RU2019109061A - Composition for the treatment of gynecological and proctological diseases accompanied by oxidative stress - Google Patents

Claims (2)

Composition for the treatment of gynecological and proctological diseases accompanied by oxidative stress, consisting of an antioxidant active substance and a base, characterized in that as an active substance it contains particles obtained by mixing buffer solutions of the antioxidant enzyme superoxide dismutase at a concentration of 2.5-10.0 mg / ml and polycation at a concentration of 2.5-10.0 mg / ml, where the polycation is selected from the group including protamine, polylysine and polyarginine, stirring and maintaining the mixture, followed by adding a buffer solution of polyanion at a concentration of 2.5-10, 0 mg / ml, where the polyanion is a block copolymer of polyglutamic acid and polyethylene glycol or a block copolymer of polyaspartic acid and polyethylene glycol, stirring and maintaining the resulting mixture, adding an aqueous solution of glutaraldehyde, taken in an amount that provides its molar ratio with the amino groups of the polycation 0.3-1.5, withstanding mixing the mixture, adding an aqueous solution of sodium borohydride to the mixture at a concentration of 1-2 mg / ml, purifying the mixture using a membrane filter system with a transmission limit of 90-130 kilodaltons, freeze drying of the purified mixture and mixing the lyophilisate with the base, with the following ratio of components, wt ... %: Active substance 0.01-20.00 The basis Rest