RU2022125986A - NON-PROTEIN COMPOSITIONS OF CLOSTRIDIAL TOXIN - Google Patents
NON-PROTEIN COMPOSITIONS OF CLOSTRIDIAL TOXIN Download PDFInfo
- Publication number
- RU2022125986A RU2022125986A RU2022125986A RU2022125986A RU2022125986A RU 2022125986 A RU2022125986 A RU 2022125986A RU 2022125986 A RU2022125986 A RU 2022125986A RU 2022125986 A RU2022125986 A RU 2022125986A RU 2022125986 A RU2022125986 A RU 2022125986A
- Authority
- RU
- Russia
- Prior art keywords
- poloxamer
- trehalose
- sucrose
- methionine
- edta
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 42
- 231100001102 clostridial toxin Toxicity 0.000 title claims 13
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 46
- HDTRYLNUVZCQOY-LIZSDCNHSA-N Trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 30
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 30
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 26
- 229940044519 Poloxamer 188 Drugs 0.000 claims 26
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 26
- 229920001993 poloxamer 188 Polymers 0.000 claims 26
- 239000005720 sucrose Substances 0.000 claims 26
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 229960000502 Poloxamer Drugs 0.000 claims 12
- 239000002738 chelating agent Substances 0.000 claims 12
- 239000007788 liquid Substances 0.000 claims 12
- 229920001983 poloxamer Polymers 0.000 claims 12
- 229960004308 ACETYLCYSTEINE Drugs 0.000 claims 10
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 10
- 239000011780 sodium chloride Substances 0.000 claims 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 9
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 9
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 9
- 239000008103 glucose Substances 0.000 claims 9
- 239000000594 mannitol Substances 0.000 claims 9
- 235000010355 mannitol Nutrition 0.000 claims 9
- 239000000600 sorbitol Substances 0.000 claims 9
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 7
- 108010043024 Botulinum Toxins Proteins 0.000 claims 5
- 230000003078 antioxidant Effects 0.000 claims 5
- 239000003963 antioxidant agent Substances 0.000 claims 5
- 235000006708 antioxidants Nutrition 0.000 claims 5
- 229950008882 Polysorbate Drugs 0.000 claims 4
- 229920000136 polysorbate Polymers 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 3
- 229960003330 Pentetic Acid Drugs 0.000 claims 3
- 229940074410 Trehalose Drugs 0.000 claims 3
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- 229960004793 Sucrose Drugs 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 125000003372 histidine group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 2
- 239000008247 solid mixture Substances 0.000 claims 2
- 206010003119 Arrhythmia Diseases 0.000 claims 1
- 229940095259 Butylated Hydroxytoluene Drugs 0.000 claims 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical group CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 1
- 206010007521 Cardiac arrhythmias Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000006883 Neuromuscular Disease Diseases 0.000 claims 1
- 208000006641 Skin Disease Diseases 0.000 claims 1
- 235000021120 animal protein Nutrition 0.000 claims 1
- 229940053031 botulinum toxin Drugs 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims 1
Claims (105)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62/394,009 | 2016-09-13 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2019110875A Division RU2019110875A (en) | 2016-09-13 | 2017-09-13 | NON-PROTEIN CLOSTRIDIAL TOXIN COMPOSITIONS |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2022125986A true RU2022125986A (en) | 2022-11-03 |
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