RU2016110223A - 5-aryl-4-benzoyl-3-hydroxy-1- (4-guanidylsulfonylphenyl) -3-pyrrolin-2-ones analgesics - Google Patents

5-aryl-4-benzoyl-3-hydroxy-1- (4-guanidylsulfonylphenyl) -3-pyrrolin-2-ones analgesics Download PDF

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RU2016110223A
RU2016110223A RU2016110223A RU2016110223A RU2016110223A RU 2016110223 A RU2016110223 A RU 2016110223A RU 2016110223 A RU2016110223 A RU 2016110223A RU 2016110223 A RU2016110223 A RU 2016110223A RU 2016110223 A RU2016110223 A RU 2016110223A
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Russia
Prior art keywords
guanidylsulfonylphenyl
pyrrolin
benzoyl
aryl
hydroxy
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RU2016110223A
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Russian (ru)
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RU2644161C2 (en
Inventor
Владимир Леонидович Гейн
Ольга Васильевна Бобровская
Ирина Валерьевна Ковтоногова
Светлана Викторовна Чащина
Игорь Борисович Яковлев
Original Assignee
государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ПГФА Минздрава России)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (2)

Анальгетические средства на основе 5-арил-4-бензоил-3-гидрокси-1-(4-гуанидилсульфонилфенил)-3-пирролин-2-онов указанной формулы:Analgesic agents based on 5-aryl-4-benzoyl-3-hydroxy-1- (4-guanidylsulfonylphenyl) -3-pyrrolin-2-ones of the indicated formula:
Figure 00000001
Figure 00000001
RU2016110223A 2016-03-21 2016-03-21 Analgesic agents based on 5-aryl-4-benzoyl-3-hydroxy-1-(4-guanidylsulfonylphenyl)-3-pyrrolin-2-ones RU2644161C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2016110223A RU2644161C2 (en) 2016-03-21 2016-03-21 Analgesic agents based on 5-aryl-4-benzoyl-3-hydroxy-1-(4-guanidylsulfonylphenyl)-3-pyrrolin-2-ones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016110223A RU2644161C2 (en) 2016-03-21 2016-03-21 Analgesic agents based on 5-aryl-4-benzoyl-3-hydroxy-1-(4-guanidylsulfonylphenyl)-3-pyrrolin-2-ones

Publications (2)

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RU2016110223A true RU2016110223A (en) 2017-09-26
RU2644161C2 RU2644161C2 (en) 2018-02-08

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RU2016110223A RU2644161C2 (en) 2016-03-21 2016-03-21 Analgesic agents based on 5-aryl-4-benzoyl-3-hydroxy-1-(4-guanidylsulfonylphenyl)-3-pyrrolin-2-ones

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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2259369C2 (en) * 2003-11-04 2005-08-27 Пермская государственная фармацевтическая академия 5-aryl-1-phenyl-4-heteroyl-3-hydroxy-3-pyrroline-2-ones eliciting antibacterial activity
RU2429229C1 (en) * 2009-12-28 2011-09-20 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ПГФА Росздрава) 5-(4-hydroxyphenyl)-4-(4-methoxybenzoyl)-3-hydroxy-1-(2,2-dimethoxyethyl)-3-pyrrolin-2-one, exhibiting analgesic and antipyretic properties

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Effective date: 20180322