-15

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RU2020133706A Division RU2804663C2 (en) 2018-03-15 2019-03-08 Method of producing two 4-{[(2s)-2-{4-[5-chloro-2-(1h-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2h)-il} butanoyl]amino}-2-fluorobenzamide derivatives

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