RU2022118872A - METHOD FOR OBTAINING 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND INTERMEDIATE PRODUCTS FOR THEIR SYNTHESIS - Google Patents

METHOD FOR OBTAINING 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND INTERMEDIATE PRODUCTS FOR THEIR SYNTHESIS Download PDF

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RU2022118872A
RU2022118872A RU2022118872A RU2022118872A RU2022118872A RU 2022118872 A RU2022118872 A RU 2022118872A RU 2022118872 A RU2022118872 A RU 2022118872A RU 2022118872 A RU2022118872 A RU 2022118872A RU 2022118872 A RU2022118872 A RU 2022118872A
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Russia
Prior art keywords
compound
salt
formula
organic acid
obtaining
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RU2022118872A
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Russian (ru)
Inventor
Хирому ТАКИГУТИ
Акинобу ХИГАСИ
Такаси ИНАБА
Такаси ВАТАНАБЕ
Цубаса ТАКЕИТИ
Андерс Кларсков ПЕТЕРСЕН
Пер ВЕДСУ
Ким Лебек ЕНСЕН
Ян БОРНХОЛДТ
Сорен ЭБДРЮП
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Джапан Тобакко Инк.
Лео Фарма А/С
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Publication of RU2022118872A publication Critical patent/RU2022118872A/en

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Claims (26)

1. Способ получения соединения, имеющего формулу [17]1. Method for obtaining a compound having the formula [17]
Figure 00000001
Figure 00000001
 или его соли с использованием соединения, имеющего формулу [31]or a salt thereof using a compound having the formula [31]
Figure 00000002
Figure 00000002
 или его соли с органической кислотой, включающий следующие стадии, на которых: or its salt with an organic acid, comprising the following stages, in which: (1) соединение, имеющее формулу [31], или его соль с органической кислотой вводят в реакцию с соединением, имеющим формулу [12](1) a compound having the formula [31] or an organic acid salt thereof is reacted with a compound having the formula [12]
Figure 00000003
Figure 00000003
 или его солью с получением соединения, имеющего формулу [14]or its salt to obtain a compound having the formula [14]
Figure 00000004
Figure 00000004
 или его соли; и or its salts; and (2) осуществляют цианоацетилирование соединения, имеющего формулу [14], или его соли с получением соединения, имеющего формулу [17], или его соли. (2) carrying out cyanoacetylation of a compound having the formula [14] or a salt thereof to obtain a compound having the formula [17] or a salt thereof. 2. Способ по п. 1, дополнительно включающий стадию, на которой к соединению, имеющему формулу [31], добавляют органическую кислоту с получением соли соединения, имеющего формулу [31], с органической кислотой. 2. The method of claim 1, further comprising adding an organic acid to a compound having the formula [31] to form a salt of the compound having the formula [31] with an organic acid. 3. Способ по п. 1 или 2, где соль с органической кислотой представляет собой дисукцинат или оксалат. 3. The method according to claim 1 or 2, wherein the organic acid salt is a disuccinate or an oxalate. 4. Способ по любому из пп. 1, 2 и 3, дополнительно включающий стадию, на которой соединение, имеющее формулу [31], или его соль с органической кислотой получают из соединения, имеющего формулу [28]4. The method according to any one of paragraphs. 1, 2 and 3, further comprising a step in which a compound having the formula [31] or an organic acid salt thereof is obtained from a compound having the formula [28]
Figure 00000005
Figure 00000005
 или его соли с органической кислотой. or its salts with an organic acid. 5. Способ по п. 4, дополнительно включающий стадию, на которой к соединению, имеющему формулу [28], добавляют органическую кислоту с получением соли соединения, имеющего формулу [28], с органической кислотой. 5. The method of claim 4, further comprising adding an organic acid to a compound having the formula [28] to form a salt of the compound having the formula [28] with an organic acid. 6. Способ по п. 4 или 5, где соль соединения, имеющего формулу [28], с органической кислотой представляет собой оксалат. 6. The method according to claim 4 or 5, where the salt of the compound having the formula [28] with an organic acid is an oxalate. 7. Соединение, имеющее формулу [31]7. Compound having the formula [31]
Figure 00000006
Figure 00000006
 или его соль с органической кислотой. or its salt with an organic acid. 8. Соединение по п. 7, представляющее собой соль с органической кислотой, где соль представляет собой дисукцинат или оксалат. 8. The compound according to claim 7, which is a salt with an organic acid, where the salt is a disuccinate or oxalate. 9. Соль соединения, имеющего формулу [28]9. Salt of a compound having the formula [28]
Figure 00000005
Figure 00000005
 с органической кислотой. with organic acid. 10. Соль по п. 9, где соль с органической кислотой представляет собой оксалат. 10. The salt of claim 9 wherein the organic acid salt is an oxalate.
RU2022118872A 2016-12-21 2017-12-20 METHOD FOR OBTAINING 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND INTERMEDIATE PRODUCTS FOR THEIR SYNTHESIS RU2022118872A (en)

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JP2016-247607 2016-12-21

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RU2019122691A Division RU2776802C2 (en) 2016-12-21 2017-12-20 Method for production of 7h-pyrrolo[2,3-d]pyrimidine derivatives and intermediate compounds for their synthesis

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RU2022118872A true RU2022118872A (en) 2022-08-11

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