RU2016102983A - METHOD FOR PRODUCING FURACILIN - Google Patents

METHOD FOR PRODUCING FURACILIN Download PDF

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Publication number
RU2016102983A
RU2016102983A RU2016102983A RU2016102983A RU2016102983A RU 2016102983 A RU2016102983 A RU 2016102983A RU 2016102983 A RU2016102983 A RU 2016102983A RU 2016102983 A RU2016102983 A RU 2016102983A RU 2016102983 A RU2016102983 A RU 2016102983A
Authority
RU
Russia
Prior art keywords
producing
furacilin
sulfuric acid
semicarbazide
base
Prior art date
Application number
RU2016102983A
Other languages
Russian (ru)
Other versions
RU2673491C2 (en
Inventor
Людмила Александровна Солодухина
Людмила Александровна Абросимова
Original Assignee
Открытое акционерное общество "Ирбитский химико-фармацевтический завод"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Открытое акционерное общество "Ирбитский химико-фармацевтический завод" filed Critical Открытое акционерное общество "Ирбитский химико-фармацевтический завод"
Priority to RU2016102983A priority Critical patent/RU2673491C2/en
Publication of RU2016102983A publication Critical patent/RU2016102983A/en
Application granted granted Critical
Publication of RU2673491C2 publication Critical patent/RU2673491C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/345—Nitrofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C07D307/48—Furfural

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (1)

Способ получения фурацилина, по которому осуществляют конденсацию 5-нитрофурфурола с семикарбазидом основанием, полученным конденсацией гидразин-гидрата и мочевины, отличающийся тем, что при получении семикарбазида основания в реакционную массу до ее разбавления водой и охлаждения добавляют серную кислоту для получения рН реакционной массы в пределах 3,5-4,5, при этом для конденсации 5-нитрофурфурола с семикарбазидом основанием используют раствор воды и серной кислоты с процентным содержанием серной кислоты в растворе 4-9%.A method of producing furatsilin, in which 5-nitrofurfurol is condensed with semicarbazide with a base obtained by condensation of hydrazine hydrate and urea, characterized in that upon receipt of the semicarbazide base in the reaction mass, sulfuric acid is added to it to be diluted with water and cooled to obtain a pH of the reaction mass within 3.5-4.5, while for the condensation of 5-nitrofurfural with semicarbazide base, a solution of water and sulfuric acid with a percentage of sulfuric acid in the solution of 4-9% is used.
RU2016102983A 2016-01-29 2016-01-29 Method for obtaining furacilin RU2673491C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2016102983A RU2673491C2 (en) 2016-01-29 2016-01-29 Method for obtaining furacilin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016102983A RU2673491C2 (en) 2016-01-29 2016-01-29 Method for obtaining furacilin

Publications (2)

Publication Number Publication Date
RU2016102983A true RU2016102983A (en) 2017-08-03
RU2673491C2 RU2673491C2 (en) 2018-11-27

Family

ID=59631957

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016102983A RU2673491C2 (en) 2016-01-29 2016-01-29 Method for obtaining furacilin

Country Status (1)

Country Link
RU (1) RU2673491C2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238226A (en) * 1962-02-19 1966-03-01 Nat Polychemicals Inc Synthesis of hydrazine, semi-carbazide, and hydrazinedicarbonamide
US4482738A (en) * 1983-08-01 1984-11-13 Olin Corporation Process for preparing semicarbazide hydrochloride

Also Published As

Publication number Publication date
RU2673491C2 (en) 2018-11-27

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