RU2019113148A - Костный имплантат - Google Patents

Костный имплантат Download PDF

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Publication number
RU2019113148A
RU2019113148A RU2019113148A RU2019113148A RU2019113148A RU 2019113148 A RU2019113148 A RU 2019113148A RU 2019113148 A RU2019113148 A RU 2019113148A RU 2019113148 A RU2019113148 A RU 2019113148A RU 2019113148 A RU2019113148 A RU 2019113148A
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RU
Russia
Prior art keywords
bone implant
mass
bioactive glass
film
microns
Prior art date
Application number
RU2019113148A
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English (en)
Inventor
Фредрик ОЛЛИЛА
Нина ЛИНДФОРС
Роберт БЬЕРКЕНХЕЙМ
Густав СТРЕМБЕРГ
Лена ХУПА
Петер УППСТУ
Юкка ПАЯРИНЕН
Original Assignee
Бонэлайв Байоматириалс Ой
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Бонэлайв Байоматириалс Ой filed Critical Бонэлайв Байоматириалс Ой
Publication of RU2019113148A publication Critical patent/RU2019113148A/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30225—Flat cylinders, i.e. discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30317—The prosthesis having different structural features at different locations within the same prosthesis
    • A61F2002/30322—The prosthesis having different structural features at different locations within the same prosthesis differing in surface structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30968—Sintering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00329—Glasses, e.g. bioglass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Geometry (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Claims (17)

1. Костный имплантат, который содержит
пористое тело, содержащее частицы биоактивного стекла, имеющие размер частицы по меньшей мере 500 мкм, где композиция биоактивного стекла содержит 45-59% масс. SiO2, 18-25% масс. Na2O, 17-25% масс. CaO и 0,1-6% масс. P2O5, и
пленку толщиной 10-200 мкм, выполненную из биосовместимого полимера и расположенную по меньшей мере частично вокруг тела.
2. Костный имплантат по п. 1, в котором пленку располагают вокруг тела так, чтобы покрывать часть тела, находящуюся в контакте с мышцей, фасцией или надкостницей, когда имплантат имплантируют в кость.
3. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором полимер выбирают из группы, состоящей из полилактида, полигликолида, сополимера (лактид-гликолид), поликапролактона, природных коллагеновых полимеров и их смесей с полиэтиленгликолем.
4. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором размер частиц биоактивного стекла составляет 500-3150 мкм.
5. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором толщина пленки составляет 100-200 мкм.
6. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором пленка содержит биоактивное стекло.
7. Костный имплантат по п. 6, в котором биоактивное стекло пленки имеет форму порошка, имеющего усредненный размер частицы меньше чем 45 мкм.
8. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором в состав биоактивного стекла входит 45-54% масс. SiO2, 22-25% масс. Na2O, 19-25% масс. CaO и 3,5-6% масс. P2O5.
9. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором в состав биоактивного стекла входит 53% масс. SiO2, 23% масс. Na2O, 20% масс. CaO и 4% масс. P2O5.
10. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором тело имеет форму диска и пленку располагают вокруг сторон диска.
11. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором тело присутствует в форме спеченных биоактивных стеклянных частиц.
12. Костный имплантат в соответствии с любым из пп. 1-9, в котором тело присутствует в форме частиц биоактивного стекла, удерживаемых вместе биоразрушаемым полимером.
13. Костный имплантат по п. 12, в котором биоразрушаемый полимер выбирают из группы, состоящей из полилактида, полигликолида, сополимера (лактид-гликолид), поликапролактона, полиэтиленгликоля, коллагена и их смесей.
14. Способ изготовления костного имплантата в соответствии с любым из пп. 1-13, который включает формирование пористого тела, содержащего частицы биоактивного стекла, размещение пленки, выполненной из биосовместимого полимера, по меньшей мере частично вокруг пористого тела и нагревание комбинации до температуры стеклования биосовместимого полимера.
15. Способ по п. 14, в котором пористое тело, содержащее частицы биоактивного стекла, изготавливают с использованием формы и либо спекания, либо полимерного соединительного материала.
RU2019113148A 2016-10-05 2017-10-04 Костный имплантат RU2019113148A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16192500 2016-10-05
EP16192500.3 2016-10-05
PCT/FI2017/050693 WO2018065665A1 (en) 2016-10-05 2017-10-04 A bone implant

Publications (1)

Publication Number Publication Date
RU2019113148A true RU2019113148A (ru) 2020-11-06

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ID=57103889

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Country Link
US (1) US20200038547A1 (ru)
EP (1) EP3522944B1 (ru)
JP (1) JP2019535338A (ru)
KR (1) KR20190073349A (ru)
CN (1) CN110099700A (ru)
AU (1) AU2017339120A1 (ru)
BR (1) BR112019005021B1 (ru)
CA (1) CA3038608A1 (ru)
CL (1) CL2019000792A1 (ru)
CO (1) CO2019002492A2 (ru)
FI (1) FI3522944T3 (ru)
MX (1) MX2019003946A (ru)
PE (1) PE20190858A1 (ru)
RU (1) RU2019113148A (ru)
WO (1) WO2018065665A1 (ru)

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CN116036386B (zh) * 2023-02-22 2024-04-30 天津纳博特医疗器械有限公司 一种可吸收玻纤增强聚乳酸复合材料及颅颌面钉板系统

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Publication number Publication date
WO2018065665A1 (en) 2018-04-12
JP2019535338A (ja) 2019-12-12
CA3038608A1 (en) 2018-04-12
KR20190073349A (ko) 2019-06-26
US20200038547A1 (en) 2020-02-06
CL2019000792A1 (es) 2019-06-14
EP3522944B1 (en) 2024-04-03
BR112019005021B1 (pt) 2023-01-10
BR112019005021A2 (pt) 2019-06-04
FI3522944T3 (fi) 2024-06-17
PE20190858A1 (es) 2019-06-18
CN110099700A (zh) 2019-08-06
MX2019003946A (es) 2019-06-10
EP3522944A1 (en) 2019-08-14
EP3522944A4 (en) 2020-06-17
AU2017339120A1 (en) 2019-04-18
CO2019002492A2 (es) 2019-05-31

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