RU2019143623A - Fusion protein containing modified methionine-free protein GroEL and polyphemusin I polypeptide dimer - Google Patents

Fusion protein containing modified methionine-free protein GroEL and polyphemusin I polypeptide dimer Download PDF

Info

Publication number
RU2019143623A
RU2019143623A RU2019143623A RU2019143623A RU2019143623A RU 2019143623 A RU2019143623 A RU 2019143623A RU 2019143623 A RU2019143623 A RU 2019143623A RU 2019143623 A RU2019143623 A RU 2019143623A RU 2019143623 A RU2019143623 A RU 2019143623A
Authority
RU
Russia
Prior art keywords
polyphemusin
groel
fusion protein
modified methionine
containing modified
Prior art date
Application number
RU2019143623A
Other languages
Russian (ru)
Other versions
RU2760578C2 (en
RU2019143623A3 (en
Inventor
Владимир Андреевич Зенин
Мария Сергеевна Юркова
Эльчин Гусейнгулу оглы Садыхов
Алексей Николаевич Федоров
Виктор Васильевич Суровцев
Светлана Нуржауевна Суанбекова
Наталья Вячеславовна Чертова
Алексей Андреевич Богомолов
Original Assignee
федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) filed Critical федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН)
Priority to RU2019143623A priority Critical patent/RU2760578C2/en
Publication of RU2019143623A publication Critical patent/RU2019143623A/en
Publication of RU2019143623A3 publication Critical patent/RU2019143623A3/ru
Application granted granted Critical
Publication of RU2760578C2 publication Critical patent/RU2760578C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Claims (1)

Слитый белок, содержащий модифицированный безметиониновый белок GroEL, имеющий в кодирующей части полилинкер и слитый с ним в области полилинкера димер полипептида полифемузина I, имеющего 39 аминокислот, в котором два полипептида полифемузина I, имеющего 18 аминокислот следующей последовательности RRWCFRVCYRGFCYRKCR, связаны линкером GSG, высокоэкспрессируемый в клетке-хозяине.A fusion protein containing a modified methionine-free protein GroEL, having a polylinker in the coding part and a dimer of polyphemusin I polypeptide having 39 amino acids fused to it in the polylinker region, in which two polyphemusin I polypeptides having 18 amino acids in the following sequence are linked in the following sequence RRWCFRVCYRGFCYRKCR, which is highly pressurized by the linker GSG host cell.
RU2019143623A 2019-12-25 2019-12-25 FUSED PROTEIN CONTAINING MODIFIED METHIONINE-FREE GroEL PROTEIN AND POLYPHEMUSINE I POLYPEPTIDE DIMER RU2760578C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2019143623A RU2760578C2 (en) 2019-12-25 2019-12-25 FUSED PROTEIN CONTAINING MODIFIED METHIONINE-FREE GroEL PROTEIN AND POLYPHEMUSINE I POLYPEPTIDE DIMER

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2019143623A RU2760578C2 (en) 2019-12-25 2019-12-25 FUSED PROTEIN CONTAINING MODIFIED METHIONINE-FREE GroEL PROTEIN AND POLYPHEMUSINE I POLYPEPTIDE DIMER

Publications (3)

Publication Number Publication Date
RU2019143623A true RU2019143623A (en) 2021-06-25
RU2019143623A3 RU2019143623A3 (en) 2021-06-25
RU2760578C2 RU2760578C2 (en) 2021-11-29

Family

ID=76504450

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019143623A RU2760578C2 (en) 2019-12-25 2019-12-25 FUSED PROTEIN CONTAINING MODIFIED METHIONINE-FREE GroEL PROTEIN AND POLYPHEMUSINE I POLYPEPTIDE DIMER

Country Status (1)

Country Link
RU (1) RU2760578C2 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2385065A1 (en) * 2007-11-01 2011-11-09 Perseid Therapeutics LLC Immunosuppressive polypeptides and nucleic acids

Also Published As

Publication number Publication date
RU2760578C2 (en) 2021-11-29
RU2019143623A3 (en) 2021-06-25

Similar Documents

Publication Publication Date Title
PE20190352A1 (en) GDF 15 FUSION PROTEINS AND USES OF THEM
PE20191033A1 (en) HETERODIMERIC FC FUSION PROTEINS IL 15 / IL 15R (alpha)
ES2676023T3 (en) IL-22 polypeptides and IL-22 Fc fusion proteins and methods of use
ES2676499T3 (en) Fc fusion proteins comprising new linkers or arrangements
HRP20200871T1 (en) Modified rsv f proteins and methods of their use
AR080229A1 (en) FIBRONECTINE ARMAZON DOMAIN PROTEINS THAT JOIN IL -23 (INTERLEUCINE 23)
UY31123A1 (en) NATURAL FUSION PROTEINS
AR071874A1 (en) ARMAZON DOMAIN PROTEINS BASED ON MULTIVALENT FIBRONECTINE
RU2018141360A (en) CONTORSBODY - SINGLE-CHAIN BINDING TARGET AGENT
MX2021000047A (en) Pd1-4-1bbl variant fusion protein and methods of use thereof.
ATE546533T1 (en) RECOMBINANT EXPRESSION OF PROTEINS IN A DISULFIDE-BRIDGED, TWO-CHAIN FORM
AR047729A1 (en) THERAPEUTIC ANTIBODIES THAT BIND APOLIPOPROTEIN E (APOE)
MX2021000263A (en) SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF.
PH12020551134A1 (en) Fc variants with enhanced binding to fcrn and prolonged half-life
EA201791238A1 (en) METHODS AND COMPOSITIONS IN WHICH OPTIONS OF KLOTHO POLYPEPTIDES ARE USED
WO2016115511A3 (en) Vegf variant polypeptide compositions
RU2017132689A (en) Fc α-chain fused high affinity IgE receptor
CL2017000200A1 (en) Enhanced host cell to produce proteins
DK1246917T3 (en) Human Stra6 polypeptides
EA201792274A1 (en) FUSED MOLECULES OPTION III RECEPTOR EPIDERMAL GROWTH FACTOR MESOTELIN AND METHODS OF THEIR APPLICATION
EA201391546A1 (en) ANTI-TRACT FUSE PROTEIN
ATE466874T1 (en) POLYPEPTIDES RELATED TO DOMAIN 1 SCYTOVIRIN
RU2019143623A (en) Fusion protein containing modified methionine-free protein GroEL and polyphemusin I polypeptide dimer
GB201102700D0 (en) Protein secretion
EA202091713A1 (en) BIOLOGICAL SYNTHESIS OF AMINO ACID CHAINS FOR OBTAINING PEPTIDES AND PROTEINS