RU2015140599A - UREA DERIVATIVES AND THEIR APPLICATION AS PROTEIN INHIBITORS, BINDING FATTY ACIDS - Google Patents
UREA DERIVATIVES AND THEIR APPLICATION AS PROTEIN INHIBITORS, BINDING FATTY ACIDS Download PDFInfo
- Publication number
- RU2015140599A RU2015140599A RU2015140599A RU2015140599A RU2015140599A RU 2015140599 A RU2015140599 A RU 2015140599A RU 2015140599 A RU2015140599 A RU 2015140599A RU 2015140599 A RU2015140599 A RU 2015140599A RU 2015140599 A RU2015140599 A RU 2015140599A
- Authority
- RU
- Russia
- Prior art keywords
- substituted
- ureido
- cycloalkyl
- compound according
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
- C07C273/1863—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety from urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
Claims (56)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13160088.4 | 2013-03-20 | ||
EP13160088 | 2013-03-20 | ||
PCT/EP2014/055224 WO2014146995A1 (en) | 2013-03-20 | 2014-03-17 | Urea derivatives and their use as fatty-acid binding protein (fabp) inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2015140599A true RU2015140599A (en) | 2017-04-26 |
RU2642454C2 RU2642454C2 (en) | 2018-01-25 |
Family
ID=47900931
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2015140599A RU2642454C2 (en) | 2013-03-20 | 2014-03-17 | Urea derivatives and their application as inhibitors of fatty acids connecting protein |
Country Status (13)
Country | Link |
---|---|
US (1) | US9278918B2 (en) |
EP (1) | EP2991967A1 (en) |
JP (1) | JP6235048B2 (en) |
KR (1) | KR101804650B1 (en) |
CN (1) | CN105308020B (en) |
AR (1) | AR095570A1 (en) |
BR (1) | BR112015024109A2 (en) |
CA (1) | CA2898534C (en) |
HK (1) | HK1214238A1 (en) |
MX (1) | MX2015013365A (en) |
RU (1) | RU2642454C2 (en) |
TW (1) | TWI629258B (en) |
WO (1) | WO2014146995A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10421756B2 (en) | 2015-07-06 | 2019-09-24 | Rodin Therapeutics, Inc. | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase |
HUE057041T2 (en) | 2015-07-06 | 2022-04-28 | Alkermes Inc | Hetero-halo inhibitors of histone deacetylase |
SG10201912107UA (en) | 2016-10-06 | 2020-02-27 | Daiichi Sankyo Co Ltd | Urea derivative |
PL3570834T3 (en) | 2017-01-11 | 2022-05-23 | Alkermes, Inc. | Bicyclic inhibitors of histone deacetylase |
RS63343B1 (en) | 2017-08-07 | 2022-07-29 | Alkermes Inc | Bicyclic inhibitors of histone deacetylase |
CN113401281B (en) * | 2021-08-17 | 2021-11-02 | 南通御美津精密工业有限公司 | Closing device for ship body anchor recess outer plate opening |
KR20240065110A (en) * | 2021-09-15 | 2024-05-14 | 셀로람 인코포레이티드 | FABP4/5 inhibitors, methods of use and preparation |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0091596B1 (en) * | 1982-04-08 | 1991-09-11 | Shell Internationale Researchmaatschappij B.V. | Hydantoins, their preparation and application |
IL135176A0 (en) * | 1997-11-10 | 2001-05-20 | Bristol Myers Squibb Co | Benzothiazole derivatives and pharmaceutical compositions containing the same |
US6727247B2 (en) * | 2001-12-10 | 2004-04-27 | Hoffman-La Roche Inc. | Substituted benzothiazole amide derivatives |
ATE430728T1 (en) * | 2002-10-21 | 2009-05-15 | Janssen Pharmaceutica Nv | SUBSTITUTED TETRALINES AND INDANES AND THEIR USE |
US7202269B2 (en) | 2003-10-30 | 2007-04-10 | Janssen Pharmaceutica N.V. | GlyT2 modulators |
FR2869903B1 (en) * | 2004-05-06 | 2006-06-23 | Galderma Res & Dev | NOVEL BI-AROMATIC RECEPTOR ACTIVATOR COMPOUNDS OF THE PPARY TYPE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS |
JP4047365B2 (en) * | 2006-01-11 | 2008-02-13 | 生化学工業株式会社 | Cycloalkanecarboxamide derivative and method for producing the same |
EP2040690B1 (en) * | 2006-06-28 | 2014-08-06 | Sanofi | Inhibitors of cxcr2 |
US20120004273A1 (en) * | 2007-01-20 | 2012-01-05 | Nadia Mamoona Ahmad | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
WO2009034062A1 (en) * | 2007-09-11 | 2009-03-19 | Glaxo Group Limited | Compounds which inhibit the glycine transporter and uses thereof in medicine |
AU2009314299A1 (en) * | 2008-11-12 | 2010-05-20 | Merck Sharp & Dohme Corp. | Inhibitors of fatty acid binding protein (FABP) |
-
2014
- 2014-03-17 BR BR112015024109A patent/BR112015024109A2/en not_active Application Discontinuation
- 2014-03-17 MX MX2015013365A patent/MX2015013365A/en active IP Right Grant
- 2014-03-17 JP JP2015560724A patent/JP6235048B2/en not_active Expired - Fee Related
- 2014-03-17 EP EP14710294.1A patent/EP2991967A1/en not_active Withdrawn
- 2014-03-17 CA CA2898534A patent/CA2898534C/en active Active
- 2014-03-17 AR ARP140101193A patent/AR095570A1/en unknown
- 2014-03-17 RU RU2015140599A patent/RU2642454C2/en active
- 2014-03-17 TW TW103109994A patent/TWI629258B/en not_active IP Right Cessation
- 2014-03-17 KR KR1020157025421A patent/KR101804650B1/en active IP Right Grant
- 2014-03-17 WO PCT/EP2014/055224 patent/WO2014146995A1/en active Application Filing
- 2014-03-17 CN CN201480016538.XA patent/CN105308020B/en not_active Expired - Fee Related
-
2015
- 2015-09-17 US US14/857,007 patent/US9278918B2/en not_active Expired - Fee Related
-
2016
- 2016-02-23 HK HK16102014.0A patent/HK1214238A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR101804650B1 (en) | 2018-01-10 |
WO2014146995A1 (en) | 2014-09-25 |
CA2898534C (en) | 2017-09-19 |
BR112015024109A2 (en) | 2017-07-18 |
MX2015013365A (en) | 2016-01-08 |
CN105308020B (en) | 2018-01-26 |
US9278918B2 (en) | 2016-03-08 |
EP2991967A1 (en) | 2016-03-09 |
CN105308020A (en) | 2016-02-03 |
US20160002152A1 (en) | 2016-01-07 |
HK1214238A1 (en) | 2016-07-22 |
RU2642454C2 (en) | 2018-01-25 |
JP2016514106A (en) | 2016-05-19 |
AR095570A1 (en) | 2015-10-28 |
JP6235048B2 (en) | 2017-11-22 |
CA2898534A1 (en) | 2014-09-25 |
KR20150119357A (en) | 2015-10-23 |
TW201514138A (en) | 2015-04-16 |
TWI629258B (en) | 2018-07-11 |
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