RU2017145143A3 - - Google Patents
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- RU2017145143A3 RU2017145143A3 RU2017145143A RU2017145143A RU2017145143A3 RU 2017145143 A3 RU2017145143 A3 RU 2017145143A3 RU 2017145143 A RU2017145143 A RU 2017145143A RU 2017145143 A RU2017145143 A RU 2017145143A RU 2017145143 A3 RU2017145143 A3 RU 2017145143A3
- Authority
- RU
- Russia
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562168171P | 2015-05-29 | 2015-05-29 | |
| US62/168,171 | 2015-05-29 | ||
| US201562232658P | 2015-09-25 | 2015-09-25 | |
| US62/232,658 | 2015-09-25 | ||
| US201562245382P | 2015-10-23 | 2015-10-23 | |
| US62/245,382 | 2015-10-23 | ||
| PCT/US2016/034304 WO2016196185A1 (en) | 2015-05-29 | 2016-05-26 | Non-human animals having a disruption in a c9orf72 locus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020115485A Division RU2823721C2 (en) | 2015-05-29 | 2016-05-26 | ANIMALS, OTHER THAN HUMANS, WITH DISTURBANCE IN LOCUS C9orf72 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017145143A RU2017145143A (en) | 2019-07-02 |
| RU2017145143A3 true RU2017145143A3 (en) | 2019-10-17 |
| RU2725737C2 RU2725737C2 (en) | 2020-07-03 |
Family
ID=56194557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017145143A RU2725737C2 (en) | 2015-05-29 | 2016-05-26 | Non-human animals with disturbance in locus c9orf72 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10285388B2 (en) |
| EP (2) | EP3302048B1 (en) |
| JP (3) | JP6619822B2 (en) |
| KR (2) | KR102190661B1 (en) |
| CN (1) | CN107920498A (en) |
| AU (2) | AU2016270587B2 (en) |
| BR (1) | BR112017025507A2 (en) |
| CA (1) | CA2986048C (en) |
| ES (1) | ES2784360T3 (en) |
| HK (1) | HK1248465A1 (en) |
| IL (2) | IL255385A0 (en) |
| MX (1) | MX2017015369A (en) |
| RU (1) | RU2725737C2 (en) |
| SG (1) | SG10201911257YA (en) |
| WO (1) | WO2016196185A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017109757A1 (en) * | 2015-12-23 | 2017-06-29 | Crispr Therapeutics Ag | Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration |
| SG10202102997UA (en) | 2016-09-30 | 2021-04-29 | Regeneron Pharma | Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus |
| WO2018133139A1 (en) | 2017-01-21 | 2018-07-26 | 宁波知明生物科技有限公司 | Application of paeoniflorin-6'-o-benzene sulfonate in medicine for treating sjögren's syndrome |
| CN107693542B (en) * | 2017-09-05 | 2020-03-10 | 中山大学附属第三医院 | Construction method and application of systemic lupus erythematosus animal model |
| CN109452229B (en) * | 2018-11-19 | 2021-10-22 | 百奥赛图(北京)医药科技股份有限公司 | Preparation method and application of caninized PD-1 gene modified animal model |
| US11690362B2 (en) | 2018-12-20 | 2023-07-04 | Regeneran Pharmaceuticals, Inc. | Nuclease-mediated repeat expansion |
| JP7574195B2 (en) * | 2019-01-04 | 2024-10-28 | ジェネクスト テクノロジーズ インコーポレイテッド | In vivo radical dosimetry and protein footprinting of hydroxyl radicals in vivo |
| CN113046390B (en) * | 2020-03-09 | 2024-01-09 | 百奥赛图江苏基因生物技术有限公司 | Humanized non-human animal of CSF1R gene, construction method and application thereof |
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| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| WO1999005266A2 (en) | 1997-07-26 | 1999-02-04 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) * | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| AUPR451401A0 (en) | 2001-04-20 | 2001-05-24 | Monash University | A method of nuclear transfer |
| US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
| EP2767161B1 (en) | 2004-10-19 | 2018-02-07 | Regeneron Pharmaceuticals, Inc. | Method for generating an non-human animal homozygous for a genetic modification |
| CN101117633B (en) | 2006-08-03 | 2011-07-20 | 上海交通大学附属儿童医院 | Nucleus transplantation method |
| JP2008307007A (en) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth |
| DK2255013T3 (en) | 2008-02-15 | 2016-09-12 | Synthetic Genomics Inc | Methods for in vitro joining and combinatorial assembly of nucleic acid molecules. |
| US8470594B2 (en) * | 2008-04-15 | 2013-06-25 | President And Fellows Of Harvard College | Methods for identifying agents that affect the survival of motor neurons |
| RU2425880C2 (en) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Method of producing transgene mice |
| CA3104704A1 (en) | 2009-08-14 | 2011-02-17 | Revivicor, Inc. | Multi-transgenic pigs for diabetes treatment |
| US8354389B2 (en) | 2009-08-14 | 2013-01-15 | Regeneron Pharmaceuticals, Inc. | miRNA-regulated differentiation-dependent self-deleting cassette |
| WO2013030588A1 (en) * | 2011-08-31 | 2013-03-07 | The University Of Manchester | Method for diagnosing a neurodegenerative disease |
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| EP3442596A1 (en) | 2016-04-14 | 2019-02-20 | Université de Lausanne | Treatment and/or prevention of dna-triplet repeat diseases or disorders |
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| SG10202102997UA (en) | 2016-09-30 | 2021-04-29 | Regeneron Pharma | Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus |
| JP7211940B2 (en) | 2016-10-28 | 2023-01-24 | ジェネトン | Compositions and methods for the treatment of myotonic dystrophy |
| EP3532615A1 (en) | 2016-10-28 | 2019-09-04 | Genethon | Compositions and methods for the treatment of myotonic dystrophy |
| WO2018165541A1 (en) | 2017-03-10 | 2018-09-13 | The Board Of Regents Of The University Of Texas System | Treatment of fuchs' endothelial corneal dystrophy |
| JP7327803B2 (en) | 2017-05-09 | 2023-08-16 | ユニバーシティ オブ マサチューセッツ | Method of treating amyotrophic lateral sclerosis (ALS) |
| CN111526720B (en) | 2017-10-24 | 2023-01-31 | 桑格摩生物治疗股份有限公司 | Methods and compositions for treating rare diseases |
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2016
- 2016-05-26 EP EP16731693.4A patent/EP3302048B1/en active Active
- 2016-05-26 WO PCT/US2016/034304 patent/WO2016196185A1/en active Application Filing
- 2016-05-26 KR KR1020177037383A patent/KR102190661B1/en active IP Right Grant
- 2016-05-26 CN CN201680031520.6A patent/CN107920498A/en active Pending
- 2016-05-26 KR KR1020207035238A patent/KR102377189B1/en active IP Right Grant
- 2016-05-26 AU AU2016270587A patent/AU2016270587B2/en active Active
- 2016-05-26 CA CA2986048A patent/CA2986048C/en active Active
- 2016-05-26 SG SG10201911257YA patent/SG10201911257YA/en unknown
- 2016-05-26 MX MX2017015369A patent/MX2017015369A/en unknown
- 2016-05-26 BR BR112017025507-3A patent/BR112017025507A2/en not_active Application Discontinuation
- 2016-05-26 JP JP2017561678A patent/JP6619822B2/en active Active
- 2016-05-26 US US15/165,307 patent/US10285388B2/en active Active
- 2016-05-26 RU RU2017145143A patent/RU2725737C2/en active
- 2016-05-26 ES ES16731693T patent/ES2784360T3/en active Active
- 2016-05-26 EP EP20158032.1A patent/EP3689139A1/en active Pending
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2017
- 2017-11-01 IL IL255385A patent/IL255385A0/en active IP Right Grant
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2018
- 2018-06-08 HK HK18107516.0A patent/HK1248465A1/en unknown
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2019
- 2019-03-27 US US16/366,826 patent/US11547101B2/en active Active
- 2019-09-09 JP JP2019163680A patent/JP6884831B2/en active Active
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2021
- 2021-03-24 AU AU2021201827A patent/AU2021201827B2/en active Active
- 2021-05-12 JP JP2021080959A patent/JP2021118745A/en not_active Withdrawn
- 2021-09-05 IL IL286176A patent/IL286176A/en unknown