RU2015116931A - Усовершенствованный способ очистки факторов роста молока и их продукты - Google Patents
Усовершенствованный способ очистки факторов роста молока и их продукты Download PDFInfo
- Publication number
- RU2015116931A RU2015116931A RU2015116931A RU2015116931A RU2015116931A RU 2015116931 A RU2015116931 A RU 2015116931A RU 2015116931 A RU2015116931 A RU 2015116931A RU 2015116931 A RU2015116931 A RU 2015116931A RU 2015116931 A RU2015116931 A RU 2015116931A
- Authority
- RU
- Russia
- Prior art keywords
- lactoferrin
- growth factors
- milk
- rnase
- treatment
- Prior art date
Links
- 239000003102 growth factor Substances 0.000 title claims abstract 22
- 238000000034 method Methods 0.000 title claims abstract 21
- 235000013336 milk Nutrition 0.000 title claims abstract 21
- 239000008267 milk Substances 0.000 title claims abstract 21
- 210000004080 milk Anatomy 0.000 title claims abstract 21
- 238000004140 cleaning Methods 0.000 title 1
- 108010063045 Lactoferrin Proteins 0.000 claims abstract 25
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims abstract 25
- 235000021242 lactoferrin Nutrition 0.000 claims abstract 25
- 229940078795 lactoferrin Drugs 0.000 claims abstract 25
- 238000001914 filtration Methods 0.000 claims abstract 19
- 150000003839 salts Chemical class 0.000 claims abstract 19
- 102000006382 Ribonucleases Human genes 0.000 claims abstract 14
- 108010083644 Ribonucleases Proteins 0.000 claims abstract 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract 10
- 239000000706 filtrate Substances 0.000 claims abstract 10
- 239000011780 sodium chloride Substances 0.000 claims abstract 5
- 238000000746 purification Methods 0.000 claims abstract 2
- 102100032241 Lactotransferrin Human genes 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 5
- 210000003205 muscle Anatomy 0.000 claims 4
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 102100022987 Angiogenin Human genes 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 206010061728 Bone lesion Diseases 0.000 claims 1
- 102000016970 Follistatin Human genes 0.000 claims 1
- 108010014612 Follistatin Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 108010056852 Myostatin Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 108010072788 angiogenin Proteins 0.000 claims 1
- 230000037182 bone density Effects 0.000 claims 1
- 208000016253 exhaustion Diseases 0.000 claims 1
- 230000014101 glucose homeostasis Effects 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000004379 membrane Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 230000037257 muscle growth Effects 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 102000010445 Lactoferrin Human genes 0.000 abstract 10
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Water Supply & Treatment (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2012904391A AU2012904391A0 (en) | 2012-10-08 | Improved process for purifying milk proteins and products thereof | |
| AU2012904391 | 2012-10-08 | ||
| AU2013204850 | 2013-04-12 | ||
| AU2013204850A AU2013204850B2 (en) | 2012-10-08 | 2013-04-12 | Improved process for purifying milk proteins and products thereof |
| PCT/AU2013/001154 WO2014056026A1 (en) | 2012-10-08 | 2013-10-08 | Improved process for purifying growth factors from milk and products thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015116931A true RU2015116931A (ru) | 2016-11-27 |
Family
ID=50476774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015116931A RU2015116931A (ru) | 2012-10-08 | 2013-10-08 | Усовершенствованный способ очистки факторов роста молока и их продукты |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20150232823A1 (enExample) |
| EP (1) | EP2904007A4 (enExample) |
| JP (1) | JP2016500662A (enExample) |
| KR (1) | KR20150079618A (enExample) |
| CN (1) | CN104736560A (enExample) |
| AU (1) | AU2013204850B2 (enExample) |
| BR (1) | BR112015007675A2 (enExample) |
| CA (1) | CA2887003A1 (enExample) |
| IN (1) | IN2015DN02968A (enExample) |
| NZ (1) | NZ631827A (enExample) |
| RU (1) | RU2015116931A (enExample) |
| WO (1) | WO2014056026A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3636657A1 (en) | 2018-10-08 | 2020-04-15 | Ablynx N.V. | Chromatography-free antibody purification method |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2584727B1 (fr) * | 1985-07-11 | 1988-06-17 | Roussel Uclaf | Procede d'extraction de proteines du lait, produits, application du procede, et compositions pharmaceutiques |
| US5221734A (en) * | 1987-10-01 | 1993-06-22 | Ciba-Geigy Corporation | Process for preparing a polypeptide growth factor for milk |
| GB8729031D0 (en) * | 1987-12-11 | 1988-01-27 | Express Foods Group Ltd | Isolation of immunoglobulin rich fraction from whey |
| JPH05202098A (ja) * | 1992-01-29 | 1993-08-10 | Snow Brand Milk Prod Co Ltd | 乳質原料から生理活性物質の製造法 |
| JPH09509165A (ja) * | 1994-02-16 | 1997-09-16 | ファーミング ベスローテン フェンノートシャップ | ミルクからのラクトフェリンの分離 |
| AUPM534794A0 (en) * | 1994-04-28 | 1994-05-19 | Gropep Pty Ltd | Modified milk growth factor |
| NL1005677C2 (nl) * | 1997-03-27 | 1998-09-29 | Campina Melkunie Bv | Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan. |
| EP1409538B1 (en) * | 2001-07-20 | 2009-01-07 | Campina B.V. | Process for obtaining growth factor (tgf-beta and igf-1), lactoperoxidase and immunoglobulins preparations from milk products having low mutual cross-contamination |
| US6875459B2 (en) * | 2001-09-10 | 2005-04-05 | Henry B. Kopf | Method and apparatus for separation of milk, colostrum, and whey |
| CN101027080A (zh) * | 2004-03-04 | 2007-08-29 | Gtc生物治疗有限公司 | 用高效切向流过滤进行蛋白质分级的方法 |
| US20050208638A1 (en) * | 2004-03-22 | 2005-09-22 | Chao Wu | Process for preparing bioactive protein-enriched whey products |
| WO2006029518A1 (en) * | 2004-09-14 | 2006-03-23 | Nexcell Biosciences Inc. | Isolation of growth and differentiating factors from colostrum |
| FR2901796A1 (fr) * | 2006-05-31 | 2007-12-07 | Lab Francais Du Fractionnement | Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait |
| CN101724013B (zh) * | 2008-10-24 | 2012-05-30 | 哈尔滨康普乳品有限公司 | 从牛初乳中工业化分离纯化免疫球蛋白a、免疫球蛋白g和乳铁蛋白的方法 |
| RU2579661C2 (ru) * | 2009-01-28 | 2016-04-10 | Жан-Поль ПЕРРОДЭН | Способ производства лактоферрина, фракция, содержащая лактоферрин, и ее применения |
| WO2011113100A1 (en) * | 2010-03-17 | 2011-09-22 | Murray Goulburn Co-Operative Co. Limited | Method of treating a bone disorder |
-
2013
- 2013-04-12 AU AU2013204850A patent/AU2013204850B2/en not_active Ceased
- 2013-10-08 BR BR112015007675A patent/BR112015007675A2/pt not_active IP Right Cessation
- 2013-10-08 JP JP2015534885A patent/JP2016500662A/ja active Pending
- 2013-10-08 WO PCT/AU2013/001154 patent/WO2014056026A1/en not_active Ceased
- 2013-10-08 CN CN201380055327.2A patent/CN104736560A/zh active Pending
- 2013-10-08 CA CA 2887003 patent/CA2887003A1/en not_active Abandoned
- 2013-10-08 US US14/434,272 patent/US20150232823A1/en not_active Abandoned
- 2013-10-08 NZ NZ631827A patent/NZ631827A/en not_active IP Right Cessation
- 2013-10-08 KR KR1020157010221A patent/KR20150079618A/ko not_active Withdrawn
- 2013-10-08 EP EP13844822.0A patent/EP2904007A4/en not_active Withdrawn
- 2013-10-08 RU RU2015116931A patent/RU2015116931A/ru not_active Application Discontinuation
-
2015
- 2015-04-09 IN IN2968DEN2015 patent/IN2015DN02968A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013204850A1 (en) | 2014-04-24 |
| WO2014056026A1 (en) | 2014-04-17 |
| AU2013204850B2 (en) | 2015-06-25 |
| EP2904007A4 (en) | 2016-05-18 |
| JP2016500662A (ja) | 2016-01-14 |
| EP2904007A1 (en) | 2015-08-12 |
| IN2015DN02968A (enExample) | 2015-09-18 |
| BR112015007675A2 (pt) | 2017-07-04 |
| US20150232823A1 (en) | 2015-08-20 |
| KR20150079618A (ko) | 2015-07-08 |
| CN104736560A (zh) | 2015-06-24 |
| NZ631827A (en) | 2017-01-27 |
| CA2887003A1 (en) | 2014-04-17 |
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