RU2015134067A - The method of processing calcium phosphate coatings on implants - Google Patents

The method of processing calcium phosphate coatings on implants Download PDF

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Publication number
RU2015134067A
RU2015134067A RU2015134067A RU2015134067A RU2015134067A RU 2015134067 A RU2015134067 A RU 2015134067A RU 2015134067 A RU2015134067 A RU 2015134067A RU 2015134067 A RU2015134067 A RU 2015134067A RU 2015134067 A RU2015134067 A RU 2015134067A
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RU
Russia
Prior art keywords
calcium phosphate
solution
product
temperature
metabolites
Prior art date
Application number
RU2015134067A
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Russian (ru)
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RU2617252C2 (en
Inventor
Александр Анатольевич Марков
Леонид Борисович Козлов
Татьяна Харитоновна Тимохина
Константин Сергеевич Сергеев
Андрей Михайлович Машкин
Наталья Борисовна Перунова
Ирина Васильевна Медведева
Original Assignee
федеральное государственное бюджетное образовательное учреждение высшего образования "Тюменский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Тюменский ГМУ Минздрава России)
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Application filed by федеральное государственное бюджетное образовательное учреждение высшего образования "Тюменский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Тюменский ГМУ Минздрава России) filed Critical федеральное государственное бюджетное образовательное учреждение высшего образования "Тюменский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Тюменский ГМУ Минздрава России)
Priority to RU2015134067A priority Critical patent/RU2617252C2/en
Publication of RU2015134067A publication Critical patent/RU2015134067A/en
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Publication of RU2617252C2 publication Critical patent/RU2617252C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (1)

Способ обработки кальций-фосфатных покрытий на имплантатах включает внесение фосфата кальция в 5-20%=ный раствор ортофосфорной кислоты до насыщения, имплантат помещают в этот раствор и проводят гальваническое нанесение кальция-фосфатного покрытия при напряжении 80-400 B, частоте импульсов 50-150 Гц, плотности тока 0,2-1,0 А/мм2, в течение 10-60 мин, времени импульсов 50-300 мкс, pH электролита 6,5-8,0 и температуре электролита 25-40°C, изделие промывают дистиллированной водой, проводят обжиг изделия при температуре 400-1200°C в течение 30-60 мин до образования коралловидной разветвленной структуры покрытия толщиной 5-80 мкм, затем изделие помещают в раствор с метаболитами пробиотика на 10-30 мин при температуре 18-25°C, а раствор с метаболитами получают следующим образом: жидкую питательную среду с бактериями в стационарной фазе и/или фазе отмирания бактерий пропускают через бактериальный фильтр для получения чистой взвеси метаболитов бактерий.A method for processing calcium phosphate coatings on implants involves the addition of calcium phosphate in a 5-20% = phosphoric acid solution to saturation, the implant is placed in this solution and galvanic deposition of calcium phosphate coating is carried out at a voltage of 80-400 V, pulse frequency 50-150 Hz, current density 0.2-1.0 A / mm 2 , for 10-60 minutes, pulse time 50-300 μs, pH of the electrolyte 6.5-8.0 and the temperature of the electrolyte 25-40 ° C, the product is washed distilled water, the product is fired at a temperature of 400-1200 ° C for 30-60 minutes until the formation of coral visible branched coating structure with a thickness of 5-80 microns, then the product is placed in a solution with probiotic metabolites for 10-30 minutes at a temperature of 18-25 ° C, and a solution with metabolites is obtained as follows: a liquid nutrient medium with bacteria in the stationary phase and / or during the death phase, bacteria are passed through a bacterial filter to obtain a clean suspension of bacterial metabolites.
RU2015134067A 2015-08-14 2015-08-14 Method of calcium-phosphate coatings processing on implants RU2617252C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2015134067A RU2617252C2 (en) 2015-08-14 2015-08-14 Method of calcium-phosphate coatings processing on implants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2015134067A RU2617252C2 (en) 2015-08-14 2015-08-14 Method of calcium-phosphate coatings processing on implants

Publications (2)

Publication Number Publication Date
RU2015134067A true RU2015134067A (en) 2017-02-20
RU2617252C2 RU2617252C2 (en) 2017-04-24

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RU2015134067A RU2617252C2 (en) 2015-08-14 2015-08-14 Method of calcium-phosphate coatings processing on implants

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU184036U1 (en) * 2018-03-06 2018-10-12 Александр Викторович Валентиенко Dental capillary-porous implant for weak bone tissue

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2206642C2 (en) * 2000-01-31 2003-06-20 Мамаев Анатолий Иванович Method for modifying medical products (alternatives)
RU2394601C2 (en) * 2008-10-09 2010-07-20 Федеральное агентство по науке и инновациям Method of modifying surface of implants from titanium and its alloys
RU2423150C1 (en) * 2009-11-23 2011-07-10 Государственное образовательное учреждение высшего профессионального образования "Томский политехнический университет" Calcium-phosphate biologically active coating of implant and method of deposition

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RU2617252C2 (en) 2017-04-24

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Effective date: 20190815